<?xml version="1.0" encoding="us-ascii"?>
<!-- DFS ActiveDisclosure(SM) XBRL Schema Document - http://www.dfsco.com/financial-services/ -->
<!-- Creation Date      : 2017-04-27T02:17:32.5115529+00:00 -->
<!-- Version            : 2.4.5.10 -->
<!-- Package ID         : C04E13A3F22AA2F0C53D7F02B779504E-0000789019-001703 -->
<!-- Copyright (c) 2017 Donnelley Financial, LLC. All Rights Reserved. -->
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        <link:definition>100230 - Disclosure - STOCKHOLDERS&apos; EQUITY</link:definition>
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  <element id="msft_FutureMinimumLeasePaymentsUnderNonCancellableCapitalLeasesTable" name="FutureMinimumLeasePaymentsUnderNonCancellableCapitalLeasesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="msft_ShareRepurchasesLineItems" name="ShareRepurchasesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="msft_ShareRepurchasesTable" name="ShareRepurchasesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="msft_ShareRepurchaseProgramTwentyThirteenMember" name="ShareRepurchaseProgramTwentyThirteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="msft_ShareRepurchaseProgramTwentySixteenMember" name="ShareRepurchaseProgramTwentySixteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="msft_DividendsLineItems" name="DividendsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="msft_DividendsTable" name="DividendsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="msft_AccumulatedTranslationAdjustmentAndOtherMember" name="AccumulatedTranslationAdjustmentAndOtherMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</schema>


