v3.24.0.1
Income taxes - Income tax rate (Details)
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Income Tax Disclosure [Abstract]      
Federal statutory income tax rate 21.00% 21.00% 21.00%
State income taxes, net of federal benefit 18.50% 13.00% 7.20%
Research and development tax credits 2.40% 2.40% 2.00%
Other permanent differences 2.60% 0.80% (0.10%)
Change in deferred tax asset valuation allowance (44.50%) (37.20%) (30.10%)