Income Taxes - Schedule of Reconciliation between Effective Tax Rate and Statutory Rate (Details) - USD ($) $ in Millions |
12 Months Ended | ||||||
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Dec. 31, 2022 |
Dec. 31, 2021 |
Dec. 31, 2020 |
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| Effective Income Tax Rate Reconciliation, Amount [Abstract] | |||||||
| U.S. federal statutory tax rate | $ 82.1 | $ 53.9 | $ 62.6 | ||||
| State income tax, net of federal benefit | 5.4 | 8.9 | 5.3 | ||||
| Permanent items | 0.6 | 5.2 | 2.6 | ||||
| Research and development credits | (23.3) | (28.9) | (24.4) | ||||
| Foreign tax credit | 0.0 | (3.7) | 0.0 | ||||
| Foreign rate differential | 27.7 | 20.9 | 9.8 | ||||
| Stock and officers compensation | (1.2) | (20.4) | (28.7) | ||||
| Collaboration agreement milestone share-based payment | (52.9) | 0.0 | 0.0 | ||||
| Change in statutory tax rates | 1.0 | (10.0) | (4.1) | ||||
| Other | 1.3 | (0.4) | 0.1 | ||||
| Change in valuation allowance | 8.9 | 14.4 | (275.0) | ||||
| Income taxes at effective rates | $ 49.6 | $ 39.9 | [1] | $ (251.8) | [1] | ||
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- Definition Effective Income Tax Rate Reconciliation, Collaboration Agreement Milestone, Share-based Payment No definition available.
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- Definition Effective Income Tax Reconciliation, Permanent Items No definition available.
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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- References No definition available.
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations, attributable to increase (decrease) in the income tax rates. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to foreign income tax expense (benefit). Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition The amount of income tax expense or benefit for the period computed by applying the domestic federal statutory tax rates to pretax income from continuing operations. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount of reported income tax expense (benefit) in excess of (less than) expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to nondeductible expense for award under share-based payment arrangement. Includes, but is not limited to, expense determined to be nondeductible upon grant or after for award under share-based payment arrangement. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other adjustments. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to state and local income tax expense (benefit). Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to foreign tax credit. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to research tax credit. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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