Document and Entity Information [Abstract] Entity Registrant Name Entity Central Index Key Trading Symbol Current Fiscal Year End Date Entity Filer Category Entity Common Stock, Shares Outstanding Document Type Document Period End Date Amendment Flag Document Fiscal Year Focus Document Fiscal Period Focus CONSOLIDATED BALANCE SHEETS Assets [Abstract] ASSETS Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Total cash and cash equivalents Cash and cash equivalents, beginning of period Cash and cash equivalents, end of period Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Prepaid expenses and other current assets Assets of Disposal Group, Including Discontinued Operation, Current Current assets of discontinued operations Total current assets of discontinued operations Total current assets of discontinued operations Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment (net) Long Lived Assets, net Property, Plant and Equipment, Net Disposal Group, Including Discontinued Operation, Long Lived Assets Long-term assets of discontinued operations Assets Total Assets Total assets Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Accrued Liabilities, Current Accrued and other current liabilities Accrued liabilities and other current liabilities Total Other Liabilities, Current Other liabilities measured at fair value Liabilities of Disposal Group, Including Discontinued Operation, Current Current liabilities of discontinued operations Total current liabilities of discontinued operations Total current liabilities of discontinued operations Liabilities, Current Total current liabilities Other liabilities Liabilities Total liabilities Commitments and Contingencies. Commitments and contingencies Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.001 par value; 5,000,000 shares authorized at December 31, 2011 and September 30, 2012; 1,213,142 shares issued and outstanding at December 31, 2011 and September 30, 2012. Aggregate preference in liquidation of $13,708,505 and $14,254,419 at December 31, 2011 and September 30, 2012, respectively Preferred stock, $0.001 par value; 5,000,000 shares authorized at December 31, 2013 and June 30, 2014; 335,273 shares issued and outstanding at December 31, 2013 and June 30, 2014. Aggregate preference in liquidation of $3,989,749 at December 31, 2013 and June 30, 2014. Common Stock, Value, Issued Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2011 and September 30, 2012; 7,745,779 and 8,434,292 shares issued and outstanding at December 31, 2011 and September 30, 2012, respectively Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2013 and June 30, 2014; 19,369,332 and 22,676,475 shares issued and outstanding at December 31, 2013 and June 30, 2014, respectively. Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income (loss) Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Total stockholders' equity Balance Balance Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Preferred Stock, Liquidation Preference, Value Preferred stock, liquidation preference value (in dollars) Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding CONSOLIDATED STATEMENTS OF OPERATIONS Revenue, Net [Abstract] Revenues: Revenue from Grants Grant revenue Revenue, Net Revenue Total revenues Costs and Expenses [Abstract] Operating expenses: Research and Development Expense Research and development Selling, General and Administrative Expense General and administrative Costs and Expenses Total operating expenses Operating Income (Loss) Operating loss Nonoperating Income (Expense) [Abstract] Other income (expense), net Other income (expense): Expense Related to Stock Purchase Agreement Change in valuation of financial instruments associated with stock purchase agreement Stock purchase agreement Represents the amount of expenses related to acquisition of common and preferred stock. Change in valuation of financial instruments associated with stock purchase agreement Change in Valuation of Economic Rights Change in valuation of Economic Rights Change in fair value of the derivative Economic Rights settled This element represents the change in the valuation of economic rights during the reporting period. Change in valuation of Economic Rights Gain (Loss) on Derivative Instruments, Net, Pretax Change in valuation of liabilities measured at fair value Change in valuation of other liabilities measured at fair value Change in valuation of other liabilities measured at fair value Foreign Currency Transaction Gain (Loss), before Tax Foreign exchange gains (losses) Foreign exchange (losses)/gains Investment Income, Interest Interest income Other Nonoperating Income Other income, net Nonoperating Income (Expense) Total other income (expense) Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Income (loss) from continuing operations before taxes Income Tax Expense (Benefit) Income tax benefit Current - total Income tax benefit Income tax benefit Income (Loss) from Continuing Operations Attributable to Parent Net income (loss) from continuing operations Net income (loss) from continuing operations Net income (loss) from continuing operations Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax [Abstract] Discontinued operations: Discontinued Operation, Income (Loss) from Discontinued Operation, before Income Tax Income from discontinued operations (Loss) income from discontinued operations Discontinued Operation, Tax Effect of Discontinued Operation (Loss) income from discontinued operations, tax Income tax on discontinued operations Income tax on discontinued operations Income (Loss) from Discontinued Operations, Net of Tax, Attributable to Parent Net income from discontinued operations Net (loss) income from discontinued operations Net income from discontinued operations Net Income (Loss) Attributable to Parent Net loss Loss for the year Net income (loss) Net income (loss) Redeemable Preferred Stocks Dividends Deemed dividends recorded Deemed dividend Deemed dividend on convertible exchangeable preferred shares The amount of dividends deemed declared in the period to preferred shareholders as a result of the preferred shares being converted into common stock. Deemed dividend on convertible exchangeable preferred shares Dividends Preferred Stocks Dividend on convertible exchangeable preferred shares The amount of dividends declared in the period to preferred shareholders even if not paid. Dividend on convertible exchangeable preferred shares Net Income (Loss) Available to Common Stockholders, Basic Net income (loss) applicable to common shareholders Earnings Per Share, Basic [Abstract] Basic earnings per common share: Income (Loss) from Continuing Operations, Per Basic Share Net income (loss) from continuing operations - Basic Net income (loss) per share, continuing operations (in dollars per share) Discontinued Operation, Income (Loss) from Discontinued Operation, Net of Tax, Per Basic Share Net income (loss) per share, discontinued operations (in dollars per share) Earnings Per Share, Basic Net income (loss) per share applicable to common shareholders (in dollars per share) Earnings Per Share, Diluted [Abstract] Diluted earnings per common share: Income (Loss) from Continuing Operations, Per Diluted Share Net income (loss) per share, continuing operations - Diluted Net income (loss) per share, continuing operations (in dollars per share) Net income (loss) from continuing operations - Diluted Discontinued Operation, Income (Loss) from Discontinued Operation, Net of Tax, Per Diluted Share Net income (loss) per share, discontinued operations (in dollars per share) Earnings Per Share, Diluted Net income (loss) per share applicable to common shareholders (in dollars per share) Weighted Average Number of Shares Outstanding, Diluted [Abstract] Weighted average shares of common stock outstanding: Weighted Average Number of Shares Outstanding, Basic Basic (in shares) Weighted average shares of common stock outstanding - Basic Weighted Average Number of Shares Outstanding, Diluted Weighted average shares of common stock outstanding - Diluted Diluted (in shares) Weighted average shares of common stock outstanding - Diluted CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Translation adjustment Other Comprehensive Income Unrealized Foreign Exchange on Intercompany Loans Net of Tax Portion Attributable to Parent Unrealized foreign exchange on intercompany loans Unrealized foreign exchange gain (loss) on intercompany loans Change in the balance sheet adjustment that results from the process of translating subsidiary financial statements and foreign equity investments into functional currency of the reporting entity, net of tax, attributable to the parent entity. If the entity's functional currency is a foreign currency, translation adjustments result from the process of translating that entity's financial statements into the reporting currency. It includes gain (loss) on foreign exchange on intercompany loans. Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Comprehensive income (loss) CONSOLIDATED STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Operating activities: Cash flows from operating activities: Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Change In Valuation Of Liabilities Measured At Fair Value Represents the change in the valuation of liabilities measured at fair value during the reporting period. Change in valuation of liabilities measured at fair value Depreciation, Depletion and Amortization Depreciation Depreciation and amortization expense Gain (Loss) on Disposition of Intangible Assets Gain on sale of patents Gain on sale of patents Share-based Compensation Stock-based compensation Stock based compensation Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Prepaid expenses, inventory and other current assets Increase (Decrease) in Accounts Payable and Other Operating Liabilities Accounts payable and other current liabilities Accounts payable, accrued liabilities and other current liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Investing activities: Payments to Acquire Property, Plant, and Equipment Purchase of property, plant and equipment Payments for (Proceeds from) Other Investing Activities Minimum royalty payments received from termination of ALIGN license agreement Proceeds from Sale of Intangible Assets Proceeds from sale of patents Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash provided by investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Financing activities: Proceeds from Issuance of Common Stock Proceeds from issuance of common stock, net of issuance costs Proceeds from issuance of common stock, warrants and economic rights, net of issuance costs Payments of Ordinary Dividends, Preferred Stock and Preference Stock Payment of preferred stock dividend Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Effect of Exchange Rate on Cash and Cash Equivalents, Continuing Operations Effect of exchange rate changes on cash and cash equivalents Net Cash Provided by (Used in) Continuing Operations Net increase in cash and cash equivalents Supplemental Cash Flow Information [Abstract] Supplemental cash flow information: Supplemental disclosure of cash flows information: Cash Received During Period for [Abstract] Cash received during the period for: Proceeds from Interest Received Interest Proceeds from Income Tax Refunds Taxes Schedule of Non Cash Transactions [Abstract] Schedule of non-cash transactions: Issuance of Ordinary Shares in Lieu of Cash Bonus Issuance of Ordinary shares in lieu of cash bonus Issuance of ordinary shares in lieu of cash bonus Issuance of ordinary shares in lieu of cash bonuses. Organization of the Company Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] NATURE OF OPERATIONS AND BASIS OF PRESENTATION Organization of the Company Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Fair Value Fair Value Disclosures [Text Block] FAIR VALUE FAIR VALUE MEASUREMENTS Prepaid Expenses And Other Current Assets [Abstract] Prepaid Expenses and Other Current Assets [Text Block] PREPAID EXPENSES AND OTHER CURRENT ASSETS PREPAID EXPENSES AND OTHER CURRENT ASSETS This element represent as Prepaid Expenses and Other Current Assets. Accrued and Other Current Liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] ACCRUED AND OTHER CURRENT LIABILITIES ACCRUED LIABILITIES AND OTHER CURRENT LIABILITIES Stock-Based Compensation Arrangements Disclosure of Compensation Related Costs, Share-based Payments [Text Block] STOCK BASED COMPENSATION STOCK BASED COMPENSATION Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] COMMITMENTS AND CONTINGENCIES COMMITMENTS AND CONTINGENCIES Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] STOCKHOLDERS' EQUITY STOCKHOLDERS' EQUITY Discontinued Operations Disposal Groups, Including Discontinued Operations, Disclosure [Text Block] DISCONTINUED OPERATIONS DISCONTINUED OPERATIONS Use of Estimates, Policy [Policy Text Block] Use of Estimates Risks and Uncertainties [Policy Text Block] Risks and Uncertainties Represents the accounting policy disclosure related to risks and uncertainties. Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Revenue Recognition, Policy [Policy Text Block] Revenue Recognition Clinical Trial Accounting [Policy Text Block] Clinical Trial Accounting Describes the entity's accounting policy for clinical trials performed by contract research organizations or clinical research associates. Research and Development Expense, Policy [Policy Text Block] Research and Development Expenditures Foreign Currency Transactions and Translations Policy [Policy Text Block] Foreign Currency and Currency Translation Income Tax, Policy [Policy Text Block] Income Taxes Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Stock-based compensation Segment Reporting, Policy [Policy Text Block] Segments Earnings Per Share, Policy [Policy Text Block] Net Loss Per Common Share Comprehensive Income, Policy [Policy Text Block] Comprehensive Income (Loss) Recent Event [Policy Text Block] Recent Events Disclosure of accounting policy about the recent events occurred during the period. New Accounting Pronouncements, Policy [Policy Text Block] Accounting Standards Adopted in the Period Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Schedule of basic earnings per share and diluted earnings per share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of antidilutive shares excluded from computation of diluted net loss per share Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Schedule of financial assets and liabilities measured on a recurring basis Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Schedule of of Level 3 inputs Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block] Schedule of prepaid expenses and other current assets Schedule of Accrued Liabilities [Table Text Block] Schedule of accrued and other current liabilities Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Schedule of stock based compensation expense Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of stock option activity Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block] Schedule of restricted stock units activity Schedule of Preferred Stock Redemption Prices [Table Text Block] Schedule of redemption prices per share Tabular disclosure of redemption prices of preferred stock. Schedule of Conversions of Stock [Table Text Block] Schedule of conversion of convertible preferred stock Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Schedule of warrants outstanding Schedule of Disposal Groups, Including Discontinued Operations, Income Statement, Balance Sheet and Additional Disclosures [Table Text Block] Schedule of assets and liabilities, and product revenue, cost of goods sold and selling, general and administrative costs of discontinued operations Nature of Operations [Abstract] Nature of Operations Grants Awarded By Medical Research Council Grants awarded from United Kingdom' s Medical Research Council Represents the amount of grants awarded by the United Kingdom's Medical Research Council during the reporting period. Proceeds from Grantors Grant awarded from UK Government's Biomedical Catalyst Proceeds From Grantors 2 Grant received Cash received from grantors during the current period related to operating activities. This element represents receipts from a guarantor for the amount of guarantee provided. Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements Dilutive effect of stock options Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Employee Stock Option [Member] Stock options Restricted Stock Units (RSUs) [Member] Restricted Stock Units Restricted Stock and Restricted Stock Units Convertible Preferred Stock [Member] Preferred stock Convertible preferred stock Warrant [Member] Common stock warrants Warrants Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Net loss per common share Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Total shares excluded from calculation Segment Reporting [Abstract] Segments Number of Operating Segments Number of operating segments Number of Countries in which Entity Operates Number of geographic areas for development operations Preferred Stock, Dividends Per Share, Declared Cash dividend declared per share (in dollars per share) Preferred Stock, Dividend Rate, Percentage Dividend rate (in percent) Dividend rate on convertible exchangeable preferred stock (in percent) Fair Value Measurements, Recurring and Nonrecurring [Table] Measurement Frequency [Axis] Fair Value, Measurement Frequency [Domain] Fair Value, Measurements, Recurring [Member] Recurring basis Fair Value, Hierarchy [Axis] Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value, Inputs, Level 1 [Member] Level 1 Fair Value, Inputs, Level 2 [Member] Level 2 Fair Value, Inputs, Level 3 [Member] Level 3 Estimate of Fair Value, Fair Value Disclosure [Member] Total Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair value measurements Assets, Fair Value Disclosure [Abstract] ASSETS Cash Equivalents, at Carrying Value Cash equivalents Financial Instrument Associated with Stock Purchase Agreement Fair Value Disclosure Financial instrument associated with stock purchase agreement Represents the fair value of financial instrument associated with stock purchase agreement. Financial instrument associated with stock purchase agreement Assets, Fair Value Disclosure Total assets Total assets Liabilities, Fair Value Disclosure [Abstract] LIABILITIES Other Liabilities Fair Value [Abstract] Other liabilities measured at fair value: Guarantees, Fair Value Disclosure Fair value of the liability Scottish Enterprise agreement Other Liabilities, Fair Value Disclosure Other liabilities measured at fair value Other Derivatives Liabilities, Fair Value Disclosure Total liabilities Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Liability Class [Axis] Fair Value by Liability Class [Domain] Guarantees [Member] Guarantees Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value Balance as of December 31, 2013 Balance as of June 30, 2014 Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease) Change in valuation of Scottish Enterprise agreement Economic Rights [Member] Economic Rights Represents the contractual rights of investors under a financing agreement, to receive cash equal to specified percentage of any future litigation settlement related to the specified intellectual property, subject to a cap. Agreement [Axis] Represents the information about Represents the information about type of agreement. Agreement [Domain] Represents the information about Represents the information about type of agreement. Purchase Agreement [Member] Purchase Agreement Represents the purchase agreement. Definitive Agreement [Member] Definitive Agreement Represents definitive agreement. Litigation Case [Axis] Litigation Case [Domain] Celgene Corporation Case [Member] Celgene Corporation Represents the information pertaining to a complaint filed against Celgene Corporation, in which the company charged Celgene with infringement of the company's patents. Legal Entity [Axis] Entity [Domain] Aspire Capital Fund LLC [Member] Aspire Capital Fund, LLC Represents information pertaining to Aspire Capital Fund, LLC. Stock Issued During Period, Shares, Issued for Cash Number of shares issued under purchase agreement Issue of common stock on share purchase agreement (in shares) Stock Issued During Period, Value, Issued for Cash Purchase price for shares issued under purchase agreement Issue of common stock on share purchase agreement Common Stock Purchase Agreement Shares Shares committed to purchase Represents the number of shares of common stock committed to purchase under the purchase agreement. Common Stock Purchase Agreement Term Period Period of common stock purchase agreement Represents the term of the common stock purchase agreement. Receivables, Fair Value Disclosure Fair value of financial instrument Derivative, Gain (Loss) on Derivative, Net Decrease in the fair value of the Purchase Agreement Schedule of Guarantor Obligations [Table] Guarantor Obligations, Nature [Axis] Guarantor Obligations, Nature [Domain] Performance Guarantee [Member] Scottish Enterprise Agreement Derivative Guarantor Obligations [Line Items] Scottish Enterprise Agreement Guarantor Obligations, Maximum Exposure, Undiscounted Maximum guaranteed amount potentially due to SE Guarantor Obligations Modified Payment for which Parties Agreed Modified payment for which parties agreed Represents the modified payment that will be paid by the entity for which the parties agreed. Guarantor Obligations Amount Paid Amount paid Represents the amount paid by the entity under the guarantee or each group of similar guarantees. Guarantor Obligations Potential Amount to be Paid if Staffing Levels Reduced below Prescribed Levels Potential amount to be paid if staffing levels reduced below the prescribed levels Represents the potential amount to be paid, if staffing levels reduced below the prescribed levels. Fair Value Assumptions, Expected Volatility Rate Expected volatility (as a percent) Probability of falling below a minimum staffing level (as a percent) Fair Value Assumptions Probability of Falling Staffing Level below Minimum Prescribed Levels within Prescribed Time Period Probability of falling below a minimum staffing level within prescribed time period (as a percent) Represents the probability assumption of falling staffing level below minimum prescribed levels within prescribed time period used in valuing an instrument. Deferred Income Taxes and Other Tax Receivable, Current Research and development tax credit receivable Prepaid Expense, Current Prepayments Grants Receivable, Current Grant receivable Sales Tax Receivable Current Sales tax receivable Carrying amount as of the balance sheet date of amounts sales tax receivable. For classified balance sheets, represents the current amount receivable, that is amounts expected to be collected within one year or the normal operating cycle, if longer. Deposits Assets, Current Deposits Other Assets, Current Other current assets Accrued Research and Development Costs Current Accrued research and development Represents the carrying value, as of the balance sheet date, of obligations incurred through that date and payable arising from research and development transactions. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Professional Fees, Current Accrued legal and professional fees Other Accrued Liabilities, Current Other current liabilities Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Title of Individual [Axis] Title of Individual with Relationship to Entity [Domain] Executive Officer [Member] Executive officers Range [Axis] Range [Domain] Minimum [Member] Minimum Maximum [Member] Maximum Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Stock-based compensation Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Vesting period Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Income Statement Location [Axis] Income Statement Location [Domain] General and Administrative Expense [Member] General and administrative Research and Development Expense [Member] Research and development Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] Stock-based compensation Allocated Share-based Compensation Expense Stock-based compensation costs before income taxes Compensation cost Award Type [Axis] Award Type [Domain] Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Options Number of Options Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Options outstanding at December 31, 2013 (in shares) Options outstanding at June 30, 2014 (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Granted (in shares) Options granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Issue of common stock upon exercise of stock options (in shares) Stock option exercised (in shares) Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Cancelled / forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares, Beginning Balance Unvested at June 30, 2014 Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number Vested and exercisable at June 30, 2014 Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward] Weighted Average Exercise Price Per Share Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Options outstanding at December 31, 2013 (in dollars per share) Options outstanding at June 30, 2014 (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Cancelled / forfeited (in dollars per share) Share Based Compensation Arrangement by Share Based Payment Award, Options, Unvested Weighted Average Exercise Price Unvested at June 30, 2014 (in dollars per share) As of the balance sheet date, the weighted-average exercise price for unvested stock options. Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Vested and exercisable at June 30, 2014 (in dollars per share) Share Based Compensation Arrangement by Share Based Payment Award, Options, Weighted Average Remaining Contractual Term [Abstract] Weighted Average Remaining Contractual Term (Years) Weighted Average Remaining Contractual Term (years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Options outstanding Share Based Compensation Arrangement by Share Based Payment Award Options Unvested Weighted Average Remaining Contractual Term Unvested at the end of the period Weighted average remaining contractual term for unvested options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Vested and exercisable at the end of the period Share Based Compensation Arrangement by Share Based Payment Award, Options, Intrinsic Value [Abstract] Aggregate Intrinsic Value Aggregate Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Options outstanding Share Based Compensation Arrangement by Share Based Payment Award, Options, Unvested Intrinsic Value Unvested at the end of the period Represents the amount of difference between fair value of the underlying shares reserved for issuance and exercise price of options unvested. Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Vested and exercisable at the end of the period Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Number of shares reserved for issuance Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Expiration period Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Nonvested activity Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Non-vested at the beginning of the period (in shares) Non-vested at December 31, 2013 (in shares) Non-vested at June 30, 2014 (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Roll Forward] Weighted Average Grant Date Value Per Share Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Non-vested at December 31, 2013 (in dollars per share) Non-vested at June 30, 2014 (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Granted (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Additional General Disclosures [Abstract] Stock based compensation, additional disclosures Share Based Compensation Arrangement by Share Based Payment Award, Forfeiture Rate Forfeiture rate (as a percent) Represents the forfeiture rate used to estimate the pre-vesting option forfeitures. Share Based Compensation Arrangement by Share Based Payment Award, Fair Value Assumptions, Number of Securities Used to Calculate Weighted Average Risk Free Interest Rate Number of Federal Reserve securities whose weighted average is used for calculation of weighted average risk-free interest rate Represents the number of Federal Reserve securities whose weighted average is used for calculation of weighted average risk-free interest rate. License agreement potential future milestone payments Future milestone payments payable The potential future milestone payments required to be made under certain contractual agreements. Schedule of Stock by Class [Table] Preferred Stock Redemption Period [Axis] The periods over which the redemption price is in effect. Preferred Stock Redemption Period [Domain] The period over which the redemption price is in effect. Preferred Stock Redemption Period from Year 1, November 2013 to 31, October 2014 [Member] Year from November 1, 2013 to October 31, 2014 Represents the period from November 1, 2013 to October 31, 2014. Preferred Stock Redemption Period from Year 1, November 2014 and Thereafter [Member] November 1, 2014 and thereafter Represents the period from November 1, 2014 and thereafter. Class of Stock [Line Items] Stockholders' equity Stockholders equity Preferred Stock, Redemption Price Per Share Redemption price per share (in dollars per share) Class of Stock [Axis] Class of Stock [Domain] Common Stock [Member] Common stock Preferred Stock, Liquidation Preference Per Share Liquidation preference (in dollars per share) Preferred Stock Convertible Conversion Ratio Number of shares to be issued for each preferred stock upon conversion Represents the ratio applied to the preferred stock for purposes of determining the number of shares of the common stock into which the preferred stock will be converted. Convertible Preferred Stock Conversion Price Per Share Conversion price (in dollars per share) The price per share of the conversion feature embedded in the convertible preferred stock. Common Stock, Capital Shares Reserved for Future Issuance Shares reserved for future issuance upon conversion Number of series of Preferred Stock Number of series of Preferred Stock Number of series Represents the number of series of preferred stock. Share Price Closing price of stock (in dollars per share) Share price (in dollars per share) Preferred Stock Conversion Obligation Common Stock Closing Sales Price as Percentage of Conversion Price Percentage of the closing sales price of the entity's common stock that the conversion price must exceed in order for the preferred stock to be convertible Represents the percentage of the closing sales price of the entity's common stock for at least 20 days within 30 trading days that the closing sales price of the entity's common stock must exceed the conversion price in order for the preferred stock to be convertible. Preferred Stock Conversion Obligation Common Stock Closing Sales Price Number of Trading Days Number of trading days within 30 trading days in which the closing price of the entity's common stock must exceed the conversion price for the preferred stock to be convertible Represents the number of trading days within a period of 30 consecutive trading days the closing price of the entity's common stock must exceed the applicable price in order for the preferred stock to be convertible. Preferred Stock Conversion Obligation Number of Trading Days Number of trading days during which the closing price of the entity's common stock must exceed the conversion price for at least 20 days in order for the preferred stock to be convertible Represents the number of trading days during which the closing price of the entity's common stock must exceed the applicable conversion price for at least 20 days in order for the preferred stock to be convertible. Preferred Stock Conversion Obligation Thirty Day Trading Period Ending within Number of Trading Days Prior to Notice of Automatic Conversion Number of trading days prior to notice of automatic conversion Represents the number of trading days within 30-day trading period required to be ended prior to notice of automatic conversion. Preferred Stock Number of Quarters in which Cash Dividends not Paid Number of quarters in which no preferred stock dividends have been paid Represents the number of quarters in which cash dividends have not been paid on preferred stock Number of Board of Directors to be elected by Preferred Stock Holders upon Failure to Pay Dividends on Preferred Stock Number of Board of Directors to be elected by Preferred Stock holders if entity fails to pay dividends on Preferred Stock Represents the number of Board of Directors to be elected by Preferred Stock holders if the entity fails to pay dividends on preferred stock. Number of Board of Directors Elected by Preferred Stock Holders Due to Failure to Pay Dividends on Preferred Stock Number of Board of Directors elected by the Preferred Stock holders when the entity failed to pay dividends on Preferred Stock Represents the number of Board of Directors nominated by Preferred Stock holders when the entity failed to pay dividends on preferred stock for six quarters. Debt Instrument, Interest Rate, Stated Percentage Interest rate (as a percent) Preferred Stock Exchange Rate Principal Amount of Notes Used in Calculation Debt principal amount per share, basis for exchange (in dollars per share) Represents the unit of measurement in dollars which establishes the exchange rate of the preferred stock into debt. Debt Instrument, Term Debt instrument, term Conversion of Stock, Shares Converted Preferred shares exchanged (in shares) Preferred shares exchanged Stock Issued During Period, Shares, Conversion of Convertible Securities Preferred stock conversion (in shares) Number of shares issued upon conversion Total shares of common stock issued Equity Offering [Table] Table that contains information on capital units issued under different types of offering. Equity Components [Axis] Equity Component [Domain] Equity Offering Components [Axis] Pertinent information classified by type of offering. Equity Offering Component [Domain] The information related to capital units issued by different types of offering. April 2014 Issuance [Member] April 2014 Issuance Represents information about issuance of shares in April 2014. Equity Offering [Line Items] Common Stock Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Stock Issued During Period, Shares, New Issues Issue of common stock for cash in an underwritten public offering, net of expenses (in shares) Shares sold (in shares) Number of common stock issued Number of common shares sold into underwriting agreement (in shares) Shares Issued, Price Per Share Share price per share Stock Issued During Period, Value, New Issues Issue of common stock for cash in an underwritten public offering, net of expenses Proceeds from sale of common stock, net of certain fees and expenses Gross proceeds from issuance of common stock Proceed from public offering Conversion Of Convertible Preferred Stock [Abstract] Conversion of Convertible Preferred Stock Common Stock Issued [Abstract] Shares of common stock issued: Stock Issued During Period Shares Conversion of Convertible Securities at Stated Convertible Option At stated convertible option (in shares) Represents the total number of shares issued upon conversion of preferred shares at stated convertible option. At stated conversion terms Stock Issued During Period Shares Conversion of Convertible Securities Incremental Shares Incremental shares issued under the exchange transaction Represents the incremental number of shares issued under the exchange transaction upon conversion of preferred shares. November 2013 Stock Issuance [Member] November 2013 stock issuance Represents information pertaining to the stock issuance in November 2013. December 2012 Stock Issuance [Member] December 2012 stock issuance Represents information pertaining to the stock issuance in December 2012. May 2013 Sale Of Common Stock [Member] May 2013 sale of common stock Represents information pertaining to the sale of common stock in May 2013. March 2012 Sale of Common Stock and Economic Rights [Member] March 2012 Sale of Common Stock and Economic Rights Represents information pertaining to the sale of common stock and economic rights in March 2012. July 2011 Stock Issuance [Member] July 2011 stock issuance Represents the information pertaining to stock issuance in July 2011. October 2010 Stock Issuance [Member] October 2010 stock issuance Represents information pertaining to stock issuance in October 2010. January 2010 Stock Issuance, One [Member] January 2010 stock issuance, one Represents the information pertaining to stock issuance in January 2010, one. January 2010 Stock Issuance, Two [Member] January 2010 stock issuance, two Represents the information pertaining to stock issuance in January 2010, two. July 2009 Stock Issuance [Member] July 2009 Series II stock issuance Represents information pertaining to Series II stock issuance in July 2009. Purchase Obligation Common stock purchase agreement, purchase commitment Stock Issued During Period, Shares, Issued for Noncash Consideration Stock issued for non-cash consideration Stock issued in lieu of commitment fee Common Stock Underwriting Agreement Shares Shares committed for sale under agreement Represents the number of shares that the entity agreed to sale under the underwriting agreement. Development Stage Entities, Equity Issuance, Per Share Amount Price per share (in dollars per share) Offering price (in dollars per share) Number Of Shares Issued During Period Subject To Underwriters Over Allotment Option Number of share sold that were subject to the underwriters' over-allotment option Represents the number of shares issued during the period, which were subject to the underwriters' over-allotment option. Stock Issued During Period, Value, Issued for Services Issue of shares in lieu of cash bonus Fair value of common stock issued Proceeds from Issuance or Sale of Equity Net proceeds Equity Issuance Per Share Amount, Number of Days Used to Calculate Average Closing Price Number of days used to calculate average closing price Represents the number of days used to calculate the average closing price of the entity's common stock. Financing Agreement Amount to be Paid as Percentage of Future Litigation Settlement Received Amount to be paid as percentage of future litigation settlement amount received Represents the amount to be paid as percentage of future litigation settlement amount received related to the specified intellectual property, subject to a cap. Equity Issuance Lock Up Period Lock-up period from the date of issuance Represents the lock-up period from the date of issuance for the shares issued at closing. Economic Right Settled For Payments Change in valuation of Economic Rights Change in fair value of the derivative Economic Rights settled for payments This element represents amount of economic right settled for payments. Change in valuation of Economic Rights Class of Warrant or Right [Abstract] Warrants outstanding Common stock warrants Class of Warrant or Right, Outstanding Warrants outstanding Common Shares Issuable Class of Warrant or Right, Exercise Price of Warrants or Rights Weighted Average Exercise Price (in dollars per share) Exercise price of warrants (in dollars per share) Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights Number of shares of common stock issued in connection with warrants Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Table] Disposal Group Name [Axis] Disposal Groups, Including Discontinued Operations, Name [Domain] Product Promotion and Sale Operation [Member] ALIGN products Represents information pertaining to product promotion and sale operation, that has been discontinued. Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] Discontinued operations Disposal Group, Including Discontinued Operation, Income Statement Disclosures [Abstract] Reclassification of operating results from continuing operations to loss from discontinued operations Disposal Group, Including Discontinued Operation, Interest Income Interest income Assets of Disposal Group, Including Discontinued Operation, Current [Abstract] Current assets of discontinued operations: Disposal Group Including Discontinued Operation Short Term Portion of Minimum Royalty Arrangement Receivable Net Short-term portion of minimum royalty arrangement receivable, net For the disposal group, including a component of the entity (discontinued operation), the aggregate of amount of short-term portion of minimum royalty arrangement receivable. Disposal Group Including Discontinued Operation Returns Indemnification Receivable Net Returns indemnification receivable For the disposal group, including a component of the entity (discontinued operation), the aggregate of amount of returns indemnification receivable. Assets of Disposal Group, Including Discontinued Operation, Noncurrent [Abstract] Long-term assets of discontinued operations: Disposal Group Including Discontinued Operation Long Term Portion of Minimum Royalty Arrangement Receivable Net Long-term portion of minimum royalty arrangement receivable, net For the disposal group, including a component of the entity (discontinued operation), the aggregate of amount of long-term portion of minimum royalty arrangement receivable. Assets of Disposal Group, Including Discontinued Operation Total assets of discontinued operations Total assets of discontinued operations Liabilities of Disposal Group, Including Discontinued Operation, Current [Abstract] Current liabilities of discontinued operations: Disposal Group Including Discontinued Operation Returns Provision Returns provision For the disposal group, including a component of the entity (discontinued operation), the amount of returns provision. Net Income Loss Available To Common Stockholders Basic And Diluted Represents net income from continuing operations after adjustments for dividends on preferred stock (declared in the period), cumulative preferred stock (accumulated for the period), dilutive convertible securities were converted, options or warrants were exercised, or that other shares were issued upon the satisfaction of certain conditions. Net loss per share, continuing operations - Basic and diluted (in dollars per share) Basic and diluted (in dollars per share) Numerator for earnings per share for Income (loss) from continuing operations - Basic and Diluted Numerator for earnings per share for Income (loss) from continuing operations - Basic and Diluted Prepaid Expense and Other Assets, Current [Abstract] Reclassification, Policy [Policy Text Block] Reclassification