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  <xsd:element name="TemporaryEquitySubscriptionsAndCarryingAmountAttributableToParent" id="kpti_TemporaryEquitySubscriptionsAndCarryingAmountAttributableToParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RoyaltyAndSublicensePayment" id="kpti_RoyaltyAndSublicensePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesAllowanceForImprovements" id="kpti_OperatingLeasesAllowanceForImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="AmountOfOperatingLeaseForWhichAllowanceForImprovementsIsProvided" id="kpti_AmountOfOperatingLeaseForWhichAllowanceForImprovementsIsProvided" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AnnualInterestRate" id="kpti_AnnualInterestRate" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SecurityDepositWhichMayBeReducedInFuture" id="kpti_SecurityDepositWhichMayBeReducedInFuture" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="OperatingLeaseScheduledRentPaymentsDue" id="kpti_OperatingLeaseScheduledRentPaymentsDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="IncreaseDecreaseInDeferredRent" id="kpti_IncreaseDecreaseInDeferredRent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="EmployeeStockPurchasePIanMember" id="kpti_EmployeeStockPurchasePIanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" id="kpti_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriod" id="kpti_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriod" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod" id="kpti_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LesseeLeasingArrangementsOperatingLeasesNumberOfAdditionalLeaseTerm" id="kpti_LesseeLeasingArrangementsOperatingLeasesNumberOfAdditionalLeaseTerm" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LesseeLeasingArrangementsOperatingLeasesAdditionalExtensionTerm" id="kpti_LesseeLeasingArrangementsOperatingLeasesAdditionalExtensionTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
</xsd:schema>


