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  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:element name="ClassCWarrantsMember" id="isr_ClassCWarrantsMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="ClassOfWarrantOrRightCorrected" id="isr_ClassOfWarrantOrRightCorrected" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element name="ClassOfWarrantOrRightCorrectedInPeriodExercisePriceOfWarrantsOrRights" id="isr_ClassOfWarrantOrRightCorrectedInPeriodExercisePriceOfWarrantsOrRights" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:perShareItemType" />
  <xsd:element name="ClassOfWarrantOrRightExercisedInPeriodExercisePriceOfWarrantsOrRights" id="isr_ClassOfWarrantOrRightExercisedInPeriodExercisePriceOfWarrantsOrRights" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:perShareItemType" />
  <xsd:element name="ClassOfWarrantOrRightIssued" id="isr_ClassOfWarrantOrRightIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element name="ClassOfWarrantOrRightIssuedInPeriodExercisePriceOfWarrantsOrRights" id="isr_ClassOfWarrantOrRightIssuedInPeriodExercisePriceOfWarrantsOrRights" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="us-types:perUnitItemType" />
  <xsd:element name="ClassOfWarrantOrRightOutstandingAbstract" id="isr_ClassOfWarrantOrRightOutstandingAbstract" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element name="ClassOfWarrantOrRightTerm" id="isr_ClassOfWarrantOrRightTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType" />
  <xsd:element name="ClassOfWarrantOrRightWeightedAverageExercisePriceAbstract" id="isr_ClassOfWarrantOrRightWeightedAverageExercisePriceAbstract" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element name="CommonStockPurchaserWarrantsMember" id="isr_CommonStockPurchaserWarrantsMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="CommonUnitWarrantsMember" id="isr_CommonUnitWarrantsMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="ConvertiblePreferredStockMaximumOwnershipInterest" id="isr_ConvertiblePreferredStockMaximumOwnershipInterest" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType" />
  <xsd:element name="DocumentAndEntityInformationAbstract" id="isr_DocumentAndEntityInformationAbstract" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element name="GrossProceedsFromIssuanceOfStock" id="isr_GrossProceedsFromIssuanceOfStock" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="IssuanceOfCommonStockInConnectionWithWarrantExercisesNetOfIssuanceCostsShares" id="isr_IssuanceOfCommonStockInConnectionWithWarrantExercisesNetOfIssuanceCostsShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" />
  <xsd:element name="LiabilityForCommonStockIssuable" id="isr_LiabilityForCommonStockIssuable" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="OverAllotmentWarrantsMember" id="isr_OverAllotmentWarrantsMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="PatentRightsKnowhowAndLicenseAgreementsMember" id="isr_PatentRightsKnowhowAndLicenseAgreementsMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="PaymentsForUnderwritingFeesCosts" id="isr_PaymentsForUnderwritingFeesCosts" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="PaymentsOfStockIssuanceCostsCommissionExpense" id="isr_PaymentsOfStockIssuanceCostsCommissionExpense" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="PaymentsOfStockIssuanceCostsLegalAndAccountingExpense" id="isr_PaymentsOfStockIssuanceCostsLegalAndAccountingExpense" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="PaymentsOfStockIssuanceCostsListingExpense" id="isr_PaymentsOfStockIssuanceCostsListingExpense" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="PaymentsOfStockIssuanceCostsOtherExpenses" id="isr_PaymentsOfStockIssuanceCostsOtherExpenses" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="PercentageOfRoyaltyRatePayableOnNetSales" id="isr_PercentageOfRoyaltyRatePayableOnNetSales" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType" />
  <xsd:element name="PreferredUnitWarrantsMember" id="isr_PreferredUnitWarrantsMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="ProvisionForReductionOfDoubtfulAccounts" id="isr_ProvisionForReductionOfDoubtfulAccounts" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="RangeOfExercisePriceFiveMember" id="isr_RangeOfExercisePriceFiveMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="RangeOfExercisePriceFourMember" id="isr_RangeOfExercisePriceFourMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="RangeOfExercisePriceOneMember" id="isr_RangeOfExercisePriceOneMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="RangeOfExercisePriceSevenMember" id="isr_RangeOfExercisePriceSevenMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="RangeOfExercisePriceSixMember" id="isr_RangeOfExercisePriceSixMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="RangeOfExercisePriceThreeMember" id="isr_RangeOfExercisePriceThreeMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="RangeOfExercisePriceTwoMember" id="isr_RangeOfExercisePriceTwoMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="ScheduleOfProceedsFromCommonStockOfferingTableTextBlock" id="isr_ScheduleOfProceedsFromCommonStockOfferingTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="isr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptonsOutstandingAggregateIntrinsicValueAbstract" id="isr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptonsOutstandingAggregateIntrinsicValueAbstract" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
  <xsd:element name="WarrantsAndRightsCorrected" id="isr_WarrantsAndRightsCorrected" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="WarrantsAndRightsExercised" id="isr_WarrantsAndRightsExercised" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xsd:element name="WarrantsExpirationDate" id="isr_WarrantsExpirationDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:dateItemType" />
  <xsd:element name="WarrantsIssuedIn2011Member" id="isr_WarrantsIssuedIn2011Member" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="WarrantsIssuedIn2011TwoMember" id="isr_WarrantsIssuedIn2011TwoMember" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="WarrantsIssuedIn2013Member" id="isr_WarrantsIssuedIn2013Member" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="WarrantsIssuedInNovember2010Member" id="isr_WarrantsIssuedInNovember2010Member" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xsd:element name="WarrantsValueAbstract" id="isr_WarrantsValueAbstract" nillable="true" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType" />
</xsd:schema>


