101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Condensed Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Condensed Consolidated Statements of Operations link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Condensed Consolidated Statements of Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 107 - Statement - Condensed Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Organization link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Collaborations and License Agreements link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Accrued Expenses link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Loans Payable link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Stock-based Compensation link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Strategic Restructuring link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Facility Lease Exit link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Legal Proceedings link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Accrued Expenses (Tables) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Loans Payable (Tables) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Stock-based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Strategic Restructuring (Tables) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Facility Lease Exit (Tables) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Organization - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Available for Sale Securities (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Marketable Securities in Unrealized Loss Position (Detail) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Summary of Cash Equivalents and Marketable Securities Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Potential Common Shares Excluded from Calculation of Net Loss Per Common Share (Detail) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Stock Based Compensation Expense for Equity-Classified Awards (Detail) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Collaborations and License Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Loans Payable - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Future Minimum Payments Under Loans Payable (Detail) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Stock Option Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Assumptions Used in Black Scholes Pricing Model for New Grants (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Restricted Stock Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Strategic Restructuring - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Restructuring Activity Recorded in Operating Expenses and Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Facility Lease Exit - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Components of Lease Exit Activity Recorded in Current and Long-Term Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Legal Proceedings -Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink