NET PRODUCT REVENUES - Summary of Net Product Revenues (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Disaggregation of Revenue [Line Items]
Total revenues	$ 659,825	$ 318,754	$ 1,154,158	$ 638,044
Net product revenues
Disaggregation of Revenue [Line Items]
Total revenues	410,088	305,705	775,251	582,033
ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	77,244	91,458	146,461	193,951
AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	230,109	132,136	425,350	233,904
GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	62,127	57,899	120,183	105,805
OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	40,608	24,212	83,257	48,373
United States \| ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	22,112	25,560	38,651	55,377
United States \| AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	148,463	96,469	278,701	175,482
United States \| GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	41,225	35,196	79,956	65,487
United States \| OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	15,744	8,794	29,076	17,851
Europe \| ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	37,074	56,393	81,764	116,071
Europe \| AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	56,760	14,405	100,493	21,173
Europe \| GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	16,314	14,051	31,629	28,522
Europe \| OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	20,503	12,216	41,930	25,525
Rest of World \| ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	18,058	9,505	26,046	22,503
Rest of World \| AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	24,886	21,262	46,156	37,249
Rest of World \| GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	4,588	8,652	8,598	11,796
Rest of World \| OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	$ 4,361	$ 3,202	$ 12,251	$ 4,997