| Schedule of warrant activities |
| | | | | | | | | | | Weighted | | | | ADSs | | Average | | | | Underlying | | Exercise Price | | | | Warrants | | Per ADS | | Outstanding at December 31, 2022 | | 280,735 | | $ | 24.71 | * | Granted Warrants | | 583,333 | | | 12.00 | | Granted Pre-Funded Warrants | | 170,833 | | | — | | Exercised Pre-Funded Warrants | | (170,833) | | | — | | Outstanding and exercisable at September 30, 2023 | | 864,068 | | $ | 16.13 | |
| * | Includes the reduction of the exercise price from $60.00 per ADS to $13.20 per ADS for Common Warrants issued in the August Offering to investors who participated in both the Company’s August Offering and February Offering, see above. |
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| | | | | | | | | | | Weighted | | | | ADSs | | Average | | | | Underlying | | Exercise Price | | | | Warrants | | Per Share | | Outstanding at December 31, 2020 | | 8,991 | | $ | 683.04 | * | Granted | | 2,449 | | | 597.00 | * | Outstanding at December 31, 2021 | | 11,440 | | $ | 664.68 | * | Granted | | 448,779 | | | 134.52 | ** | Terminated | | (19,362) | | | 597.00 | * | Exercised – Cashless and Pre Funded Warrants | | (160,122) | | | — | | Outstanding and exercisable at December 31, 2022 | | 280,735 | | $ | 64.20 | ** |
* | Note that the exercise price of certain warrants was reduced from $597 to $0 on July 14, 2022 and to refer to Note 5 |
** | Note that the exercise price of certain warrants were reduced from $60.00 to $13.20 on February 24, 2023 and refer to Note 18 |
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