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Financial Instruments link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Cash and Cash Equivalents link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Fair Value of Assets and Liabilities link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Investments link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Property and Equipment link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Restricted Cash link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Collaborations link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Comprehensive Income (Loss) link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Stock-Based Compensation link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Net Loss per Common Share Applicable to Common Stockholders link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Common Stock Warrant and Option Exercises and Employee Stock Purchases link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Related Party Transactions link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Financing link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - New Accounting Pronouncements - Recently Issued (Policies) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Fair Value of Assets and Liabilities (Tables) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Investments (Tables) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Property and Equipment (Tables) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Comprehensive Income (Loss) (Tables) link:calculationLink link:presentationLink link:definitionLink 129 - 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Tabular Disclosure of Major Components of Property and Equipment and Related Accumulated Depreciation (Detail) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Property and Equipment - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Restricted Cash - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Collaborations - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Comprehensive Income (Loss) - Changes in Accumulated Balance of the Component of Other Comprehensive Gain (Loss) (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Comprehensive Income (Loss) - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Stock-Based Compensation - Schedule of Assumptions Used to Determine Fair Value of Stock Options Granted During Period (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Net Loss per Common Share Applicable to Common Stockholders - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Common Stock Warrant and Option Exercises and Employee Stock Purchases - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Related Party Transactions - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 147 - Disclosure - Financing - Additional Information 1 (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Financing - Additional Information 2 (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Financing - May 2013 Follow-on Underwritten Public Offering (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Financing - Additional Information 3 (Detail) link:calculationLink link:presentationLink link:definitionLink