v3.25.0.1
Income Taxes (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Reconciliation of the Company's expected federal income tax provision (benefit) to the actual income tax provision    
Tax computed at federal statutory rate $ (39,115) $ (33,794)
State tax, net of federal tax benefit (8,429) (4,851)
Non-deductible compensation 35 25
Permanent differences 22 (2,305)
Stock compensation 8,560 12,801
R&D tax credits (7,672) (5,773)
Reserve for uncertain tax positions 8,612 4,254
Other (135) 1,928
Valuation allowance 38,122 27,715
Income tax expense 0 0
Deferred tax assets:    
Capitalized R&D expense 127,559 134,209
Net operating losses 147,019 112,810
R&D tax credits 63,126 55,492
Intangible asset amortization 8,692 9,220
Deferred revenue 1,147 144
Stock compensation 7,836 8,322
Lease liability 17,925 21,761
Other 788 672
Total deferred tax assets 374,092 342,630
Deferred tax liabilities:    
Depreciation (2,212) (5,639)
Right-of-use assets (9,796) (13,029)
Total deferred tax liabilities (12,008) (18,668)
Net of deferred tax assets and liabilities 362,084 323,962
Valuation allowance (362,084) (323,962)
Net deferred tax assets $ 0 $ 0