v3.25.0.1
Income taxes (Tables)
12 Months Ended
Dec. 31, 2024
Income taxes  
Schedule of components of net loss before tax provision from income taxes

The components of net loss before income tax provision are as follows (in thousands):

​

​

​

​

​

​

​

​

​

​

​

​

Year Ended

​

​

December 31, 

​

    

2024

    

2023

    

2022

United Kingdom

​

$

(179,610)

​

$

(182,980)

​

$

(116,275)

United States

​

 

5,814

​

 

3,773

​

 

2,034

Total

​

$

(173,796)

​

$

(179,207)

​

$

(114,241)

Schedule of components of the benefit for income taxes

The components of the (benefit from) provision for income taxes are as follows (in thousands):

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Year Ended

​

​

​

December 31, 

​

    

​

2024

    

2023

    

2022

Current income tax provision (benefit)

 

​

​

  

 

​

  

 

​

  

Federal

​

​

$

283

​

$

(1,180)

​

$

2,048

State

​

​

 

178

​

 

(669)

​

 

1,404

Total current income tax provision (benefit)

​

​

 

461

​

 

(1,849)

​

 

3,452

Deferred income tax (benefit) provision

​

​

 

  

​

 

  

​

 

  

Federal

​

​

 

(3,772)

​

 

2,513

​

 

(4,111)

State

​

​

 

(1,454)

​

 

793

​

 

(865)

Total deferred income tax (benefit) provision

​

​

 

(5,226)

​

 

3,306

​

 

(4,976)

Total (benefit from) provision for income taxes

​

​

$

(4,765)

​

$

1,457

​

$

(1,524)

Schedule of reconciliation of the provision (benefit) for income taxes

​

​

​

​

​

​

​

​

​

​

​

Year Ended

​

​

​

December 31, 

​

​

    

2024

    

2023

 

2022

​

(Benefit from) provision for income taxes at statutory rate

 

25.0

%  

23.5

%

19.0

%

Increases (decreases) resulting from:

​

​

​

​

​

​

​

Tax credits

 

3.7

%

0.6

%

0.4

%

Change in valuation allowance

 

(11.2)

%

(14.8)

%

(16.8)

%

Net losses surrendered for research credit

 

(14.2)

%

(11.1)

%

(6.5)

%

Impact of statutory rate change

​

—

%

2.7

%

11.3

%

Impact of foreign exchange rates

​

(1.0)

%

(0.1)

%

(9.9)

%

Other

 

0.4

%

(1.6)

%

3.8

%

Effective income tax rate

 

2.7

%

(0.8)

%

1.3

%

Schedule of significant components of the Company's current and deferred tax assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

​

​

​

​

​

​

​

​

​

​

​

​

December 31, 

​

    

2024

    

2023

Deferred tax assets:

​

​

​

​

​

​

Operating loss carryforwards

​

$

81,492

​

$

66,555

Research credit carryforwards

​

 

3,362

​

 

—

Operating lease liability

​

​

2,641

​

​

3,680

Share-based compensation

​

​

21,035

​

​

15,577

Depreciation & amortization

​

​

1,508

​

​

—

Accrued expenses and other

​

 

1,952

​

 

2,742

Total deferred tax assets

​

 

111,990

​

 

88,554

Deferred tax liabilities:

​

​

​

​

​

​

Operating lease right-of-use asset

​

​

(2,201)

​

​

(3,389)

Total deferred tax liabilities

​

 

(2,201)

​

 

(3,389)

Valuation allowance

​

 

(99,672)

​

 

(80,274)

Net deferred tax assets

​

$

10,117

​

$

4,891