Basic loss per share is computed by dividing net loss attributable to ordinary shareholders by the weighted-average number of ordinary shares outstanding:


	Year Ended December 31,
	2023			2022
	(in thousands except share and per share data)
Numerator:
Net loss attributable to ordinary shareholders	$	(57,513	)	$	(161,823	)
Denominator:
Weighted-average ordinary shares outstanding		106,097,268			78,855,810
Net loss per share, basic and diluted	$	(0.54	)	$	(2.05	)

As of December 31, 2023 and 2022, there were 7,093,656 vested and exercisable Pre-Funded Warrants outstanding to purchase ordinary shares at an exercise price of $0.0001 per share. The Pre-Funded Warrants are included in the weighted-average shares outstanding used in the calculation of basic net loss per share as the exercise price is negligible and the warrants are fully vested and exercisable.

The Company’s potentially dilutive shares, which include outstanding share options to purchase ordinary shares and RSUs, are considered to be ordinary share equivalents and are only included in the calculation of diluted net loss per share when their effect is dilutive.

The following potential ordinary shares, presented based on amounts outstanding at each period end, were excluded from the calculation of diluted net loss per share attributable to ordinary shareholders for the periods indicated because including them would have had an anti-dilutive effect:


	As of December 31,
	2023		2022
Options to purchase ordinary shares		14,107,710		9,682,054
RSUs		637,557		934,342
Series A preferred shares		3,901,348		3,901,348