<?xml version="1.0" encoding="US-ASCII" standalone="no"?>
    <!-- Field: Doc-Info; Name: Generator; Value: GoFiler Complete; Version: 5.25b -->
    <!-- Field: Doc-Info; Name: VendorURI; Value: https://www.novaworks.com -->
    <!-- Field: Doc-Info; Name: Status; Value: 0x00000000 -->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
    <link:roleRef roleURI="http://celularity.com/role/Cover" xlink:href="celu-20240930.xsd#Cover" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/BalanceSheets" xlink:href="celu-20240930.xsd#BalanceSheets" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/BalanceSheetsParenthetical" xlink:href="celu-20240930.xsd#BalanceSheetsParenthetical" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/StatementsOfOperationsAndComprehensiveLoss" xlink:href="celu-20240930.xsd#StatementsOfOperationsAndComprehensiveLoss" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/StatementsOfStockholdersEquity" xlink:href="celu-20240930.xsd#StatementsOfStockholdersEquity" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/StatementsOfCashFlows" xlink:href="celu-20240930.xsd#StatementsOfCashFlows" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/NatureOfBusiness" xlink:href="celu-20240930.xsd#NatureOfBusiness" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="celu-20240930.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/FairValueOfFinancialAssetsAndLiabilities" xlink:href="celu-20240930.xsd#FairValueOfFinancialAssetsAndLiabilities" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/Inventory" xlink:href="celu-20240930.xsd#Inventory" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/PrepaidExpensesAndOtherCurrentAssets" xlink:href="celu-20240930.xsd#PrepaidExpensesAndOtherCurrentAssets" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/PropertyAndEquipmentNet" xlink:href="celu-20240930.xsd#PropertyAndEquipmentNet" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/GoodwillAndIntangibleAssetsNet" xlink:href="celu-20240930.xsd#GoodwillAndIntangibleAssetsNet" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/AccruedExpensesAndOtherCurrentLiabilities" xlink:href="celu-20240930.xsd#AccruedExpensesAndOtherCurrentLiabilities" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/Debt" xlink:href="celu-20240930.xsd#Debt" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/Leases" xlink:href="celu-20240930.xsd#Leases" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/CommitmentsAndContingencies" xlink:href="celu-20240930.xsd#CommitmentsAndContingencies" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/Equity" xlink:href="celu-20240930.xsd#Equity" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/Stock-basedCompensation" xlink:href="celu-20240930.xsd#Stock-basedCompensation" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/RevenueRecognition" xlink:href="celu-20240930.xsd#RevenueRecognition" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/LicenseAndDistributionAgreements" xlink:href="celu-20240930.xsd#LicenseAndDistributionAgreements" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/BenefitPlan" xlink:href="celu-20240930.xsd#BenefitPlan" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/IncomeTaxes" xlink:href="celu-20240930.xsd#IncomeTaxes" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SegmentInformation" xlink:href="celu-20240930.xsd#SegmentInformation" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/RelatedPartyTransactions" xlink:href="celu-20240930.xsd#RelatedPartyTransactions" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SubsequentEvents" xlink:href="celu-20240930.xsd#SubsequentEvents" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:href="celu-20240930.xsd#SummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="celu-20240930.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/FairValueOfFinancialAssetsAndLiabilitiesTables" xlink:href="celu-20240930.xsd#FairValueOfFinancialAssetsAndLiabilitiesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/InventoryTables" xlink:href="celu-20240930.xsd#InventoryTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/PrepaidExpensesAndOtherCurrentAssetsTables" xlink:href="celu-20240930.xsd#PrepaidExpensesAndOtherCurrentAssetsTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/PropertyAndEquipmentNetTables" xlink:href="celu-20240930.xsd#PropertyAndEquipmentNetTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/GoodwillAndIntangibleAssetsNetTables" xlink:href="celu-20240930.xsd#GoodwillAndIntangibleAssetsNetTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/AccruedExpensesAndOtherCurrentLiabilitiesTables" xlink:href="celu-20240930.xsd#AccruedExpensesAndOtherCurrentLiabilitiesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/DebtTables" xlink:href="celu-20240930.xsd#DebtTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/LeasesTables" xlink:href="celu-20240930.xsd#LeasesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/EquityTables" xlink:href="celu-20240930.xsd#EquityTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/Stock-basedCompensationTables" xlink:href="celu-20240930.xsd#Stock-basedCompensationTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/RevenueRecognitionTables" xlink:href="celu-20240930.xsd#RevenueRecognitionTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/IncomeTaxesTables" xlink:href="celu-20240930.xsd#IncomeTaxesTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SegmentInformationTables" xlink:href="celu-20240930.xsd#SegmentInformationTables" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/NatureOfBusinessDetailsNarrative" xlink:href="celu-20240930.xsd#NatureOfBusinessDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfPropertyAndEquipmentEstimatedUsefulLifeDetails" xlink:href="celu-20240930.xsd#ScheduleOfPropertyAndEquipmentEstimatedUsefulLifeDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfBasicAndDilutedNetIncomeLossPerShareDetails" xlink:href="celu-20240930.xsd#ScheduleOfBasicAndDilutedNetIncomeLossPerShareDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfPotentiallyDilutiveSecuritiesDetails" xlink:href="celu-20240930.xsd#ScheduleOfPotentiallyDilutiveSecuritiesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:href="celu-20240930.xsd#SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfFinancialAssetsAndLiabilitiesMeasuresAtFairValueDetails" xlink:href="celu-20240930.xsd#ScheduleOfFinancialAssetsAndLiabilitiesMeasuresAtFairValueDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfReconciliationOfContingentConsiderationObligationsDetails" xlink:href="celu-20240930.xsd#ScheduleOfReconciliationOfContingentConsiderationObligationsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfRoll-forwardOfAggregateFairValuesOfCompanysWarrantLiabilitiesDetails" xlink:href="celu-20240930.xsd#ScheduleOfRoll-forwardOfAggregateFairValuesOfCompanysWarrantLiabilitiesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfFairValueOfLiabilityWarrantsDetails" xlink:href="celu-20240930.xsd#ScheduleOfFairValueOfLiabilityWarrantsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfSponsorWarrantsDetails" xlink:href="celu-20240930.xsd#ScheduleOfSponsorWarrantsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfMay2022PipeWarrantsAnd2023RegisteredDirectWarrantsDetails" xlink:href="celu-20240930.xsd#ScheduleOfMay2022PipeWarrantsAnd2023RegisteredDirectWarrantsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfConvertibleNoteValuationModelDetails" xlink:href="celu-20240930.xsd#ScheduleOfConvertibleNoteValuationModelDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfReconciliationOfContingentStockConsiderationObligationMeasuredOnRecurringBasisDetails" xlink:href="celu-20240930.xsd#ScheduleOfReconciliationOfContingentStockConsiderationObligationMeasuredOnRecurringBasisDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfReconciliationOfYorkvilleDebtMeasuredOnMeasuredBasisDetails" xlink:href="celu-20240930.xsd#ScheduleOfReconciliationOfYorkvilleDebtMeasuredOnMeasuredBasisDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfYorkvilleShort-termDebtValuationModelDetails" xlink:href="celu-20240930.xsd#ScheduleOfYorkvilleShort-termDebtValuationModelDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/FairValueOfFinancialAssetsAndLiabilitiesDetailsNarrative" xlink:href="celu-20240930.xsd#FairValueOfFinancialAssetsAndLiabilitiesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfMajorClassesOfInventoriesDetails" xlink:href="celu-20240930.xsd#ScheduleOfMajorClassesOfInventoriesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfInventoryReservesDetails" xlink:href="celu-20240930.xsd#ScheduleOfInventoryReservesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/InventoryDetailsNarrative" xlink:href="celu-20240930.xsd#InventoryDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfPrepaidExpensesAndOtherCurrentAssetsDetails" xlink:href="celu-20240930.xsd#ScheduleOfPrepaidExpensesAndOtherCurrentAssetsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfPropertyAndEquipmentNetDetails" xlink:href="celu-20240930.xsd#ScheduleOfPropertyAndEquipmentNetDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/PropertyAndEquipmentNetDetailsNarrative" xlink:href="celu-20240930.xsd#PropertyAndEquipmentNetDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfCarryingValuesOfGoodwillAssignedToOperatingSegmentsDetails" xlink:href="celu-20240930.xsd#ScheduleOfCarryingValuesOfGoodwillAssignedToOperatingSegmentsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfIntangibleAssetsNetDetails" xlink:href="celu-20240930.xsd#ScheduleOfIntangibleAssetsNetDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfAggregateAmortizationExpenseRelatedToIntangibleAssetsDetails" xlink:href="celu-20240930.xsd#ScheduleOfAggregateAmortizationExpenseRelatedToIntangibleAssetsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/GoodwillAndIntangibleAssetsNetDetailsNarrative" xlink:href="celu-20240930.xsd#GoodwillAndIntangibleAssetsNetDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesDetails" xlink:href="celu-20240930.xsd#ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/DebtDetailsNarrative" xlink:href="celu-20240930.xsd#DebtDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfLeaseCostsDetails" xlink:href="celu-20240930.xsd#ScheduleOfLeaseCostsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfCashAndNon-cashActivityRelatedToLeaseLiabilitiesDetails" xlink:href="celu-20240930.xsd#ScheduleOfCashAndNon-cashActivityRelatedToLeaseLiabilitiesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfFutureMinimumPaymentsUnderNon-cancelableOperatingLeasesDetails" xlink:href="celu-20240930.xsd#ScheduleOfFutureMinimumPaymentsUnderNon-cancelableOperatingLeasesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/LeasesDetailsNarrative" xlink:href="celu-20240930.xsd#LeasesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/CommitmentsAndContingenciesDetailsNarrative" xlink:href="celu-20240930.xsd#CommitmentsAndContingenciesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SummaryOfWarrantsDetails" xlink:href="celu-20240930.xsd#SummaryOfWarrantsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SummaryOfWarrantsDetailsParenthetical" xlink:href="celu-20240930.xsd#SummaryOfWarrantsDetailsParenthetical" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/EquityDetailsNarrative" xlink:href="celu-20240930.xsd#EquityDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfWeightedAverageGrantFairValueOfStockOptionsUsingBlack-scholesOption-pricingModelDetails" xlink:href="celu-20240930.xsd#ScheduleOfWeightedAverageGrantFairValueOfStockOptionsUsingBlack-scholesOption-pricingModelDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfStockOptionActivityDetails" xlink:href="celu-20240930.xsd#ScheduleOfStockOptionActivityDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfActivityRelatedToRsuStock-basedPaymentAwardsDetails" xlink:href="celu-20240930.xsd#ScheduleOfActivityRelatedToRsuStock-basedPaymentAwardsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfStock-basedCompensationExpenseDetails" xlink:href="celu-20240930.xsd#ScheduleOfStock-basedCompensationExpenseDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/Stock-basedCompensationDetailsNarrative" xlink:href="celu-20240930.xsd#Stock-basedCompensationDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfDisaggregatedRevenueByProductAndServicesDetails" xlink:href="celu-20240930.xsd#ScheduleOfDisaggregatedRevenueByProductAndServicesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfChangesInDeferredRevenueFromContractLiabilitiesDetails" xlink:href="celu-20240930.xsd#ScheduleOfChangesInDeferredRevenueFromContractLiabilitiesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/LicenseAndDistributionAgreementsDetailsNarrative" xlink:href="celu-20240930.xsd#LicenseAndDistributionAgreementsDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/BenefitPlanDetailsNarrative" xlink:href="celu-20240930.xsd#BenefitPlanDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfCurrentAndDeferredTaxProvisionDetails" xlink:href="celu-20240930.xsd#ScheduleOfCurrentAndDeferredTaxProvisionDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfReconciliationOfU.sFederalStatutoryIncomeTaxDetails" xlink:href="celu-20240930.xsd#ScheduleOfReconciliationOfU.sFederalStatutoryIncomeTaxDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:href="celu-20240930.xsd#ScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfUnrecognizedTaxBenefitsDetails" xlink:href="celu-20240930.xsd#ScheduleOfUnrecognizedTaxBenefitsDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/IncomeTaxesDetailsNarrative" xlink:href="celu-20240930.xsd#IncomeTaxesDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfFinancialInformationBySegmentDetails" xlink:href="celu-20240930.xsd#ScheduleOfFinancialInformationBySegmentDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SegmentInformationDetailsNarrative" xlink:href="celu-20240930.xsd#SegmentInformationDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:href="celu-20240930.xsd#RelatedPartyTransactionsDetailsNarrative" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetails" xlink:href="celu-20240930.xsd#ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfReconciliationOfConvertibleNoteReceivableMeasuredOnRecurringBasisDetails" xlink:href="celu-20240930.xsd#ScheduleOfReconciliationOfConvertibleNoteReceivableMeasuredOnRecurringBasisDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfReconciliationOfWarrantLiabilitiesMeasuredOnRecurringBasisDetails" xlink:href="celu-20240930.xsd#ScheduleOfReconciliationOfWarrantLiabilitiesMeasuredOnRecurringBasisDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfJanuary20224BridgeLoanDetails" xlink:href="celu-20240930.xsd#ScheduleOfJanuary20224BridgeLoanDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfDebtDetails" xlink:href="celu-20240930.xsd#ScheduleOfDebtDetails" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/ScheduleOfChangesInDeferredRevenueFromContractLiabilitiesDetailsParenthetical" xlink:href="celu-20240930.xsd#ScheduleOfChangesInDeferredRevenueFromContractLiabilitiesDetailsParenthetical" xlink:type="simple" />
    <link:roleRef roleURI="http://celularity.com/role/SubsequentEventsDetailsNarrative" xlink:href="celu-20240930.xsd#SubsequentEventsDetailsNarrative" xlink:type="simple" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Cover" xlink:title="00000001 - Document - Cover" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/BalanceSheets" xlink:title="00000002 - Statement - Condensed Consolidated Balance Sheets">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaapAssetsCurrent" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent" xlink:label="loc_us-gaapAccountsAndOtherReceivablesNetCurrent" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapAccountsAndOtherReceivablesNetCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_PromissoryNotesReceivable" xlink:label="loc_CELUPromissoryNotesReceivable" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_CELUPromissoryNotesReceivable" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaapInventoryNet" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapInventoryNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets" xlink:label="loc_us-gaapAssets" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapAssetsCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaapGoodwill" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapGoodwill" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaapIntangibleAssetsNetExcludingGoodwill" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapIntangibleAssetsNetExcludingGoodwill" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaapOperatingLeaseRightOfUseAsset" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOperatingLeaseRightOfUseAsset" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashNoncurrent" xlink:label="loc_us-gaapRestrictedCashNoncurrent" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapRestrictedCashNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNoncurrent" xlink:label="loc_us-gaapInventoryNoncurrent" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapInventoryNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaapOtherAssetsNoncurrent" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapOtherAssetsNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaapLiabilitiesCurrent" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaapAccountsPayableCurrent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccountsPayableCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities" xlink:label="loc_us-gaapAccruedLiabilitiesAndOtherLiabilities" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedLiabilitiesAndOtherLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_AccruedResearchAndDevelopmentSoftware" xlink:label="loc_CELUAccruedResearchAndDevelopmentSoftware" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_CELUAccruedResearchAndDevelopmentSoftware" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShortTermBorrowings" xlink:label="loc_us-gaapShortTermBorrowings" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapShortTermBorrowings" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ShortTermDebtUnaffiliated" xlink:label="loc_CELUShortTermDebtUnaffiliated" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_CELUShortTermDebtUnaffiliated" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_OtherShortTermDebt" xlink:label="loc_CELUOtherShortTermDebt" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_CELUOtherShortTermDebt" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_OtherShortTermDebtDueToRelatedParty" xlink:label="loc_CELUOtherShortTermDebtDueToRelatedParty" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_CELUOtherShortTermDebtDueToRelatedParty" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ShortTermDebtRelatedParties" xlink:label="loc_CELUShortTermDebtRelatedParties" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_CELUShortTermDebtRelatedParties" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ShortTermDebtRelatedParty" xlink:label="loc_CELUShortTermDebtRelatedParty" />
      <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_CELUShortTermDebtRelatedParty" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerLiabilityCurrent" xlink:label="loc_us-gaapContractWithCustomerLiabilityCurrent" />
      <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapContractWithCustomerLiabilityCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaapLiabilities" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapLiabilitiesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent" xlink:label="loc_us-gaapContractWithCustomerLiabilityNoncurrent" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapContractWithCustomerLiabilityNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_us-gaapBusinessCombinationContingentConsiderationLiability" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapBusinessCombinationContingentConsiderationLiability" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="loc_us-gaapOperatingLeaseLiabilityNoncurrent" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapOperatingLeaseLiabilityNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_WarrantLiability" xlink:label="loc_CELUWarrantLiability" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_CELUWarrantLiability" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet" xlink:label="loc_us-gaapDeferredIncomeTaxLiabilitiesNet" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapDeferredIncomeTaxLiabilitiesNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaapOtherLiabilitiesNoncurrent" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapOtherLiabilitiesNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:label="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaapPreferredStockValue" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapPreferredStockValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaapCommonStockValue" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapCommonStockValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaapAdditionalPaidInCapital" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapAdditionalPaidInCapital" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaapAccumulatedOtherComprehensiveIncomeLossNetOfTax" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapAccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaapRetainedEarningsAccumulatedDeficit" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="loc_us-gaapRetainedEarningsAccumulatedDeficit" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquity" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaapCommitmentsAndContingencies" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapCommitmentsAndContingencies" xlink:type="arc" weight="1" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapStockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/BalanceSheetsParenthetical" xlink:title="00000003 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/StatementsOfOperationsAndComprehensiveLoss" xlink:title="00000004 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss">
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_OperatingIncomeCostsAndExpenses" xlink:label="loc_CELUOperatingIncomeCostsAndExpenses" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostOfRevenue" xlink:label="loc_us-gaapCostOfRevenue" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_us-gaapCostOfRevenue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaapResearchAndDevelopmentExpense" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_us-gaapResearchAndDevelopmentExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_SoftwareCeaseUseCosts" xlink:label="loc_CELUSoftwareCeaseUseCosts" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_CELUSoftwareCeaseUseCosts" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaapSellingGeneralAndAdministrativeExpense" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_us-gaapSellingGeneralAndAdministrativeExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ChangeInFairValueOfContingentConsiderationLiability" xlink:label="loc_CELUChangeInFairValueOfContingentConsiderationLiability" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_CELUChangeInFairValueOfContingentConsiderationLiability" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillImpairmentLoss" xlink:label="loc_us-gaapGoodwillImpairmentLoss" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_us-gaapGoodwillImpairmentLoss" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InProcessResearchAndDevelopmentImpairment" xlink:label="loc_CELUInProcessResearchAndDevelopmentImpairment" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_CELUInProcessResearchAndDevelopmentImpairment" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaapAmortizationOfIntangibleAssets" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUOperatingIncomeCostsAndExpenses" xlink:to="loc_us-gaapAmortizationOfIntangibleAssets" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaapOperatingIncomeLoss" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaapRevenueFromContractWithCustomerExcludingAssessedTax" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapRevenueFromContractWithCustomerExcludingAssessedTax" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_CELUOperatingIncomeCostsAndExpenses" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaapNonoperatingIncomeExpense" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncome" xlink:label="loc_us-gaapOtherNonoperatingIncome" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapOtherNonoperatingIncome" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingExpense" xlink:label="loc_us-gaapOtherNonoperatingExpense" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapOtherNonoperatingExpense" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaapFairValueAdjustmentOfWarrants" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapFairValueAdjustmentOfWarrants" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ChangeInFairValueOfDebt" xlink:label="loc_CELUChangeInFairValueOfDebt" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_CELUChangeInFairValueOfDebt" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaapGainsLossesOnExtinguishmentOfDebt" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapGainsLossesOnExtinguishmentOfDebt" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_OtherNonoperatingIncomeExpenses" xlink:label="loc_CELUOtherNonoperatingIncomeExpenses" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_CELUOtherNonoperatingIncomeExpenses" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="loc_us-gaapOperatingIncomeLoss" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="loc_us-gaapNonoperatingIncomeExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapIncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaapIncomeTaxExpenseBenefit" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapIncomeTaxExpenseBenefit" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:label="loc_us-gaapOtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossFinancialLiabilityFairValueOptionAfterTaxAndReclassificationAdjustmentAttributableToParent" xlink:label="loc_us-gaapOtherComprehensiveIncomeLossFinancialLiabilityFairValueOptionAfterTaxAndReclassificationAdjustmentAttributableToParent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:to="loc_us-gaapOtherComprehensiveIncomeLossFinancialLiabilityFairValueOptionAfterTaxAndReclassificationAdjustmentAttributableToParent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaapComprehensiveIncomeNetOfTax" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapComprehensiveIncomeNetOfTax" xlink:to="loc_us-gaapNetIncomeLoss" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapComprehensiveIncomeNetOfTax" xlink:to="loc_us-gaapOtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/StatementsOfStockholdersEquity" xlink:title="00000005 - Statement - Condensed Consolidated Statements of Stockholders&apos; Equity" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/StatementsOfCashFlows" xlink:title="00000006 - Statement - Condensed Consolidated Statements of Cash Flows">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss" xlink:label="loc_us-gaapProfitLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapProfitLoss" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaapDepreciationDepletionAndAmortization" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDepreciationDepletionAndAmortization" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_NonCashLeaseExpense" xlink:label="loc_CELUNonCashLeaseExpense" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUNonCashLeaseExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits" xlink:label="loc_us-gaapDeferredIncomeTaxesAndTaxCredits" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDeferredIncomeTaxesAndTaxCredits" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaapProvisionForDoubtfulAccounts" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapProvisionForDoubtfulAccounts" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProvisionForInventoryObsolescence" xlink:label="loc_CELUProvisionForInventoryObsolescence" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUProvisionForInventoryObsolescence" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaapFairValueAdjustmentOfWarrants" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapFairValueAdjustmentOfWarrants" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InventoryImpairment" xlink:label="loc_CELUInventoryImpairment" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUInventoryImpairment" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillImpairmentLoss" xlink:label="loc_us-gaapGoodwillImpairmentLoss" />
      <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapGoodwillImpairmentLoss" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill" xlink:label="loc_us-gaapImpairmentOfIntangibleAssetsExcludingGoodwill" />
      <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapImpairmentOfIntangibleAssetsExcludingGoodwill" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeBenefitsAndShareBasedCompensation" xlink:label="loc_us-gaapEmployeeBenefitsAndShareBasedCompensation" />
      <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapEmployeeBenefitsAndShareBasedCompensation" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:label="loc_us-gaapBusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" />
      <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapBusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_AcquiredInProcessResearchAndDevelopment" xlink:label="loc_CELUAcquiredInProcessResearchAndDevelopment" />
      <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUAcquiredInProcessResearchAndDevelopment" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_IssuanceOfCommonStockForStemCellsToBeUsedInResearchAndDevelopment" xlink:label="loc_CELUIssuanceOfCommonStockForStemCellsToBeUsedInResearchAndDevelopment" />
      <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUIssuanceOfCommonStockForStemCellsToBeUsedInResearchAndDevelopment" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_IssuanceOfCommonStockToPalantirAsConsiderationForSettlementAgreement" xlink:label="loc_CELUIssuanceOfCommonStockToPalantirAsConsiderationForSettlementAgreement" />
      <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUIssuanceOfCommonStockToPalantirAsConsiderationForSettlementAgreement" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_IssuanceOfCommonStockRelatingToDebtExtension" xlink:label="loc_CELUIssuanceOfCommonStockRelatingToDebtExtension" />
      <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUIssuanceOfCommonStockRelatingToDebtExtension" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_DiscountsArisingFromRWILoanArrangementRelatedParty" xlink:label="loc_CELUDiscountsArisingFromRWILoanArrangementRelatedParty" />
      <link:calculationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUDiscountsArisingFromRWILoanArrangementRelatedParty" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_FairValueOfWarrantModificationForProfessionalServices" xlink:label="loc_CELUFairValueOfWarrantModificationForProfessionalServices" />
      <link:calculationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUFairValueOfWarrantModificationForProfessionalServices" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ChangeInFairValueOfDebt" xlink:label="loc_CELUChangeInFairValueOfDebt" />
      <link:calculationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUChangeInFairValueOfDebt" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ChangeInFairValueOfContingentStockConsideration" xlink:label="loc_CELUChangeInFairValueOfContingentStockConsideration" />
      <link:calculationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUChangeInFairValueOfContingentStockConsideration" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet" xlink:label="loc_us-gaapIncreaseDecreaseInOtherOperatingCapitalNet" />
      <link:calculationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOtherOperatingCapitalNet" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_IssuanceOfCommonStockRelatingToDebtExtensionAndCommitmentFee" xlink:label="loc_CELUIssuanceOfCommonStockRelatingToDebtExtensionAndCommitmentFee" />
      <link:calculationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUIssuanceOfCommonStockRelatingToDebtExtensionAndCommitmentFee" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaapGainsLossesOnExtinguishmentOfDebt" />
      <link:calculationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapGainsLossesOnExtinguishmentOfDebt" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_NonCashInterestExpense" xlink:label="loc_CELUNonCashInterestExpense" />
      <link:calculationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUNonCashInterestExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsReceivable" />
      <link:calculationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsReceivable" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaapIncreaseDecreaseInInventories" />
      <link:calculationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInInventories" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaapIncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" />
      <link:calculationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsPayable" />
      <link:calculationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsPayable" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities" />
      <link:calculationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_AccruedResearchDevelopmentSoftware" xlink:label="loc_CELUAccruedResearchDevelopmentSoftware" />
      <link:calculationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUAccruedResearchDevelopmentSoftware" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_IncreaseDecreaseInRightOfUseAssetsAndLeaseLiabilities" xlink:label="loc_CELUIncreaseDecreaseInRightOfUseAssetsAndLeaseLiabilities" />
      <link:calculationArc order="31" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_CELUIncreaseDecreaseInRightOfUseAssetsAndLeaseLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability" xlink:label="loc_us-gaapIncreaseDecreaseInOperatingLeaseLiability" />
      <link:calculationArc order="32" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInOperatingLeaseLiability" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:label="loc_us-gaapIncreaseDecreaseInContractWithCustomerLiability" />
      <link:calculationArc order="33" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInContractWithCustomerLiability" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProceedsFromSanuwaveConvertibleNote" xlink:label="loc_CELUProceedsFromSanuwaveConvertibleNote" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_CELUProceedsFromSanuwaveConvertibleNote" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment" xlink:label="loc_us-gaapPaymentsToAcquireInProcessResearchAndDevelopment" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquireInProcessResearchAndDevelopment" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProceedsFromRWISeniorSecuredBridgeLoanAndWarrantsRelatedParty" xlink:label="loc_CELUProceedsFromRWISeniorSecuredBridgeLoanAndWarrantsRelatedParty" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUProceedsFromRWISeniorSecuredBridgeLoanAndWarrantsRelatedParty" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProceedsFromWarrantsAndShortTermDebtRelatedParties" xlink:label="loc_CELUProceedsFromWarrantsAndShortTermDebtRelatedParties" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUProceedsFromWarrantsAndShortTermDebtRelatedParties" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProceedsFromShortTermDebtUnaffiliated" xlink:label="loc_CELUProceedsFromShortTermDebtUnaffiliated" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUProceedsFromShortTermDebtUnaffiliated" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="loc_us-gaapRepaymentsOfShortTermDebt" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapRepaymentsOfShortTermDebt" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProceedsFromIssuanceOfSeniorSecuredBridgeLoanAndWarrantsRelatedParty" xlink:label="loc_CELUProceedsFromIssuanceOfSeniorSecuredBridgeLoanAndWarrantsRelatedParty" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUProceedsFromIssuanceOfSeniorSecuredBridgeLoanAndWarrantsRelatedParty" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="loc_us-gaapProceedsFromShortTermDebt" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromShortTermDebt" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProceedsFromTheSaleOfCommonStockInAtmOffering" xlink:label="loc_CELUProceedsFromTheSaleOfCommonStockInAtmOffering" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUProceedsFromTheSaleOfCommonStockInAtmOffering" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_PaymentsOfAtTheMarketOfferingCostsAndCommissions" xlink:label="loc_CELUPaymentsOfAtTheMarketOfferingCostsAndCommissions" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUPaymentsOfAtTheMarketOfferingCostsAndCommissions" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_RepaymentsOfShortTermDebtUnaffiliated" xlink:label="loc_CELURepaymentsOfShortTermDebtUnaffiliated" />
      <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELURepaymentsOfShortTermDebtUnaffiliated" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_PaymentOfSepaCommitmentFee" xlink:label="loc_CELUPaymentOfSepaCommitmentFee" />
      <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUPaymentOfSepaCommitmentFee" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_RepaymentsOfShortTermDebtRelatedParty" xlink:label="loc_CELURepaymentsOfShortTermDebtRelatedParty" />
      <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELURepaymentsOfShortTermDebtRelatedParty" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromOtherShortTermDebt" xlink:label="loc_us-gaapProceedsFromOtherShortTermDebt" />
      <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromOtherShortTermDebt" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_ProceedsFromOtherShortTermDebtRelatedParty" xlink:label="loc_CELUProceedsFromOtherShortTermDebtRelatedParty" />
      <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_CELUProceedsFromOtherShortTermDebtRelatedParty" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement" xlink:label="loc_us-gaapProceedsFromIssuanceOfPrivatePlacement" />
      <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromIssuanceOfPrivatePlacement" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="loc_us-gaapProceedsFromStockOptionsExercised" />
      <link:calculationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromStockOptionsExercised" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaapPaymentsRelatedToTaxWithholdingForShareBasedCompensation" />
      <link:calculationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapPaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering" xlink:label="loc_us-gaapProceedsFromIssuanceInitialPublicOffering" />
      <link:calculationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromIssuanceInitialPublicOffering" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsOfDebtIssuanceCosts" xlink:label="loc_us-gaapPaymentsOfDebtIssuanceCosts" />
      <link:calculationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapPaymentsOfDebtIssuanceCosts" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:type="arc" weight="1" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/NatureOfBusiness" xlink:title="999007 - Disclosure - Nature of Business" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SummaryOfSignificantAccountingPolicies" xlink:title="999008 - Disclosure - Summary of Significant Accounting Policies" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/FairValueOfFinancialAssetsAndLiabilities" xlink:title="999009 - Disclosure - Fair Value of Financial Assets and Liabilities" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Inventory" xlink:title="999010 - Disclosure - Inventory" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/PrepaidExpensesAndOtherCurrentAssets" xlink:title="999011 - Disclosure - Prepaid Expenses and Other Current Assets" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/PropertyAndEquipmentNet" xlink:title="999012 - Disclosure - Property and Equipment, Net" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/GoodwillAndIntangibleAssetsNet" xlink:title="999013 - Disclosure - Goodwill and Intangible Assets, Net" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/AccruedExpensesAndOtherCurrentLiabilities" xlink:title="999014 - Disclosure - Accrued Expenses and Other Current Liabilities" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Debt" xlink:title="999015 - Disclosure - Debt" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Leases" xlink:title="999016 - Disclosure - Leases" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/CommitmentsAndContingencies" xlink:title="999017 - Disclosure - Commitments and Contingencies" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Equity" xlink:title="999018 - Disclosure - Equity" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Stock-basedCompensation" xlink:title="999019 - Disclosure - Stock-Based Compensation" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/RevenueRecognition" xlink:title="999020 - Disclosure - Revenue Recognition" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/LicenseAndDistributionAgreements" xlink:title="999021 - Disclosure - License and Distribution Agreements" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/BenefitPlan" xlink:title="999022 - Disclosure - Benefit Plan" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/IncomeTaxes" xlink:title="999023 - Disclosure - Income Taxes" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SegmentInformation" xlink:title="999024 - Disclosure - Segment Information" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/RelatedPartyTransactions" xlink:title="999025 - Disclosure - Related Party Transactions" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SubsequentEvents" xlink:title="999026 - Disclosure - Subsequent Events" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:title="999027 - Disclosure - Summary of Significant Accounting Policies (Policies)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:title="999028 - Disclosure - Summary of Significant Accounting Policies (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/FairValueOfFinancialAssetsAndLiabilitiesTables" xlink:title="999029 - Disclosure - Fair Value of Financial Assets and Liabilities (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/InventoryTables" xlink:title="999030 - Disclosure - Inventory (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/PrepaidExpensesAndOtherCurrentAssetsTables" xlink:title="999031 - Disclosure - Prepaid Expenses and Other Current Assets (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/PropertyAndEquipmentNetTables" xlink:title="999032 - Disclosure - Property and Equipment, Net (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/GoodwillAndIntangibleAssetsNetTables" xlink:title="999033 - Disclosure - Goodwill and Intangible Assets, Net (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/AccruedExpensesAndOtherCurrentLiabilitiesTables" xlink:title="999034 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/DebtTables" xlink:title="999035 - Disclosure - Debt (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/LeasesTables" xlink:title="999036 - Disclosure - Leases (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/EquityTables" xlink:title="999037 - Disclosure - Equity (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Stock-basedCompensationTables" xlink:title="999038 - Disclosure - Stock-Based Compensation (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/RevenueRecognitionTables" xlink:title="999039 - Disclosure - Revenue Recognition (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/IncomeTaxesTables" xlink:title="999040 - Disclosure - Income Taxes (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SegmentInformationTables" xlink:title="999041 - Disclosure - Segment Information (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/NatureOfBusinessDetailsNarrative" xlink:title="999042 - Disclosure - Nature of Business (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfPropertyAndEquipmentEstimatedUsefulLifeDetails" xlink:title="999043 - Disclosure - Schedule of Property and Equipment Estimated Useful Life (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfBasicAndDilutedNetIncomeLossPerShareDetails" xlink:title="999044 - Disclosure - Schedule of Basic and Diluted Net Income Loss Per Share (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfPotentiallyDilutiveSecuritiesDetails" xlink:title="999045 - Disclosure - Schedule of Potentially Dilutive Securities (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SummaryOfSignificantAccountingPoliciesDetailsNarrative" xlink:title="999046 - Disclosure - Summary of Significant Accounting Policies (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfFinancialAssetsAndLiabilitiesMeasuresAtFairValueDetails" xlink:title="999047 - Disclosure - Schedule of Financial Assets and Liabilities Measures at Fair Value (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfReconciliationOfContingentConsiderationObligationsDetails" xlink:title="999048 - Disclosure - Schedule of Reconciliation of Contingent Consideration Obligations (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfRoll-forwardOfAggregateFairValuesOfCompanysWarrantLiabilitiesDetails" xlink:title="999049 - Disclosure - Schedule of Roll-forward of the Aggregate Fair Values of Company&#8217;s Warrant Liabilities (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfFairValueOfLiabilityWarrantsDetails" xlink:title="999050 - Disclosure - Schedule of Fair Value of Liability Warrants (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfSponsorWarrantsDetails" xlink:title="999051 - Disclosure - Schedule of Sponsor Warrants (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfMay2022PipeWarrantsAnd2023RegisteredDirectWarrantsDetails" xlink:title="999052 - Disclosure - Schedule of May 2022 PIPE Warrants and 2023 Registered Direct Warrants (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfConvertibleNoteValuationModelDetails" xlink:title="999053 - Disclosure - Schedule of Convertible Note Valuation Model (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfReconciliationOfContingentStockConsiderationObligationMeasuredOnRecurringBasisDetails" xlink:title="999054 - Disclosure - Schedule of Reconciliation of the Contingent Stock Consideration Obligation Measured on a Recurring Basis (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfReconciliationOfYorkvilleDebtMeasuredOnMeasuredBasisDetails" xlink:title="999055 - Disclosure - Schedule of Reconciliation of Yorkville Debt Measured on a Measured Basis (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfYorkvilleShort-termDebtValuationModelDetails" xlink:title="999056 - Disclosure - Schedule of Yorkville Short-term Debt Valuation Model (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/FairValueOfFinancialAssetsAndLiabilitiesDetailsNarrative" xlink:title="999057 - Disclosure - Fair Value of Financial Assets and Liabilities (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfMajorClassesOfInventoriesDetails" xlink:title="999058 - Disclosure - Schedule of Major Classes of Inventories (Details)">
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InventoryGrossCurrentAndNoncurrent" xlink:label="loc_CELUInventoryGrossCurrentAndNoncurrent" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InventoryRawMaterialsCurrentAndNoncurrent" xlink:label="loc_CELUInventoryRawMaterialsCurrentAndNoncurrent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUInventoryGrossCurrentAndNoncurrent" xlink:to="loc_CELUInventoryRawMaterialsCurrentAndNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InventoryWorkInProgressCurrentAndNoncurrent" xlink:label="loc_CELUInventoryWorkInProgressCurrentAndNoncurrent" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUInventoryGrossCurrentAndNoncurrent" xlink:to="loc_CELUInventoryWorkInProgressCurrentAndNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InventoryFinishedGoodsCurrentAndNoncurrent" xlink:label="loc_CELUInventoryFinishedGoodsCurrentAndNoncurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUInventoryGrossCurrentAndNoncurrent" xlink:to="loc_CELUInventoryFinishedGoodsCurrentAndNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InventoryNetCurrentAndNoncurrent" xlink:label="loc_CELUInventoryNetCurrentAndNoncurrent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUInventoryNetCurrentAndNoncurrent" xlink:to="loc_CELUInventoryGrossCurrentAndNoncurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_InventoryReserveCurrentAndNoncurrent" xlink:label="loc_CELUInventoryReserveCurrentAndNoncurrent" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_CELUInventoryNetCurrentAndNoncurrent" xlink:to="loc_CELUInventoryReserveCurrentAndNoncurrent" xlink:type="arc" weight="-1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfInventoryReservesDetails" xlink:title="999059 - Disclosure - Schedule of Inventory Reserves (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/InventoryDetailsNarrative" xlink:title="999060 - Disclosure - Inventory (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfPrepaidExpensesAndOtherCurrentAssetsDetails" xlink:title="999061 - Disclosure - Schedule of Prepaid Expenses and Other Current Assets (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_PrepaidClinicalExpense" xlink:label="loc_CELUPrepaidClinicalExpense" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" xlink:to="loc_CELUPrepaidClinicalExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidInsurance" xlink:label="loc_us-gaapPrepaidInsurance" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" xlink:to="loc_us-gaapPrepaidInsurance" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherPrepaidExpenseCurrent" xlink:label="loc_us-gaapOtherPrepaidExpenseCurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" xlink:to="loc_us-gaapOtherPrepaidExpenseCurrent" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfPropertyAndEquipmentNetDetails" xlink:title="999062 - Disclosure - Schedule of Property and Equipment, Net (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaapPropertyPlantAndEquipmentGross" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:to="loc_us-gaapPropertyPlantAndEquipmentGross" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaapAccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:to="loc_us-gaapAccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:type="arc" weight="-1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/PropertyAndEquipmentNetDetailsNarrative" xlink:title="999063 - Disclosure - Property and Equipment, Net (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfCarryingValuesOfGoodwillAssignedToOperatingSegmentsDetails" xlink:title="999064 - Disclosure - Schedule Of Carrying Values Of Goodwill Assigned To Operating Segments (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfIntangibleAssetsNetDetails" xlink:title="999065 - Disclosure - Schedule of Intangible Assets, Net (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfAggregateAmortizationExpenseRelatedToIntangibleAssetsDetails" xlink:title="999066 - Disclosure - Schedule of Aggregate Amortization Expense Related to Intangible Assets (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/GoodwillAndIntangibleAssetsNetDetailsNarrative" xlink:title="999067 - Disclosure - Goodwill and Intangible Assets, Net (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesDetails" xlink:title="999068 - Disclosure - Schedule of Accrued Expenses and Other Current Liabilities (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccruedLiabilitiesCurrent" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_AccruedClinicalTrialExpense" xlink:label="loc_CELUAccruedClinicalTrialExpense" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccruedLiabilitiesCurrent" xlink:to="loc_CELUAccruedClinicalTrialExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaapAccruedProfessionalFeesCurrent" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedProfessionalFeesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaapEmployeeRelatedLiabilitiesCurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapEmployeeRelatedLiabilitiesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_AccrualsForConstructionInProgress" xlink:label="loc_CELUAccrualsForConstructionInProgress" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccruedLiabilitiesCurrent" xlink:to="loc_CELUAccrualsForConstructionInProgress" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_AccruedComplianceFee" xlink:label="loc_CELUAccruedComplianceFee" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccruedLiabilitiesCurrent" xlink:to="loc_CELUAccruedComplianceFee" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapOtherAccruedLiabilitiesCurrent" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapOtherAccruedLiabilitiesCurrent" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/DebtDetailsNarrative" xlink:title="999069 - Disclosure - Debt (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfLeaseCostsDetails" xlink:title="999070 - Disclosure - Schedule of Lease Costs (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfCashAndNon-cashActivityRelatedToLeaseLiabilitiesDetails" xlink:title="999071 - Disclosure - Schedule of Cash and Non-cash Activity Related to the lease Liabilities (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfFutureMinimumPaymentsUnderNon-cancelableOperatingLeasesDetails" xlink:title="999072 - Disclosure - Schedule of Future Minimum Payments under Non-Cancelable Operating Leases (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueYearTwo" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueYearTwo" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueYearThree" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueYearThree" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour" xlink:label="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueYearFour" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDueYearFour" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="celu-20240930.xsd#CELU_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" xlink:label="loc_CELULesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLesseeOperatingLeaseLiabilityPaymentsDue" xlink:to="loc_CELULesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/LeasesDetailsNarrative" xlink:title="999073 - Disclosure - Leases (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/CommitmentsAndContingenciesDetailsNarrative" xlink:title="999074 - Disclosure - Commitments and Contingencies (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SummaryOfWarrantsDetails" xlink:title="999075 - Disclosure - Summary of the Warrants (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SummaryOfWarrantsDetailsParenthetical" xlink:title="999076 - Disclosure - Summary of the Warrants (Details) (Parenthetical)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/EquityDetailsNarrative" xlink:title="999077 - Disclosure - Equity (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfWeightedAverageGrantFairValueOfStockOptionsUsingBlack-scholesOption-pricingModelDetails" xlink:title="999078 - Disclosure - Schedule of Weighted Average Grant Fair Value of Stock Options using Black-Scholes Option-pricing Model (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfStockOptionActivityDetails" xlink:title="999079 - Disclosure - Schedule of Stock Option Activity (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfActivityRelatedToRsuStock-basedPaymentAwardsDetails" xlink:title="999080 - Disclosure - Schedule of Activity Related to RSU Stock-Based Payment Awards (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfStock-basedCompensationExpenseDetails" xlink:title="999081 - Disclosure - Schedule of Stock-based Compensation Expense (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/Stock-basedCompensationDetailsNarrative" xlink:title="999082 - Disclosure - Stock-Based Compensation (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfDisaggregatedRevenueByProductAndServicesDetails" xlink:title="999083 - Disclosure - Schedule of Disaggregated Revenue by Product And Services (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfChangesInDeferredRevenueFromContractLiabilitiesDetails" xlink:title="999084 - Disclosure - Schedule of Changes in Deferred Revenue from Contract Liabilities (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/LicenseAndDistributionAgreementsDetailsNarrative" xlink:title="999085 - Disclosure - License and Distribution Agreements (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/BenefitPlanDetailsNarrative" xlink:title="999086 - Disclosure - Benefit Plan (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfCurrentAndDeferredTaxProvisionDetails" xlink:title="999087 - Disclosure - Schedule of Current and Deferred Tax Provision (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfReconciliationOfU.sFederalStatutoryIncomeTaxDetails" xlink:title="999088 - Disclosure - Schedule of Reconciliation of the U.S federal statutory income tax (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:title="999089 - Disclosure - Schedule of Deferred tax assets and liabilities (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfUnrecognizedTaxBenefitsDetails" xlink:title="999090 - Disclosure - Schedule of Unrecognized Tax Benefits (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/IncomeTaxesDetailsNarrative" xlink:title="999091 - Disclosure - Income Taxes (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfFinancialInformationBySegmentDetails" xlink:title="999092 - Disclosure - Schedule of Financial Information by Segment (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SegmentInformationDetailsNarrative" xlink:title="999093 - Disclosure - Segment Information (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:title="999094 - Disclosure - Related Party Transactions (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetails" xlink:title="999095 - Disclosure - Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfReconciliationOfConvertibleNoteReceivableMeasuredOnRecurringBasisDetails" xlink:title="999096 - Disclosure - Schedule of Reconciliation of Convertible Note Receivable Measured on Recurring Basis (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfReconciliationOfWarrantLiabilitiesMeasuredOnRecurringBasisDetails" xlink:title="999097 - Disclosure - Schedule of Reconciliation of Warrant Liabilities Measured on Recurring Basis (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfJanuary20224BridgeLoanDetails" xlink:title="999098 - Disclosure - Schedule of January 20224 Bridge Loan (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfDebtDetails" xlink:title="999099 - Disclosure - Schedule of Debt (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/ScheduleOfChangesInDeferredRevenueFromContractLiabilitiesDetailsParenthetical" xlink:title="999100 - Disclosure -  Schedule of Changes in Deferred Revenue from Contract Liabilities (Details) (Parenthetical)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://celularity.com/role/SubsequentEventsDetailsNarrative" xlink:title="999101 - Disclosure - Subsequent Events (Details Narrative)" />
</link:linkbase>
