Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Axis]
Regulatory and sales milestones
Regulatory And Sales Milestones [Member]
Regulatory and sales milestones.
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Healios Framework Agreement
Healios Framework Agreement [Member]
Healios Framework Agreement
Income Statement [Abstract]
Income Statement [Abstract]
Stock options granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Healios
Healios License Agreement [Member]
Healios license agreement.
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Document Fiscal Period Focus
Document Fiscal Period Focus
Deposits and other
Deposits And Other Assets Non Current
Deposits And Other Assets Non Current
Property, Plant and Equipment [Abstract]
Weighted average shares outstanding, diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Preferred stock, shares outstanding (in shares)
Preferred stock shares, beginning balance (in shares)
Preferred stock shares, ending balance (in shares)
Preferred Stock, Shares Outstanding
Accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Property and equipment, gross
Property, Plant and Equipment, Gross
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Accrual, beginning balance
Accrual, ending balance
Restructuring Reserve
Common stock, $0.001 par value; 600,000,000 shares authorized with 275,109,746 and 242,844,180 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively
Common Stock, Value, Issued
Revenue recognized from performance obligations satisfied in previous periods
Contract with Customer, Performance Obligation Satisfied in Previous Period
Preferred Stock
Preferred Stock [Member]
Statistical Measurement [Domain]
Statistical Measurement [Domain]
Depreciation
Depreciation
Number of material performance obligations
Number Of Material Performance Obligations
Number Of Material Performance Obligations
Schedule of Instruments Excluded from Calculation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Additional paid-in capital
Additional Paid in Capital, Common Stock
Award exercise price (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Cash and cash equivalents at beginning of the period
Cash and cash equivalents at end of the period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Current liabilities:
Liabilities, Current [Abstract]
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Net loss
Net Income (Loss) Attributable to Parent
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Deferred revenue - Healios
Contract with Customer, Liability, Current
Stock-based awards (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Over Time
Transferred over Time [Member]
Equity Component [Domain]
Equity Component [Domain]
Amendment Flag
Amendment Flag
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Accounts payable to Healios
Accounts Payable, Related Parties, Current
Net loss and comprehensive loss
Net and comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Vesting percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Related Party [Domain]
Related Party [Domain]
Plan Name [Axis]
Plan Name [Axis]
Entity Current Reporting Status
Entity Current Reporting Status
Cash payments
Payments for Restructuring
Shares of common stock outstanding (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Common Stock, Outstanding, Number
Share-based Compensation Arrangement by Share-based Payment Award, Common Stock, Outstanding, Number
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Number of business segments
Number of Operating Segments
Chief Executive Officer
Chief Executive Officer [Member]
Consolidated entity, excluding related party
Consolidated Entity Excluding Related Party [Member]
Consolidated Entity Excluding Related Party [Member]
Employee severance and benefits
Employee Severance [Member]
Plan Name [Domain]
Plan Name [Domain]
Accounts payable to Healios
Increase (Decrease) In Accounts Payable, Related To Collaborative Arrangements
Increase (Decrease) In Accounts Payable, Related To Collaborative Arrangements
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Counterparty Name [Axis]
Counterparty Name [Axis]
Award Type [Axis]
Award Type [Axis]
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Operating lease liabilities, current
Operating Lease, Liability, Current
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Costs and expenses
Costs and Expenses [Abstract]
Equity purchase agreement, value
Stock Issuable During Period Value Equity Purchase Agreement
Stock issuable during period value equity purchase agreement.
Title of Individual [Domain]
Title of Individual [Domain]
Change in Accounting Estimate by Type [Axis]
Change in Accounting Estimate by Type [Axis]
Other income (expense), net
Other Nonoperating Income (Expense)
Change in Accounting Estimate, Type [Domain]
Change in Accounting Estimate, Type [Domain]
Restructuring Charges
Restructuring and Related Activities Disclosure [Text Block]
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Maximum
Maximum [Member]
Investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Issuance of common stock
Stock Issued During Period, Value, New Issues
2019 Equity And Incentive Compensation Plan
2019 Equity And Incentive Compensation Plan [Member]
2019 Equity And Incentive Compensation Plan [Member]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Stock-based awards
Share-Based Payment Arrangement [Member]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Deferred revenue - Healios
Increase (Decrease) in Contract with Customer, Liability
Total current assets
Assets, Current
Schedule of Property and Equipment, net
Property, Plant and Equipment [Table Text Block]
Exercise period (in days)
Class Of Warrant Or Right, Exercise Period
Class Of Warrant Or Right, Exercise Period
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Document Type
Document Type
Revenue recognized
Contract with Customer, Liability, Revenue Recognized
Point in Time
Transferred at Point in Time [Member]
Entity Small Business
Entity Small Business
Stockholders’ Equity and Warrants
Stockholders' Equity Note Disclosure [Text Block]
Operating right-of-use assets, net
Operating Lease, Right-of-Use Asset, Amortization Expense
Expected compensation expense per month
Salary And Wage, Officer, Expected Compensation Expense Per Month
Salary And Wage, Officer, Expected Compensation Expense Per Month
Revenues
Revenues [Abstract]
Restructuring Type [Axis]
Restructuring Type [Axis]
Product and Service [Domain]
Product and Service [Domain]
Unrecognized compensation cost of unvested stock awards
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Entity Shell Company
Entity Shell Company
Percentage of reduction in workforce
Restructuring And Related Cost, Reduction In Workforce, Percentage
Restructuring And Related Cost, Reduction In Workforce, Percentage
Property and Equipment, net
Property, Plant and Equipment Disclosure [Text Block]
The Inducement Award, Four-Year Vesting
The Inducement Award, Four-Year Vesting [Member]
The Inducement Award, Four-Year Vesting
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset [Domain]
Title of 12(b) Security
Title of 12(b) Security
Background and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Healios
Healios
Affiliated Entity [Member]
Consolidated Entities [Axis]
Consolidated Entities [Axis]
Subsequent Event
Subsequent Event [Member]
Document Period End Date
Document Period End Date
Tranche One
Share-Based Payment Arrangement, Tranche One [Member]
Total costs and expenses
Costs and Expenses
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Class of Stock [Line Items]
Class of Stock [Line Items]
Issuance of common stock under equity compensation plan (in shares)
Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture
Total assets
Assets
Earnings Per Share [Abstract]
Earnings Per Share [Abstract]
Income Statement Location [Axis]
Income Statement Location [Axis]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Accrued expenses and other
Accrued Liabilities, Current
Schedule of Restructuring and Related Costs [Table]
Schedule of Restructuring and Related Costs [Table]
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Accrued compensation and related benefits
Employee-related Liabilities, Current
Accounts payable
Accounts Payable, Current
Restructuring charges
Charges
Restructuring Charges
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Prepaid expenses and other
Prepaid Expense and Other Assets, Current
Net Loss per Share
Earnings Per Share [Text Block]
Healios warrants
Warrant [Member]
Entity Filer Category
Entity Filer Category
Proceeds from issuance of common stock, net of issuance cost
Proceeds from Issuance of Common Stock
Weighted average shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Award Type [Domain]
Award Type [Domain]
Shares called by warrants (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Non-Cash Transactions
Restructuring Reserve, Settled without Cash
Inducement Awards Plan
Inducement Awards Plan [Member]
Inducement Awards Plan [Member]
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Entity Registrant Name
Entity Registrant Name
Security Exchange Name
Security Exchange Name
Issuance of common stock (in shares)
Issuance of common stock, new issues (in shares)
Stock Issued During Period, Shares, New Issues
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Subsequent Events
Subsequent Events [Text Block]
Preferred stock, at stated value; 10,000,000 shares authorized, and no shares issued and outstanding at June 30, 2022 and December 31, 2021
Preferred Stock, Value, Issued
Restructuring Reserve [Roll Forward]
Restructuring Reserve [Roll Forward]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
General and Administrative Expense
General and Administrative Expense [Member]
Contract revenue from Healios
Total disaggregated revenues
Revenue from Contract with Customer, Excluding Assessed Tax
Entity Address, City or Town
Entity Address, City or Town
Accounts receivable from Healios - billed and unbilled
Increase (Decrease) in Accounts Receivable, Related Parties
Cover [Abstract]
Restructuring and Related Activities [Abstract]
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Minimum
Minimum [Member]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Entity Emerging Growth Company
Entity Emerging Growth Company
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Going Concern
Substantial Doubt about Going Concern [Text Block]
Shares retained for withholding tax payments on stock-based awards
Payment, Tax Withholding, Share-Based Payment Arrangement
Total liabilities and stockholders’ equity
Liabilities and Equity
Trading Symbol
Trading Symbol
Entity File Number
Entity File Number
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Related Party [Axis]
Related Party [Axis]
Timing of Transfer of Good or Service [Domain]
Timing of Transfer of Good or Service [Domain]
Advance from Healios
Contract with Customer, Liability, Noncurrent
Research and development
Research and Development Expense
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accelerated depreciation
Restructuring and Related Cost, Accelerated Depreciation
Laboratory equipment
Equipment [Member]
Title of Individual [Axis]
Title of Individual [Axis]
Restricted stock units granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Current Fiscal Year End Date
Current Fiscal Year End Date
Vesting [Axis]
Vesting [Axis]
Net loss per share, diluted (in dollars per share)
Earnings Per Share, Diluted
Equipment and leasehold improvements not yet in service
Equipment And Leasehold Improvement Not Yet In Service [Member]
Equipment And Leasehold Improvement Not Yet In Service
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Aspire Capital
Aspire [Member]
Aspire.
Tranche Two
Share-Based Payment Arrangement, Tranche Two [Member]
Awards vesting period (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Subsequent Events [Abstract]
Subsequent Events [Abstract]
Warrant One
Warrant One [Member]
Warrant One
Total revenues
Revenues
Total current liabilities
Liabilities, Current
Other
Other Restructuring [Member]
Accounts payable, accrued expenses and other
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Income Taxes
Income Tax Disclosure [Text Block]
Restructuring Cost and Reserve [Line Items]
Restructuring Cost and Reserve [Line Items]
Milestones obligated to pay
Revenue From Contract With Customer, Milestones Obligation To Pay
Revenue From Contract With Customer, Milestones Obligation To Pay
Exercise price of warrant (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Net loss per share, basic (in dollars per share)
Earnings Per Share, Basic
Award expiration period (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Accounts receivable, payments due within period of invoicing
Contract with Customer, Asset, Threshold Period Past Due
Unbilled accounts receivable
Unbilled Account Receivable Related To Collaborative Arrangements
Unbilled Account Receivable Related To Collaborative Arrangements
Entity Address, Address Line One
Entity Address, Address Line One
Legal and professional fees
Legal And Professional Fees [Member]
Legal And Professional Fees [Member]
Counterparty Name [Domain]
Counterparty Name [Domain]
Purchases of equipment
Payments to Acquire Machinery and Equipment
Total stockholders’ equity (deficit)
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Product and Service [Axis]
Product and Service [Axis]
Vesting [Domain]
Vesting [Domain]
Entity Interactive Data Current
Entity Interactive Data Current
Sale of additional shares at an average price (in dollars per share)
Issuance Of Stock Price Per Share
Issuance of stock price per share.
Chief Operating Officer
Chief Operating Officer [Member]
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Equity [Abstract]
Equity [Abstract]
Accumulated Deficit
Retained Earnings [Member]
Subsequent Event [Table]
Subsequent Event [Table]
Entity Tax Identification Number
Entity Tax Identification Number
Common stock authorized for equity incentive plan (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Common Stock
Common Stock [Member]
Issuance of common stock under equity compensation plan
Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture
Shares available for issuance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Statement [Table]
Statement [Table]
Schedule of Contract Revenues Disaggregated by Timing of Revenue Recognition
Disaggregation of Revenue [Table Text Block]
Document Quarterly Report
Document Quarterly Report
Consolidated Entities [Domain]
Consolidated Entities [Domain]
Current assets:
Assets, Current [Abstract]
Operating lease liabilities, non-current
Operating Lease, Liability, Noncurrent
Unbilled accounts receivable from Healios
Unbilled Receivables, Current
Statistical Measurement [Axis]
Statistical Measurement [Axis]
(Decrease) Increase in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Schedule of Restructuring Reserve by Type of Expenses
Schedule of Restructuring Reserve by Type of Cost [Table Text Block]
Number of future milestones achieved
Number of Future Milestones Achieved
Number of future milestones achieved.
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Accounts receivable from Healios
Accounts Receivable, after Allowance for Credit Loss, Current
Entity Central Index Key
Entity Central Index Key
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Equity Components [Axis]
Equity Components [Axis]
Warrant Two
Warrant Two [Member]
Warrant Two
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Collaborative Arrangements and Revenue Recognition
Collaborative Arrangement Disclosure [Text Block]
Timing of Transfer of Good or Service [Axis]
Timing of Transfer of Good or Service [Axis]
Document Fiscal Year Focus
Document Fiscal Year Focus
Potential revenue from milestones
Revenue From Contract With Customer, Potential Revenue From Milestones
Revenue From Contract With Customer, Potential Revenue From Milestones
Operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
City Area Code
City Area Code
Chief Financial Officer
Chief Financial Officer [Member]
General and administrative
General and Administrative Expense
Assets
Assets [Abstract]
Statement [Line Items]
Statement [Line Items]
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
The Inducement Award
The Inducement Award [Member]
The Inducement Award
Accounting Standards Not Yet Adopted
Accounting Standards Update and Change in Accounting Principle [Text Block]
Financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Operating right-of-use assets, net
Operating Lease, Right-of-Use Asset
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense
Warrants outstanding (in shares)
Warrants issued (in shares)
Class of Warrant or Right, Outstanding
Other long-term liabilities
Other Liabilities, Noncurrent
Type of Restructuring [Domain]
Type of Restructuring [Domain]
Document Transition Report
Document Transition Report
Local Phone Number
Local Phone Number
Ownership percentage in common stock for exercise cap to be triggered
Class Of Warrant Or Right, Common Stock Ownership Percentage Triggered
Class Of Warrant Or Right, Common Stock Ownership Percentage Triggered
The Inducement Award, Performance Based Vesting
The Inducement Award, Performance Based Vesting [Member]
The Inducement Award, Performance Based Vesting
Loss from impairment of assets
Impairment charge of equipment assets
Asset Impairment Charges
Office equipment and leasehold improvements
Office Equipment And Leasehold Improvements [Member]
Office equipment and leasehold improvements.
Loss from operations
Operating Income (Loss)
Accrued clinical trial related costs
Accrued Clinical Trial Costs Current
Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to clinical trial services received from vendors, such as accrued contract research organization costs, patient costs, clinical site costs and clinical product cost. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Research and Development Expense
Research and Development Expense [Member]
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Recently Issued Accounting Standards
New Accounting Pronouncements, Policy [Policy Text Block]
Prepaid expenses, deposits and other
Increase (Decrease) in Prepaid Expense and Other Assets
Common stock, shares outstanding (in shares)
Common stock, beginning balance (in shares)
Common stock, ending balance (in shares)
Common Stock, Shares, Outstanding
Service revenue
Service [Member]