Inventory Disclosure [Abstract] Inventory Inventory Disclosure [Text Block] Restructuring Charges [Abstract] Schedule of Restructuring and Related Costs [Table] Schedule of Restructuring and Related Costs [Table] Restructuring Cost and Reserve [Axis] Restructuring Type [Axis] Type of Restructuring [Domain] Type of Restructuring [Domain] Facility Closing [Member] Facility Closing [Member] Termination Benefits [Member] Employee Severance [Member] Asset Impairment [Member] Asset Impairment [Member] Asset Impairment [Member] Restructuring Cost and Reserve [Line Items] Restructuring Cost and Reserve [Line Items] Number of restructurings implemented Number of Restructurings Implemented Number of Restructurings Implemented Aggregate reduction in headcount Restructuring and Related Cost, Number of Positions Eliminated, Inception to Date Restructuring charge (credit) Restructuring Charges Restructuring reserve Restructuring Reserve Expected additional payment for restructuring Restructuring and Related Cost, Expected Cost Restructuring reserve, settled with cash Payments for Restructuring Proceeds from subtenants Proceeds from Subtenants Proceeds from Subtenants Proceeds from sale of property and equipment Proceeds from Sale of Property, Plant, and Equipment Restructuring reserve, cash settlement net of proceeds Restructuring Reserve, Cash Settlement Net of Proceeds Restructuring Reserve, Cash Settlement Net of Proceeds Share-based Compensation [Abstract] Stock-Based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Award Type [Axis] Award Type [Axis] Award Type [Domain] Equity Award [Domain] Employee Stock Option [Member] Employee Stock Option [Member] Employee Stock Purchase Plan [Member] Employee Stock [Member] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Weighted average grant date fair value Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Risk-free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Volatility Rate Expected life Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Shares [Roll Forward] Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Options outstanding at beginning of period, Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Granted, Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Exercised, Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Forfeited, Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Expired, Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period Options outstanding at end of period, Shares Exercisable at end of period, Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Weighted Average Exercise Price [Roll Forward] Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Options outstanding at beginning of period, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Granted, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Exercised, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Forfeited, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Expired, Weighted Average Exercise Price Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Options outstanding at end of period, Weighted Average Exercise Price Exercisable at end of period, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Options outstanding at end of period, Weighted Average Remaining Contractual Term Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Exercisable at end of period, Weighted Average Remaining Contractual Term Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Options outstanding at end of period, Aggregate Intrinsic Value, in dollars Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Exercisable at end of period, Aggregate Intrinsic Value, in dollars Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Summary Of Components Of Restructuring Liability Schedule of Restructuring Reserve by Type of Cost [Table Text Block] Earnings Per Share [Abstract] Net Loss Per Share Earnings Per Share [Text Block] Fair Value Disclosures [Abstract] Schedule Of Fair Value Of Financial Assets Measured On A Recurring Basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Schedule Of Estimated Fair Value Of Outstanding Debt Fair Value, Liabilities Measured on Recurring Basis [Table Text Block] Schedule of Assumptions Used Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Table Text Block] Warrants and Rights Note Disclosure [Abstract] Schedule Of Warrants To Purchase Common Stock Outstanding And Exercisable Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Restructurings Restructuring and Related Activities Disclosure [Text Block] Class of Warrant or Right [Table] Class of Warrant or Right [Table] Class of Warrant or Right [Axis] Class of Warrant or Right [Axis] Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] Issued On January 22, 2014 [Member] Warrants Issued On January Twenty Second Two Thousand And Fourteen [Member] Warrants Issued On January Twenty Second Two Thousand And Fourteen [Member] Class of Warrant or Right [Line Items] Class of Warrant or Right [Line Items] Public offering of common stock Stock Issued During Period, Shares, New Issues Share price (dollars per share) Share Price Net proceeds from public offering Proceeds from Issuance of Common Stock Warrants outstanding Class of Warrant or Right, Outstanding Warrant exercise price (in dollars per warrant) Class of Warrant or Right, Exercise Price of Warrants or Rights Warrant period Class of Warrant or Right, Period Class of Warrant or Right, Period Warrant repricing terms on exercise of extension option Warrant Repricing Terms on Exercise of Extension Option Warrant Repricing Terms on Exercise of Extension Option Fair value of warrants Warrants and Rights Outstanding Unrealized gain on warrants Unrealized Gain (Loss) on Derivatives Statement of Cash Flows [Abstract] Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Net loss Net Income (Loss) Attributable to Parent Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation and amortization Depreciation, Depletion and Amortization Stock-based compensation expense Share-based Compensation Accretion of debt discount Amortization of Debt Discount (Premium) Changes in the fair value of warrants Fair Value Adjustment of Warrants Other Other Noncash Income (Expense) Changes in assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Trade and other receivables Increase (Decrease) in Accounts and Other Receivables Inventory Increase (Decrease) in Inventories Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Accounts payable, accrued compensation, and other accrued liabilities Increase (Decrease) in Accounts Payable and Accrued Liabilities Clinical trial liabilities Increase (Decrease) in Accrued Liabilities Restructuring liability Increase (Decrease) in Restructuring Reserve Other long-term liabilities Increase (Decrease) in Other Operating Liabilities Deferred revenue Increase (Decrease) in Deferred Revenue Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Proceeds from maturities of restricted cash and investments Increase (Decrease) in Restricted Cash and Investments Purchase of restricted cash and investments Payments to Acquire Restricted Investments Proceeds from maturities of investments Proceeds from Sale and Maturity of Marketable Securities Purchases of investments Payments to Acquire Marketable Securities Net cash provided by investing activities Net Cash Provided by (Used in) Investing Activities Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Proceeds from issuance of common stock, net Proceeds from exercise of stock options and warrants Proceeds From Exercise Of Stock Options And Warrants, Net Of Repurchases Proceeds from exercise of stock options and warrants, net of repurchases Proceeds from employee stock purchase plan Proceeds from Stock Plans Principal payments on debt Proceeds from (Repayments of) Notes Payable Net cash provided by (used in) financing activities Net Cash Provided by (Used in) Financing Activities Net increase (decrease) in cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) Cash and cash equivalents at beginning of period Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Supplemental cash flow disclosure - non-cash financing activity: Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Issuance of warrants in connection with amendment to convertible notes Debt Conversion, Converted Instrument, Amount Investments, Debt and Equity Securities [Abstract] Schedule of Available-for-Sale Securities Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Summary of Cash and Investments by Security Type Unrealized Gain (Loss) on Investments [Table Text Block] Summary of Available-for-Sale Securities by Contractual Maturity Investments Classified by Contractual Maturity Date [Table Text Block] Debt Disclosure [Abstract] Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Senior Subordinated Notes [Member] Senior Subordinated Notes [Member] Secured Convertible Notes Due June 2015 [Member] Secured Convertible Notes Due June Two Thousand And Fifteen [Member] Secured Convertible Notes Due June Two Thousand And Fifteen [Member] Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] 4.25% Convertible Senior Subordinated Notes due August 15, 2019 [Member] Convertible Senior Subordinated Notes due August 15, 2019, 4.25% [Member] Convertible Senior Subordinated Notes due 2019, 4.25% [Member] Deerfield Financing [Member] Deerfield Financing [Member] Deerfield Financing [Member] Interest Payment Type [Axis] Interest Payment Type [Axis] Interest Payment Type [Axis] Interest Payment Type [Domain] Interest Payment Type [Domain] [Domain] for Interest Payment Type [Axis] Coupon Interest [Member] Coupon Interest [Member] Coupon Interest [Member] Payment-in-Kind Interest [Member] Payment-in-Kind Interest [Member] Payment-in-Kind Interest [Member] Debt Instrument [Line Items] Debt Instrument [Line Items] Debt, interest rate Debt Instrument, Interest Rate, Stated Percentage Debt, principal amount Debt Instrument, Face Amount Balance of unamortized closing fees and expenses Debt Instruments, Unamortized Closing Fees And Expenses Debt instruments, unamortized closing fees and expenses. Convertible debt Convertible Debt Principal eligible for extension option Principal Eligible for Extension Option Principal Eligible for Extension Option Debt instrument, interest rate, stated percentage after extension option election Debt Instrument, Interest Rate, Stated Percentage after Extension Option Election Debt Instrument, Interest Rate, Stated Percentage after Extension Option Election Debt instrument, discount Debt Instrument, Unamortized Discount Risks and Uncertainties [Abstract] Concentrations of Credit Risk Concentration Risk Disclosure [Text Block] Restricted Stock Units (RSUs) [Member] Restricted Stock Units (RSUs) [Member] Shares [Roll Forward] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] RSUs outstanding at beginning of period, Shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Awarded, Shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Released, Shares Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Released Share based compensation arrangement by share based payment award equity instruments other than options released. Forfeited, Shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period RSUs outstanding at end of period, Shares Weighted Average Grant DateFair Value [Roll Forward] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] RSUs outstanding at beginning of period, Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Awarded, Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Released, Weighted Average Grant Date Fair Value Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Released In Period Weighted Average Grant Date Fair Value Share based compensation arrangement by share based payment award equity instruments other than options released in period weighted average grant date fair value. Forfeited, Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value RSUs outstanding at end of period, Weighted Average Grant Date Fair Value RSUs outstanding at end of period, Weighted Average Remaining Contractual Term Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms RSUs outstanding at end of period, Aggregate Intrinsic Value, in dollars Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Share based compensation arrangement by share based payment award equity instruments other than options aggregate intrinsic value. Secured Debt [Member] Secured Debt [Member] Term Loan [Member] Term Loan [Member] Term Loan [Member] Line of Credit [Member] Line of Credit [Member] Deerfield Notes [Member] Secured Convertible Notes due June 2015 [Member] Secured Convertible Notes due June 2015 [Member] Silicon Valley Bank term loan and Line of Credit [Member] Silicon Valley Bank Loan And Security Agreement [Member] Silicon Valley Bank Loan And Security Agreement [Member] Stated coupon interest Interest Expense, Coupon Interest Coupon Interest on Debt Convertible Debt Silicon Valley Bank term loan Loans Payable to Bank Silicon Valley Bank Line of Credit Notes Payable Total debt Long-term Debt Less: current portion Long-term Debt, Current Maturities Long-term debt Long-term Debt, Excluding Current Maturities Amortization of debt discount and debt issuance costs Amortization of Financing Costs and Discounts Interest Expense, Debt Interest Expense, Debt Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Investment Type [Axis] Investment Type [Axis] Investments [Domain] Investments [Domain] Money market funds [Member] Money Market Funds [Member] Commercial paper [Member] Commercial Paper [Member] Corporate bonds [Member] Corporate Bond Securities [Member] U.S. Treasury and government sponsored enterprises [Member] US Government-sponsored Enterprises Debt Securities [Member] Municipal bonds [Member] Municipal Bonds [Member] Fair Value, Hierarchy [Axis] Fair Value, Hierarchy [Axis] Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Level 1 [Member] Fair Value, Inputs, Level 1 [Member] Level 2 [Member] Fair Value, Inputs, Level 2 [Member] Level 3 [Member] Fair Value, Inputs, Level 3 [Member] Total [Member] Estimate of Fair Value Measurement [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Total fair value of financial assets Assets, Fair Value Disclosure, Recurring Warrants Derivative Liability Total financial liabilities Liabilities, Fair Value Disclosure, Recurring Measurement Basis [Axis] Fair Value Measurement [Domain] Portion at Fair Value Measurement [Member] Portion at Fair Value Measurement [Member] Carrying Amount [Member] Reported Value Measurement [Member] Fair Value [Member] Fair values of financial instruments Debt Instrument, Fair Value Disclosure Debt Debt Disclosure [Text Block] Schedule of Inventory Schedule of Inventory, Current [Table Text Block] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs, by Report Line [Axis] Income Statement Location [Axis] Employee Service Share-based Compensation, Allocation of Recognized Period Costs, Report Line [Domain] Income Statement Location [Domain] Research and development expense [Member] Research and Development Expense [Member] Selling, general and administrative expense [Member] Selling, General and Administrative Expenses [Member] Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] Total employee stock-based compensation expense Allocated Share-based Compensation Expense Raw materials Inventory, Raw Materials, Net of Reserves Work in process Inventory, Work in Process, Net of Reserves Finished goods Inventory, Finished Goods, Net of Reserves Total Inventory, Net Exercise Price per Share Expiration Date Warrants, Expiration Date Warrants, expiration date. Number of Shares Fair Value Measurements Fair Value Disclosures [Text Block] Concentration Risk [Table] Concentration Risk [Table] Geographical [Axis] Geographical [Axis] Geographical [Domain] Geographical [Domain] UNITED STATES UNITED STATES Concentration Risk Type [Axis] Concentration Risk Type [Axis] Concentration Risk Type [Domain] Concentration Risk Type [Domain] Geographic Concentration Risk [Member] Geographic Concentration Risk [Member] Revenue from Rights Concentration Risk [Member] Customer Concentration Risk [Member] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Accounts Receivable [Member] Accounts Receivable [Member] Sales [Member] Sales [Member] Revenue, Rights Granted [Member] Revenue, Rights Granted [Member] Sales Revenue, Goods, Net [Member] Sales Revenue, Goods, Net [Member] Major Customers [Axis] Customer [Axis] Name of Major Customer [Domain] Customer [Domain] European Distribution Partner [Member] Sobi [Member] Sobi [Member] Bristol-Myers Squibb [Member] Bristol Myers Squibb [Member] Bristol-Myers Squibb [Member]. Diplomat Specialty Pharmacy [Member] Diplomat Specialty Pharmacy [Member] Diplomat Specialty Pharmacy Concentration Risk [Line Items] Concentration Risk [Line Items] Concentration risk, percentage Concentration Risk, Percentage Statement of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets, Current [Abstract] Cash and cash equivalents Short-term investments Short-term Investments Short-term restricted cash and investments Restricted Cash and Investments, Current Trade and other receivables Receivables, Net, Current Inventory Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Total current assets Assets, Current Long-term investments Long-term Investments Long-term restricted cash and investments Restricted Cash and Investments, Noncurrent Property and equipment, net Property, Plant and Equipment, Net Goodwill Goodwill Other assets Other Assets, Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities and Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Accounts payable Accounts Payable, Current Accrued clinical trial liabilities Accrued Liabilities, Current Accrued compensation and benefits Accrued Employee Benefits, Current Other accrued liabilities Other Accrued Liabilities, Current Current portion of convertible notes Convertible Debt, Current Current portion of loans payable Notes Payable, Current Current portion of restructuring Restructuring Reserve, Current Deferred revenue Deferred Revenue, Current Total current liabilities Liabilities, Current Long-term portion of convertible notes Convertible Debt, Noncurrent Long-term portion of loans payable Notes Payable, Noncurrent Long-term portion of restructuring Restructuring Reserve, Noncurrent Other long-term liabilities Other Liabilities, Noncurrent Total liabilities Liabilities Commitments Commitments and Contingencies Stockholders' Equity: Stockholders' Equity Attributable to Parent [Abstract] Preferred stock Preferred Stock, Value, Issued Common stock, $0.001 par value; 400,000,000 shares authorized; issued and outstanding: 195,088,645 and 184,533,651 shares at June 30, 2014 and December 31, 2013, respectively Common Stock, Value, Issued Additional paid-in capital Additional Paid in Capital Accumulated other comprehensive income Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated deficit Retained Earnings (Accumulated Deficit) Total stockholders’ equity Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest Total liabilities and stockholders' equity Liabilities and Equity Income Statement [Abstract] Revenues: Revenues [Abstract] Net product revenues Sales Revenue, Goods, Net License and contract revenues License, Contract, and Collaboration Reimbursement Revenue License, Contract, and Collaboration Reimbursement Revenue Total revenues Revenue, Net Operating expenses: Operating Expenses [Abstract] Cost of goods sold Cost of Goods Sold Research and development Research and Development Expense Selling, general and administrative Selling, General and Administrative Expense Restructuring charge Total operating expenses Operating Expenses Loss from operations Operating Income (Loss) Other income (expense), net: Nonoperating Income (Expense) [Abstract] Interest income and other, net Other Nonoperating Income Interest expense Interest Expense Total other income (expense), net Nonoperating Income (Expense) Net loss Net loss per share, basic and diluted, in dollars per share Earnings Per Share, Basic and Diluted Shares used in computing basic and diluted net loss per share, in shares Weighted Average Number of Shares Outstanding, Basic and Diluted Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Convertible debt [Member] Convertible Debt Securities [Member] Outstanding stock options, unvested RSUs and ESPP contributions [Member] Stock Compensation Plan [Member] Warrants [Member] Warrant [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Net loss, in dollars Shares used in computing basic and diluted net loss per share Potentially dilutive shares Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Schedule Of Allocated Employee Stock-Based Compensation Expenses Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Schedule Of Fair Value Of Employee Share-Based Payments Awards Estimated Using The Assumptions And Weighted Average Fair Values Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Summary Of All Stock Option Activity Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Summary Of All RSU Activity Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Fair Value Inputs, Liabilities, Quantitative Information [Table] Fair Value Inputs, Liabilities, Quantitative Information [Table] Liability Class [Axis] Liability Class [Axis] Fair Value by Liability Class [Domain] Fair Value by Liability Class [Domain] Warrant liability [Member] Derivative Financial Instruments, Liabilities [Member] Fair Value Inputs, Liabilities, Quantitative Information [Line Items] Fair Value Inputs, Liabilities, Quantitative Information [Line Items] Fair value of warrants Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value Risk-free interest rate Fair Value Assumptions, Risk Free Interest Rate Dividend yield Fair Value Assumptions, Expected Dividend Rate Volatility Fair Value Assumptions, Expected Volatility Rate Average expected life Fair Value Assumptions, Expected Term Net carrying amount of the liability component Unamortized discount of the liability component Unamortized Debt Issuance Expense Face amount Total interest expense Common Stock And Warrants Common Stock And Warrants Disclosure [Text Block] Common Stock And Warrants Disclosure [Text Block] Cash and Investments Cash, Cash Equivalents, and Investments [Text Block] Cash, Cash Equivalents, and Investments [Text Block] Schedule of Available-for-sale Securities [Table] Schedule of Available-for-sale Securities [Table] Cash and Investments [Axis] Cash and Investments [Axis] Cash and Investments [Axis] Cash and Investments [Domain] Cash and Investments [Domain] [Domain] for Cash and Investments [Axis] Cash and cash equivalents [Member] Cash Equivalents [Member] Short-term investments [Member] Short-term Investments [Member] Short-term restricted cash and investments [Member] Restricted Cash and Investments, Short-term [Member] Restricted Cash and Investments, Short-term [Member] Long-term investments [Member] Long Term Investments [Member] Long-Term Investments [Member] Long-term restricted cash and investments [Member] Restricted Cash and Investments, Long-term [Member] Restricted Cash and Investments, Long-term [Member] Silicon Valley Bank Loan And Security Agreement [Member] Schedule of Available-for-sale Securities [Line Items] Schedule of Available-for-sale Securities [Line Items] Amortized Cost Cash, Cash Equivalents, and Available-for-sale Securities, Amortized Cost Basis Cash, Cash Equivalents, and Available-for-sale Securities, Amortized Cost Basis Gross Unrealized Gains Cash, Cash Equivalents, and Available-for-sale Securities, Gross Unrealized Gain Accumulated in Investments Cash, Cash Equivalents, and Available-for-sale Securities, Gross Unrealized Gain Accumulated in Investments Gross Unrealized Losses Cash, Cash Equivalents, and Available-for-sale Securities, Gross Unrealized Loss Accumulated in Investments Cash, Cash Equivalents, and Available-for-sale Securities, Gross Unrealized Loss Accumulated in Investments Fair Value Cash, Cash Equivalents, and Available-for-sale Securities Cash, Cash Equivalents, and Available-for-sale Securities Debt collateral, number of required investment accounts Debt Collateral, Number of Required Investment Accounts Debt Collateral, Number of Required Investment Accounts Debt collateral, number of affiliate banks Debt Collateral, Number of Affiliate Banks Debt Collateral, Number of Affiliate Banks Collateral balance Debt, Collateral Balance Debt, collateral balance. Amortized Cost Available-for-sale Securities, Amortized Cost Basis Gross Unrealized Gains Available-for-sale Securities, Gross Unrealized Gain Accumulated in Investments Available-for-sale Securities, Gross Unrealized Gain Accumulated in Investments Gross Unrealized Losses Available-for-sale Securities, Gross Unrealized Loss Accumulated in Investments Available-for-sale Securities, Gross Unrealized Loss Accumulated in Investments Fair Value Available-for-sale Securities Gain (loss) on sale of investments Gain (Loss) on Sale of Investments Number of investments in an unrealized loss position, less than 1 year Available-for-sale, Securities in Unrealized Loss Positions, Qualitative Disclosure, Number of Positions, Less than One Year Unrealized loss position, less than 1 year Available-for-sale Securities, Continuous Unrealized Loss Position, Less than Twelve Months, Fair Value Number of investments in an unrealized loss position, greater than 1 year Available-for-sale, Securities in Unrealized Loss Positions, Qualitative Disclosure, Number of Positions, Greater than or Equal to One Year Unrealized loss position, greater than 1 year Available-for-sale Securities, Continuous Unrealized Loss Position, Twelve Months or Longer, Fair Value Mature within One Year Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value After One Year through Two Years Available-for-sale Securities, Debt Maturities, Year Two Through Five, Fair Value Document And Entity Information [Abstract] Document And Entity Information Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Entity Filer Category Entity Filer Category Current Fiscal Year End Date Current Fiscal Year End Date Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Schedule Of Reconciliation Of Basic And Diluted Net Income (Loss) Per Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Schedule Of Potential Shares Of Common Stock Not Included In Computation Of Diluted Net Loss Per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization and Summary of Significant Accounting Policies Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Schedule Of Debt Schedule of Debt [Table Text Block] Summary Of The Liability Component Of The 2019 Notes Schedule of Long-term Debt Instruments [Table Text Block] Facility Charges [Member] Other [Member] Other Restructuring [Member] Restructuring Reserve [Roll Forward] Restructuring Reserve [Roll Forward] Restructuring liability Cash payments Adjustments or non-cash credits Restructuring Reserve, Accrual Adjustment Proceeds from sale of assets Restructuring Reserve, Proceeds from Sale of Property, Plant, and Equipment Restructuring Reserve, Proceeds from Sale of Property, Plant, and Equipment Restructuring liability Operations [Table] Operations [Table] Operations [Table] Range [Axis] Range [Axis] Range [Domain] Range [Domain] Minimum [Member] Minimum [Member] Maximum [Member] Maximum [Member] Glaxo Smith Kline [Member] Glaxo Smith Kline [Member] Glaxo Smith Kline [Member]. Operations [Line Items] Operations [Line Items] Operations [Line Items] Number of trials in process with expected results in current fiscal year Number of Trials In Process With Expected Results in Current Fiscal Year Number of CRPC Trials In Process With Expected Results in Current Fiscal Year Number of trials in process Number of Trials in Process Number of Trials in Process Operating cycle Annual Operating Cycle Annual Operating Cycle Number of operating segments Number of Operating Segments Percent of royalty on net sale Percent of royalty on net sale Percent of royalty on net sale. Statement of Comprehensive Income [Abstract] Other comprehensive income (loss) Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Performance Stock Options [Member] Performance Stock Options [Member] Performance Based Stock Options [Member] Options outstanding, in shares Grant date fair value Performance Grants Not Probable Grant Date Fair Value Performance Grants Not Probable - Grant Date Fair Value Unrecognized compensation expense Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized compensation expense, weighted-average period for recognition (in years) Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Common stock, par value, in dollars per share Common Stock, Par or Stated Value Per Share Common stock, shares authorized Common Stock, Shares Authorized Common stock, shares issued Common Stock, Shares, Issued Common stock, shares outstanding Common Stock, Shares, Outstanding Schedules of concentration risk Schedules of Concentration of Risk, by Risk Factor [Table Text Block] Organization Organization [Policy Text Block] Organization [Policy Text Block] Basis of Consolidation Consolidation, Policy [Policy Text Block] Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Fiscal Period, Policy Fiscal Period, Policy [Policy Text Block] Segment Information Segment Reporting, Policy [Policy Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Revenue Recognition Revenue Recognition, Policy [Policy Text Block] Cost of Goods Sold Cost of Sales, Policy [Policy Text Block] Recently Issued Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block]