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<!-- Creation Date      : 2019-02-27T22:07:14.7535088+00:00 -->
<!-- Version            : 3.3.6989.14284 -->
<!-- Package ID         : 7843f527158544e5adb0b9607f2f4db5 -->
<!-- Copyright (c) 2019 Donnelley Financial, LLC. All Rights Reserved. -->
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  <element id="nvcr_DocumentDocumentAndEntityInformationAbstract" name="DocumentDocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ReceivablesAndPrepaidExpenses" name="ReceivablesAndPrepaidExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="nvcr_FieldEquipmentNetNoncurrent" name="FieldEquipmentNetNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="nvcr_SeverancePayFundNoncurrent" name="SeverancePayFundNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="nvcr_EmployeeRelatedLiabilitiesNonCurrent" name="EmployeeRelatedLiabilitiesNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="nvcr_StockIssuedDuringPeriodSharesExerciseOfOptionsAndWarrants" name="StockIssuedDuringPeriodSharesExerciseOfOptionsAndWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="nvcr_StockIssuedDuringPeriodValueExerciseOfOptionsAndWarrants" name="StockIssuedDuringPeriodValueExerciseOfOptionsAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
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  <element id="nvcr_PaymentsToAcquireOfFieldEquipment" name="PaymentsToAcquireOfFieldEquipment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
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  <element id="nvcr_FinancialStatementsCurrenciesPolicyPolicyTextBlock" name="FinancialStatementsCurrenciesPolicyPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="nvcr_ShortTermInvestmentsAndRestrictedCashPolicyPolicyTextBlock" name="ShortTermInvestmentsAndRestrictedCashPolicyPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <element id="nvcr_ShippingAndHandlingCostsRelatedToCustomerPolicyTextBlock" name="ShippingAndHandlingCostsRelatedToCustomerPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <element id="nvcr_FirstGenerationOptuneSystemFieldEquipmentMember" name="FirstGenerationOptuneSystemFieldEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="nvcr_ComputersAndLaboratoryEquipmentMember" name="ComputersAndLaboratoryEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="nvcr_AdvancesAndReceivablesFromSuppliers" name="AdvancesAndReceivablesFromSuppliers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
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  <element id="nvcr_FinishedGoodsMember" name="FinishedGoodsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ProductionStageGoodsMember" name="ProductionStageGoodsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="nvcr_FacilityInUSMember" name="FacilityInUSMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="nvcr_OperatingLeaseAgreementExpirationPeriod" name="OperatingLeaseAgreementExpirationPeriod" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <element id="nvcr_LicenseAndCollaborationAgreementMember" name="LicenseAndCollaborationAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="nvcr_NonRefundableUpFrontLicenseFeeAmount" name="NonRefundableUpFrontLicenseFeeAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="nvcr_RegulatoryAndCommercialMilestonePayments" name="RegulatoryAndCommercialMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
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  <element id="nvcr_TwoThousandFifteenPlanMember" name="TwoThousandFifteenPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_DebtInstrumentRepaymentDate" name="DebtInstrumentRepaymentDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardIncreaseInNumberOfSharesAvailableForIssuancePercentage" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardIncreaseInNumberOfSharesAvailableForIssuancePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfIncreaseInSharesOutstanding" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfIncreaseInSharesOutstanding" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_SalesAndMarketingMember" name="SalesAndMarketingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeitedAndCancelledWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeitedAndCancelledWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="nvcr_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRange" name="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRange" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="nvcr_ExercisePriceRangeOneMember" name="ExercisePriceRangeOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ExercisePriceRangeTwoMember" name="ExercisePriceRangeTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ExercisePriceRangeThreeMember" name="ExercisePriceRangeThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ExercisePriceRangeFourMember" name="ExercisePriceRangeFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ExercisePriceRangeFiveMember" name="ExercisePriceRangeFiveMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ExercisePriceRangeSixMember" name="ExercisePriceRangeSixMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_ExercisePriceRangeSevenMember" name="ExercisePriceRangeSevenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="nvcr_AmortizationOfTreasuryBillsPremium" name="AmortizationOfTreasuryBillsPremium" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="nvcr_InterestIncome" name="InterestIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="nvcr_OthersCountriesMember" name="OthersCountriesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</schema>


