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<link:definition>008 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</link:definition>
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<link:definition>012 - Disclosure - STOCK BASED COMPENSATION</link:definition>
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<link:definition>014 - Disclosure - STOCKHOLDERS' EQUITY</link:definition>
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<link:definition>019 - Disclosure - PREPAID EXPENSES AND OTHER CURRENT ASSETS (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>021 - Disclosure - STOCK BASED COMPENSATION (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>022 - Disclosure - STOCKHOLDERS' EQUITY (Tables)</link:definition>
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<link:definition>023 - Disclosure - DISCONTINUED OPERATIONS (Tables)</link:definition>
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<link:definition>024 - Disclosure - NATURE OF OPERATIONS AND BASIS OF PRESENTATION (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>025 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>026 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>027 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 2)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>028 - Disclosure - FAIR VALUE (Details)</link:definition>
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<link:definition>029 - Disclosure - FAIR VALUE (Details 1)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>030 - Disclosure - FAIR VALUE (Details 2)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>031 - Disclosure - FAIR VALUE (Details 3)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>032 - Disclosure - PREPAID EXPENSES AND OTHER CURRENT ASSETS (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>033 - Disclosure - ACCRUED AND OTHER CURRENT LIABILITIES (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>034 - Disclosure - STOCK BASED COMPENSATION (Details)</link:definition>
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<link:definition>035 - Disclosure - STOCK BASED COMPENSATION (Details 1)</link:definition>
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<link:definition>036 - Disclosure - STOCK BASED COMPENSATION (Details 2)</link:definition>
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<link:definition>037 - Disclosure - STOCK BASED COMPENSATION (Details 3)</link:definition>
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<link:definition>038 - Disclosure - STOCK BASED COMPENSATION (Details 4)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>039 - Disclosure - STOCK BASED COMPENSATION (Details 5)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>040 - Disclosure - COMMITMENTS AND CONTINGENCIES (Details)</link:definition>
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<link:definition>041 - Disclosure - STOCKHOLDERS' EQUITY (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>042 - Disclosure - STOCKHOLDERS' EQUITY (Details 2)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>043 - Disclosure - STOCKHOLDERS' EQUITY (Details 3)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>044 - Disclosure - STOCKHOLDERS' EQUITY (Details 4)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>045 - Disclosure - STOCKHOLDERS' EQUITY (Details 5)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>046 - Disclosure - STOCKHOLDERS' EQUITY (Details 6)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>047 - Disclosure - DISCONTINUED OPERATIONS (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
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<link:definition>048 - Disclosure - DISCONTINUED OPERATIONS (Details 2)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
<import namespace="http://fasb.org/us-types/2014-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2014/elts/us-types-2014-01-31.xsd"/>
<element name="DocumentAndEntityInformationAbstract" id="cycc_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ExpenseRelatedToStockPurchaseAgreement" id="cycc_ExpenseRelatedToStockPurchaseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ChangeInValuationOfEconomicRights" id="cycc_ChangeInValuationOfEconomicRights" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="RedeemablePreferredStocksDividends" id="cycc_RedeemablePreferredStocksDividends" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="DividendsPreferredStocks" id="cycc_DividendsPreferredStocks" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="OtherComprehensiveIncomeUnrealizedForeignExchangeOnIntercompanyLoansNetOfTaxPortionAttributableToParent" id="cycc_OtherComprehensiveIncomeUnrealizedForeignExchangeOnIntercompanyLoansNetOfTaxPortionAttributableToParent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ChangeInValuationOfLiabilitiesMeasuredAtFairValue" id="cycc_ChangeInValuationOfLiabilitiesMeasuredAtFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="CashReceivedDuringPeriodForAbstract" id="cycc_CashReceivedDuringPeriodForAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ScheduleOfNonCashTransactionsAbstract" id="cycc_ScheduleOfNonCashTransactionsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="IssuanceOfOrdinarySharesInLieuOfCashBonus" id="cycc_IssuanceOfOrdinarySharesInLieuOfCashBonus" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PrepaidExpensesAndOtherCurrentAssetsAbstract" id="cycc_PrepaidExpensesAndOtherCurrentAssetsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PrepaidExpensesAndOtherCurrentAssetsTextBlock" id="cycc_PrepaidExpensesAndOtherCurrentAssetsTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="RisksAndUncertaintiesPolicyTextBlock" id="cycc_RisksAndUncertaintiesPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ClinicalTrialAccountingPolicyTextBlock" id="cycc_ClinicalTrialAccountingPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="RecentEventPolicyTextBlock" id="cycc_RecentEventPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ScheduleOfPreferredStockRedemptionPricesTableTextBlock" id="cycc_ScheduleOfPreferredStockRedemptionPricesTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="NatureOfOperationsAbstract" id="cycc_NatureOfOperationsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="GrantsAwardedByMedicalResearchCouncil" id="cycc_GrantsAwardedByMedicalResearchCouncil" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ProceedsFromGrantors2" id="cycc_ProceedsFromGrantors2" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
 
<element name="FinancialInstrumentAssociatedWithStockPurchaseAgreementFairValueDisclosure" id="cycc_FinancialInstrumentAssociatedWithStockPurchaseAgreementFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="OtherLiabilitiesFairValueAbstract" id="cycc_OtherLiabilitiesFairValueAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="EconomicRightsMember" id="cycc_EconomicRightsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="AgreementAxis" id="cycc_AgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/> 
<element name="AgreementDomain" id="cycc_AgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PurchaseAgreementMember" id="cycc_PurchaseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="DefinitiveAgreementMember" id="cycc_DefinitiveAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="CelgeneCorporationCaseMember" id="cycc_CelgeneCorporationCaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="AspireCapitalFundLLCMember" id="cycc_AspireCapitalFundLLCMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="CommonStockPurchaseAgreementShares" id="cycc_CommonStockPurchaseAgreementShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="CommonStockPurchaseAgreementTermPeriod" id="cycc_CommonStockPurchaseAgreementTermPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="GuarantorObligationsModifiedPaymentForWhichPartiesAgreed" id="cycc_GuarantorObligationsModifiedPaymentForWhichPartiesAgreed" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
 
<element name="GuarantorObligationsAmountPaid" id="cycc_GuarantorObligationsAmountPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="GuarantorObligationsPotentialAmountToBePaidIfStaffingLevelsReducedBelowPrescribedLevels" id="cycc_GuarantorObligationsPotentialAmountToBePaidIfStaffingLevelsReducedBelowPrescribedLevels" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="FairValueAssumptionsProbabilityOfFallingStaffingLevelBelowMinimumPrescribedLevelsWithinPrescribedTimePeriod" id="cycc_FairValueAssumptionsProbabilityOfFallingStaffingLevelBelowMinimumPrescribedLevelsWithinPrescribedTimePeriod" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="SalesTaxReceivableCurrent" id="cycc_SalesTaxReceivableCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="AccruedResearchAndDevelopmentCostsCurrent" id="cycc_AccruedResearchAndDevelopmentCostsCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageExercisePrice" id="cycc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="cycc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageRemainingContractualTerm" id="cycc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" id="cycc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedIntrinsicValue" id="cycc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsUnvestedIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardForfeitureRate" id="cycc_ShareBasedCompensationArrangementByShareBasedPaymentAwardForfeitureRate" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsNumberOfSecuritiesUsedToCalculateWeightedAverageRiskFreeInterestRate" id="cycc_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsNumberOfSecuritiesUsedToCalculateWeightedAverageRiskFreeInterestRate" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="LicenseAgreementPotentialFutureMilestonePayments" id="cycc_LicenseAgreementPotentialFutureMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockRedemptionPeriodAxis" id="cycc_PreferredStockRedemptionPeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/> 
<element name="PreferredStockRedemptionPeriodDomain" id="cycc_PreferredStockRedemptionPeriodDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockRedemptionPeriodFromYear1November2013To31October2014Member" id="cycc_PreferredStockRedemptionPeriodFromYear1November2013To31October2014Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockRedemptionPeriodFromYear1November2014AndThereafterMember" id="cycc_PreferredStockRedemptionPeriodFromYear1November2014AndThereafterMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockConvertibleConversionRatio" id="cycc_PreferredStockConvertibleConversionRatio" type="xbrli:decimalItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ConvertiblePreferredStockConversionPricePerShare" id="cycc_ConvertiblePreferredStockConversionPricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="NumberOfSeriesOfPreferredStock" id="cycc_NumberOfSeriesOfPreferredStock" type="xbrli:integerItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockConversionObligationCommonStockClosingSalesPriceAsPercentageOfConversionPrice" id="cycc_PreferredStockConversionObligationCommonStockClosingSalesPriceAsPercentageOfConversionPrice" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockConversionObligationCommonStockClosingSalesPriceNumberOfTradingDays" id="cycc_PreferredStockConversionObligationCommonStockClosingSalesPriceNumberOfTradingDays" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockConversionObligationNumberOfTradingDays" id="cycc_PreferredStockConversionObligationNumberOfTradingDays" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockConversionObligationThirtyDayTradingPeriodEndingWithinNumberOfTradingDaysPriorToNoticeOfAutomaticConversion" id="cycc_PreferredStockConversionObligationThirtyDayTradingPeriodEndingWithinNumberOfTradingDaysPriorToNoticeOfAutomaticConversion" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockNumberOfQuartersInWhichCashDividendsNotPaid" id="cycc_PreferredStockNumberOfQuartersInWhichCashDividendsNotPaid" type="xbrli:integerItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="NumberOfBoardOfDirectorsToBeElectedByPreferredStockHoldersUponFailureToPayDividendsOnPreferredStock" id="cycc_NumberOfBoardOfDirectorsToBeElectedByPreferredStockHoldersUponFailureToPayDividendsOnPreferredStock" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="NumberOfBoardOfDirectorsElectedByPreferredStockHoldersDueToFailureToPayDividendsOnPreferredStock" id="cycc_NumberOfBoardOfDirectorsElectedByPreferredStockHoldersDueToFailureToPayDividendsOnPreferredStock" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="PreferredStockExchangeRatePrincipalAmountOfNotesUsedInCalculation" id="cycc_PreferredStockExchangeRatePrincipalAmountOfNotesUsedInCalculation" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="EquityOfferingTable" id="cycc_EquityOfferingTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/> 
<element name="EquityOfferingComponentsAxis" id="cycc_EquityOfferingComponentsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem"/> 
<element name="EquityOfferingComponentDomain" id="cycc_EquityOfferingComponentDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="April2014IssuanceMember" id="cycc_April2014IssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="EquityOfferingLineItems" id="cycc_EquityOfferingLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ConversionOfConvertiblePreferredStockAbstract" id="cycc_ConversionOfConvertiblePreferredStockAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="CommonStockIssuedAbstract" id="cycc_CommonStockIssuedAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesAtStatedConvertibleOption" id="cycc_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesAtStatedConvertibleOption" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesIncrementalShares" id="cycc_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesIncrementalShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="November2013StockIssuanceMember" id="cycc_November2013StockIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="December2012StockIssuanceMember" id="cycc_December2012StockIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="May2013SaleOfCommonStockMember" id="cycc_May2013SaleOfCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="March2012SaleOfCommonStockAndEconomicRightsMember" id="cycc_March2012SaleOfCommonStockAndEconomicRightsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="July2011StockIssuanceMember" id="cycc_July2011StockIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="October2010StockIssuanceMember" id="cycc_October2010StockIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="January2010StockIssuanceOneMember" id="cycc_January2010StockIssuanceOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="January2010StockIssuanceTwoMember" id="cycc_January2010StockIssuanceTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="July2009StockIssuanceMember" id="cycc_July2009StockIssuanceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="CommonStockUnderwritingAgreementShares" id="cycc_CommonStockUnderwritingAgreementShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="NumberOfSharesIssuedDuringPeriodSubjectToUnderwritersOverAllotmentOption" id="cycc_NumberOfSharesIssuedDuringPeriodSubjectToUnderwritersOverAllotmentOption" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="EquityIssuancePerShareAmountNumberOfDaysUsedToCalculateAverageClosingPrice" id="cycc_EquityIssuancePerShareAmountNumberOfDaysUsedToCalculateAverageClosingPrice" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="FinancingAgreementAmountToBePaidAsPercentageOfFutureLitigationSettlementReceived" id="cycc_FinancingAgreementAmountToBePaidAsPercentageOfFutureLitigationSettlementReceived" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="EquityIssuanceLockUpPeriod" id="cycc_EquityIssuanceLockUpPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="EconomicRightSettledForPayments" id="cycc_EconomicRightSettledForPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ClassOfWarrantOrRightAbstract" id="cycc_ClassOfWarrantOrRightAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="ProductPromotionAndSaleOperationMember" id="cycc_ProductPromotionAndSaleOperationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="DisposalGroupIncludingDiscontinuedOperationShortTermPortionOfMinimumRoyaltyArrangementReceivableNet" id="cycc_DisposalGroupIncludingDiscontinuedOperationShortTermPortionOfMinimumRoyaltyArrangementReceivableNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="DisposalGroupIncludingDiscontinuedOperationReturnsIndemnificationReceivableNet" id="cycc_DisposalGroupIncludingDiscontinuedOperationReturnsIndemnificationReceivableNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="DisposalGroupIncludingDiscontinuedOperationLongTermPortionOfMinimumRoyaltyArrangementReceivableNet" id="cycc_DisposalGroupIncludingDiscontinuedOperationLongTermPortionOfMinimumRoyaltyArrangementReceivableNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="DisposalGroupIncludingDiscontinuedOperationReturnsProvision" id="cycc_DisposalGroupIncludingDiscontinuedOperationReturnsProvision" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/> 
<element name="NetIncomeLossAvailableToCommonStockholdersBasicAndDiluted" id="cycc_NetIncomeLossAvailableToCommonStockholdersBasicAndDiluted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" nillable="true" xbrli:balance="credit"/>
</schema>


