Cover [Abstract] Document Type Entity Registrant Name Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Ex Transition Period Entity Central Index Key Amendment Flag Amendment Description CONSOLIDATED BALANCE SHEETS Assets Current assets: Cash and cash equivalents Short-term investments Total short-term investments Prepaid expenses and other current assets Total prepaid expenses and other current assets Assets, Current Total current assets Property and equipment, net Operating lease right-of-use assets Other long-term assets Assets [Default Label] Total assets Liabilities and Stockholders' Equity Current liabilities: Accounts payable Accrued liabilities and other liabilities current. Accrued and other current liabilities Total accrued and other current liabilities Operating lease liabilities Current Liabilities, Current Total current liabilities Operating lease liabilities, net of current portion Non-current Other liabilities Liabilities Total liabilities Commitments and contingencies (Note 5) Stockholders' equity: Preferred stock, $0.0001 par value; 10,000,000 shares authorized as of December 31, 2024 and December 31, 2023, respectively; no shares issued and outstanding at December 31, 2024 and December 31, 2023, respectively Common stock, $0.0001 par value; 150,000,000 shares authorized at December 31, 2024 and December 31, 2023, respectively; 28,985,019 and 27,762,703 shares issued and outstanding at December 31, 2024 and December 31, 2023, respectively Additional paid-in capital Accumulated other comprehensive (loss) income Accumulated other comprehensive gain Accumulated deficit Stockholders' Equity Attributable to Parent Ending balance, value Beginning balance, value Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred stock, par value Preferred stock, par value Preferred stock, shares authorized Preferred stock, shares authorized Preferred stock, shares issued Preferred stock, shares outstanding Common stock, par value Common stock, par value Common stock, shares authorized Common stock, shares authorized Common stock, shares issued Common stock, shares outstanding CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Operating expenses: Research and development General and administrative Operating Expenses Total operating expenses Operating Income (Loss) Loss from operations Other income (expense): Interest income Interest income Interest income Other Nonoperating Income (Expense) Other expense: Nonoperating Income (Expense) Total other income Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Net loss before income taxes Provision for income taxes Total tax provision Net loss Net loss Comprehensive loss: Other comprehensive loss: Debt Securities, Trading, Unrealized Gain (Loss) Unrealized (loss) gain on securities Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Net loss per share, basic and diluted Net loss per share, basic Earnings Per Share, Diluted Net loss per share, diluted Weighted-average shares of common stock outstanding, basic and diluted Weighted-average shares of common stock outstanding, basic Weighted-average common stock outstanding, basic Weighted Average Number of Shares Outstanding, Diluted Weighted-average shares of common stock outstanding, diluted Weighted-average common stock outstanding, diluted CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY Statement [Table] Equity Components [Axis] Equity Component [Domain] Common Stock [Member] Common Stock Additional Paid-in Capital [Member] Additional Paid-in Capital AOCI Attributable to Parent [Member] Accumulated Other Comprehensive Gain/(Loss) Retained Earnings [Member] Accumulated Deficit Statement [Line Items] Shares, Outstanding Ending balance, shares Beginning balance, shares Debt Securities, Trading, Unrealized Gain Unrealized gain on investments Stock Issued During Period, Value, New Issues Issuance of common stock in connection with ATM, net Number of shares issued Issuance of common stock in connection with ATM, net, shares Issuance of common stock upon exercise of stock options Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Options Exercised Issuance of common stock upon exercise of stock options (in shares) Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock under ESPP Shares issued Issuance of common stock under ESPP, shares Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Vesting of restricted stock units Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Vesting of restricted stock units, shares Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture Stock based compensation Net Income (Loss) Attributable to Parent Consolidated net loss Net loss CONSOLIDATED STATEMENTS OF CASH FLOWS Cash flow from operating activities: Adjustments to reconcile net loss to net cash used in operating activities: Stock-based compensation expense Stock-based compensation expense Depreciation and amortization expense Operating Lease, Impairment Loss Impairment of right-of-use asset Accretion of discounts and amortization of premiums on investments, net Accretion of discounts and amortization of premiums on investments, net Changes in operating assets and liabilities: Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase (Decrease) in Other Noncurrent Assets Other long-term assets Increase (Decrease) in Accounts Payable Accounts payable Accrued and other liabilities Operating lease asset and liability, net. Increase Decrease In Operating Lease Asset And Liability Operating lease assets and liabilities, net Increase (Decrease) in Other Operating Liabilities Other liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Cash flow from investing activities: Payments to Acquire Short-Term Investments Purchases of short-term investments Maturities of short-term investments Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Net Cash Provided by (Used in) Investing Activities Net cash provided by investing activities Cash flow from financing activities: Proceeds from sale of common stock in connection with ATM, net Proceeds from issuance of common stock Payments of Stock Issuance Costs Payments for offering costs Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Excluding Option Exercised Proceeds from issuance of common stock under ESPP Proceeds from Stock Options Exercised Proceeds from issuance of common stock upon exercise of stock options Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net increase in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Cash and cash equivalents at the end of the period Cash and cash equivalents at the beginning of the year Supplemental disclosure of noncash investing and financing activities: Right-of-use asset obtained in exchange for operating lease liability ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES Basis of Presentation and Significant Accounting Policies [Text Block] BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES FAIR VALUE OF FINANCIAL INSTRUMENTS Fair Value Disclosures [Text Block] FAIR VALUE OF FINANCIAL INSTRUMENTS BALANCE SHEET COMPONENTS Supplemental Balance Sheet Disclosures [Text Block] BALANCE SHEET COMPONENTS COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] COMMITMENTS AND CONTINGENCIES STOCKHOLDERS' EQUITY Stockholders' Equity Note Disclosure [Text Block] STOCKHOLDERS' EQUITY SHARE-BASED COMPENSATION Share-Based Payment Arrangement [Text Block] SHARE-BASED COMPENSATION INCOME TAXES Income Tax Disclosure [Text Block] INCOME TAXES SEGMENT REPORTING Segment Reporting Disclosure [Text Block] SEGMENT REPORTING Basis of Presentation Use of Estimates Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Short-term investment [Policy Text Block] Short-term Investments [Policy Text Block] Short-term Investments Concentration of Credit Risk Comprehensive Loss Fair Value Measurements Prepaid expenses and other current assets [Policy Text Block] Prepaid Expenses and Other Current Assets [Policy Text Block] Prepaid Expenses and Other Current Assets Property, Plant and Equipment, Policy [Policy Text Block] Property and Equipment, Net Impairment of Long-lived Assets Leases Research and Development Expenses Compensation Related Costs, Policy [Policy Text Block] Stock-Based Compensation Income Tax, Policy [Policy Text Block] Income Taxes Segment Reporting Net Loss Per Share Recently Issued and Recently Adopted Accounting Pronouncements Recently Issued Accounting Pronouncements SCHEDULE OF NET LOSS PER SHARE SCHEDULE OF POTENTIALLY DILUTIVE SECURITIES NOT INCLUDED IN THE CALCULATION OF DILUTED NET LOSS PER SHARE SCHEDULE OF FAIR VALUE INSTRUMENTS SCHEDULE OF SHORT TERM INVESTMENTS SCHEDULE OF SHORT-TERM INVESTMENTS WITH UNREALIZED LOSSES Schedule Of Prepaid Expenses And Other Current Assets [Table Text Block] Schedule of Prepaid Expenses And Other Current Asset [Table Text Block] SCHEDULE OF PREPAID EXPENSES AND OTHER CURRENT ASSETS SCHEDULE OF ACCRUED AND OTHER CURRENT LIABILITIES SCHEDULE OF FUTURE MINIMUM ANNUAL LEASE PAYMENTS FOR OPERATING LEASES Tabular disclosure of components of operating leases. Schedule of Components of Operating Leases [Table Text Block] SCHEDULE OF COMPONENTS OF OPERATING LEASES SCHEDULE OF SUPPLEMENTAL CASH FLOW Lease, Cost [Table Text Block] SCHEDULE OF OPERATING LEASE EXPENSE Tabular disclosure of common stock shares reserved on and as converted basis for future issuance. SCHEDULE OF COMMON STOCK SHARES RESERVED FOR ON AND AS-CONVERTED BASIS, FOR FUTURE ISSUANCE SCHEDULE OF OPTION ACTIVITY UNDER 2021 PLAN AND 2018 PLAN SCHEDULE OF UNVESTED STOCK UNIT ACTIVITY SCHEDULE OF UNVESTED RESTRICTED STOCK UNIT ACTIVITY SCHEDULE OF FAIR VALUE OF STOCK OPTIONS ASSUMPTIONS SCHEDULE OF STOCK-BASED COMPENSATION EXPENSE SUMMARY OF COMPONENTS OF NET DEFERRED TAX ASSETS SUMMARY OF RECONCILIATION OF FEDERAL INCOME TAX RATE SUMMARY OF GROSS UNRECOGNIZED TAX BENEFITS Schedule of Segment Reporting Information, by Segment [Table Text Block] Summary of significant expense categories for the segment Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Counterparty Name [Axis] Counterparty Name [Domain] Information pertaining to BofA Securities, Inc. BofA Securities, Inc. [Member] BofA Securities, Inc. Subsidiary, Sale of Stock [Line Items] Sale of Stock Dividends, Common Stock, Cash Cash dividend Sale of Stock, Consideration Received on Transaction Aggregate amount of shares Sale of Stock, Number of Shares Issued in Transaction Shares sold Represents the value of the common stock remaining which can be sold from time to time under the ATM ("At-the-Market") Program. Value of Remaining Common Stock Available For Sale Under ATM Program Value of remaining common stock available for sale under ATM Program Cash and cash equivalents and short-term investments Statistical Measurement [Axis] Statistical Measurement [Domain] Minimum Minimum Maximum [Member] Maximum Property, Plant and Equipment, Useful Life Leasehold improvements are amortized over the remaining life Impairment, Long-Lived Asset, Held-for-Use Impairment losses Expiration period Expiration period Number of Operating Segments Number of Operating Segments Net loss available to common stockholders Net loss attributable to common stockholders Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Share-Based Payment Arrangement, Option [Member] Stock options Options to purchase common stock Restricted Stock Units (RSUs) [Member] Unvested restricted stock units Restricted stock awards and units Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Antidilutive Securities Fair Value, Recurring and Nonrecurring [Table] Financial Instrument [Axis] Financial Instruments [Domain] US Government Agencies Debt Securities [Member] Agency bonds Corporate Debt Securities [Member] Corporate debt securities Commercial Paper [Member] Commercial paper US Treasury Securities [Member] U.S. Treasury bills Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Domain] Money Market Funds [Member] Money market funds Measurement Frequency [Axis] Measurement Frequency [Domain] Fair Value, Recurring [Member] Fair Value, Recurring Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Domain] Fair Value, Inputs, Level 1 [Member] Fair Value, Inputs, Level 1 Fair Value, Inputs, Level 2 [Member] Fair Value, Inputs, Level 2 Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis Cash Equivalents, at Carrying Value Total cash equivalents Assets, Fair Value Disclosure Total fair value of assets Schedule of Fair Value, off-Balance-Sheet Risks [Table] Fair Value, off-Balance-Sheet Risks, Disclosure Information [Line Items] Fair Value, off-Balance-Sheet Risks, Disclosure Information Maturity term for debt securities classified as available for sale. Debt Securities Available For Sale Maturity Term Maturity term Debt Securities, Available-for-Sale, Amortized Cost, after Allowance for Credit Loss Amortized cost Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Gross unrealized gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Gross unrealized losses Debt Securities, Available-for-Sale Estimated fair value Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Noncurrent Accrued interest receivable Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Noncurrent, Statement of Financial Position [Extensible Enumeration] Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table] Debt Securities, Available-for-Sale, Unrealized Loss Position [Line Items] Debt Securities, Available-for-Sale, Unrealized Loss Position Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months Short-term investments, Less than 12 months, Fair Value Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Short-term investments, Less than 12 months, Unrealized Losses Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer Short-term investments, 12 months or Greater, Fair Value Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Short-term investments, 12 months or Greater, Unrealized Losses Debt Securities, Available-for-Sale, Unrealized Loss Position Short-term investments, Total Fair Value Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss Short-term investments, Total Unrealized Losses Other current assets Prepaid expenses Prepaid research and development. Prepaid research and development Employee-related Liabilities, Current Accrued payroll and other employee benefits Other Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Research and Development Current Accrued research and development Schedule of Restructuring and Related Costs [Table] Restructuring Cost and Reserve [Line Items] Restructuring Cost and Reserve Restructuring and Related Cost, Number of Positions Eliminated, Inception to Date Number of individuals terminated or notified of their upcoming termination Restructuring and Related Cost, Number of Positions Eliminated, Inception to Date Percent Percentage of number of individuals terminated or notified of their upcoming termination Restructuring and Related Cost, Incurred Cost Incurred costs Payments for Restructuring Severance benefits Liabilities associated with the Workforce Reduction Plan Lessee, Lease, Description [Table] Lease Contractual Term [Axis] Lease Contractual Term [Domain] Waltham Lease [Member] Waltham Lease Waltham Lease Foster City Lease [Member] Foster City Lease Foster City Lease Lessee, Lease, Description [Line Items] Lessee, Lease, Description Area of land Area of land Operating lease term Operating lease term Lessee, Operating Lease, Existence of Option to Extend [true false] Lease, option to extend Lessee, Operating Lease, Renewal Term Renewal term Increase in rent square foot value. Increase Rental Amount Increase of rental value for square foot Payment for rent Payment for rent Lease increase in rent percentage. Lease rent percentage Lease rent percentage 2022 2025 Lessee, Operating Lease, Liability, to be Paid Total operating lease payments Lessee, Operating Lease, Liability, Undiscounted Excess Amount Less: Amount representing interest Operating Lease, Liability Present value of net minimum lease payments Present value of net minimum lease payments Operating lease liabilities: Weighted-average remaining lease term (in years) Weighted-average incremental borrowing rate Operating Lease, Payments Cash paid included in operating cash flows Operating lease Short-term lease Lease, Cost Total rent expense Schedule of Stock by Class [Table] Class of Stock [Line Items] Class of Stock Represents the information pertaining to number of votes for each share of common stock. Number Of Votes For Each Share Of Common Stock Number of votes for each share of common stock Award Type [Axis] Award Type [Domain] Share-Based Payment Arrangement [Member] Employee stock purchase plan awards Common Stock, Capital Shares Reserved for Future Issuance Common stock reserved for future issuance Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Plan Name [Axis] Plan Name [Domain] 2021 Stock Option and Incentive Plan [Member] 2021 Stock Option and Incentive Plan 2021 Plan 2018 Plan [Member] 2018 Plan 2021 Plan and 2018 Plan [Member] 2021 Plan and 2018 Plan Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award Percentage on total number of shares outstanding Number of shares authorized Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized Number of additional shares authorized ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod Common stock available for issuance, awards granted Options Granted Options granted Common stock options granted and outstanding Options Outstanding, ending balance Options Outstanding, beginning balance Options outstanding Number of units, Granted Restricted stock units award Stock option grants per share Percentage of common stock purchase price Duration of offering period for share-based compensation arrangement by share-based payment award. Share Based Compensation Arrangement By Share Based Payment Award, Offering Period Offering period Discount percentage on marker price Unrecognized stock based compensation Unrecognized stock-based compensation weighted-average period Vested term Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Weighted-Average Exercise Price Outstanding, ending balance Weighted-Average Exercise Price Outstanding, beginning balance Weighted- Average Remaining Contractual Term, Outstanding Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Aggregate Intrinsic Value Outstanding, ending balance Aggregate Intrinsic Value Outstanding, beginning balance Weighted-Average Exercise Price, Granted Weighted-Average Exercise Price, Exercised Options, Cancelled/Forfeited Options, Cancelled/Forfeited Weighted-Average Exercise Price, Cancelled/Forfeited Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number Options, Vested and exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price Weighted-Average Exercise Price, Vested and exercisable Weighted- Average Remaining Contractual Term, Vested and exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value Aggregate Intrinsic Value, Vested and exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Number of units, Ending Number of units, beginning Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Weighted Average Grant date fair value, Ending Weighted Average Grant date fair value, beginning Number of units, Vested Number of units, Vested Weighted Average Grant date fair value, Vested Number of units, forfeited Number of units, forfeited Weighted Average Grant date fair value, Forfeited Expected term (in years) Expected volatility, minimum Expected volatility, maximum Risk-free interest rate, minimum Risk-free interest rate, maximum Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Income Statement Location [Axis] Income Statement Location [Domain] Research and Development Expense [Member] Research and Development Expense General and Administrative Expense [Member] General and Administrative Expense Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Share-Based Payment Arrangement, Expensed and Capitalized, Amount Share-Based Payment Arrangement, Expense Stock-based compensation expense Operating Loss Carryforwards [Table] Income Tax Authority [Axis] Income Tax Authority [Domain] Domestic Tax Authority [Member] Domestic Tax Authority State and Local Jurisdiction [Member] State and Local Jurisdiction Tax Credit Carryforward [Axis] Tax Credit Carryforward, Name [Domain] Research Tax Credit Carryforward [Member] Research Tax Credit Carryforward Operating Loss Carryforwards [Line Items] Operating loss carryforwards Operating loss carryforwards Deferred tax assets valuation allowance Less: valuation allowance Deferred tax assets valuation allowance NOL carryforwards NOL carryforwards Research credit carryforwards Research credit carryforwards Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from capitalized research and development costs. Deferred Tax Assets, Capitalized Research and Development Costs Capitalized R&D Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost Stock based compensation Deferred Tax Assets, Other Other Deferred Tax Assets, Gross Gross deferred tax assets Deferred Tax Assets, Net of Valuation Allowance Total deferred tax assets Deferred Tax Liabilities, Other Other Deferred Tax Liabilities, Net Total deferred tax liabilities Deferred Tax Assets, Net Net deferred tax assets (liabilities) U.S. Federal statutory income tax rate U.S. Federal statutory income tax rate State taxes State taxes Permanent and other differences Permanent and other differences Stock-based compensation Stock-based compensation Effective Income Tax Rate Reconciliation Research and Development Credits. Research and development credits Research and development credits Change in valuation allowance Change in valuation allowance Unrecognized Tax Benefits Ending balance of unrecognized tax benefits Beginning balance of unrecognized tax benefits Additions based on tax positions related to the current year Additions based on tax positions related to the current year Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions Additions based on tax positions related to the prior year Schedule of Segment Reporting Information, by Segment [Table] Segments [Axis] Segments [Domain] Information pertaining to the Life Science segement. Life Science Segment [Member] Life Science Segment Reporting Information [Line Items] Number of Reportable Segments Number of reportable segments Amount of expense associated with the AV-101 clinical trials. AV 101 Clinical Trials AV-101 clinical trials Labor and Related Expense Employee costs Professional Fees Professional fees and services The amount of stock-based compensation. Stock-based Compensation Expenses Stock-based compensation Expenses associated with chemistry, manufacturing and controls. Chemistry, Manufacturing, and Controls Expenses Chemistry, manufacturing, and controls Amount of other expense (income) and loss (gain) calculated as difference between segment revenue and separately disclosed expense category to arrive at segment profit (loss). Segment Reporting, Other Segment Item, Amount Other segment items