v3.25.0.1
Consolidated Statements of Changes in Stockholder's Equity - USD ($)
$ in Thousands
Total
Common Stock [Member]
Additional Paid-In Capital [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2021 $ 198,662 $ 10 $ 1,857,430 $ (2,090) $ (1,656,688)
Beginning balance, Shares at Dec. 31, 2021   97,524,000      
Issuance of common stock in follow-on offering, net of offering costs 380,120 $ 1 380,119    
Issuance of common stock in follow-on offering, shares   8,564,000      
Issuance of common stock upon exercise of stock options 21,483   21,483    
Issuance of common stock upon exercise of stock options, shares   1,223,000      
Issuance of shares in exchange of Convertible Notes, including issuance cost 129,636   129,636    
Issuance of shares in exchange of Convertible Notes, including issuance cost, shares   3,073,000      
Forfeiture of accrued interest in exchange of Convertible Notes 1,287   1,287    
Vesting of restricted stock units, net of shares withheld for taxes (5,682)   (5,682)    
Vesting of restricted stock units, net of shares withheld for taxes. shares   252,000      
Share-based compensation expense 91,085   91,085    
Issuance of common stock to employee stock purchase plan 4,238   4,238    
Issuance of common stock to employee stock purchase plan, shares   136,000      
Unrealized loss on available-for-sale investments (1)     (1)  
Unrealized gain (loss) on pension benefit plan 1,646     1,646  
Net loss (652,172)       (652,172)
Foreign currency translation (430)     (430)  
Ending balance at Dec. 31, 2022 169,872 $ 11 2,479,596 (875) (2,308,860)
Ending balance, Shares at Dec. 31, 2022   110,772,000      
Issuance of common stock and pre-funded warrants in common stock offering 384,387 $ 1 384,386    
Issuance of common stock and pre-funded warrants in common stock offering, shares   4,008,000      
Issuance of common stock upon exercise of stock options 71,274   71,274    
Issuance of common stock upon exercise of stock options, shares   3,858,000      
Vesting of restricted stock units, net of shares withheld for taxes (11,040)   (11,040)    
Vesting of restricted stock units, net of shares withheld for taxes. shares   806,000      
Share-based compensation expense 105,945   105,945    
Issuance of common stock to employee stock purchase plan 5,378   5,378    
Issuance of common stock to employee stock purchase plan, shares   112,000      
Unrealized gain (loss) on pension benefit plan (2,618)     (2,618)  
Net loss (528,628)       (528,628)
Foreign currency translation (49)     (49)  
Ending balance at Dec. 31, 2023 194,521 $ 12 3,035,539 (3,542) (2,837,488)
Ending balance, Shares at Dec. 31, 2023   119,556,000      
Issuance of common stock and pre-funded warrants in common stock offering, shares   80,956      
Exercise of pre-funded warrants, shares   2,300,000      
Proceeds from settlement of capped call 98,763   98,763    
Issuance of common stock upon exercise of stock options $ 14,316   14,316    
Issuance of common stock upon exercise of stock options, shares 1,080,000 1,080,000      
Vesting of restricted stock units, net of shares withheld for taxes $ (57)   (57)    
Vesting of restricted stock units, net of shares withheld for taxes. shares   1,417,000      
Share-based compensation expense 114,128   114,128    
Issuance of common stock to employee stock purchase plan 4,512   4,512    
Issuance of common stock to employee stock purchase plan, shares   142,000      
Unrealized gain (loss) on pension benefit plan 591     591  
Net loss (197,878)       (197,878)
Foreign currency translation (357)     (357)  
Ending balance at Dec. 31, 2024 $ 228,539 $ 12 $ 3,267,201 $ (3,308) $ (3,035,366)
Ending balance, Shares at Dec. 31, 2024   124,495,000