Equity Incentive Plans - Summary of Share-based Compensation Expense (Detail) - USD ($) $ in Thousands |
12 Months Ended | ||
|---|---|---|---|
Dec. 31, 2024 |
Dec. 31, 2023 |
Dec. 31, 2022 |
|
| Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
| Share-based compensation expense | $ 114,128 | $ 105,945 | $ 91,085 |
| Research and Development Expense [Member] | |||
| Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
| Share-based compensation expense | 41,267 | 45,644 | 42,052 |
| Selling, General and Administrative [Member] | |||
| Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
| Share-based compensation expense | $ 72,861 | $ 60,301 | $ 49,033 |