<?xml version="1.0" encoding="US-ASCII" standalone="no"?>
    <!-- Field: Doc-Info; Name: Generator; Value: GoFiler Complete; Version: 5.2a -->
    <!-- Field: Doc-Info; Name: VendorURI; Value: http://www.novaworks.co -->
    <!-- Field: Doc-Info; Name: Source; Value: GnbtS%2D1.xfr; Date: 2020%2D02%2D14T20:35:18Z -->
    <!-- Field: Doc-Info; Name: Status; Value: 0x80130002 -->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
    <link:roleRef roleURI="http://generex.com/role/DocumentAndEntityInformation" xlink:href="gnbt-20191031.xsd#DocumentAndEntityInformation" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/ConsolidatedBalanceSheets" xlink:href="gnbt-20191031.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="gnbt-20191031.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveLossIncome" xlink:href="gnbt-20191031.xsd#ConsolidatedStatementsOfOperationsAndComprehensiveLossIncome" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Statement-ConsolidatedStatementsOfChangesInStockholdersEquity" xlink:href="gnbt-20191031.xsd#Statement-ConsolidatedStatementsOfChangesInStockholdersEquity" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="gnbt-20191031.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/OrganizationAndBusiness" xlink:href="gnbt-20191031.xsd#OrganizationAndBusiness" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="gnbt-20191031.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/LoanFromRelatedParties" xlink:href="gnbt-20191031.xsd#LoanFromRelatedParties" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/CommitmentsAndContingencies" xlink:href="gnbt-20191031.xsd#CommitmentsAndContingencies" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Leases" xlink:href="gnbt-20191031.xsd#Leases" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/PropertyAndEquipment" xlink:href="gnbt-20191031.xsd#PropertyAndEquipment" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/StockholdersEquity" xlink:href="gnbt-20191031.xsd#StockholdersEquity" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/RedeemableNon-controllingInterest" xlink:href="gnbt-20191031.xsd#RedeemableNon-controllingInterest" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Inventory" xlink:href="gnbt-20191031.xsd#Inventory" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/NotesPayable" xlink:href="gnbt-20191031.xsd#NotesPayable" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/IncomeTaxes" xlink:href="gnbt-20191031.xsd#IncomeTaxes" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/NetIncomePerShareEps" xlink:href="gnbt-20191031.xsd#NetIncomePerShareEps" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/GoodwillAndIntangibleAssets" xlink:href="gnbt-20191031.xsd#GoodwillAndIntangibleAssets" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions" xlink:href="gnbt-20191031.xsd#Acquisitions" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/DerivativeLiability" xlink:href="gnbt-20191031.xsd#DerivativeLiability" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Warrants" xlink:href="gnbt-20191031.xsd#Warrants" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Stock-basedCompensation" xlink:href="gnbt-20191031.xsd#Stock-basedCompensation" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/SubsequentEvents" xlink:href="gnbt-20191031.xsd#SubsequentEvents" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="gnbt-20191031.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="gnbt-20191031.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/LeasesTables" xlink:href="gnbt-20191031.xsd#LeasesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/PropertyAndEquipmentTables" xlink:href="gnbt-20191031.xsd#PropertyAndEquipmentTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/InventoryTables" xlink:href="gnbt-20191031.xsd#InventoryTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/IncomeTaxesTables" xlink:href="gnbt-20191031.xsd#IncomeTaxesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/NetIncomePerShareEpsTables" xlink:href="gnbt-20191031.xsd#NetIncomePerShareEpsTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/GoodwillAndIntangibleAssetsTables" xlink:href="gnbt-20191031.xsd#GoodwillAndIntangibleAssetsTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/AcquisitionsTables" xlink:href="gnbt-20191031.xsd#AcquisitionsTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/DerivativeLiabilityTables" xlink:href="gnbt-20191031.xsd#DerivativeLiabilityTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/WarrantsTables" xlink:href="gnbt-20191031.xsd#WarrantsTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Stock-basedCompensationTables" xlink:href="gnbt-20191031.xsd#Stock-basedCompensationTables" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/OrganizationOfBusinessAndGoingConcernDetailsNarrative" xlink:href="gnbt-20191031.xsd#OrganizationOfBusinessAndGoingConcernDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:href="gnbt-20191031.xsd#SummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:href="gnbt-20191031.xsd#SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/LoanFromRelatedPartiesDetailsNarrative" xlink:href="gnbt-20191031.xsd#LoanFromRelatedPartiesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/CommitmentsAndContingenciesDetailsNarrative" xlink:href="gnbt-20191031.xsd#CommitmentsAndContingenciesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/LeasesDetails" xlink:href="gnbt-20191031.xsd#LeasesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/LeasesDetailsNarrative" xlink:href="gnbt-20191031.xsd#LeasesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/PropertyAndEquipmentDetails" xlink:href="gnbt-20191031.xsd#PropertyAndEquipmentDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/PropertyAndEquipmentDetailsNarrative" xlink:href="gnbt-20191031.xsd#PropertyAndEquipmentDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/StockholdersEquityDetailsNarrative" xlink:href="gnbt-20191031.xsd#StockholdersEquityDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/RedeemableNon-controllingInterestDetailsNarrative" xlink:href="gnbt-20191031.xsd#RedeemableNon-controllingInterestDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/InventoryDetails" xlink:href="gnbt-20191031.xsd#InventoryDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/NotesPayableDetailsNarrative" xlink:href="gnbt-20191031.xsd#NotesPayableDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/IncomeTaxes-DeferredIncomeTaxesDetails" xlink:href="gnbt-20191031.xsd#IncomeTaxes-DeferredIncomeTaxesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/IncomeTaxes-ReconciliationOfEffectiveTaxRateDetails" xlink:href="gnbt-20191031.xsd#IncomeTaxes-ReconciliationOfEffectiveTaxRateDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/IncomeTaxesDetailsNarrative" xlink:href="gnbt-20191031.xsd#IncomeTaxesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/NetLossIncomePerShareEps-ComputationOfDilutedEpsDetails" xlink:href="gnbt-20191031.xsd#NetLossIncomePerShareEps-ComputationOfDilutedEpsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/NetIncomePerShareEps-ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetails" xlink:href="gnbt-20191031.xsd#NetIncomePerShareEps-ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/GoodwillAndIntangibleAssetsIntangibleAssetsDetails" xlink:href="gnbt-20191031.xsd#GoodwillAndIntangibleAssetsIntangibleAssetsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/GoodwillAndIntangibleAssetsEstimatedAmortizationExpenseDetails" xlink:href="gnbt-20191031.xsd#GoodwillAndIntangibleAssetsEstimatedAmortizationExpenseDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/GoodwillAndIntangibleAssetsChangesInValueOfGoodwillDetails" xlink:href="gnbt-20191031.xsd#GoodwillAndIntangibleAssetsChangesInValueOfGoodwillDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/GoodwillAndIntangibleAssetsDetailsNarrative" xlink:href="gnbt-20191031.xsd#GoodwillAndIntangibleAssetsDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-NetPurchasePriceOfNgdxDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-NetPurchasePriceOfNgdxDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-FairValueAssumptionsUsedInAccountingForWarrantsDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-FairValueAssumptionsUsedInAccountingForWarrantsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-FairValueAssumptionsUsedInAccountingForCallOptionsDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-FairValueAssumptionsUsedInAccountingForCallOptionsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-PurchasePriceAllocatedAsOfAcquisitionDateDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-PurchasePriceAllocatedAsOfAcquisitionDateDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-SummaryOfAcquisitionDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-SummaryOfAcquisitionDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-FairValueOfMedisourceAcquisitionDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-FairValueOfMedisourceAcquisitionDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-FairValueOfPantheonAcquisitionDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-FairValueOfPantheonAcquisitionDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-EstimatedAmortizationExpenseDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-EstimatedAmortizationExpenseDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-PurchasePriceAsOfRegentysAcquisitionDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-PurchasePriceAsOfRegentysAcquisitionDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-PurchasePriceAsOfOlaregenAcquisitionDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-PurchasePriceAsOfOlaregenAcquisitionDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-IntangibleAssetsDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-IntangibleAssetsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Acquisitions-UnauditedSupplementalProFormaDataDetails" xlink:href="gnbt-20191031.xsd#Acquisitions-UnauditedSupplementalProFormaDataDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/AcquisitionsDetailsNarrative" xlink:href="gnbt-20191031.xsd#AcquisitionsDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/DerivativeLiabilityDetails" xlink:href="gnbt-20191031.xsd#DerivativeLiabilityDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/WarrantsDetails" xlink:href="gnbt-20191031.xsd#WarrantsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/WarrantsDetailsNarrative" xlink:href="gnbt-20191031.xsd#WarrantsDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Stock-basedCompensation-CommonStockOptionsGrantedForfeitedOrExpiredAndExercisedDetails" xlink:href="gnbt-20191031.xsd#Stock-basedCompensation-CommonStockOptionsGrantedForfeitedOrExpiredAndExercisedDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Stock-basedCompensation-FairValueAssumptionsUsedInBlack-scholesOption-pricingDetails" xlink:href="gnbt-20191031.xsd#Stock-basedCompensation-FairValueAssumptionsUsedInBlack-scholesOption-pricingDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/Stock-basedCompensationDetailsNarrative" xlink:href="gnbt-20191031.xsd#Stock-basedCompensationDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://generex.com/role/SubsequentEventsDetailsNarrative" xlink:href="gnbt-20191031.xsd#SubsequentEventsDetailsNarrative" xlink:type="simple" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/DocumentAndEntityInformation" xlink:title="00000001 - Document - Document and Entity Information" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/ConsolidatedBalanceSheets" xlink:title="00000002 - Statement - CONSOLIDATED BALANCE SHEETS">
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaapAssetsCurrent" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsReceivableNet" xlink:label="loc_us-gaapAccountsReceivableNet" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapAccountsReceivableNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaapInventoryNet" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapInventoryNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaapOtherAssetsCurrent" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapOtherAssetsCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaapAssets" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapAssetsCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_CallOptions" xlink:label="loc_GNBTCallOptions" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_GNBTCallOptions" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaapGoodwill" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapGoodwill" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaapFiniteLivedIntangibleAssetsNet" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapFiniteLivedIntangibleAssetsNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssets" xlink:label="loc_us-gaapOtherAssets" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOtherAssets" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaapOperatingLeaseRightOfUseAsset" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOperatingLeaseRightOfUseAsset" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaapLiabilitiesCurrent" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NotesPayable" xlink:label="loc_us-gaapNotesPayable" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapNotesPayable" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_LoansFromRelatedParties" xlink:label="loc_GNBTLoansFromRelatedParties" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_GNBTLoansFromRelatedParties" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxLiabilitiesCurrent" xlink:label="loc_us-gaapDeferredTaxLiabilitiesCurrent" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapDeferredTaxLiabilitiesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityCurrent" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapOperatingLeaseLiabilityCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaapLiabilities" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapLiabilitiesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_WarrantsToBeIssued" xlink:label="loc_GNBTWarrantsToBeIssued" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_GNBTWarrantsToBeIssued" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DerivativeLiabilitiesNoncurrent" xlink:label="loc_us-gaapDerivativeLiabilitiesNoncurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapDerivativeLiabilitiesNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_CommonStockPayableNoncurrent" xlink:label="loc_GNBTCommonStockPayableNoncurrent" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_GNBTCommonStockPayableNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaapStockholdersEquity" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaapPreferredStockValue" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapPreferredStockValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaapCommonStockValue" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapCommonStockValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="loc_us-gaapAdditionalPaidInCapitalCommonStock" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapAdditionalPaidInCapitalCommonStock" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaapAccumulatedOtherComprehensiveIncomeLossNetOfTax" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapAccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterest" xlink:label="loc_us-gaapMinorityInterest" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapMinorityInterest" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_CommonStockPayable" xlink:label="loc_GNBTCommonStockPayable" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_GNBTCommonStockPayable" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaapRetainedEarningsAccumulatedDeficit" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapRetainedEarningsAccumulatedDeficit" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquity" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount" xlink:label="loc_us-gaapRedeemableNoncontrollingInterestEquityCarryingAmount" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapRedeemableNoncontrollingInterestEquityCarryingAmount" xlink:type="arc" weight="1" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapStockholdersEquity" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:title="00000003 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveLossIncome" xlink:title="00000004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE (LOSS) INCOME">
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GrossProfit" xlink:label="loc_us-gaapGrossProfit" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaapRevenues" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGrossProfit" xlink:to="loc_us-gaapRevenues" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostOfRevenue" xlink:label="loc_us-gaapCostOfRevenue" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGrossProfit" xlink:to="loc_us-gaapCostOfRevenue" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaapOperatingExpenses" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaapResearchAndDevelopmentExpense" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapResearchAndDevelopmentExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaapGeneralAndAdministrativeExpense" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapGeneralAndAdministrativeExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaapProvisionForDoubtfulAccounts" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapProvisionForDoubtfulAccounts" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaapOperatingIncomeLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapGrossProfit" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapOperatingExpenses" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="loc_us-gaapNetIncomeLossAvailableToCommonStockholdersBasic" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLossAvailableToCommonStockholdersBasic" xlink:to="loc_us-gaapNetIncomeLoss" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest" xlink:label="loc_us-gaapNetIncomeLossAttributableToNoncontrollingInterest" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLossAvailableToCommonStockholdersBasic" xlink:to="loc_us-gaapNetIncomeLossAttributableToNoncontrollingInterest" xlink:type="arc" weight="-1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Statement-ConsolidatedStatementsOfChangesInStockholdersEquity" xlink:title="00000005 - Statement - Statement - CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS&apos; EQUITY" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/ConsolidatedStatementsOfCashFlows" xlink:title="00000006 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS">
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapNetIncomeLoss" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaapDepreciationDepletionAndAmortization" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDepreciationDepletionAndAmortization" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaapShareBasedCompensation" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapShareBasedCompensation" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaapBusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapBusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAssetImpairmentCharges" xlink:label="loc_us-gaapOtherAssetImpairmentCharges" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapOtherAssetImpairmentCharges" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="loc_us-gaapAmortizationOfDebtDiscountPremium" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapAmortizationOfDebtDiscountPremium" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_NoncashInterestExpenseFromIssuanceOnDebtDerivative" xlink:label="loc_GNBTNoncashInterestExpenseFromIssuanceOnDebtDerivative" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_GNBTNoncashInterestExpenseFromIssuanceOnDebtDerivative" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_ChangeInFairValueOfDerivativeLiabilitiesConvertibleNotes" xlink:label="loc_GNBTChangeInFairValueOfDerivativeLiabilitiesConvertibleNotes" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_GNBTChangeInFairValueOfDerivativeLiabilitiesConvertibleNotes" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_ChangeInFairValueOfDerivativeLiabilitiesConvertibleWarrants" xlink:label="loc_GNBTChangeInFairValueOfDerivativeLiabilitiesConvertibleWarrants" />
      <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_GNBTChangeInFairValueOfDerivativeLiabilitiesConvertibleWarrants" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_ChangeInFairValueOfDerivativeLiabilitiesDownsideProtection" xlink:label="loc_GNBTChangeInFairValueOfDerivativeLiabilitiesDownsideProtection" />
      <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_GNBTChangeInFairValueOfDerivativeLiabilitiesDownsideProtection" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsReceivable" />
      <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsReceivable" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaapIncreaseDecreaseInInventories" />
      <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInInventories" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsPayableAndAccruedLiabilities" />
      <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet" xlink:label="loc_us-gaapIncreaseDecreaseInAccruedInterestReceivableNet" />
      <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccruedInterestReceivableNet" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet" xlink:label="loc_us-gaapIncreaseDecreaseInOtherOperatingCapitalNet" />
      <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOtherOperatingCapitalNet" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaapIncreaseDecreaseInOtherOperatingAssets" />
      <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOtherOperatingAssets" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaapProvisionForDoubtfulAccounts" />
      <link:calculationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapProvisionForDoubtfulAccounts" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetImpairment" xlink:label="loc_us-gaapGoodwillAndIntangibleAssetImpairment" />
      <link:calculationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapGoodwillAndIntangibleAssetImpairment" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaapGainsLossesOnExtinguishmentOfDebt" />
      <link:calculationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapGainsLossesOnExtinguishmentOfDebt" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfLeasedAsset" xlink:label="loc_us-gaapAmortizationOfLeasedAsset" />
      <link:calculationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapAmortizationOfLeasedAsset" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInDueToRelatedParties" xlink:label="loc_us-gaapIncreaseDecreaseInDueToRelatedParties" />
      <link:calculationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInDueToRelatedParties" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherCurrentLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInOtherCurrentLiabilities" />
      <link:calculationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOtherCurrentLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets" xlink:label="loc_us-gaapPaymentsToAcquireIntangibleAssets" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquireIntangibleAssets" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets" xlink:label="loc_us-gaapGainLossOnDispositionOfAssets" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapGainLossOnDispositionOfAssets" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GainLossOnDispositionOfIntangibleAssets" xlink:label="loc_us-gaapGainLossOnDispositionOfIntangibleAssets" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapGainLossOnDispositionOfIntangibleAssets" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_CashReceivedInAcquisitionOfBusiness" xlink:label="loc_GNBTCashReceivedInAcquisitionOfBusiness" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_GNBTCashReceivedInAcquisitionOfBusiness" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInNotesPayableRelatedParties" xlink:label="loc_us-gaapIncreaseDecreaseInNotesPayableRelatedParties" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInNotesPayableRelatedParties" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RepaymentsOfNotesPayable" xlink:label="loc_us-gaapRepaymentsOfNotesPayable" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapRepaymentsOfNotesPayable" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromNotesPayable" xlink:label="loc_us-gaapProceedsFromNotesPayable" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromNotesPayable" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_InvestmentInSubsidiaryByNoncontrollingInterest" xlink:label="loc_GNBTInvestmentInSubsidiaryByNoncontrollingInterest" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_GNBTInvestmentInSubsidiaryByNoncontrollingInterest" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaapCashAndCashEquivalentsPeriodIncreaseDecrease" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:type="arc" weight="1" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents" xlink:label="loc_us-gaapEffectOfExchangeRateOnCashAndCashEquivalents" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="loc_us-gaapEffectOfExchangeRateOnCashAndCashEquivalents" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/OrganizationAndBusiness" xlink:title="00000007 - Disclosure - Organization of Business and Going Concern" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/SummaryOfSignificantAccountingPolicies" xlink:title="00000008 - Disclosure - Summary of Significant Accounting Policies" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/LoanFromRelatedParties" xlink:title="00000009 - Disclosure - Loans from Related Parties" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/CommitmentsAndContingencies" xlink:title="00000010 - Disclosure - Commitments and Contingencies" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Leases" xlink:title="00000011 - Disclosure - Leases" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/PropertyAndEquipment" xlink:title="00000012 - Disclosure - Property and Equipment" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/StockholdersEquity" xlink:title="00000013 - Disclosure - Stockholders&apos; Equity" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/RedeemableNon-controllingInterest" xlink:title="00000014 - Disclosure - Redeemable Non-Controlling Interest" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Inventory" xlink:title="00000015 - Disclosure - Inventory" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/NotesPayable" xlink:title="00000016 - Disclosure - Notes Payable" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/IncomeTaxes" xlink:title="00000017 - Disclosure - Income Taxes" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/NetIncomePerShareEps" xlink:title="00000018 - Disclosure - Net Income Per Share (EPS)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/GoodwillAndIntangibleAssets" xlink:title="00000019 - Disclosure - Goodwill and Intangible Assets" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions" xlink:title="00000020 - Disclosure - Acquisitions" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/DerivativeLiability" xlink:title="00000021 - Disclosure - Derivative Liability" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Warrants" xlink:title="00000022 - Disclosure - Warrants" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Stock-basedCompensation" xlink:title="00000023 - Disclosure - Stock-Based Compensation" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/SubsequentEvents" xlink:title="00000024 - Disclosure - Subsequent Events" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:title="00000025 - Disclosure - Summary of Significant Accounting Policies (Policies)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:title="00000026 - Disclosure - Summary of Significant Accounting Policies (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/LeasesTables" xlink:title="00000027 - Disclosure - Leases (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/PropertyAndEquipmentTables" xlink:title="00000028 - Disclosure - Property and Equipment (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/InventoryTables" xlink:title="00000029 - Disclosure - Inventory (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/IncomeTaxesTables" xlink:title="00000030 - Disclosure - Income Taxes (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/NetIncomePerShareEpsTables" xlink:title="00000031 - Disclosure - Net Income Per Share (EPS) (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/GoodwillAndIntangibleAssetsTables" xlink:title="00000032 - Disclosure - Goodwill and Intangible Assets (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/AcquisitionsTables" xlink:title="00000033 - Disclosure - Acquisitions (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/DerivativeLiabilityTables" xlink:title="00000034 - Disclosure - Derivative Liability (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/WarrantsTables" xlink:title="00000035 - Disclosure - Warrants (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Stock-basedCompensationTables" xlink:title="00000036 - Disclosure - Stock-Based Compensation (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/OrganizationOfBusinessAndGoingConcernDetailsNarrative" xlink:title="00000037 - Disclosure - Organization of Business and Going Concern (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/SummaryOfSignificantAccountingPoliciesDetails" xlink:title="00000038 - Disclosure - Summary of Significant Accounting Policies (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:title="00000039 - Disclosure - Summary of Significant Accounting Policies (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/LoanFromRelatedPartiesDetailsNarrative" xlink:title="00000040 - Disclosure - Loan from Related Parties (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/CommitmentsAndContingenciesDetailsNarrative" xlink:title="00000041 - Disclosure - Commitments and Contingencies (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/LeasesDetails" xlink:title="00000042 - Disclosure - Leases (Details)">
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueCurrent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" xlink:to="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInTwoYears" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" xlink:to="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInThreeYears" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" xlink:to="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInFourYears" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" xlink:to="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInFiveYears" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" xlink:to="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueThereafter" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" xlink:to="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="loc_us-gaapOperatingLeaseLiability" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeaseLiability" xlink:to="loc_us-gaapOperatingLeasesFutureMinimumPaymentsDue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="gnbt-20191031.xsd#GNBT_ImputedInterest" xlink:label="loc_GNBTImputedInterest" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingLeaseLiability" xlink:to="loc_GNBTImputedInterest" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/LeasesDetailsNarrative" xlink:title="00000043 - Disclosure - Leases (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/PropertyAndEquipmentDetails" xlink:title="00000044 - Disclosure - Property and Equipment (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/PropertyAndEquipmentDetailsNarrative" xlink:title="00000045 - Disclosure - Property and Equipment (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/StockholdersEquityDetailsNarrative" xlink:title="00000046 - Disclosure - Stockholders&apos; Equity (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/RedeemableNon-controllingInterestDetailsNarrative" xlink:title="00000047 - Disclosure - Redeemable Non-Controlling Interest (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/InventoryDetails" xlink:title="00000048 - Disclosure - Inventory (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/NotesPayableDetailsNarrative" xlink:title="00000049 - Disclosure - Notes Payable (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/IncomeTaxes-DeferredIncomeTaxesDetails" xlink:title="00000050 - Disclosure - Income Taxes - Deferred income taxes (Details)">
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaapDeferredTaxAssetsGross" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_us-gaapDeferredTaxAssetsOperatingLossCarryforwards" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapDeferredTaxAssetsOperatingLossCarryforwards" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:label="loc_us-gaapDeferredTaxAssetsOther" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapDeferredTaxAssetsOther" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IntangibleAssetsCurrent" xlink:label="loc_us-gaapIntangibleAssetsCurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapDeferredTaxAssetsGross" xlink:to="loc_us-gaapIntangibleAssetsCurrent" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/IncomeTaxes-ReconciliationOfEffectiveTaxRateDetails" xlink:title="00000051 - Disclosure - Income Taxes - Reconciliation of effective tax rate (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/IncomeTaxesDetailsNarrative" xlink:title="00000052 - Disclosure - Income Taxes (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/NetLossIncomePerShareEps-ComputationOfDilutedEpsDetails" xlink:title="00000053 - Disclosure - Net (Loss) / Income Per Share (&#8220;EPS&#8221;) - Computation of diluted EPS (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/NetIncomePerShareEps-ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetails" xlink:title="00000054 - Disclosure - Net Income Per Share (&#8220;EPS&#8221;) - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/GoodwillAndIntangibleAssetsIntangibleAssetsDetails" xlink:title="00000055 - Disclosure - Goodwill and Intangible Assets: Intangible assets (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/GoodwillAndIntangibleAssetsEstimatedAmortizationExpenseDetails" xlink:title="00000056 - Disclosure - Goodwill and Intangible Assets: Estimated amortization expense (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/GoodwillAndIntangibleAssetsChangesInValueOfGoodwillDetails" xlink:title="00000057 - Disclosure - Goodwill and Intangible Assets: Changes in value of goodwill (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/GoodwillAndIntangibleAssetsDetailsNarrative" xlink:title="00000058 - Disclosure - Goodwill and Intangible Assets (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-NetPurchasePriceOfNgdxDetails" xlink:title="00000059 - Disclosure - Acquisitions - Net purchase price of NGDx (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-FairValueAssumptionsUsedInAccountingForWarrantsDetails" xlink:title="00000060 - Disclosure - Acquisitions - Fair Value Assumptions Used in Accounting for Warrants (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-FairValueAssumptionsUsedInAccountingForCallOptionsDetails" xlink:title="00000061 - Disclosure - Acquisitions - Fair Value Assumptions Used in Accounting for Call Options (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-PurchasePriceAllocatedAsOfAcquisitionDateDetails" xlink:title="00000062 - Disclosure - Acquisitions - Purchase price allocated as of acquisition date (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-SummaryOfAcquisitionDetails" xlink:title="00000063 - Disclosure - Acquisitions - Summary of Acquisition (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-FairValueOfMedisourceAcquisitionDetails" xlink:title="00000064 - Disclosure - Acquisitions - Fair Value of the Medisource Acquisition (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-FairValueOfPantheonAcquisitionDetails" xlink:title="00000065 - Disclosure - Acquisitions - Fair Value of the Pantheon Acquisition (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-EstimatedAmortizationExpenseDetails" xlink:title="00000066 - Disclosure - Acquisitions - Estimated amortization expense (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-PurchasePriceAsOfRegentysAcquisitionDetails" xlink:title="00000067 - Disclosure - Acquisitions - Purchase price as of the Regentys acquisition (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-PurchasePriceAsOfOlaregenAcquisitionDetails" xlink:title="00000068 - Disclosure - Acquisitions - Purchase price as of the Olaregen acquisition (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-IntangibleAssetsDetails" xlink:title="00000069 - Disclosure - Acquisitions - Intangible assets (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Acquisitions-UnauditedSupplementalProFormaDataDetails" xlink:title="00000070 - Disclosure - Acquisitions - Unaudited Supplemental Pro Forma Data (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/AcquisitionsDetailsNarrative" xlink:title="00000071 - Disclosure - Acquisitions (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/DerivativeLiabilityDetails" xlink:title="00000072 - Disclosure - Derivative Liability (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/WarrantsDetails" xlink:title="00000073 - Disclosure - Warrants (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/WarrantsDetailsNarrative" xlink:title="00000074 - Disclosure - Warrants (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Stock-basedCompensation-CommonStockOptionsGrantedForfeitedOrExpiredAndExercisedDetails" xlink:title="00000075 - Disclosure - Stock-Based Compensation - Common stock options granted, forfeited or expired and exercised (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Stock-basedCompensation-FairValueAssumptionsUsedInBlack-scholesOption-pricingDetails" xlink:title="00000076 - Disclosure - Stock-Based Compensation - Fair value assumptions used in Black-Scholes option-pricing (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/Stock-basedCompensationDetailsNarrative" xlink:title="00000077 - Disclosure - Stock-Based Compensation (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://generex.com/role/SubsequentEventsDetailsNarrative" xlink:title="00000078 - Disclosure - Subsequent Events (Details Narrative)" />
</link:linkbase>


