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  <element name="CashAndCashEquivalentsAmortizedCost" id="icpt_CashAndCashEquivalentsAmortizedCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" />
  <element name="CashAndCashEquivalentsAndInvestmentsAmortizedCost" id="icpt_CashAndCashEquivalentsAndInvestmentsAmortizedCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" />
  <element name="CashAndCashEquivalentsAndInvestmentsGrossUnrealizedGains" id="icpt_CashAndCashEquivalentsAndInvestmentsGrossUnrealizedGains" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" />
  <element id="icpt_CashAndCashEquivalentsAndInvestmentsUnrealizedLosses" name="CashAndCashEquivalentsAndInvestmentsUnrealizedLosses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element name="CashAndCashEquivalentsAndInvestmentsFairValueDisclosure" id="icpt_CashAndCashEquivalentsAndInvestmentsFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" />
  <element name="CorporateDebtSecuritiesAtCarryingValue" id="icpt_CorporateDebtSecuritiesAtCarryingValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" />
  <element name="EarningsPerShareNumeratorAbstract" id="icpt_EarningsPerShareNumeratorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <element name="EarningsPerShareDenominatorAbstract" id="icpt_EarningsPerShareDenominatorAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" />
  <element id="icpt_RestrictedStockUnits" name="RestrictedStockUnits" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_WeightedAverageNumberDilutedSharesAdjustment" name="WeightedAverageNumberDilutedSharesAdjustment" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element name="InvestmentSecuritiesAbstract" id="icpt_InvestmentSecuritiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true" />
  <element id="icpt_SellingStockholdersMember" name="SellingStockholdersMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_ScenarioUpFrontPaymentMember" name="ScenarioUpFrontPaymentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_ScenarioMilestonePaymentMember" name="ScenarioMilestonePaymentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_ScenarioMilestoneForDevelopmentPaymentMember" name="ScenarioMilestoneForDevelopmentPaymentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_ScenarioMilestoneForRegulatoryApprovalPaymentMember" name="ScenarioMilestoneForRegulatoryApprovalPaymentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_ScenarioMilestoneForSalesPaymentMember" name="ScenarioMilestoneForSalesPaymentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_LicenseAgreementSalesMilestonesBenchmark" name="LicenseAgreementSalesMilestonesBenchmark" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="icpt_SignificantAgreementsLineItems" name="SignificantAgreementsLineItems" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="icpt_InterceptPharmaceuticalsIncorporatedMember" name="InterceptPharmaceuticalsIncorporatedMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_RevaluationOfWarrants" name="RevaluationOfWarrants" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="icpt_SignificantAgreementsAbstract" name="SignificantAgreementsAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="icpt_NonCashWarrantRevaluationCharge" name="NonCashWarrantRevaluationCharge" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="icpt_WarrantLiabilityRealizedAndUnrealizedLosses" name="WarrantLiabilityRealizedAndUnrealizedLosses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="icpt_WarrantExercises" name="WarrantExercises" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="icpt_ScotHAtwoodVsInterceptPharmaceuticalsIncorporatedMember" name="ScotHAtwoodVsInterceptPharmaceuticalsIncorporatedMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_GeorgeBurtonVsInterceptPharmaceuticalsIncorporatedMember" name="GeorgeBurtonVsInterceptPharmaceuticalsIncorporatedMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_OtherComprehensiveIncomeBeforeForeignCurrencyTranslationNetGainLoss" name="OtherComprehensiveIncomeBeforeForeignCurrencyTranslationNetGainLoss" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="icpt_RestrictedStockAwardMember" name="RestrictedStockAwardMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_RestrictedStockUnitMember" name="RestrictedStockUnitMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_WeightedAverageNumberOfOptionsExcludedFromCalculationOfDilutedSharesAdjustment" name="WeightedAverageNumberOfOptionsExcludedFromCalculationOfDilutedSharesAdjustment" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_WeightedAverageNumberOfWarrantsExcludedFromCalculationOfDilutedSharesAdjustment" name="WeightedAverageNumberOfWarrantsExcludedFromCalculationOfDilutedSharesAdjustment" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="icpt_RestatementAmountRelatedNonEmployeeOptionsValuation" name="RestatementAmountRelatedNonEmployeeOptionsValuation" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="icpt_RestatementIncreaseDecreaseInAdditionalPaidInCapital" name="RestatementIncreaseDecreaseInAdditionalPaidInCapital" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="icpt_RestatementIncreaseDecreaseInRetainedEarningsAccumulatedDeficit" name="RestatementIncreaseDecreaseInRetainedEarningsAccumulatedDeficit" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="icpt_RestatementIncreaseDecreaseInResearchAndDevelopmentExpenses" name="RestatementIncreaseDecreaseInResearchAndDevelopmentExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
</schema>


