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        <link:roleType roleURI="http://n2off.com/role/ConsolidatedEntityDetailsNarrative" id="ConsolidatedEntityDetailsNarrative">
          <link:definition>999058 - Disclosure - A CONSOLIDATED ENTITY (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfOtherLiabilitiesDetails" id="ScheduleOfOtherLiabilitiesDetails">
          <link:definition>999059 - Disclosure - SCHEDULE OF OTHER LIABILITIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/CommitmentAndContingentLiabilitiesDetailsNarrative" id="CommitmentAndContingentLiabilitiesDetailsNarrative">
          <link:definition>999060 - Disclosure - COMMITMENT AND CONTINGENT LIABILITIES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfOperatingLeaseCostDetails" id="ScheduleOfOperatingLeaseCostDetails">
          <link:definition>999061 - Disclosure - SCHEDULE OF OPERATING LEASE COST (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeaseDetails" id="ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeaseDetails">
          <link:definition>999062 - Disclosure - SCHEDULE OF SUPPLEMENTAL CASH FLOW INFORMATION RELATED TO OPERATING LEASE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSupplementalBalanceSheetInformationRelatedToOperatingLeasesDetails" id="ScheduleOfSupplementalBalanceSheetInformationRelatedToOperatingLeasesDetails">
          <link:definition>999063 - Disclosure - SCHEDULE OF SUPPLEMENTAL BALANCE SHEET INFORMATION RELATED TO OPERATING LEASES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfMinimumLeasePaymentsUnderNon-CancelableLeasesDetails" id="ScheduleOfMinimumLeasePaymentsUnderNon-CancelableLeasesDetails">
          <link:definition>999064 - Disclosure - SCHEDULE OF MINIMUM LEASE PAYMENTS UNDER NON- CANCELABLE LEASES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/LeasesDetailsNarrative" id="LeasesDetailsNarrative">
          <link:definition>999065 - Disclosure - LEASES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetailsParenthetical" id="ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetailsParenthetical">
          <link:definition>999066 - Disclosure - SCHEDULE OF TRANSACTIONS AND BALANCES WITH RELATED PARTIES (Details) (Parenthetical)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/CommonStockDetailsNarrative" id="CommonStockDetailsNarrative">
          <link:definition>999067 - Disclosure - COMMON STOCK (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfStockOptionActivityDetails" id="ScheduleOfStockOptionActivityDetails">
          <link:definition>999068 - Disclosure - SCHEDULE OF STOCK OPTION ACTIVITY (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfEstimatedFairValueOfOptionsGrantedDetails" id="ScheduleOfEstimatedFairValueOfOptionsGrantedDetails">
          <link:definition>999069 - Disclosure - SCHEDULE OF ESTIMATED FAIR VALUE OF OPTIONS GRANTED (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfEstimatedFairValueOfOptionsGrantedDetailsParenthetical" id="ScheduleOfEstimatedFairValueOfOptionsGrantedDetailsParenthetical">
          <link:definition>999070 - Disclosure - SCHEDULE OF ESTIMATED FAIR VALUE OF OPTIONS GRANTED (Details) (Parenthetical)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/StockOptionsDetailsNarrative" id="StockOptionsDetailsNarrative">
          <link:definition>999071 - Disclosure - STOCK OPTIONS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/WarrantsDetailsNarrative" id="WarrantsDetailsNarrative">
          <link:definition>999072 - Disclosure - WARRANTS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfCostOfSalesDetails" id="ScheduleOfCostOfSalesDetails">
          <link:definition>999073 - Disclosure - SCHEDULE OF COST OF SALES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfResearchAndDevelopmentExpensesDetails" id="ScheduleOfResearchAndDevelopmentExpensesDetails">
          <link:definition>999074 - Disclosure - SCHEDULE OF RESEARCH AND DEVELOPMENT EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfGeneralAndAdministrativeExpensesDetails" id="ScheduleOfGeneralAndAdministrativeExpensesDetails">
          <link:definition>999075 - Disclosure - SCHEDULE OF GENERAL AND ADMINISTRATIVE EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfFinancingExpensesNetDetails" id="ScheduleOfFinancingExpensesNetDetails">
          <link:definition>999076 - Disclosure - SCHEDULE OF FINANCING EXPENSES NET (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfIncomeTaxExpensesDetails" id="ScheduleOfIncomeTaxExpensesDetails">
          <link:definition>999077 - Disclosure - SCHEDULE OF INCOME TAX EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" id="ScheduleOfDeferredTaxAssetsAndLiabilitiesDetails">
          <link:definition>999078 - Disclosure - SCHEDULE OF DEFERRED TAX ASSETS AND LIABILITIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/IncomeTaxDetailsNarrative" id="IncomeTaxDetailsNarrative">
          <link:definition>999079 - Disclosure - INCOME TAX (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfBasicAndDilutedLossPerShareDetails" id="ScheduleOfBasicAndDilutedLossPerShareDetails">
          <link:definition>999080 - Disclosure - SCHEDULE OF BASIC AND DILUTED LOSS PER SHARE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetails" id="ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetails">
          <link:definition>999081 - Disclosure - SCHEDULE OF TRANSACTIONS AND BALANCES WITH RELATED PARTIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/RelatedPartiesDetailsNarrative" id="RelatedPartiesDetailsNarrative">
          <link:definition>999082 - Disclosure - RELATED PARTIES (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSegmentReportingProfitAndLossDetails" id="ScheduleOfSegmentReportingProfitAndLossDetails">
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          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSalesToCustomersDetails" id="ScheduleOfSalesToCustomersDetails">
          <link:definition>999085 - Disclosure - SCHEDULE OF SALES TO CUSTOMERS (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfInformationOnLongLivedAssetsDetails" id="ScheduleOfInformationOnLongLivedAssetsDetails">
          <link:definition>999086 - Disclosure - SCHEDULE OF INFORMATION ON LONG LIVED ASSETS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/GeographicAreasAndMajorCustomersDetailsNarrative" id="GeographicAreasAndMajorCustomersDetailsNarrative">
          <link:definition>999087 - Disclosure - GEOGRAPHIC AREAS AND MAJOR CUSTOMERS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/SubsequentEventsDetailsNarrative" id="SubsequentEventsDetailsNarrative">
          <link:definition>999088 - Disclosure - SUBSEQUENT EVENTS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfInformationRelatedToOperationsOfReportableOperatingSegmentsDetails" id="ScheduleOfInformationRelatedToOperationsOfReportableOperatingSegmentsDetails">
          <link:definition>999089 - Disclosure - SCHEDULE OF INFORMATION RELATED TO OPERATIONS OF REPORTABLE OPERATING SEGMENTS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/EventsDuringPeriodDetailsNarrative" id="EventsDuringPeriodDetailsNarrative">
          <link:definition>999090 - Disclosure - EVENTS DURING THE PERIOD (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGranted" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGranted" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisSolarProject" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisSolarProject" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CumulativeResearchAndDevelopmentGrantsReceived" name="CumulativeResearchAndDevelopmentGrantsReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromSaleOfPropertyPlantAndEquipmentCost" name="ProceedsFromSaleOfPropertyPlantAndEquipmentCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_EquitySecuritiesFvNiMeasurementInputTerm" name="EquitySecuritiesFvNiMeasurementInputTerm" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GrossLoss" name="GrossLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DebtInstrumentInvestmentRate" name="DebtInstrumentInvestmentRate" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IncreaseInPercentageOfOwnership" name="IncreaseInPercentageOfOwnership" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ShareCapitalPercentage" name="ShareCapitalPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ExchangeCapitalForSharePrice" name="ExchangeCapitalForSharePrice" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_RoyaltyDescription" name="RoyaltyDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PercentageOfNetRevenues" name="PercentageOfNetRevenues" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_MaximumCompensationPercentageOfGrossProfit" name="MaximumCompensationPercentageOfGrossProfit" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_BonusAmount" name="BonusAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ReimbursementExpenses" name="ReimbursementExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_SuccessFees" name="SuccessFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_LesseeOperatingAdditionalLeaseTermOfContract" name="LesseeOperatingAdditionalLeaseTermOfContract" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdditionalPaymentsForRent" name="AdditionalPaymentsForRent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ConsultantFees" name="ConsultantFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_NumberOfSharesIssuable" name="NumberOfSharesIssuable" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_MonthlyConsultancyFee" name="MonthlyConsultancyFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IncreaseInMonthlyConsultancyFee" name="IncreaseInMonthlyConsultancyFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CashPayment" name="CashPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdditionalOneTimeBonus" name="AdditionalOneTimeBonus" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdditionalOneTimeBonusShares" name="AdditionalOneTimeBonusShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromOverAllotmentOption" name="ProceedsFromOverAllotmentOption" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StockholdersEquityDescription" name="StockholdersEquityDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfStockIssued" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfStockIssued" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CashFee" name="CashFee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PurchaseAgreementPercentage" name="PurchaseAgreementPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdvanceNotice" name="AdvanceNotice" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdvanceOrAcquiringPaymentDescription" name="AdvanceOrAcquiringPaymentDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdvancesDiscountPercentage" name="AdvancesDiscountPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PurchaseAgreementDescription" name="PurchaseAgreementDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StructuringFee" name="StructuringFee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_SharesAggregatePurchaseAmount" name="SharesAggregatePurchaseAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PreAdvanceForPurchaseOfShares" name="PreAdvanceForPurchaseOfShares" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromStandbyEquityPurchaseAgreement" name="ProceedsFromStandbyEquityPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DebtInstrumentDefaultInterestRatePercentage" name="DebtInstrumentDefaultInterestRatePercentage" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValue" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_BankChargesAndOtherFinanceExpensesNet" name="BankChargesAndOtherFinanceExpensesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FinancingIncomeNet" name="FinancingIncomeNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DeferredTaxOperatingLeaseLiabilities" name="DeferredTaxOperatingLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GeneralAndAdministrativeExpenses" name="GeneralAndAdministrativeExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CommonStockOutstandingPercentage" name="CommonStockOutstandingPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AnnualFees" name="AnnualFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_UnallocatedCosts" name="UnallocatedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PreferredStockAndCommonStockVotingRights" name="PreferredStockAndCommonStockVotingRights" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CommonStockExceedsPercentage" name="CommonStockExceedsPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
</schema>
