Entity Central Index Key Research and development And General And Administrative Expense. Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity Public Float Entity Public Float Accrued lease exit charge current. Statement Of Financial Position [Abstract] Assets Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Marketable securities Marketable Securities Current Accounts receivable Accounts Receivable Net Current Restricted cash Restricted Cash And Cash Equivalents At Carrying Value Prepaid expenses and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Property and equipment, net Property Plant And Equipment Net Other assets Other Assets Noncurrent Total assets Assets Liabilities and stockholders’ equity Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses Accrued Liabilities Current Lease exit obligation Accrued Lease Exit Charge Current Loans payable, net of discount Loans Payable Current Deferred revenue Deferred Revenue Current Estimated settlement liability (Note 16) Loss Contingency Accrual Carrying Value Current Deferred rent Deferred Rent Credit Current Total current liabilities Liabilities Current Loans payable, net of current portion and discount Long Term Loans Payable Deferred revenue, net of current portion Deferred Revenue Noncurrent Other liabilities Other Liabilities Noncurrent Commitments and contingencies (Note 8) Commitments And Contingencies Stockholders’ equity: Stockholders Equity [Abstract] Preferred stock, $.001 par value: 5,000 shares authorized; no shares issued and outstanding Preferred Stock Value Common stock, $.001 par value: 200,000 and 100,000 shares authorized at December 31, 2015 and 2014, respectively; 58,182 and 52,289 shares issued and outstanding at December 31, 2015 and 2014, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ equity Stockholders Equity Total liabilities and stockholders’ equity Liabilities And Stockholders Equity Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized Preferred Stock Shares Authorized Preferred stock, shares issued Preferred Stock Shares Issued Preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Income Statement [Abstract] Collaboration revenue Revenues Operating expenses: Operating Expenses [Abstract] Research and development Research And Development Expense General and administrative General And Administrative Expense Restructuring and lease exit Restructuring Charges Operating Expenses, Total Operating Expenses Loss from operations Operating Income Loss Other income and expense: Nonoperating Income Expense [Abstract] Other (expense) income, net Other Nonoperating Income Expense Interest expense Interest Expense Interest income Investment Income Interest Other expense, net Nonoperating Income Expense Net loss Net Income Loss Basic and diluted net loss per share: Earnings Per Share Basic And Diluted [Abstract] Net loss per share Earnings Per Share Basic And Diluted Weighted average number of common shares outstanding Weighted Average Number Of Share Outstanding Basic And Diluted Statement Of Income And Comprehensive Income [Abstract] Net loss Other comprehensive (loss) income: Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Unrealized (losses) gains on available-for-sale securities Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax Foreign currency translation adjustment Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax Comprehensive loss Comprehensive Income Net Of Tax Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Statement Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Shares Common Stock [Member] Additional Paid-in Capital Additional Paid In Capital [Member] Accumulated Other Comprehensive Loss Accumulated Other Comprehensive Income [Member] Accumulated Deficit Retained Earnings [Member] Subsidiary Sale Of Stock Subsidiary Sale Of Stock [Axis] Sale Of Stock Name Of Transaction Sale Of Stock Name Of Transaction [Domain] At the market sale agreement. At-The-Market Sale Agreement At The Market Sale Agreement [Member] Statement Scenario Statement Scenario [Axis] Scenario Unspecified Scenario Unspecified [Domain] Equity classified awards. Equity-classified awards Equity Classified Awards [Member] Liability Classified Awards [Member] Liability Classified Awards Liability Classified Awards [Member] After Initial Public Offering [Member] follow-on stock offering After Initial Public Offering [Member] Statement [Line Items] Statement [Line Items] Beginning Balance (in shares) Beginning Balance Exercise of stock options (in shares) Stock Issued During Period Shares Stock Options Exercised Exercise of stock options Stock Issued During Period Value Stock Options Exercised Stock-based compensation expense related to equity-classified awards Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Issuance of common stock to settle liability-classified share awards granted to directors (in shares) Stock Issued During Period Shares Share Based Compensation Issuance of common stock to settle liability-classified share awards granted to directors Stock Issued During Period Value Share Based Compensation Issuance of common stock under employee stock purchase plan (in shares) Stock Issued During Period Shares Employee Stock Purchase Plans Issuance of common stock under employee stock purchase plan Stock Issued During Period Value Employee Stock Purchase Plan Issuance of common stock (in shares) Stock Issued During Period Shares New Issues Issuance of common stock Stock Issued During Period Value New Issues Issuance of warrants in connection with loans payable Adjustments To Additional Paid In Capital Warrant Issued Issuance of restricted stock awards, net of forfeitures Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures Forfeiture of restricted stock awards (in shares) Stock Issued During Period Shares Share Based Compensation Forfeited Forfeiture of restricted stock awards Stock Issued During Period Value Share Based Compensation Forfeited Change in unrealized gain/loss on investments Cumulative translation adjustment Cumulative Translation Adjustment Net Of Tax Period Increase Decrease Ending Balance (in shares) Ending Balance Issuance of common stock, issuance costs Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Non cash interest expense. Increase (Decrease) in Tenant Improvement Allowance Receivable Current Increase Decrease In Lease Exit Obligation. Increase decrease in deferred rent. Statement Of Cash Flows [Abstract] Operating activities Net Cash Provided By Used In Operating Activities Continuing Operations [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation and amortization Depreciation And Amortization Net loss (gain) on disposal of property and equipment Gain Loss On Sale Of Property Plant Equipment Impairment of property and equipment Asset Impairment Charges Stock-based compensation Share Based Compensation Non-cash interest expense Non Cash Interest Expense Amortization of premiums and discounts on investments Accretion Amortization Of Discounts And Premiums Investments Changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable Increase Decrease In Accounts Receivable Tenant improvement allowance receivable Increase Decrease In Tenant Improvement Allowance Receivable Current Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other noncurrent assets Increase Decrease In Other Noncurrent Assets Restricted cash Increase Decrease In Restricted Cash For Operating Activities Accounts payable Increase Decrease In Accounts Payable Accrued expenses Increase Decrease In Accrued Liabilities Lease exit obligation Increase Decrease In Lease Exit Obligation Deferred revenue Increase Decrease In Deferred Revenue Other liabilities Increase Decrease In Other Operating Liabilities Estimated settlement liability Loss Contingency Accrual Carrying Value Period Increase Decrease Deferred rent Increase Decrease In Deferred Rent Net cash used in operating activities Net Cash Provided By Used In Operating Activities Continuing Operations Investing activities Net Cash Provided By Used In Investing Activities Continuing Operations [Abstract] Purchases of property and equipment Payments To Acquire Property Plant And Equipment Purchases of marketable securities Payments To Acquire Marketable Securities Proceeds from maturities and sales of marketable securities Proceeds From Sale And Maturity Of Marketable Securities Proceeds from sale of property and equipment Proceeds From Sale Of Property Plant And Equipment Net cash (used in) provided by investing activities Net Cash Provided By Used In Investing Activities Continuing Operations Financing activities Net Cash Provided By Used In Financing Activities Continuing Operations [Abstract] Proceeds from issuance of common stock, net of issuance costs Proceeds From Issuance Of Common Stock Proceeds from issuance of stock for stock-based compensation arrangements Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Proceeds from issuance of loans payable Proceeds From Issuance Of Long Term Debt Payments of debt issuance cost Payments Of Financing Costs Principal payments on loans payable Repayments Of Debt Net cash (used in) provided by financing activities Net Cash Provided By Used In Financing Activities Continuing Operations Net (decrease) increase in cash and cash equivalents Cash And Cash Equivalents Period Increase Decrease Effect of exchange rate changes on cash and cash equivalents Effect Of Exchange Rate On Cash And Cash Equivalents Cash and cash equivalents at beginning of period Cash and cash equivalents at end of period Supplemental cash flow and noncash investing and financing activities Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract] Cash paid for interest Interest Paid Non-cash financing activity Noncash Investing And Financing Items [Abstract] Fair value of warrants issued in connection with long-term debt Fair Value Adjustment Of Warrants Organization Consolidation And Presentation Of Financial Statements [Abstract] Nature of Business and Organization Nature Of Operations Accounting Policies [Abstract] Significant Accounting Policies Significant Accounting Policies [Text Block] Earnings Per Share [Abstract] Loss Per Common Share Earnings Per Share [Text Block] Property Plant And Equipment [Abstract] Property and Equipment Property Plant And Equipment Disclosure [Text Block] Payables And Accruals [Abstract] Accrued Expenses Accounts Payable And Accrued Liabilities Disclosure [Text Block] Debt Disclosure [Abstract] Loans Payable Debt Disclosure [Text Block] Collaborative and License Arrangement Disclosure Collaborations and License Agreements Collaborative And License Arrangement Disclosure [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Equity [Abstract] Common Stock and Warrants Stockholders Equity Note Disclosure [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Stock-Based Compensation Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Compensation And Retirement Disclosure [Abstract] Employee Benefit Plan Pension And Other Postretirement Benefits Disclosure [Text Block] Restructuring And Related Activities [Abstract] Strategic Restructuring Restructuring And Related Activities Disclosure [Text Block] Facility lease exit obligation disclosure. Facility lease exit. Facility Lease Exit [Abstract] Facility Lease Exit Facility Lease Exit Obligation Disclosure [Text Block] Quarterly Financial Information Disclosure [Abstract] Quarterly Results (Unaudited) Quarterly Financial Information [Text Block] Legal Actions Legal Matters And Contingencies [Text Block] Revenue Recognition Revenue Recognition Policy [Text Block] Principles of Consolidation Consolidation Policy [Text Block] Research and Development Expenses Research And Development Expense Policy Cash and Cash Equivalents Cash And Cash Equivalents Policy [Text Block] Marketable Securities Marketable Securities Policy Concentrations of Credit Risk Concentration Risk Credit Risk Fair Value Measurements Fair Value Measurement Policy Policy [Text Block] Property and Equipment Property Plant And Equipment Policy [Text Block] Long-lived Assets Impairment Or Disposal Of Long Lived Assets Policy [Text Block] Stock-Based Compensation Share Based Compensation Option And Incentive Plans Policy