Significant agreements - Ionis Collaboration Agreement (Details) $ in Millions |
1 Months Ended | ||
|---|---|---|---|
|
Jul. 09, 2021
USD ($)
item
|
Apr. 30, 2023
USD ($)
|
Dec. 31, 2021
USD ($)
|
|
| Ionis | |||
| Significant agreements. | |||
| Period for which research and discovery activities will be performed with no additional consideration | 3 years | ||
| Upfront cash payment | $ 31.0 | ||
| Number of payments of a mid-single-digit million dollar, failing to achieve the specified development diligence | item | 3 | ||
| Number of collaboration targets | item | 4 | ||
| Number of years over which royalty is payable | 10 years | ||
| Amended Ionis | |||
| Significant agreements. | |||
| Upfront cash payment | $ 1.6 | ||
| Third Ionis Amendment | |||
| Significant agreements. | |||
| Upfront cash payment | $ 0.8 | ||