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Share-Based Compensation
 6 Months Ended
Jun. 30, 2024
Share-Based Payment Arrangement [Abstract]  
Share-Based Compensation Share-Based Compensation
Total share-based compensation expense related to all of the Company's share-based awards, including stock options and restricted stock units (“RSUs”), granted to employees and directors recognized during the six-month periods ended June 30, 2024 and 2023, was comprised of the following (in thousands):
Three Months Ended June 30,Six Months Ended June 30,
2024202320242023
Inventoriable costs$491 $420 $908 $762 
Selling, general and administrative10,808 8,725 20,025 15,705 
Research and development5,071 4,081 9,280 7,198 
Total share-based compensation expense$16,370 $13,226 $30,213 $23,665 
Information regarding the stock options activity, including with respect to grants to employees and directors under the Amended and Restated 2018 Equity Incentive Plan (the Amended 2018 Plan) and 2019 Inducement Award Plan (the 2019 Inducement Plan) as of June 30, 2024, and changes during the six-month period then ended, are summarized as follows:
Number of
Shares		Weighted-
Average
Exercise
Price		Weighted-
Average
Contractual
Life
Outstanding at December 31, 20234,239,982$28.22 5.2 years
Options granted 202417,288
Options exercised 2024(574,301)
Options canceled or expired 2024(9,347)
Outstanding at June 30, 20243,673,622$29.38 5.1 years
Vested and expected to vest at June 30, 20243,673,622$29.38 
Exercisable at June 30, 20243,320,956$26.94 4.7 years
The fair value of the time-based RSUs is based on the closing price of the Company’s common stock on the date of grant. Information regarding the time-based RSU activity, including with respect to grants to employees under the Amended 2018 Plan and 2019 Inducement Plan, and changes during the six-month period ended June 30, 2024 is summarized as follows:
Number of
Shares		Weighted-Average
Grant Date
Fair Value Per Share		Weighted-
Average
Contractual
Life
Outstanding at December 31, 20231,645,130$48.92 1.0 year
Time-based RSUs granted in 20241,033,819
Time-based RSUs vested in 2024(719,864)
Time-based RSUs cancelled in 2024(29,622)
Outstanding at June 30, 20241,929,463$59.99 1.4 years
As of June 30, 2024, there were $99.6 million of unrecognized compensation costs estimated related to unvested time-based RSUs.