Accounting Policies [Abstract] Accounting Policies [Abstract] Accounts and Other Receivables [Line Items] Accounts and Other Receivables [Line Items] Accounts and Other Receivables [Line Items] Accounts and Other Receivables [Table] Accounts and Other Receivables [Table] Accounts and Other Receivables [Table] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued expenses and other current liabilities Accounts Payable, Current Accounts payable Accounts Receivable, Net, Current Receivables from collaboration Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses Related Party Accrued Expenses Related Party Accrued expense associated with intellectual property Accrued interest of related party debt. Accrued Interest Of Related Party Debt Accrued interest of related party debt Accrued Liabilities, Current Accrued expenses and other current liabilities Accrued expenses and other current liabilities Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Less accumulated depreciation and amortization Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss AOCI Attributable to Parent [Member] Accumulated Other Comprehensive Income (Loss) Achievement of Product Sales Milestone [Member] Achievement of Product Sales Milestone [Member] Product Sales Milestones Additional Paid in Capital, Common Stock Additional paid-in capital Additional Paid-in Capital [Member] Additional Paid-in Capital Adjustments to Additional Paid in Capital, Convertible Debt with Conversion Feature Commitment to deliver common shares pursuant to Deerfield conversion to additional paid-in capital Adjustments to Additional Paid in Capital, Other Remeasurement of performance based grants pursuant to the modification of terms Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Reclassification of warrant liability to equity Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation Adjustments to Additional Paid in Capital, Share-based Compensation, Restricted Stock Unit or Restricted Stock Award, Requisite Service Period Recognition Restricted stock units taxes paid in cash Adjustments To Additional Paid In Capital Stock Option Issued Upon Debt Conversion Adjustments To Additional Paid In Capital Stock Option Issued Upon Debt Conversion Discount on notes-for-stock exchange Adjustments to Additional Paid in Capital, Warrant Issued Issuance of warrant liability Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash provided by (used in) operating activities: Agreement. Agreements [Axis] Agreements [Axis] Agreements. Agreements [Domain] Agreements [Domain] Alfred Mann Foundation [Member] Alfred Mann Foundation [Member] Mann Foundation Allocated Share-based Compensation Expense Share based compensation Stock based compensation expense related to stock award plans and the ESPP Amended Agreement [Member] Amended Agreement [Member] Amended Agreement Amendment Flag Amendment Flag Amortization of Debt Discount (Premium) Accretion expense- debt discount Premium of issuance of 2018 debt Amortization of Financing Costs Accretion expense- debt issuance cost Amortization of Financing Costs and Discounts Accretion of debt issuance costs Amortization period of lease hold improvements. Amortization Period Of Lease Hold Improvements Amortization period of lease hold improvements Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Potentially dilutive securities outstanding Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Area Of Office Space Leased Area Of Office Space Leased Area of office space leased Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Asset Impairment Charges Asset impairment charges Impairment charge Assets Total Assets [Abstract] ASSETS Assets, Current Total current assets Assets, Current [Abstract] Current assets: Securities or Other Assets Sold under Agreements to Repurchase [Axis] Securities or Other Assets Sold under Agreements to Repurchase [Axis] Assets Sold under Agreements to Repurchase, Type [Domain] Assets Sold under Agreements to Repurchase, Type [Domain] Available borrowings under the loan agreement. Available Borrowings Under Loan Agreement Available borrowings under loan agreement Available Loan Balance Cancelled Available Loan Balance Cancelled Aggregate principal amount cancelled Award Type [Axis] Award Type [Axis] Shares used to compute basic and diluted net loss per share applicable to common stockholders. Basic And Diluted Weighted Average Number Of Shares Outstanding Weighted average common shares used to compute basic and diluted net loss per share Basis of Presentation. Basis Of Presentation Policy [Text Block] Basis of Presentation Building Improvements [Member] Building Improvements Building [Member] Buildings Business. Business Policy [Text Block] Business CALIFORNIA CALIFORNIA Cancellation of principal on note payable to related party. Cancellation Of Principal On Note Payable To Related Party Reduction of principal on note payable to principal stockholder upon issuance of common stock and exercise of warrants Reported Value Measurement [Member] Reported Value Measurement Cash and Cash Equivalents, at Carrying Value CASH AND CASH EQUIVALENTS, END OF PERIOD CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD Cash and cash equivalents Cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Class of Stock [Line Items] Class of Stock [Line Items] Class of warrant exercisable period. Class Of Warrant Exercisable Period Warrants exercisable period Class Of Warrant Exercise Price Of Warrants Stated As Percentage Of Offering Price Class Of Warrant Exercise Price Of Warrants Stated As Percentage Of Offering Price Percentage of shares of common stock issued for offering Class of Warrant or Right, Exercise Price of Warrants or Rights Exercise price of restricted warrants per share in connection with the offering Class of Warrant or Right, Number of Securities Called by Warrants or Rights Number of warrants are exercisable Class of Warrant or Right, Outstanding Restricted warrants issued to purchase number of common stock for offering Class Of Warrants Or Rights Expiration Date Class Of Warrants Or Rights Expiration Date Warrants expiration, date Clinical Trial Expense Clinical Trial Expense [Policy Text Block] Clinical Trial Expenses Collaboration and License Agreement [Member] Collaboration and License Agreement [Member] License and Collaboration Agreement with Sanofi Collaborative Arrangement Disclosure [Text Block] Collaboration arrangement Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Commitments and Contingencies Commitments and contingencies Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Text Block] Commitments and contingencies Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies, Policy [Policy Text Block] Contingencies Commitments and Contingencies [Table] Commitments and Contingencies [Table] Commitments and Contingencies [Table] Common and preferred stock. Common And Preferred Stock [Text Block] Common and preferred stock Common Stock, Capital Shares Reserved for Future Issuance Shares reserved for issuance Common stock issued to by party. Common Stock Issued To By Party [Axis] Common Stock Issued To By Party [Axis] Common stock issued to by party. Common Stock Issued To By Party [Domain] Common Stock Issued To By Party [Domain] Common stock loaned under share lending agreement, shares. Common Stock Loaned Under Share Lending Agreement Shares Common stock loaned under share lending agreement, shares Return of loaned common stock (in shares) Return of loaned common stock (in shares) Common Stock Loaned Under Share Lending Agreement Value Common Stock Loaned Under Share Lending Agreement Value Return of loaned common stock Common Stock [Member] Common Stock Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Common Stock, Value, Issued Common stock, $0.01 par value - 550,000,000 shares authorized at December 31, 2015 and 2014, respectively; 428,670,943 and 406,059,089 shares issued and outstanding at December 31, 2015 and 2014, respectively Compensation and Retirement Disclosure [Abstract] Compensation and Retirement Disclosure [Abstract] Compensation Related Costs, Policy [Policy Text Block] Stock-Based Compensation Components of Deferred Tax Assets [Abstract] Deferred tax assets: Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Comprehensive Income, Policy [Policy Text Block] Comprehensive Loss Computer equipment and software. Computer Equipment And Software [Member] Computer Equipment and Software Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Consideration Received Consideration Received Total consideration received Consolidation, Policy [Policy Text Block] Principles of Consolidation Construction in Progress Expenditures Incurred but Not yet Paid Non-cash construction in progress and property and equipment Construction in Progress [Member] Construction in Progress Construction Payable, Current Construction in progress Consultant [Member] Consultant [Member] Consultant Contingent Liability Contingent Liability Contingent liability for milestone payments Convertible Debt [Line Items] Convertible Debt [Line Items] Convertible Debt [Line Items] Convertible Debt Securities [Member] Convertible Debt Securities Convertible Debt [Table] Convertible Debt [Table] Convertible Debt [Table] Convertible Notes Payable, Noncurrent Senior convertible notes - long term Convertible Notes Payable, Current Senior convertible notes - current Credit Facility [Axis] Credit Facility [Axis] Credit Facility [Domain] Credit Facility [Domain] Current Federal Tax Expense (Benefit) U.S. federal Current Fiscal Year End Date Current Fiscal Year End Date Current Foreign Tax Expense (Benefit) Non-U.S. Current Income Tax Expense (Benefit) Total current Current Income Tax Expense (Benefit), Continuing Operations [Abstract] Current Current State and Local Tax Expense (Benefit) U.S. state Danbury Facility [Member] Danbury Facility [Member] Danbury Facility Debt Conversion, Converted Instrument, Amount Principal amount of debt converted Debt Conversion, Converted Instrument, Shares Issued Number of shares issued up on conversion of debt Debt Conversion, Original Debt, Amount Aggregate principal amount for conversion Issuance of common stock pursuant to debt conversion by Deerfield Debt Disclosure [Abstract] Debt Disclosure [Abstract] Debt Disclosure [Text Block] Facility Agreement Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Basis Spread on Variable Rate Interest rate (LIBOR) Long-term Debt, Gross Carrying value Net carrying amount Debt Instrument, Convertible, Conversion Price Conversion price of shares Debt Instrument, Convertible, Conversion Ratio No of convertible shares Debt Instrument, Convertible, Threshold Consecutive Trading Days Consecutive trading days Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Percentage of conversion price equaling stock price Debt Instrument, Convertible, Threshold Trading Days Number of trading days Debt Instrument, Date of First Required Payment Principal repayment schedule, start date Debt Instrument Date Of Last Required Payment Debt Instrument Date Of Last Required Payment Principal repayment schedule, end date Debt Instrument, Description of Variable Rate Basis Description of variable rate interest Debt Instrument, Face Amount Debt facility principal amount Principal amount Debt Instrument, Fair Value Disclosure Estimated fair value Debt Instrument, Interest Rate, Stated Percentage Senior notes, effective interest rate Debt Instrument [Line Items] Debt Instrument [Line Items] Debt Instrument, Maturity Date Maturity date Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Debt Instrument, Redemption, Description Debt Instrument, redemption description Debt Instrument, Redemption Price, Percentage Percentage of repurchase price Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Debt Instrument, Unamortized Discount Uncreated debt discount Debt Instrument, Unamortized Premium Unamortized premium Debt Issuance Cost Debt Issuance Cost Debt, Policy [Policy Text Block] Milestone Rights Deerfield Management Company Lp [Member] Deerfield Management Company Lp [Member] Deerfield Deferred Costs, Noncurrent Deferred cost Deferred Costs, Current Deferred product costs from collaboration Deferred Federal Income Tax Expense (Benefit) U.S. federal Deferred Foreign Income Tax Expense (Benefit) Non-U.S. Deferred Income Tax Expense (Benefit) Total deferred Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract] Deferred Deferred Other Tax Expense (Benefit) Valuation Allowance Deferred Product Costs From Collaboration [Policy Text Block] Deferred Product Costs From Collaboration [Policy Text Block] Deferred product costs from collaboration Deferred Revenue Deferred revenue from collaboration product shipments Deferred Revenue, Current Deferred payments from collaboration Deferred State and Local Income Tax Expense (Benefit) U.S. state Deferred Tax Asset Increase Decrease in Equity Deferred Tax Asset Increase Decrease in Equity Amount Equity would be increased Deferred Tax Assets Capitalized Costs Deferred Tax Assets Capitalized Costs Capitalized patent costs Deferred Tax Assets Capitalized Research Expenses Deferred Tax Assets Capitalized Research Expenses Capitalized research Deferred Tax Assets, Deferred Income Payments from collaboration Deferred Tax Assets, Gross Total net deferred tax assets Deferred Tax Assets [Line Items] Deferred Tax Assets [Line Items] Deferred Tax Assets [Line Items] Deferred Tax Assets Loss on Purchase Commitment Deferred Tax Assets Loss on Purchase Commitment Loss on purchase commitment Deferred Tax Assets Milestone Rights Deferred Tax Assets Milestone Rights Milestone Rights Deferred Tax Assets, Net of Valuation Allowance Net deferred tax assets Deferred Tax Assets, Operating Loss Carryforwards Net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Domestic Federal operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration Research and development credits not subject to expiration Deferred Tax Assets, Operating Loss Carryforwards, State and Local State operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration Research and development credits subject to expiration Deferred Tax Assets, Other Depreciation Deferred Tax Assets [Table] Deferred Tax Assets [Table] Deferred Tax Assets [Table] Deferred Tax Assets, Tax Credit Carryforwards, Research Research and development credits Deferred Tax Assets, Tax Deferred Expense Accrued expenses Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost Non-qualified stock option expense Deferred Tax Assets, Tax Deferred Expense, Other Other Deferred Tax Assets, Valuation Allowance Valuation allowance Deficit accumulated during the development stage member. Deficit Accumulated During Development Stage [Member] Deficit Accumulated During the Development Stage Defined Benefit Plan, Contributions by Employer Employer contribution savings retirement plan Defined Benefit Plans and Other Postretirement Benefit Plans Disclosures [Table] Defined Benefit Plans and Other Postretirement Benefit Plans Disclosures [Table] Defined Benefit Plans and Other Postretirement Benefit Plans Table Text Block [Line Items] Defined Benefit Plans and Other Postretirement Benefit Plans Table Text Block [Line Items] Depreciation, Depletion and Amortization, Nonproduction Depreciation and accretion Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Table] Depreciation and Other Amortization Expenses [Table] Depreciation and Other Amortization Expenses [Table] Depreciation, Depletion and Amortization Depreciation and amortization expense Development Milestone Events [Member] Development Milestone Events [Member] Development Milestone Event Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock award plans Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block] Stock Based Award Plans Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Information [Table] Document Information [Table]