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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2021-03-11T19:29:45.4442937+00:00 -->
<!-- Version            : 5.0.1.571 -->
<!-- Package ID         : 56c5dc8f7eb54b0981f166d341368d72 -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="itrm_RoyaltyLinkedNotesNoncurrent" name="RoyaltyLinkedNotesNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_FinancingTransactionCosts" name="FinancingTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RedenominationOfShareCapital" name="RedenominationOfShareCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_TemporaryEquityRedenominationOfShareCapital" name="TemporaryEquityRedenominationOfShareCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_TemporaryEquitySharesConversionOfConvertiblePreferredStock" name="TemporaryEquitySharesConversionOfConvertiblePreferredStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_TemporaryEquityValueConversionOfConvertiblePreferredStock" name="TemporaryEquityValueConversionOfConvertiblePreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_SeriesBConvertiblePreferredSharesMember" name="SeriesBConvertiblePreferredSharesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_NoncashGainLossOnShortTermInvestments" name="NoncashGainLossOnShortTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_InterestOnShortTermInvestments" name="InterestOnShortTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_ProceedsFromPrivatePlacementAndRightsOfferingNetOfTransactionsCosts" name="ProceedsFromPrivatePlacementAndRightsOfferingNetOfTransactionsCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_ExchangeableSeniorSubordinatedNotesDueTwoThousandTwentyFiveMember" name="ExchangeableSeniorSubordinatedNotesDueTwoThousandTwentyFiveMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PrepaidExpensesAndOtherCurrentAssetsTextBlock" name="PrepaidExpensesAndOtherCurrentAssetsTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RoyaltyLinkedNotesDisclosuresTextBlock" name="RoyaltyLinkedNotesDisclosuresTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_GoingConcernPolicyTextBlock" name="GoingConcernPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_COVID19GlobalPandemicPolicyTextBlock" name="COVID19GlobalPandemicPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_AccruedResearchAndDevelopmentExpensesPolicyTextBlock" name="AccruedResearchAndDevelopmentExpensesPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_PatentCostsPolicyTextBlock" name="PatentCostsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_GrantAwardsPolicyTextBlock" name="GrantAwardsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_ResearchAndDevelopmentCreditsPolicyTextBlock" name="ResearchAndDevelopmentCreditsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RoyaltyLinkedNotesPolicyTextBlock" name="RoyaltyLinkedNotesPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_OrdinaryShareWarrantPolicyTextBlock" name="OrdinaryShareWarrantPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RetirementPlanPolicyTextBlock" name="RetirementPlanPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_PropertyPlantAndEquipmentEstimatedUsefulLifeTableTextBlock" name="PropertyPlantAndEquipmentEstimatedUsefulLifeTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_OperatingExpensesByGeographicAreasTableTextBlock" name="OperatingExpensesByGeographicAreasTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_BlackScholesAndBinomialLatticePricingModelsMember" name="BlackScholesAndBinomialLatticePricingModelsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_ScheduleOfRightOfUseAssetsAndLeaseLiabilitiesTableTextBlock" name="ScheduleOfRightOfUseAssetsAndLeaseLiabilitiesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_ScheduleOfRoyaltyLinkedNotesTableTextBlock" name="ScheduleOfRoyaltyLinkedNotesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RoyaltyLinkedNotesAbstract" name="RoyaltyLinkedNotesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PerformanceRSUMember" name="PerformanceRSUMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems" name="OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_OrganizationConsolidationAndPresentationOfFinancialStatementsTable" name="OrganizationConsolidationAndPresentationOfFinancialStatementsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PrivatePlacementAndRightsOfferingMember" name="PrivatePlacementAndRightsOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_RoyaltyLinkedSubordinatedNotesMember" name="RoyaltyLinkedSubordinatedNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_RightsOfferingInConnectionWithPrivatePlacementMember" name="RightsOfferingInConnectionWithPrivatePlacementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SecuritiesMember" name="SecuritiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_IterumTherapeuticsUSLimitedMember" name="IterumTherapeuticsUSLimitedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SiliconValleyBankMember" name="SiliconValleyBankMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PaycheckProtectionProgramMember" name="PaycheckProtectionProgramMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_DirectOfferingMember" name="DirectOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_JuneThreeSecuritiesPurchaseAgreementMember" name="JuneThreeSecuritiesPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_JuneThirtySecuritiesPurchaseAgreementMember" name="JuneThirtySecuritiesPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_OctoberOfferingMember" name="OctoberOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PreFundedWarrantsMember" name="PreFundedWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_OctoberTwentyTwoSecuritiesPurchaseAgreementMember" name="OctoberTwentyTwoSecuritiesPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_ShareConsolidationBasisNominalValuePerShare" name="ShareConsolidationBasisNominalValuePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_ShareConsolidationBasisRenominalisationValuePerShare" name="ShareConsolidationBasisRenominalisationValuePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_AggregateInitialOfferingPriceOfSecuritiesAuthorizedToIssue" name="AggregateInitialOfferingPriceOfSecuritiesAuthorizedToIssue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_UnitPricePerDebtInstrument" name="UnitPricePerDebtInstrument" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_NumberOfDebtInstrumentsWithinEachUnit" name="NumberOfDebtInstrumentsWithinEachUnit" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DebtInstrumentPricePerUnit" name="DebtInstrumentPricePerUnit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DebtInstrumentSharesEmbeddedWithinEachUnitShares" name="DebtInstrumentSharesEmbeddedWithinEachUnitShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DebtInstrumentSharesEmbeddedWithinEachUnitValue" name="DebtInstrumentSharesEmbeddedWithinEachUnitValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DebtInstrumentPercentageOfNetRevenueFromDomesticSaleForPotentialAggregatePayments" name="DebtInstrumentPercentageOfNetRevenueFromDomesticSaleForPotentialAggregatePayments" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DebtInstrumentAggregatePotentialPaymentCappedRate" name="DebtInstrumentAggregatePotentialPaymentCappedRate" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DebtInstrumentAggregateAmountPayablePerUnit" name="DebtInstrumentAggregateAmountPayablePerUnit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DebtInstrumentSharesEmbeddedWithinEachUnitExchangePrice" name="DebtInstrumentSharesEmbeddedWithinEachUnitExchangePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DescriptionOfDeferringPaymentOnUSPayrollTaxesCARESAct" name="DescriptionOfDeferringPaymentOnUSPayrollTaxesCARESAct" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DebtInstrumentRemainingAmountAmortized" name="DebtInstrumentRemainingAmountAmortized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_GrossProceedsFromIssuanceOfCommonStock" name="GrossProceedsFromIssuanceOfCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_ClassOfWarrantOrRightWarrantsExpiryDate" name="ClassOfWarrantOrRightWarrantsExpiryDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_ClassOfWarrantOrRightWarrantsClosingDate" name="ClassOfWarrantOrRightWarrantsClosingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_PercentageOfOrdinarySharesIssuedToPurchaseAdditionalWarrants" name="PercentageOfOrdinarySharesIssuedToPurchaseAdditionalWarrants" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_PercentageOfOutstandingOrdinaryShares" name="PercentageOfOutstandingOrdinaryShares" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_PercentageOfOrdinaryShareAtElectionOfPurchaser" name="PercentageOfOrdinaryShareAtElectionOfPurchaser" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DescriptionOfSecuritiesPurchaseAgreement" name="DescriptionOfSecuritiesPurchaseAgreement" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_NetProceedsFromUnderwrittenPublicOffering" name="NetProceedsFromUnderwrittenPublicOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_UnderwrittenPublicOfferingClosingDate" name="UnderwrittenPublicOfferingClosingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RegisteredDirectOfferingClosingDate" name="RegisteredDirectOfferingClosingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_ExerciseOfUnderwritersOptionInFullToPurchaseAdditionalSharesClosingDate" name="ExerciseOfUnderwritersOptionInFullToPurchaseAdditionalSharesClosingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_CashDGSInsuredAmount" name="CashDGSInsuredAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_AccountingPoliciesLineItems" name="AccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_AccountingPoliciesTable" name="AccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_WarrantIssuedMember" name="WarrantIssuedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_TaxCutsAndJobsActOf2017Member" name="TaxCutsAndJobsActOf2017Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_LaboratoryEquipmentMember" name="LaboratoryEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_ResearchAndDevelopmentGrantAwardedAmount" name="ResearchAndDevelopmentGrantAwardedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_CostReimbursementArrangementPeriodOfRecognition" name="CostReimbursementArrangementPeriodOfRecognition" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_CostReimbursementArrangementRecognitionBeginDuringPeriod" name="CostReimbursementArrangementRecognitionBeginDuringPeriod" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RecognizedIncomeTaxPositionsMeasuredAtLargestAmountGreaterThanPercentageOfBeingRealized" name="RecognizedIncomeTaxPositionsMeasuredAtLargestAmountGreaterThanPercentageOfBeingRealized" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_NetOperatingLosesCarryBackPeriod" name="NetOperatingLosesCarryBackPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_PercentageEliminationOfTaxableIncomeLimitationsByAllowingCorporateEntitiesToFullyUtilizeNOLCarryforwardsToOffsetTaxableIncome" name="PercentageEliminationOfTaxableIncomeLimitationsByAllowingCorporateEntitiesToFullyUtilizeNOLCarryforwardsToOffsetTaxableIncome" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_PercentageDeductionOfInterestOfAdjustedTaxableIncomePlusBusinessInterestIncomeByTaxPayers" name="PercentageDeductionOfInterestOfAdjustedTaxableIncomePlusBusinessInterestIncomeByTaxPayers" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_OptionsToPurchaseOrdinarySharesMember" name="OptionsToPurchaseOrdinarySharesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_UnvestedRestrictedOrdinarySharesMember" name="UnvestedRestrictedOrdinarySharesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_UnvestedRestrictedStockUnitsMember" name="UnvestedRestrictedStockUnitsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_UnvestedPerformanceRestrictedShareUnitsMember" name="UnvestedPerformanceRestrictedShareUnitsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_DefinedContributionPlanEmployeeMinimumPercentageOnPlanAssets" name="DefinedContributionPlanEmployeeMinimumPercentageOnPlanAssets" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DefinedContributionPlanEmployeeDeferralPercentageMaximum" name="DefinedContributionPlanEmployeeDeferralPercentageMaximum" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_MilestonePayment" name="MilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_DiscountedCashFlowDiscountRate" name="DiscountedCashFlowDiscountRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_FairValueOfDerivativeLiabilityRelatedToRightsOffering" name="FairValueOfDerivativeLiabilityRelatedToRightsOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DerivativeLiabilityExchangeOptionFairValue" name="DerivativeLiabilityExchangeOptionFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DerivativeLiabilityChangeOfControlFeatureFairValue" name="DerivativeLiabilityChangeOfControlFeatureFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DebtInstrumentPricePerOrdinaryShare" name="DebtInstrumentPricePerOrdinaryShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_InitialFairValueUponIssuanceOfExchangeableNotesInPrivatePlacement" name="InitialFairValueUponIssuanceOfExchangeableNotesInPrivatePlacement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_FairValueAddedUponIssuanceOfExchangeableNotesInRightsOffering" name="FairValueAddedUponIssuanceOfExchangeableNotesInRightsOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DebtInstrumentAggregateAmountOfPaymentsOnRoyaltyLinkedSubordinated" name="DebtInstrumentAggregateAmountOfPaymentsOnRoyaltyLinkedSubordinated" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DebtInstrumentDiscountRateAppliedForRoyaltyLinkedNotes" name="DebtInstrumentDiscountRateAppliedForRoyaltyLinkedNotes" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_RefundableFDAFilingFee" name="RefundableFDAFilingFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_ShortTermDepositsCurrent" name="ShortTermDepositsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_ResearchAndDevelopmentTaxCreditReceivableCurrent" name="ResearchAndDevelopmentTaxCreditReceivableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_PrepaidResearchAndDevelopmentExpensesCurrent" name="PrepaidResearchAndDevelopmentExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_RefundableFDAFilingFeeReceived" name="RefundableFDAFilingFeeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_PrepaidExpenseAndOtherAssetsCurrentLineItems" name="PrepaidExpenseAndOtherAssetsCurrentLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PrepaidExpenseAndOtherAssetsCurrentTable" name="PrepaidExpenseAndOtherAssetsCurrentTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_LesseeOperatingLeaseTerminateTerm" name="LesseeOperatingLeaseTerminateTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_NumberOfLease" name="NumberOfLease" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_LesseeOperatingLeasesExpirationPeriod" name="LesseeOperatingLeasesExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_TerminationNoticeMember" name="TerminationNoticeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_OfficeSpaceAndCommercialPropertyMember" name="OfficeSpaceAndCommercialPropertyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_CommercialUnitMember" name="CommercialUnitMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_ScheduleOfLeaseAssetsAndLiabilitiesAbstract" name="ScheduleOfLeaseAssetsAndLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_AccruedClinicalTrialCostsCurrent" name="AccruedClinicalTrialCostsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_AccruedManufacturingExpensesCurrent" name="AccruedManufacturingExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_LoanAndSecurityAgreementEnteredDate" name="LoanAndSecurityAgreementEnteredDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RemainingBorrowingFacilityAvailableDate" name="RemainingBorrowingFacilityAvailableDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_LoanAndSecurityAgreementMember" name="LoanAndSecurityAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_WallStreetJournalPrimeRateMember" name="WallStreetJournalPrimeRateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SiliconValleyBankAndLifeSciencesFundIILimitedLiabilityCompanyMember" name="SiliconValleyBankAndLifeSciencesFundIILimitedLiabilityCompanyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_RightsOfferingMember" name="RightsOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_DebtInstrumentInterestMinimumFixedInterestRate" name="DebtInstrumentInterestMinimumFixedInterestRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_FinalPaymentFeeForLoanPercentage" name="FinalPaymentFeeForLoanPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_VoluntaryPrepaymentFeeInFirstYear" name="VoluntaryPrepaymentFeeInFirstYear" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_VoluntaryPrepaymentFeeInSecondYear" name="VoluntaryPrepaymentFeeInSecondYear" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_VoluntaryPrepaymentFeeThereafter" name="VoluntaryPrepaymentFeeThereafter" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_FinalPaymentFeeForLoan" name="FinalPaymentFeeForLoan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_ClassOfWarrantOrRightPercentageOfPurchaseOfAdditionalOrdinarySharesEqualToTermLoanDividedByExercisePriceCalledByEachWarrantOrRight" name="ClassOfWarrantOrRightPercentageOfPurchaseOfAdditionalOrdinarySharesEqualToTermLoanDividedByExercisePriceCalledByEachWarrantOrRight" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_CapitalizedFinancingTransactionCosts" name="CapitalizedFinancingTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_JanuaryTwoThousandTwentyOneThousandExchangeableNotesDueJanuaryThirtyOneTwoThousandTwentyFiveMember" name="JanuaryTwoThousandTwentyOneThousandExchangeableNotesDueJanuaryThirtyOneTwoThousandTwentyFiveMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SeptemberTwoThousandTwentyOneThousandExchangeableNotesDueJanuaryThirtyOneTwoThousandTwentyFiveMember" name="SeptemberTwoThousandTwentyOneThousandExchangeableNotesDueJanuaryThirtyOneTwoThousandTwentyFiveMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_DebtInstrumentAccruedInterest" name="DebtInstrumentAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_DebtInstrumentOutstandingPortion" name="DebtInstrumentOutstandingPortion" type="srt-types:perUnitItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_NumberOfDebtInstrumentsIssued" name="NumberOfDebtInstrumentsIssued" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_RoyaltyLinkedNotesMember" name="RoyaltyLinkedNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SulopenemMember" name="SulopenemMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_LiabilityRelatedToSaleOfFutureRoyalties" name="LiabilityRelatedToSaleOfFutureRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_AmortizationOfDiscountAndDebtIssuanceCostsRelatedToSaleOfFutureRoyalties" name="AmortizationOfDiscountAndDebtIssuanceCostsRelatedToSaleOfFutureRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_SupplierMember" name="SupplierMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_June3OfferingMember" name="June3OfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_June30OfferingMember" name="June30OfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_June30SecuritiesPurchaseAgreementMember" name="June30SecuritiesPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_June3SecuritiesPurchaseAgreementMember" name="June3SecuritiesPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PreferredStockUndesignatedMember" name="PreferredStockUndesignatedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SeriesAConvertiblePreferredSharesMember" name="SeriesAConvertiblePreferredSharesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PfizerLicenseAgreementMember" name="PfizerLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_FoundersMember" name="FoundersMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SeriesB1ConvertiblePreferredSharesMember" name="SeriesB1ConvertiblePreferredSharesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SeriesB2ConvertiblePreferredSharesMember" name="SeriesB2ConvertiblePreferredSharesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_IncreaseInCommonStockSharesAuthorized" name="IncreaseInCommonStockSharesAuthorized" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_CommonStockMaximumSharesAuthorizedForSubscription" name="CommonStockMaximumSharesAuthorizedForSubscription" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_NumberOfVotePerCommonShare" name="NumberOfVotePerCommonShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_CommonStockRightsAndPreferences" name="CommonStockRightsAndPreferences" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_MeasurementInputFairValueOfWarrantIssuedMember" name="MeasurementInputFairValueOfWarrantIssuedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_TemporaryEquitySharesIssuedPricePerShare" name="TemporaryEquitySharesIssuedPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_TemporaryEquityAdditionalSharesIssued" name="TemporaryEquityAdditionalSharesIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="itrm_TwoThousandFifteenEquityIncentivePlanMember" name="TwoThousandFifteenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_TwoThousandEighteenEquityIncentivePlanMember" name="TwoThousandEighteenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_TwoThousandFifteenEquityIncentivePlanAndTwoThousandEighteenEquityIncentivePlanMember" name="TwoThousandFifteenEquityIncentivePlanAndTwoThousandEighteenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_EmployeesAndDirectorsStockOptionsMember" name="EmployeesAndDirectorsStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_RestrictedOrdinarySharesAndOptionsAndRestrictedShareUnitsAndPerformanceRestrictedShareUnitsMember" name="RestrictedOrdinarySharesAndOptionsAndRestrictedShareUnitsAndPerformanceRestrictedShareUnitsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfRemainingRestrictedSharesVestOnMonthlyBasis" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfRemainingRestrictedSharesVestOnMonthlyBasis" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsPeriodOfRiskFreeInterestRateBasedOnEstimatedOfUSTreasuryYield" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsPeriodOfRiskFreeInterestRateBasedOnEstimatedOfUSTreasuryYield" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_IncomeTaxBenefit" name="IncomeTaxBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_IncomeTaxLineItems" name="IncomeTaxLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_IncomeTaxTable" name="IncomeTaxTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_EffectiveIncomeTaxRateReconciliationFairValueAdjustmentsOnDerivativeFinancialInstruments" name="EffectiveIncomeTaxRateReconciliationFairValueAdjustmentsOnDerivativeFinancialInstruments" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_DeferredTaxAssetsSection163JInterestExpenseLimitations" name="DeferredTaxAssetsSection163JInterestExpenseLimitations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="itrm_PotentialFutureRegulatoryAndSalesMilestonePaymentsUponAchievementOfNetSales" name="PotentialFutureRegulatoryAndSalesMilestonePaymentsUponAchievementOfNetSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="itrm_IterumBermudaMember" name="IterumBermudaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_SubsidiaryGuarantorsMember" name="SubsidiaryGuarantorsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_FebruaryUnderwrittenOfferingMember" name="FebruaryUnderwrittenOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_UnderwritingAgreementMember" name="UnderwritingAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_PursuantToUnderwritingAgreementMember" name="PursuantToUnderwritingAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_FebruarySecuritiesPurchaseAgreementMember" name="FebruarySecuritiesPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="itrm_OfferingClosingDate" name="OfferingClosingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_OptionPeriodToPurchaseAdditionalOrdinaryShares" name="OptionPeriodToPurchaseAdditionalOrdinaryShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="itrm_AdditionalOrdinarySharesThatCanBePurchasedByUnderwriter" name="AdditionalOrdinarySharesThatCanBePurchasedByUnderwriter" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
</xsd:schema>


