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  <xsd:element name="EffectiveIncomeTaxRateReconciliationExpiredNetOperatingLossCarryforwards" id="insm_EffectiveIncomeTaxRateReconciliationExpiredNetOperatingLossCarryforwards" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationAlternativeMinimumTax" id="insm_EffectiveIncomeTaxRateReconciliationAlternativeMinimumTax" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DeferredTaxLiabilitiesInProcessResearchAndDevelopment" id="insm_DeferredTaxLiabilitiesInProcessResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowances" id="insm_DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="NumberOfEquityCompensationPlans" id="insm_NumberOfEquityCompensationPlans" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="EquityInstrumentConvertibleBeneficialConversionFeature" id="insm_EquityInstrumentConvertibleBeneficialConversionFeature" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="FairValueOfWarrantsInConnectionWithDebt" id="insm_FairValueOfWarrantsInConnectionWithDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInAccruedLiabilitiesAndDeferredRentCredit" id="insm_IncreaseDecreaseInAccruedLiabilitiesAndDeferredRentCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInAccruedLeaseExpenses" id="insm_IncreaseDecreaseInAccruedLeaseExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedDuringPeriodValueAcquisitionsPreferredStock" id="insm_StockIssuedDuringPeriodValueAcquisitionsPreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ClassOfWarrantOrRightExpirationTerm" id="insm_ClassOfWarrantOrRightExpirationTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfInitialIndicationsInOrphanPatientPopulationsForWhichClinicalTrialsConducted" id="insm_NumberOfInitialIndicationsInOrphanPatientPopulationsForWhichClinicalTrialsConducted" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClinicalTrialExtendedStudyPeriod" id="insm_ClinicalTrialExtendedStudyPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OpenLabelSafetyStudyPeriod" id="insm_OpenLabelSafetyStudyPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfEntitiesIntegrated" id="insm_NumberOfEntitiesIntegrated" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="EquipmentFurnitureAndFixturesMember" id="insm_EquipmentFurnitureAndFixturesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfSharesHeldByEntityStockholdersAfterConversionAdjustment" id="insm_NumberOfSharesHeldByEntityStockholdersAfterConversionAdjustment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MutualFundsMember" id="insm_MutualFundsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CarryingValuePerShare" id="insm_CarryingValuePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NonCashChargeForBeneficialConversion" id="insm_NonCashChargeForBeneficialConversion" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ConversionPricePerShare" id="insm_ConversionPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LicensePriceDue" id="insm_LicensePriceDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="ClassOfWarrantOrRightIssued" id="insm_ClassOfWarrantOrRightIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CommonStockSharesExerciseToUnderwritersInFullOfOverAllotmentOption" id="insm_CommonStockSharesExerciseToUnderwritersInFullOfOverAllotmentOption" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="SharePriceForUnderwriter" id="insm_SharePriceForUnderwriter" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesInterPlanTransfers" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesInterPlanTransfers" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesVestingOnFirstAnniversary" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesVestingOnFirstAnniversary" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesVestingFromFirstAnniversaryThroughFourthAnniversary" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesVestingFromFirstAnniversaryThroughFourthAnniversary" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentNumberOfEqualInstallmentsFollowingFirstAnniversaryDateThroughFourthAnniversary" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentNumberOfEqualInstallmentsFollowingFirstAnniversaryDateThroughFourthAnniversary" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentNumberOfStockOptionsVestingOnDateOfIssuanceOfQuarterlyEarnings" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentNumberOfStockOptionsVestingOnDateOfIssuanceOfQuarterlyEarnings" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentNumberOfSharesVestedInEqualInstallmentsFollowingFirstAnniversaryDateThroughFourthAnniversary" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentNumberOfSharesVestedInEqualInstallmentsFollowingFirstAnniversaryDateThroughFourthAnniversary" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingOptionsDeemedToBeGrantedOutsideIncentivePlans" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingOptionsDeemedToBeGrantedOutsideIncentivePlans" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAmountOfRequiredCumulativeRevenuesFromAllApprovedProducts" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentAmountOfRequiredCumulativeRevenuesFromAllApprovedProducts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentPeriodOfEqualInstallment" id="insm_ShareBasedCompensationArrangementByShareBasedPaymentPeriodOfEqualInstallment" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AllocatedShareBasedCompensationExpenseDueToRemeasurementOfAwards" id="insm_AllocatedShareBasedCompensationExpenseDueToRemeasurementOfAwards" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="NumberOfPatientsEnrolledInClinicalTrialsConducted" id="insm_NumberOfPatientsEnrolledInClinicalTrialsConducted" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedClinicalTrialExpensesAndManufacturingExpensesCurrent" id="insm_AccruedClinicalTrialExpensesAndManufacturingExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="StockIssuedDuringPeriodValueWarrantsGrantedInConnectionWithDebt" id="insm_StockIssuedDuringPeriodValueWarrantsGrantedInConnectionWithDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="IssuanceOfCommonStockForWarrantGrantedInConnectionWithDebt" id="insm_IssuanceOfCommonStockForWarrantGrantedInConnectionWithDebt" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedContractManufacturerExpensesCurrent" id="insm_AccruedContractManufacturerExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="IpsenAndGenentechLicenseAgreementMember" id="insm_IpsenAndGenentechLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EleisonPharmaceuticalsLicenseAgreementMember" id="insm_EleisonPharmaceuticalsLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentFeePaidToExtendInterestOnlyPeriod" id="insm_DebtInstrumentFeePaidToExtendInterestOnlyPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="StockOptionsAndRestrictedStockUnitsMember" id="insm_StockOptionsAndRestrictedStockUnitsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationChangeInStateTaxRate" id="insm_EffectiveIncomeTaxRateReconciliationChangeInStateTaxRate" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedTechnicalOperationExpenses" id="insm_AccruedTechnicalOperationExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="CollaborativeArrangementInitialTerm" id="insm_CollaborativeArrangementInitialTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementSuccessiveRenewalPeriod" id="insm_CollaborativeArrangementSuccessiveRenewalPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementPriorWrittenNoticePeriodForTerminationByEitherParty" id="insm_CollaborativeArrangementPriorWrittenNoticePeriodForTerminationByEitherParty" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementMinimumNumberOfDaysOfAdvanceNoticeForTermination" id="insm_CollaborativeArrangementMinimumNumberOfDaysOfAdvanceNoticeForTermination" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EmployeeAndDirectorsStockOptionsMember" id="insm_EmployeeAndDirectorsStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FairValueOfWarrantsOutstanding" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" id="insm_FairValueOfWarrantsOutstanding" abstract="false" />
  <xsd:element name="PARIPharmaGmbHCommercializationAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" id="insm_PARIPharmaGmbHCommercializationAgreementMember" abstract="true" />
  <xsd:element name="AdditionalTermOfContractManufacturingAgreement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" id="insm_AdditionalTermOfContractManufacturingAgreement" abstract="false" />
</xsd:schema>


