SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS - Warrants (Details) - $ / shares	9 Months Ended	12 Months Ended
Sep. 30, 2023	Dec. 31, 2022	Dec. 31, 2021
Weighted Average Exercise Price Per Share
Outstanding at December 31, 2022	$ 64.20	$ 664.68	$ 683.04
Granted		134.52	597.00
Terminated (in dollars per share)		597.00
Outstanding and exercisable at September 30, 2023		$ 64.20	$ 664.68
ADS
ADSs Underlying Warrants
Outstanding at December 31, 2022	280,735	11,440	8,991
Granted		448,779	2,449
Terminated (in shares)		(19,362)
Exercised Pre-Funded Warrants		(160,122)
Outstanding and exercisable at September 30, 2023	864,068	280,735	11,440
Weighted Average Exercise Price Per Share
Outstanding at December 31, 2022	$ 24.71
Outstanding and exercisable at September 30, 2023	$ 16.13	$ 24.71
ADS \| Warrants
ADSs Underlying Warrants
Granted	583,333
Weighted Average Exercise Price Per Share
Granted	$ 12.00
ADS \| Pre-Funded Warrants
ADSs Underlying Warrants
Granted	170,833
Exercised Pre-Funded Warrants	(170,833)

The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Number of options outstanding, including both vested and non-vested options.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

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A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Number of share options (or share units) exercised during the current period.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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