Mutual Fund Series Trust


February 3, 2023


U.S. Securities and Exchange Commission

Public Filing Desk

100 F Street, N.E.

Washington, DC 20459


Re:                  Mutual Fund Series Trust (the “Registrant”);

File Nos. 333-132541 and 811-21872

Ladies and Gentlemen:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, the undersigned certifies (i) that the form of Prospectus and Statement of Additional Information that would have been filed under paragraph (c) of Rule 497 on behalf of the Empiric Fund, does not differ from that contained in the Registrant's Post-Effective Amendment No. 514, which was filed with the Commission on January 27, 2023 and (ii) that Post-Effective Amendment No. 514 has been filed electronically with the Commission.

Very truly yours,


/s/ Jennifer Bailey

Jennifer Bailey