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<import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
<import namespace="http://xbrl.sec.gov/dei/2019-01-31" schemaLocation="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd" />
<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
<import namespace="http://fasb.org/us-types/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-types-2019-01-31.xsd" />
<import namespace="http://fasb.org/srt/2019-01-31" schemaLocation="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd" />
<import namespace="http://fasb.org/srt-types/2019-01-31" schemaLocation="http://xbrl.fasb.org/srt/2019/elts/srt-types-2019-01-31.xsd" />
<element name="PrepaidServiceFeesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_PrepaidServiceFeesCurrent" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="MiscellaneousReceivablesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_MiscellaneousReceivablesCurrent" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AccruedLicenseFeesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_AccruedLicenseFeesCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="LongTermConvertibleNotesPayableCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_LongTermConvertibleNotesPayableCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="TenderOfferProceedsHeldInTrust" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_TenderOfferProceedsHeldInTrust" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RegisteredDirectOfferProceedsHeldInTrust" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_RegisteredDirectOfferProceedsHeldInTrust" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="FinanceCharges" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_FinanceCharges" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="InterestRelatedToWarrantExtensionsAndDebtConversion" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_InterestRelatedToWarrantExtensionsAndDebtConversion" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ProceedsFromIssuanceOfCommonStockAndWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ProceedsFromIssuanceOfCommonStockAndWarrants" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="Paymentsforwarranttenderofferheldintrust" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_Paymentsforwarranttenderofferheldintrust" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ProceedsFromRegisteredDirectFinancingHeldInTrust" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ProceedsFromRegisteredDirectFinancingHeldInTrust" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PaymentsOfPrincipalOnMaturityOfShortTermConvertibleNotes" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_PaymentsOfPrincipalOnMaturityOfShortTermConvertibleNotes" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IncreaseDecreaseInMiscellaneousReceivables" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_IncreaseDecreaseInMiscellaneousReceivables" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="InterestExpenseRelatedToAccretionOfConvertibleNotesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_InterestExpenseRelatedToAccretionOfConvertibleNotesPayable" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AccruedInterestToConvertibleNotePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AccruedInterestToConvertibleNotePayable" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CommonStockIssuedForAcquisitions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_CommonStockIssuedForAcquisitions" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NonCashDerivativeLiabilityAssociatedWithConvertibleNotePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_NonCashDerivativeLiabilityAssociatedWithConvertibleNotePayable" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AccruedDividendsOnSeriesCConvertiblePreferredStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AccruedDividendsOnSeriesCConvertiblePreferredStock" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentsToAdditionalPaidInCapitalOfferingCostRelatedToWarrantTenderOffer" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalOfferingCostRelatedToWarrantTenderOffer" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IssuanceOfCommonStockInPrivateStockOfferingValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_IssuanceOfCommonStockInPrivateStockOfferingValue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentsToAdditionalPaidInCapitalOfferingCostRelatedToPrivateOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalOfferingCostRelatedToPrivateOffering" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IssuanceOfCommonStockInPrivateStockOfferingShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_IssuanceOfCommonStockInPrivateStockOfferingShare" substitutionGroup="xbrli:item" />
<element name="IssuanceOfCommonStockInRegisteredDirectOfferingShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_IssuanceOfCommonStockInRegisteredDirectOfferingShares" substitutionGroup="xbrli:item" />
<element name="IssuanceOfCommonStockInRegisteredDirectOfferingValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_IssuanceOfCommonStockInRegisteredDirectOfferingValue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssueDuringPeriodValueOfferingCostsRelatedToRegisteredDirectOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssueDuringPeriodValueOfferingCostsRelatedToRegisteredDirectOffering" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="StockIssueDuringPeriodShareOfferingCostsRelatedToRegisteredDirectOffering" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssueDuringPeriodShareOfferingCostsRelatedToRegisteredDirectOffering" substitutionGroup="xbrli:item" />
<element name="AdjustmentsToAdditionalPaidInCapitalLegalFeesInConnectionWithEquityOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalLegalFeesInConnectionWithEquityOffering" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="StockIssuedDuringPeriodValueRedemptionOfNotePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssuedDuringPeriodValueRedemptionOfNotePayable" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssuedDuringPeriodSharesRedemptionOfNotePayable" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssuedDuringPeriodSharesRedemptionOfNotePayable" substitutionGroup="xbrli:item" />
<element name="AdjustmentsToAdditionalPaidInCapitalOfferingCostsRelatedToDebtOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalOfferingCostsRelatedToDebtOffering" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentsToAdditionalPaidInCapitalDebtDiscountAndIssuanceCostsRelatedToDebtOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalDebtDiscountAndIssuanceCostsRelatedToDebtOffering" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentsToAdditionalPaidInCapitalInducementOfInterestExpenseOnWarrantExchange" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalInducementOfInterestExpenseOnWarrantExchange" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssuedDuringPeriodSeriesCConvertibleStockValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssuedDuringPeriodSeriesCConvertibleStockValue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssuedDuringPeriodSeriesCConvertibleStockShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssuedDuringPeriodSeriesCConvertibleStockShares" substitutionGroup="xbrli:item" />
<element name="DividendsOnSeriesCPreferredStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_DividendsOnSeriesCPreferredStock" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IssuanceOfPublicWarrantsThroughTenderOfferingValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_IssuanceOfPublicWarrantsThroughTenderOfferingValue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IssuanceOfPublicWarrantsThroughTenderOfferingShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_IssuanceOfPublicWarrantsThroughTenderOfferingShares" substitutionGroup="xbrli:item" />
<element name="AdjustmentsToAdditionalPaidInCapitalOfferingCostRelatedToSeriesCPreferredOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalOfferingCostRelatedToSeriesCPreferredOffering" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssuedDuringThePeriodValueOfNoteConversionAndExtensionFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssuedDuringThePeriodValueOfNoteConversionAndExtensionFees" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssuedDuringThePeriodSharesNoteConversionAndExtensionFees" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssuedDuringThePeriodSharesNoteConversionAndExtensionFees" substitutionGroup="xbrli:item" />
<element name="AdjustmentsToAdditionalPaidInCapitalInducementOfDebtConversions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_AdjustmentsToAdditionalPaidInCapitalInducementOfDebtConversions" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="FiscalYearToDateMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_FiscalYearToDateMember" substitutionGroup="xbrli:item" />
<element name="PublicWarrantTenderOfferingsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_PublicWarrantTenderOfferingsAbstract" substitutionGroup="xbrli:item" />
<element name="PublicWarrantTenderOfferingsTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_PublicWarrantTenderOfferingsTextBlock" substitutionGroup="xbrli:item" />
<element name="RegisteredDirectEquityOfferingTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_RegisteredDirectEquityOfferingTextBlock" substitutionGroup="xbrli:item" />
<element name="DebtDiscountPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_DebtDiscountPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="DebtIssuanceCostsPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_DebtIssuanceCostsPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="GoingConcernPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_GoingConcernPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="PreLaunchInventoryPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_PreLaunchInventoryPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="ServiceContractsPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ServiceContractsPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="TreasuryStockPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_TreasuryStockPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="WarrantsAtFairValueAndBeneficialConversionFeatureAtIntrinsicValueTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_WarrantsAtFairValueAndBeneficialConversionFeatureAtIntrinsicValueTableTextBlock" substitutionGroup="xbrli:item" />
<element name="RegisteredDirectEquityOfferingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_RegisteredDirectEquityOfferingMember" substitutionGroup="xbrli:item" />
<element name="ConvertibleNoteRedemptionProvisionDerivativeLiabilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ConvertibleNoteRedemptionProvisionDerivativeLiabilityMember" substitutionGroup="xbrli:item" />
<element name="IssuanceAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_IssuanceAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="SecuritizationIssuanceDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_SecuritizationIssuanceDomain" substitutionGroup="xbrli:item" />
<element name="InvestorWarrantsIssuedWithRegisteredDirectEquityOfferingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_InvestorWarrantsIssuedWithRegisteredDirectEquityOfferingMember" substitutionGroup="xbrli:item" />
<element name="ScheduleOfPurchasePriceAllocationOfBusinessAcquisitionTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ScheduleOfPurchasePriceAllocationOfBusinessAcquisitionTableTextBlock" substitutionGroup="xbrli:item" />
<element name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_SummaryOfSignificantAccountingPoliciesTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="DetachableCommonStockWarrantsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_DetachableCommonStockWarrantsMember" substitutionGroup="xbrli:item" />
<element name="ShortTermConvertibleNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ShortTermConvertibleNotesMember" substitutionGroup="xbrli:item" />
<element name="SeriesCConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_SeriesCConvertiblePreferredStockMember" substitutionGroup="xbrli:item" />
<element name="SeriesCAndBPreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_SeriesCAndBPreferredStockMember" substitutionGroup="xbrli:item" />
<element name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_SummaryOfSignificantAccountingPoliciesLineItems" substitutionGroup="xbrli:item" />
<element name="DeferredDebtIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_DeferredDebtIssuanceCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="EstimatedFutureUnvestedOptionForfeitures" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_EstimatedFutureUnvestedOptionForfeitures" substitutionGroup="xbrli:item" />
<element name="PreLaunchInventory" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_PreLaunchInventory" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="TreasuryStockParValue" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_TreasuryStockParValue" substitutionGroup="xbrli:item" />
<element name="ConvertibleNoteRedemptionProvisionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ConvertibleNoteRedemptionProvisionMember" substitutionGroup="xbrli:item" />
<element name="AgentWarrantsIssuedWithRegisteredDirectEquityOfferingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_AgentWarrantsIssuedWithRegisteredDirectEquityOfferingMember" substitutionGroup="xbrli:item" />
<element name="InceptionDateValueOfRedemptionProvisionMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_InceptionDateValueOfRedemptionProvisionMember" substitutionGroup="xbrli:item" />
<element name="ConvertibleNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ConvertibleNotesMember" substitutionGroup="xbrli:item" />
<element name="CommonStockConversionPricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_CommonStockConversionPricePerShare" substitutionGroup="xbrli:item" />
<element name="CommonStockIssuableUponConversionOfConvertibleNoteRatio" type="xbrli:pureItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_CommonStockIssuableUponConversionOfConvertibleNoteRatio" substitutionGroup="xbrli:item" />
<element name="ConstructiveDividendToPreferredStockHolders" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ConstructiveDividendToPreferredStockHolders" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ConvertibleNotesFaceAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_ConvertibleNotesFaceAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ConvertiblePromissoryNoteMaximumRedemptionAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ConvertiblePromissoryNoteMaximumRedemptionAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ConvertiblePromissoryNoteRedemptionDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ConvertiblePromissoryNoteRedemptionDescription" substitutionGroup="xbrli:item" />
<element name="ProceedsFromIssuanceOfConvertiblePromissoryNotes" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ProceedsFromIssuanceOfConvertiblePromissoryNotes" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="UndeclaredDividends" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_UndeclaredDividends" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CompanyReservesSharesForFutureConversition" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_CompanyReservesSharesForFutureConversition" substitutionGroup="xbrli:item" />
<element name="ConvertiblePreferredStockConversionPrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_ConvertiblePreferredStockConversionPrice" substitutionGroup="xbrli:item" />
<element name="DividendsPayableCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="cydy_DividendsPayableCommonStock" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantOrRightTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_ClassOfWarrantOrRightTerm" substitutionGroup="xbrli:item" />
<element name="NonCashInducementInterestExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_NonCashInducementInterestExpense" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="InvestorWarrantsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_InvestorWarrantsMember" substitutionGroup="xbrli:item" />
<element name="ConversionOfPreferredStockToCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ConversionOfPreferredStockToCommonStockMember" substitutionGroup="xbrli:item" />
<element name="NoteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_NoteMember" substitutionGroup="xbrli:item" />
<element name="January2019NoteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_January2019NoteMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandAndNineteenShortTermConvertibleNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_TwoThousandAndNineteenShortTermConvertibleNotesMember" substitutionGroup="xbrli:item" />
<element name="ConvertiblePromissoryNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ConvertiblePromissoryNotesMember" substitutionGroup="xbrli:item" />
<element name="TrancheAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_TrancheAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="TrancheDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_TrancheDomain" substitutionGroup="xbrli:item" />
<element name="TrancheOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_TrancheOneMember" substitutionGroup="xbrli:item" />
<element name="TrancheTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_TrancheTwoMember" substitutionGroup="xbrli:item" />
<element name="ConvertiblePromisssoryNotesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ConvertiblePromisssoryNotesAbstract" substitutionGroup="xbrli:item" />
<element name="WarrantsAtFairValueOfRedemptionProvision" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_WarrantsAtFairValueOfRedemptionProvision" substitutionGroup="xbrli:item" xbrli:balance="debit" />
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<element name="WarrantsAtBeneficialConversionFeature" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_WarrantsAtBeneficialConversionFeature" substitutionGroup="xbrli:item" xbrli:balance="debit" />
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<element name="SaleOfStockAndWarrantsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_SaleOfStockAndWarrantsAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="SaleOfStockAndWarrantsDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_SaleOfStockAndWarrantsDomain" substitutionGroup="xbrli:item" />
<element name="StockIssuedDuringPeriodSharesWarrantExercise" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="cydy_StockIssuedDuringPeriodSharesWarrantExercise" substitutionGroup="xbrli:item" />
<element name="TwoThousandNineteenSubscriptionAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_TwoThousandNineteenSubscriptionAgreementMember" substitutionGroup="xbrli:item" />
<element name="ActualSharesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_ActualSharesMember" substitutionGroup="xbrli:item" />
<element name="PrivateWarrantExchangeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_PrivateWarrantExchangeMember" substitutionGroup="xbrli:item" />
<element name="DirectorsAndOfficersMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_DirectorsAndOfficersMember" substitutionGroup="xbrli:item" />
<element name="TwoExecutivesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_TwoExecutivesMember" substitutionGroup="xbrli:item" />
<element name="DefinitiveSubscriptionAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="cydy_DefinitiveSubscriptionAgreementMember" substitutionGroup="xbrli:item" />
</schema>


