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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

Amount, after allowance for credit loss, of right to consideration in exchange for good or service transferred to customer when right is conditioned on something other than passage of time.

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- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Collaboration agreements - Merck Dolaflexin Agreement (Details)	12 Months Ended
	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($) target	Dec. 31, 2021 USD ($)	Sep. 30, 2023 target	Feb. 28, 2022 target
Collaboration agreements
Collaboration revenue	$ 36,855,000	$ 26,581,000	$ 43,000
Deferred revenue	125,314,000	147,653,000	$ 3,944,000
2014 Merck KGaA Agreement and 2018 Merck KGaA Supply Agreement
Collaboration agreements
Collaboration revenue	3,700,000
Deferred revenue	0	3,900,000
Contract assets	0	0
2014 Merck KGaA
Collaboration agreements
Number of targets designated \| target				6
Johnson & Johnson Agreement
Collaboration agreements
Collaboration revenue	16,600,000	24,200,000
Number of targets designated \| target					3
Deferred revenue	10,400,000	15,800,000
Contract assets	0	0
2022 Merck KGaA Agreement
Collaboration agreements
Collaboration revenue	10,700,000	$ 0
Number of targets designated \| target		2
Deferred revenue	20,200,000	$ 30,000,000
Contract assets	0	0
GSK Agreement
Collaboration agreements
Collaboration revenue	3,400,000	2,000,000
Deferred revenue	94,600,000	98,000,000
Contract assets	$ 0	$ 0