<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:217639f3-3601-4c34-a4f5-697bd18227a7,g:91c171eb-1d41-4a86-a68a-085fd4f464cb-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss" xlink:type="simple" xlink:href="bntx-20241231.xsd#ConsolidatedStatementsofProfitorLoss"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_3a87b0e7-4913-4744-b967-068b9f397b08" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_3a87b0e7-4913-4744-b967-068b9f397b08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_54099096-aa38-43ec-bece-e7c6c086e7dd" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_54099096-aa38-43ec-bece-e7c6c086e7dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SalesAndMarketingExpense_ab450a8f-8975-4dd5-b978-5f80d0f9a1e9" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SalesAndMarketingExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:to="loc_ifrs-full_SalesAndMarketingExpense_ab450a8f-8975-4dd5-b978-5f80d0f9a1e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_025848f2-1102-4142-8642-0a9ff6cc1cc0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_025848f2-1102-4142-8642-0a9ff6cc1cc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_ec499c14-0853-4377-8b78-051e7a5de40a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_ec499c14-0853-4377-8b78-051e7a5de40a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales_803b19d5-0376-4daf-8730-c5d9d0102ac7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CostOfSales"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:to="loc_ifrs-full_CostOfSales_803b19d5-0376-4daf-8730-c5d9d0102ac7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_1737874c-0515-4595-992e-0958d0f3a55b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_313ccc4c-f77f-4d4b-8c50-9095212aadfa" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_1737874c-0515-4595-992e-0958d0f3a55b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_023aac60-f23b-4ede-9790-5df270c810ff" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_8fe5fe0b-6b2c-4190-a813-f61f0fbc315a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_023aac60-f23b-4ede-9790-5df270c810ff" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_8fe5fe0b-6b2c-4190-a813-f61f0fbc315a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_ab51e193-4ad6-41bb-a76d-c7522bc4fd62" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_023aac60-f23b-4ede-9790-5df270c810ff" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_ab51e193-4ad6-41bb-a76d-c7522bc4fd62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_425f4359-10f2-414e-8ef1-b2142e8a3ce4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_c74b3860-f603-4db7-a902-f15380b43360" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_425f4359-10f2-414e-8ef1-b2142e8a3ce4" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_c74b3860-f603-4db7-a902-f15380b43360" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_69e0cab3-10e8-4cb3-868e-41de68fe18f2" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_425f4359-10f2-414e-8ef1-b2142e8a3ce4" xlink:to="loc_ifrs-full_FinanceCosts_69e0cab3-10e8-4cb3-868e-41de68fe18f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_0a1aa244-d09f-44c2-9dbe-2e53622e8899" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_425f4359-10f2-414e-8ef1-b2142e8a3ce4" xlink:to="loc_ifrs-full_FinanceIncome_0a1aa244-d09f-44c2-9dbe-2e53622e8899" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="bntx-20241231.xsd#ConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_8197983d-dcdb-408f-a527-ada4699f0e61" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_0b0b7ac3-eab0-45e8-b358-8a83d81acea3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_8197983d-dcdb-408f-a527-ada4699f0e61" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_0b0b7ac3-eab0-45e8-b358-8a83d81acea3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_487cf60e-8643-456b-bda1-1ac2b55bbaa4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_8197983d-dcdb-408f-a527-ada4699f0e61" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_487cf60e-8643-456b-bda1-1ac2b55bbaa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_28874880-39cc-4a1e-b7e8-6a56a712f6e7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_5f9b3cfc-0f08-439e-9fb7-ec4b826a2cf4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_28874880-39cc-4a1e-b7e8-6a56a712f6e7" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_5f9b3cfc-0f08-439e-9fb7-ec4b826a2cf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments_b54429ec-9862-4511-9296-8e96368fe25e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_28874880-39cc-4a1e-b7e8-6a56a712f6e7" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments_b54429ec-9862-4511-9296-8e96368fe25e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_a427ffaf-29e4-4aed-9c2d-6f07c7e5acc6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_9556fbab-bcbb-42b4-9cc2-3b7e81124b15" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_a427ffaf-29e4-4aed-9c2d-6f07c7e5acc6" xlink:to="loc_ifrs-full_ProfitLoss_9556fbab-bcbb-42b4-9cc2-3b7e81124b15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_4cfe7a8e-6882-4ded-93d9-8ec58c639b1d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_a427ffaf-29e4-4aed-9c2d-6f07c7e5acc6" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_4cfe7a8e-6882-4ded-93d9-8ec58c639b1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_765cb549-db72-4abe-ad50-f470b82071e0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_be1e1725-afc8-4596-a12a-ca66a80104cc" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_765cb549-db72-4abe-ad50-f470b82071e0" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_be1e1725-afc8-4596-a12a-ca66a80104cc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofFinancialPosition" xlink:type="simple" xlink:href="bntx-20241231.xsd#ConsolidatedStatementsofFinancialPosition"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofFinancialPosition" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_24e436f1-e4ef-4c92-961c-957464ed457e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_24e436f1-e4ef-4c92-961c-957464ed457e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialAssets_ae2b2221-65fb-46f3-82f8-b441d05acf94" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialAssets_ae2b2221-65fb-46f3-82f8-b441d05acf94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_3ed95fc2-3c97-4399-9a2f-b5318e7f2569" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RightofuseAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_RightofuseAssets_3ed95fc2-3c97-4399-9a2f-b5318e7f2569" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_7552e3ef-aa26-49e2-a9d1-2eaf6967f14e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_7552e3ef-aa26-49e2-a9d1-2eaf6967f14e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_da1d58eb-ae8d-49cd-95a6-9a9fc597b9c7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_DeferredTaxAssets_da1d58eb-ae8d-49cd-95a6-9a9fc597b9c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsAndGoodwill_77f7b520-db5c-411a-bde2-3f8c570a7d58" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IntangibleAssetsAndGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_IntangibleAssetsAndGoodwill_77f7b520-db5c-411a-bde2-3f8c570a7d58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractAssets_f3baf6ee-6071-478d-91ff-3ccabd6a9847" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentContractAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_NoncurrentContractAssets_f3baf6ee-6071-478d-91ff-3ccabd6a9847" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_b8e3b632-9474-4b45-aac6-c4a2a4b8fef4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Goodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_18b51658-a893-4773-971b-ba9794a770a0" xlink:to="loc_ifrs-full_Goodwill_b8e3b632-9474-4b45-aac6-c4a2a4b8fef4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_baa71d28-340e-4ccb-a711-9e197b7dde3a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_c6625b06-a064-4091-8c6c-0dd89265c182" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_baa71d28-340e-4ccb-a711-9e197b7dde3a" xlink:to="loc_ifrs-full_OtherReserves_c6625b06-a064-4091-8c6c-0dd89265c182" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasuryShares_f9dea77a-cc4a-4950-ab38-ac17908e5429" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TreasuryShares"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_baa71d28-340e-4ccb-a711-9e197b7dde3a" xlink:to="loc_ifrs-full_TreasuryShares_f9dea77a-cc4a-4950-ab38-ac17908e5429" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_06682a0e-54a5-4e12-a8c2-97b09db52908" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_baa71d28-340e-4ccb-a711-9e197b7dde3a" xlink:to="loc_ifrs-full_IssuedCapital_06682a0e-54a5-4e12-a8c2-97b09db52908" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CapitalReserve_2738b443-c541-4b70-96a7-d313638c06d3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CapitalReserve"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_baa71d28-340e-4ccb-a711-9e197b7dde3a" xlink:to="loc_ifrs-full_CapitalReserve_2738b443-c541-4b70-96a7-d313638c06d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_1b218de8-e6c4-4ac0-aea3-6f95676ce24e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RetainedEarnings"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_baa71d28-340e-4ccb-a711-9e197b7dde3a" xlink:to="loc_ifrs-full_RetainedEarnings_1b218de8-e6c4-4ac0-aea3-6f95676ce24e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_ff429d6c-8ee7-4d8d-828b-f7b338815866" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:to="loc_ifrs-full_CurrentProvisions_ff429d6c-8ee7-4d8d-828b-f7b338815866" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentLeaseLiabilitiesLoansAndBorrowings_184d3f68-00ff-4703-8da3-c72290aa05af" xlink:href="bntx-20241231.xsd#bntx_CurrentLeaseLiabilitiesLoansAndBorrowings"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:to="loc_bntx_CurrentLeaseLiabilitiesLoansAndBorrowings_184d3f68-00ff-4703-8da3-c72290aa05af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_d5428d3a-aefa-4961-8e35-dba5f5f18da7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:to="loc_ifrs-full_CurrentContractLiabilities_d5428d3a-aefa-4961-8e35-dba5f5f18da7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_7c42f9d3-8066-40b2-8001-aca5e1b1cfc5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_7c42f9d3-8066-40b2-8001-aca5e1b1cfc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialLiabilities_1437e4f8-120b-454c-b44b-6bc8c4be85c2" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentFinancialLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:to="loc_ifrs-full_OtherCurrentFinancialLiabilities_1437e4f8-120b-454c-b44b-6bc8c4be85c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_360ca7c6-7247-470c-aea5-64986f4d3b9e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_360ca7c6-7247-470c-aea5-64986f4d3b9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_62a5de98-ae13-42a3-801f-174125854cd6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentNonfinancialLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_60ed4194-d492-4ca8-8881-df77c4d6cb07" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_62a5de98-ae13-42a3-801f-174125854cd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentReceivables_ea580132-feda-4ffc-8617-8df5816e1542" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentReceivables"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentBiologicalAssets_2c60af93-1498-4f6a-995f-4cc3cf1fb532" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentBiologicalAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_b8da678d-7bca-4858-b75d-311ccf467fd4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Inventories"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:to="loc_ifrs-full_Inventories_b8da678d-7bca-4858-b75d-311ccf467fd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_49577d04-cb3b-4b3f-931b-7cd3da474778" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_49577d04-cb3b-4b3f-931b-7cd3da474778" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_9ea84d43-b30c-4506-8ecf-0b2648bb7d6c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:to="loc_ifrs-full_CashAndCashEquivalents_9ea84d43-b30c-4506-8ecf-0b2648bb7d6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractAssets_f4738000-d90b-4b6f-80c4-9e2cb148d8b1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentContractAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:to="loc_ifrs-full_CurrentContractAssets_f4738000-d90b-4b6f-80c4-9e2cb148d8b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialAssets_457b5cb6-25ac-47a0-8196-a262eac9f07e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentFinancialAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:to="loc_ifrs-full_OtherCurrentFinancialAssets_457b5cb6-25ac-47a0-8196-a262eac9f07e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialAssets_920f1315-0837-49aa-8eb3-85b23922bc93" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentNonfinancialAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialAssets_920f1315-0837-49aa-8eb3-85b23922bc93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_f969944d-7605-43af-b9d7-10f09c2fd4b8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_3e4b4d96-28d8-40b7-82d8-2605965829ab" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_f969944d-7605-43af-b9d7-10f09c2fd4b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_4703e14c-704e-4f46-b7a1-7c936438799c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonCurrentLeaseLiabilitiesLoansAndBorrowings_be997191-e774-4a78-b066-f035642fa591" xlink:href="bntx-20241231.xsd#bntx_NonCurrentLeaseLiabilitiesLoansAndBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_4703e14c-704e-4f46-b7a1-7c936438799c" xlink:to="loc_bntx_NonCurrentLeaseLiabilitiesLoansAndBorrowings_be997191-e774-4a78-b066-f035642fa591" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialLiabilities_bea4412a-18d5-42c4-81de-5604b486a79c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_4703e14c-704e-4f46-b7a1-7c936438799c" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialLiabilities_bea4412a-18d5-42c4-81de-5604b486a79c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractLiabilities_434f96fd-0016-4fe1-8072-e7b22a893c8c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentContractLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_4703e14c-704e-4f46-b7a1-7c936438799c" xlink:to="loc_ifrs-full_NoncurrentContractLiabilities_434f96fd-0016-4fe1-8072-e7b22a893c8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_47794347-7bcf-43c8-8282-9de4349e6cf6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_4703e14c-704e-4f46-b7a1-7c936438799c" xlink:to="loc_ifrs-full_NoncurrentProvisions_47794347-7bcf-43c8-8282-9de4349e6cf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_26eb01d0-5a0e-4bde-9fc5-2c5262b68cfb" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_4703e14c-704e-4f46-b7a1-7c936438799c" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_26eb01d0-5a0e-4bde-9fc5-2c5262b68cfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_df50c2c2-add2-4ff2-8bcd-d5452cdf646a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_4703e14c-704e-4f46-b7a1-7c936438799c" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_df50c2c2-add2-4ff2-8bcd-d5452cdf646a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_1ffbe263-12d7-4f83-82c8-da07d7ed73f0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_3d06ff59-8aa9-4e94-9eeb-53d5ea190133" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_1ffbe263-12d7-4f83-82c8-da07d7ed73f0" xlink:to="loc_ifrs-full_CurrentLiabilities_3d06ff59-8aa9-4e94-9eeb-53d5ea190133" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_ebfba907-c857-4b45-afdc-a16f94dbd0f7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_1ffbe263-12d7-4f83-82c8-da07d7ed73f0" xlink:to="loc_ifrs-full_NoncurrentLiabilities_ebfba907-c857-4b45-afdc-a16f94dbd0f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_8fcd1898-60b3-4ffe-9150-88bb849b3eb0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_645829d9-c355-4792-91eb-49779cb15b4b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8fcd1898-60b3-4ffe-9150-88bb849b3eb0" xlink:to="loc_ifrs-full_NoncurrentAssets_645829d9-c355-4792-91eb-49779cb15b4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_c925bc79-b56f-45b9-b562-6a289d535406" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8fcd1898-60b3-4ffe-9150-88bb849b3eb0" xlink:to="loc_ifrs-full_CurrentAssets_c925bc79-b56f-45b9-b562-6a289d535406" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_be5245a9-bcc4-4697-8e93-b90e6d505abd" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_1f6e9160-1907-4afe-93cd-218526a9c1ef" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_be5245a9-bcc4-4697-8e93-b90e6d505abd" xlink:to="loc_ifrs-full_Liabilities_1f6e9160-1907-4afe-93cd-218526a9c1ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_c6e7f07c-c028-4e34-9aab-74a244f5421c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_be5245a9-bcc4-4697-8e93-b90e6d505abd" xlink:to="loc_ifrs-full_Equity_c6e7f07c-c028-4e34-9aab-74a244f5421c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="bntx-20241231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceCosts_72286452-dbb6-43ae-a539-54c0d0d1764c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForFinanceCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_AdjustmentsForFinanceCosts_72286452-dbb6-43ae-a539-54c0d0d1764c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_359d128b-6016-4ee2-afe0-2d296c389497" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_359d128b-6016-4ee2-afe0-2d296c389497" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions_72d4dc5e-f248-4178-a6cc-6aecc21983c5" xlink:href="bntx-20241231.xsd#bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions_72d4dc5e-f248-4178-a6cc-6aecc21983c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceIncome_b1f4d9d1-b565-430d-bcbe-849ba48e6c6b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForFinanceIncome"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_AdjustmentsForFinanceIncome_b1f4d9d1-b565-430d-bcbe-849ba48e6c6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_91fca8cd-c0e3-478f-970a-7024997067b0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_91fca8cd-c0e3-478f-970a-7024997067b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_8108c898-00f7-4c0a-bebd-873ed948fd0b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_8108c898-00f7-4c0a-bebd-873ed948fd0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForMovementsInGovernmentGrants_687b5666-7d9d-4186-a0ff-91113b1ecdbf" xlink:href="bntx-20241231.xsd#bntx_AdjustmentsForMovementsInGovernmentGrants"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_bntx_AdjustmentsForMovementsInGovernmentGrants_687b5666-7d9d-4186-a0ff-91113b1ecdbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_ccc9e982-25cc-4409-8704-38de45e163b3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_ccc9e982-25cc-4409-8704-38de45e163b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_a8416bcb-8427-40d8-86be-7fff640f55c5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_a8416bcb-8427-40d8-86be-7fff640f55c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_ee76c294-b18b-41c4-826b-f7e70d6b6615" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_ee76c294-b18b-41c4-826b-f7e70d6b6615" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets_ab3d4e72-24cd-4cb2-a36c-c1df04da3e6d" xlink:href="bntx-20241231.xsd#bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets_ab3d4e72-24cd-4cb2-a36c-c1df04da3e6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_b65841ca-367a-4570-a36f-1c0d4f8cadaa" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_b65841ca-367a-4570-a36f-1c0d4f8cadaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_39ec57fe-b81c-492e-b1f2-df5e26ea9598" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_39ec57fe-b81c-492e-b1f2-df5e26ea9598" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_9bdfb439-cd4c-4ef1-bb88-43385f3da067" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInInventories"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_9bdfb439-cd4c-4ef1-bb88-43385f3da067" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_fd2a47d1-f41b-4578-8e51-24853cf7b925" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_fd2a47d1-f41b-4578-8e51-24853cf7b925" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ShareBasedPaymentsClassifiedAsOperatingActivities_a6f19f4a-460d-4fdd-9343-6833e4623b01" xlink:href="bntx-20241231.xsd#bntx_ShareBasedPaymentsClassifiedAsOperatingActivities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_bntx_ShareBasedPaymentsClassifiedAsOperatingActivities_a6f19f4a-460d-4fdd-9343-6833e4623b01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_GovernmentGrantsReceived_0935bc49-645f-4860-afc9-fa1533730ca8" xlink:href="bntx-20241231.xsd#bntx_GovernmentGrantsReceived"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_472c2437-681d-4f84-b287-626ee4cc3588" xlink:to="loc_bntx_GovernmentGrantsReceived_0935bc49-645f-4860-afc9-fa1533730ca8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_2c88c046-6a00-4a3e-9e3b-c073df0eedc0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_a4b5eb80-2b02-4c9b-9189-4508517139aa" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_2c88c046-6a00-4a3e-9e3b-c073df0eedc0" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_a4b5eb80-2b02-4c9b-9189-4508517139aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_f28e1845-5d35-4306-a117-bd055d5b40e6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_2c88c046-6a00-4a3e-9e3b-c073df0eedc0" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_f28e1845-5d35-4306-a117-bd055d5b40e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e3ab254f-9658-4a94-88e7-7a83cfc90623" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_2c88c046-6a00-4a3e-9e3b-c073df0eedc0" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e3ab254f-9658-4a94-88e7-7a83cfc90623" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_f3d63fca-fa32-423c-bd3c-588653644578" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidClassifiedAsFinancingActivities_f0de62e3-496f-47fb-b9dc-b48e1a1f7bfb" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsPaidClassifiedAsFinancingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_f3d63fca-fa32-423c-bd3c-588653644578" xlink:to="loc_ifrs-full_DividendsPaidClassifiedAsFinancingActivities_f0de62e3-496f-47fb-b9dc-b48e1a1f7bfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_e77bbdea-a4a4-4db3-b4f0-bf7c9d1bdf43" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_f3d63fca-fa32-423c-bd3c-588653644578" xlink:to="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_e77bbdea-a4a4-4db3-b4f0-bf7c9d1bdf43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_3ce8f6d6-3a02-4e8f-a021-2fe00e0c334c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_f3d63fca-fa32-423c-bd3c-588653644578" xlink:to="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_3ce8f6d6-3a02-4e8f-a021-2fe00e0c334c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_e0f79387-8543-4293-b178-aaecbd246a06" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_f3d63fca-fa32-423c-bd3c-588653644578" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_e0f79387-8543-4293-b178-aaecbd246a06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ShareRepurchaseProgramClassifiedAsFinancingActivities_4c31fe2a-1910-4ae8-8d08-ae0d5a111c16" xlink:href="bntx-20241231.xsd#bntx_ShareRepurchaseProgramClassifiedAsFinancingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_f3d63fca-fa32-423c-bd3c-588653644578" xlink:to="loc_bntx_ShareRepurchaseProgramClassifiedAsFinancingActivities_4c31fe2a-1910-4ae8-8d08-ae0d5a111c16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingShares_4f987f52-be71-47ac-ab1f-241028b48a60" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromIssuingShares"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_f3d63fca-fa32-423c-bd3c-588653644578" xlink:to="loc_ifrs-full_ProceedsFromIssuingShares_4f987f52-be71-47ac-ab1f-241028b48a60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_481cda6e-92d4-4f00-916d-8c3144f5777c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_InvestmentProceedsFromMaturityOfOtherFinancialAssetsClassifiedAsInvestingActivities_9e33779d-1955-43f0-89cc-33c22874a30b" xlink:href="bntx-20241231.xsd#bntx_InvestmentProceedsFromMaturityOfOtherFinancialAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_481cda6e-92d4-4f00-916d-8c3144f5777c" xlink:to="loc_bntx_InvestmentProceedsFromMaturityOfOtherFinancialAssetsClassifiedAsInvestingActivities_9e33779d-1955-43f0-89cc-33c22874a30b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_d3229227-f32c-471a-8df7-447a0cb1b35c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_481cda6e-92d4-4f00-916d-8c3144f5777c" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_d3229227-f32c-471a-8df7-447a0cb1b35c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashPaymentsToAcquireInterestsInJointVenturesClassifiedAsInvestingActivities_838f4c1a-575d-4692-8f76-90c2375b3b86" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCashPaymentsToAcquireInterestsInJointVenturesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_481cda6e-92d4-4f00-916d-8c3144f5777c" xlink:to="loc_ifrs-full_OtherCashPaymentsToAcquireInterestsInJointVenturesClassifiedAsInvestingActivities_838f4c1a-575d-4692-8f76-90c2375b3b86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities_aa60dfb7-c083-4adf-8b02-9a39fd3366ad" xlink:href="bntx-20241231.xsd#bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_481cda6e-92d4-4f00-916d-8c3144f5777c" xlink:to="loc_bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities_aa60dfb7-c083-4adf-8b02-9a39fd3366ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_3e625f2a-0048-4a34-8d46-20a81208e3be" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_481cda6e-92d4-4f00-916d-8c3144f5777c" xlink:to="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_3e625f2a-0048-4a34-8d46-20a81208e3be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ProceedsPaymentsFromSalesOrDestructionsOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_8497b7e5-6ba6-4a55-a24b-d9b08fb1d4c2" xlink:href="bntx-20241231.xsd#bntx_ProceedsPaymentsFromSalesOrDestructionsOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_481cda6e-92d4-4f00-916d-8c3144f5777c" xlink:to="loc_bntx_ProceedsPaymentsFromSalesOrDestructionsOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_8497b7e5-6ba6-4a55-a24b-d9b08fb1d4c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractAssetsDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#RevenuesfromContractswithCustomersContractAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInContractAssets_6802e985-b7d6-4b70-90ea-6033684e33da" xlink:href="bntx-20241231.xsd#bntx_IncreaseDecreaseInContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInCurrentContractAssets_3093691a-4974-42ff-a642-f35a760f702a" xlink:href="bntx-20241231.xsd#bntx_IncreaseDecreaseInCurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractAssets_6802e985-b7d6-4b70-90ea-6033684e33da" xlink:to="loc_bntx_IncreaseDecreaseInCurrentContractAssets_3093691a-4974-42ff-a642-f35a760f702a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInNonCurrentContractAssets_ec956fce-cd8a-4e18-a2e3-3b8399c78f7d" xlink:href="bntx-20241231.xsd#bntx_IncreaseDecreaseInNonCurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractAssets_6802e985-b7d6-4b70-90ea-6033684e33da" xlink:to="loc_bntx_IncreaseDecreaseInNonCurrentContractAssets_ec956fce-cd8a-4e18-a2e3-3b8399c78f7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_1f4503ca-bfcc-464b-9956-43a334f278b4" xlink:href="bntx-20241231.xsd#bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_3517c2fb-69b8-42fd-95f3-d0df43e1d342" xlink:href="bntx-20241231.xsd#bntx_CurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_1f4503ca-bfcc-464b-9956-43a334f278b4" xlink:to="loc_bntx_CurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_3517c2fb-69b8-42fd-95f3-d0df43e1d342" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonCurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_ef72b42f-40df-48b5-9ad7-bb0c0cfa454b" xlink:href="bntx-20241231.xsd#bntx_NonCurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_1f4503ca-bfcc-464b-9956-43a334f278b4" xlink:to="loc_bntx_NonCurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_ef72b42f-40df-48b5-9ad7-bb0c0cfa454b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContractAssets_0715df68-2438-4b21-86da-3124f48995a5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractAssets_8e0cd943-0bc2-41d0-be7f-6a04d497e0cf" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractAssets_0715df68-2438-4b21-86da-3124f48995a5" xlink:to="loc_ifrs-full_CurrentContractAssets_8e0cd943-0bc2-41d0-be7f-6a04d497e0cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractAssets_5d4f93b6-4d6c-4971-8d20-93a25aba6cc1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractAssets_0715df68-2438-4b21-86da-3124f48995a5" xlink:to="loc_ifrs-full_NoncurrentContractAssets_5d4f93b6-4d6c-4971-8d20-93a25aba6cc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ChangesInScopeOfConsolidationOfContractAssets_85e11796-bc89-4c9c-8cba-197cc0e1683d" xlink:href="bntx-20241231.xsd#bntx_ChangesInScopeOfConsolidationOfContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ChangesInScopeOfConsolidationNonCurrentContractAssets_0421c7dc-b977-479c-b087-b25d4a4c77b8" xlink:href="bntx-20241231.xsd#bntx_ChangesInScopeOfConsolidationNonCurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ChangesInScopeOfConsolidationOfContractAssets_85e11796-bc89-4c9c-8cba-197cc0e1683d" xlink:to="loc_bntx_ChangesInScopeOfConsolidationNonCurrentContractAssets_0421c7dc-b977-479c-b087-b25d4a4c77b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ChangesInScopeOfConsolidationOfCurrentContractAssets_5c90d5af-f384-45c0-9514-1a711fbe8d88" xlink:href="bntx-20241231.xsd#bntx_ChangesInScopeOfConsolidationOfCurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ChangesInScopeOfConsolidationOfContractAssets_85e11796-bc89-4c9c-8cba-197cc0e1683d" xlink:to="loc_bntx_ChangesInScopeOfConsolidationOfCurrentContractAssets_5c90d5af-f384-45c0-9514-1a711fbe8d88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentContractAssets_6c11d492-319c-4361-82ec-568ec67ed826" xlink:href="bntx-20241231.xsd#bntx_ReclassificationFromNonCurrentToCurrentContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractAssets_e1b826ca-07aa-46bf-8d64-c2f9cdd93edb" xlink:href="bntx-20241231.xsd#bntx_ReclassificationFromNonCurrentToCurrentCurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractAssets_6c11d492-319c-4361-82ec-568ec67ed826" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractAssets_e1b826ca-07aa-46bf-8d64-c2f9cdd93edb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractAssets_3f581b3c-e559-4aa1-b544-aa7e7bcdd17a" xlink:href="bntx-20241231.xsd#bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractAssets_6c11d492-319c-4361-82ec-568ec67ed826" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractAssets_3f581b3c-e559-4aa1-b544-aa7e7bcdd17a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationIoTradeAccountsReceivablesContractAssets_185539fb-792a-43b3-bf5c-e9c895f88210" xlink:href="bntx-20241231.xsd#bntx_ReclassificationIoTradeAccountsReceivablesContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationIoTradeAccountsReceivablesCurrentContractAssets_6414a435-e19c-46ea-a24c-a71df6726f2c" xlink:href="bntx-20241231.xsd#bntx_ReclassificationIoTradeAccountsReceivablesCurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationIoTradeAccountsReceivablesContractAssets_185539fb-792a-43b3-bf5c-e9c895f88210" xlink:to="loc_bntx_ReclassificationIoTradeAccountsReceivablesCurrentContractAssets_6414a435-e19c-46ea-a24c-a71df6726f2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationIoTradeAccountsReceivablesNonCurrentContractAssets_48b1b556-6817-4f02-9966-d5c36f0790ed" xlink:href="bntx-20241231.xsd#bntx_ReclassificationIoTradeAccountsReceivablesNonCurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationIoTradeAccountsReceivablesContractAssets_185539fb-792a-43b3-bf5c-e9c895f88210" xlink:to="loc_bntx_ReclassificationIoTradeAccountsReceivablesNonCurrentContractAssets_48b1b556-6817-4f02-9966-d5c36f0790ed" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractLiabilitiesDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#RevenuesfromContractswithCustomersContractLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInContractLiabilities_56bbe05b-028e-4f26-baad-7bf10cefb984" xlink:href="bntx-20241231.xsd#bntx_IncreaseDecreaseInContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInNonCurrentContractLiabilities_cf8db599-9cfe-458e-bb37-a5759dd203c6" xlink:href="bntx-20241231.xsd#bntx_IncreaseDecreaseInNonCurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractLiabilities_56bbe05b-028e-4f26-baad-7bf10cefb984" xlink:to="loc_bntx_IncreaseDecreaseInNonCurrentContractLiabilities_cf8db599-9cfe-458e-bb37-a5759dd203c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInCurrentContractLiabilities_ca70d8d0-6ce6-4f78-a694-e4cfc7556a98" xlink:href="bntx-20241231.xsd#bntx_IncreaseDecreaseInCurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractLiabilities_56bbe05b-028e-4f26-baad-7bf10cefb984" xlink:to="loc_bntx_IncreaseDecreaseInCurrentContractLiabilities_ca70d8d0-6ce6-4f78-a694-e4cfc7556a98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrencyEffectsOfContractLiabilities_5f9ae043-373d-4683-9f1f-e4ea68162c02" xlink:href="bntx-20241231.xsd#bntx_CurrencyEffectsOfContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrencyEffectsOfCurrentContractLiabilities_0e1973b7-39ca-4bbe-8455-c3f87423e3bc" xlink:href="bntx-20241231.xsd#bntx_CurrencyEffectsOfCurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_CurrencyEffectsOfContractLiabilities_5f9ae043-373d-4683-9f1f-e4ea68162c02" xlink:to="loc_bntx_CurrencyEffectsOfCurrentContractLiabilities_0e1973b7-39ca-4bbe-8455-c3f87423e3bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrencyEffectsOfNonCurrentContractLiabilities_8b3449fe-c6c8-4d08-8121-326fc88c5771" xlink:href="bntx-20241231.xsd#bntx_CurrencyEffectsOfNonCurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_CurrencyEffectsOfContractLiabilities_5f9ae043-373d-4683-9f1f-e4ea68162c02" xlink:to="loc_bntx_CurrencyEffectsOfNonCurrentContractLiabilities_8b3449fe-c6c8-4d08-8121-326fc88c5771" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContractLiabilities_795e9f77-d8b1-48c5-8f59-40d4ffdbe410" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_433a3749-00a8-4696-b702-dd4b4f46e5d8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractLiabilities_795e9f77-d8b1-48c5-8f59-40d4ffdbe410" xlink:to="loc_ifrs-full_CurrentContractLiabilities_433a3749-00a8-4696-b702-dd4b4f46e5d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractLiabilities_3f00d836-5b30-4873-ba3e-e61c2f506ca3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractLiabilities_795e9f77-d8b1-48c5-8f59-40d4ffdbe410" xlink:to="loc_ifrs-full_NoncurrentContractLiabilities_3f00d836-5b30-4873-ba3e-e61c2f506ca3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities_3fca3341-b68a-410b-9d74-c132845b589e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentContractLiabilitesRecognizedAsRevenue_f4107e55-27a9-49dc-946a-84377d4a1699" xlink:href="bntx-20241231.xsd#bntx_CurrentContractLiabilitesRecognizedAsRevenue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities_3fca3341-b68a-410b-9d74-c132845b589e" xlink:to="loc_bntx_CurrentContractLiabilitesRecognizedAsRevenue_f4107e55-27a9-49dc-946a-84377d4a1699" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonCurrentContractLiabilitesRecognizedAsRevenue_73da4009-e61c-49c9-b0ed-926f98c5e6a2" xlink:href="bntx-20241231.xsd#bntx_NonCurrentContractLiabilitesRecognizedAsRevenue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities_3fca3341-b68a-410b-9d74-c132845b589e" xlink:to="loc_bntx_NonCurrentContractLiabilitesRecognizedAsRevenue_73da4009-e61c-49c9-b0ed-926f98c5e6a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities_b3a42932-667b-4a01-8b71-d7158ad9be6f" xlink:href="bntx-20241231.xsd#bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractLiabilities_bc654d8b-fea4-40ce-ba28-1a06b61a29a7" xlink:href="bntx-20241231.xsd#bntx_ReclassificationFromNonCurrentToCurrentCurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities_b3a42932-667b-4a01-8b71-d7158ad9be6f" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractLiabilities_bc654d8b-fea4-40ce-ba28-1a06b61a29a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractLiabilities_dca264c7-b36a-432c-a334-262210817f65" xlink:href="bntx-20241231.xsd#bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities_b3a42932-667b-4a01-8b71-d7158ad9be6f" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractLiabilities_dca264c7-b36a-432c-a334-262210817f65" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesOtherOperatingResultDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#IncomeandExpensesOtherOperatingResultDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesOtherOperatingResultDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_aae783d3-4d8d-4d12-ab45-a0f34a944ca3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_07b61bdd-6bf5-4e81-a4a7-f75d3e4d8680" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherOperatingIncomeExpense_aae783d3-4d8d-4d12-ab45-a0f34a944ca3" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_07b61bdd-6bf5-4e81-a4a7-f75d3e4d8680" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_3f56456a-4111-4e61-93a8-9e24f3006a0d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherOperatingIncomeExpense_aae783d3-4d8d-4d12-ab45-a0f34a944ca3" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_3f56456a-4111-4e61-93a8-9e24f3006a0d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesFinanceIncomeDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#IncomeandExpensesFinanceIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesFinanceIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_ef69ae75-1523-47e9-8687-c8abe1ec363c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetForeignExchangeGain_c027c311-fdcf-4b1b-a526-a6f62f66b379" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NetForeignExchangeGain"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_ef69ae75-1523-47e9-8687-c8abe1ec363c" xlink:to="loc_ifrs-full_NetForeignExchangeGain_c027c311-fdcf-4b1b-a526-a6f62f66b379" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_FinanceIncomeFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCost_45cb273e-9315-4b1f-bedb-7c8fa7275753" xlink:href="bntx-20241231.xsd#bntx_FinanceIncomeFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_ef69ae75-1523-47e9-8687-c8abe1ec363c" xlink:to="loc_bntx_FinanceIncomeFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCost_45cb273e-9315-4b1f-bedb-7c8fa7275753" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_FinanceIncomeFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue_fdfd2a35-94fb-4b64-bb70-4f0ced2a73cf" xlink:href="bntx-20241231.xsd#bntx_FinanceIncomeFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_ef69ae75-1523-47e9-8687-c8abe1ec363c" xlink:to="loc_bntx_FinanceIncomeFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue_fdfd2a35-94fb-4b64-bb70-4f0ced2a73cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_FinanceIncomeExpense_e7947e00-b55b-41bc-80e7-af40e871def7" xlink:href="bntx-20241231.xsd#bntx_FinanceIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_f020ea8e-6fac-4542-ba06-ffa80fb7666f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_FinanceIncomeExpense_e7947e00-b55b-41bc-80e7-af40e871def7" xlink:to="loc_ifrs-full_FinanceIncome_f020ea8e-6fac-4542-ba06-ffa80fb7666f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_a3162930-0a79-48cc-ac7e-41ec9b0d4b18" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_FinanceIncomeExpense_e7947e00-b55b-41bc-80e7-af40e871def7" xlink:to="loc_ifrs-full_FinanceCosts_a3162930-0a79-48cc-ac7e-41ec9b0d4b18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_20588b4e-803d-4bc1-b5ae-57d91ce2ec8b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCostWithoutExpectedCreditLosses_ec868eb8-a1b3-4ee1-9529-491118a0ca40" xlink:href="bntx-20241231.xsd#bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCostWithoutExpectedCreditLosses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_20588b4e-803d-4bc1-b5ae-57d91ce2ec8b" xlink:to="loc_bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCostWithoutExpectedCreditLosses_ec868eb8-a1b3-4ee1-9529-491118a0ca40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetForeignExchangeLoss_1d0b6a20-d392-45fc-8500-24395dadbcf3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NetForeignExchangeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_20588b4e-803d-4bc1-b5ae-57d91ce2ec8b" xlink:to="loc_ifrs-full_NetForeignExchangeLoss_1d0b6a20-d392-45fc-8500-24395dadbcf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinanceCost_cbfc2d9b-864b-4bb9-a69f-cf61fbfe4511" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherFinanceCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_20588b4e-803d-4bc1-b5ae-57d91ce2ec8b" xlink:to="loc_ifrs-full_OtherFinanceCost_cbfc2d9b-864b-4bb9-a69f-cf61fbfe4511" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCostWithExpectedCreditLosses_c41b4bc9-2689-4e08-8cba-8ddd50e729e7" xlink:href="bntx-20241231.xsd#bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCostWithExpectedCreditLosses"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_20588b4e-803d-4bc1-b5ae-57d91ce2ec8b" xlink:to="loc_bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtAmortizedCostWithExpectedCreditLosses_c41b4bc9-2689-4e08-8cba-8ddd50e729e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue_e14b4d03-ef17-4618-8a56-79a3d71436ae" xlink:href="bntx-20241231.xsd#bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_20588b4e-803d-4bc1-b5ae-57d91ce2ec8b" xlink:to="loc_bntx_FinanceCostsFairValueAdjustmentsOfFinancialInstrumentsMeasuredAtFairValue_e14b4d03-ef17-4618-8a56-79a3d71436ae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesSummaryofEmployeeBenefitsExpenseDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#IncomeandExpensesSummaryofEmployeeBenefitsExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesSummaryofEmployeeBenefitsExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EmployeeBenefitsExpense_6727ac39-36f9-4155-a578-94ad960fc1c9" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EmployeeBenefitsExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SocialSecurityContributions_28730d25-4e37-4ae2-8a35-1be0e9ca722c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SocialSecurityContributions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_6727ac39-36f9-4155-a578-94ad960fc1c9" xlink:to="loc_ifrs-full_SocialSecurityContributions_28730d25-4e37-4ae2-8a35-1be0e9ca722c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_1882969a-3820-4731-a679-ab70624a4dc6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_6727ac39-36f9-4155-a578-94ad960fc1c9" xlink:to="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_1882969a-3820-4731-a679-ab70624a4dc6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WagesAndSalaries_207b3997-00f7-4a30-a697-f76e99d12d9f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_WagesAndSalaries"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_6727ac39-36f9-4155-a578-94ad960fc1c9" xlink:to="loc_ifrs-full_WagesAndSalaries_207b3997-00f7-4a30-a697-f76e99d12d9f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_42151465-3ec2-48a9-80a9-865efc551a2b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxExpenseIncome_fa94e023-8e64-4320-bd42-2d1a9ab316c7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxExpenseIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_42151465-3ec2-48a9-80a9-865efc551a2b" xlink:to="loc_ifrs-full_DeferredTaxExpenseIncome_fa94e023-8e64-4320-bd42-2d1a9ab316c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxExpenseIncome_3b9399de-4be3-4cdb-ad43-a2f0c91c2543" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxExpenseIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_42151465-3ec2-48a9-80a9-865efc551a2b" xlink:to="loc_ifrs-full_CurrentTaxExpenseIncome_3b9399de-4be3-4cdb-ad43-a2f0c91c2543" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectFromChangeInTaxRate_d20f6e98-e390-4add-a2b8-37659df946cd" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TaxEffectFromChangeInTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_ifrs-full_TaxEffectFromChangeInTaxRate_d20f6e98-e390-4add-a2b8-37659df946cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses_50cd93ad-288b-4dcd-a164-fa4a4e00cd11" xlink:href="bntx-20241231.xsd#bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses_50cd93ad-288b-4dcd-a164-fa4a4e00cd11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_bbcf2db7-842d-48cb-8a83-4b214cae82f6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TaxExpenseIncomeAtApplicableTaxRate"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_bbcf2db7-842d-48cb-8a83-4b214cae82f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectiveEquityTransactionCosts_673fc2e2-c5a6-46fe-beb7-0bee5fcbd958" xlink:href="bntx-20241231.xsd#bntx_TaxEffectiveEquityTransactionCosts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_bntx_TaxEffectiveEquityTransactionCosts_673fc2e2-c5a6-46fe-beb7-0bee5fcbd958" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome_3141b923-b106-46e6-bcb6-6dd1b1bb8a16" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome_3141b923-b106-46e6-bcb6-6dd1b1bb8a16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod_0c15addc-639c-41ae-8bbb-65367f6251e6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod_0c15addc-639c-41ae-8bbb-65367f6251e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonTaxEffectiveBargainPurchase_21c8d7dc-5814-4ca3-bdba-c3f7fff32708" xlink:href="bntx-20241231.xsd#bntx_NonTaxEffectiveBargainPurchase"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_bntx_NonTaxEffectiveBargainPurchase_21c8d7dc-5814-4ca3-bdba-c3f7fff32708" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectNonTaxEffectiveIncome_b6df73cb-529a-4e2e-b829-2260dda50c35" xlink:href="bntx-20241231.xsd#bntx_TaxEffectNonTaxEffectiveIncome"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_bntx_TaxEffectNonTaxEffectiveIncome_b6df73cb-529a-4e2e-b829-2260dda50c35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfChangeInValuationAllowance_cf570277-c66b-4e19-ac43-3eebf3f9fa10" xlink:href="bntx-20241231.xsd#bntx_TaxEffectOfChangeInValuationAllowance"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_bntx_TaxEffectOfChangeInValuationAllowance_cf570277-c66b-4e19-ac43-3eebf3f9fa10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfForeignTaxRates_4510f0e3-e0f1-4eba-8007-eec5e605056d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TaxEffectOfForeignTaxRates"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_ifrs-full_TaxEffectOfForeignTaxRates_4510f0e3-e0f1-4eba-8007-eec5e605056d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLossNetOfAddiitonalDeductions_1b18a376-8218-4d43-a1b4-8baab4bf566b" xlink:href="bntx-20241231.xsd#bntx_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLossNetOfAddiitonalDeductions"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_bntx_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLossNetOfAddiitonalDeductions_1b18a376-8218-4d43-a1b4-8baab4bf566b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfDeviationDueToLocalTaxBasis_11a140e1-1583-499f-8815-7ea4a0cc9f5c" xlink:href="bntx-20241231.xsd#bntx_TaxEffectOfDeviationDueToLocalTaxBasis"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_bntx_TaxEffectOfDeviationDueToLocalTaxBasis_11a140e1-1583-499f-8815-7ea4a0cc9f5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfTaxLosses_e62fe145-3fe4-46d6-9e4d-251abb502259" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TaxEffectOfTaxLosses"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_0390cdf9-0956-48c3-acef-01560767a0e4" xlink:to="loc_ifrs-full_TaxEffectOfTaxLosses_e62fe145-3fe4-46d6-9e4d-251abb502259" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherIntangibleAssetsandGoodwillSummaryofGoodwillRecognizedDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#OtherIntangibleAssetsandGoodwillSummaryofGoodwillRecognizedDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherIntangibleAssetsandGoodwillSummaryofGoodwillRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill_b8614845-aedb-480e-9449-bcae2b9b887c" xlink:href="bntx-20241231.xsd#bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsWithIndefiniteUsefulLife_725538f2-f532-437a-8645-c4dfcb05111b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IntangibleAssetsWithIndefiniteUsefulLife"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill_b8614845-aedb-480e-9449-bcae2b9b887c" xlink:to="loc_ifrs-full_IntangibleAssetsWithIndefiniteUsefulLife_725538f2-f532-437a-8645-c4dfcb05111b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_18ec4b9f-66e4-4423-b371-6704d73d7234" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill_b8614845-aedb-480e-9449-bcae2b9b887c" xlink:to="loc_ifrs-full_Goodwill_18ec4b9f-66e4-4423-b371-6704d73d7234" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofCashandCashEquivalentsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofCashandCashEquivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_5345f6d1-47de-45cd-9c17-ae20308d61c4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashEquivalents_02abc1e5-76e3-41b9-b4d0-e44f158f2302" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_5345f6d1-47de-45cd-9c17-ae20308d61c4" xlink:to="loc_ifrs-full_CashEquivalents_02abc1e5-76e3-41b9-b4d0-e44f158f2302" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Cash_4e1f1fe9-6880-40c6-a836-dc79e475afbc" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Cash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_5345f6d1-47de-45cd-9c17-ae20308d61c4" xlink:to="loc_ifrs-full_Cash_4e1f1fe9-6880-40c6-a836-dc79e475afbc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsandLiabilitiesatAmortizedCostandatFairValueDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsandLiabilitiesatAmortizedCostandatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsandLiabilitiesatAmortizedCostandatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialAssets_b176df2f-cb23-4613-a875-82e891a0e832" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialAssets_9c882cf7-166e-4e6c-8977-a9f72e890154" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentFinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialAssets_b176df2f-cb23-4613-a875-82e891a0e832" xlink:to="loc_ifrs-full_CurrentFinancialAssets_9c882cf7-166e-4e6c-8977-a9f72e890154" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssets_303826be-f634-499d-bf52-fef13738b919" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialAssets_b176df2f-cb23-4613-a875-82e891a0e832" xlink:to="loc_ifrs-full_NoncurrentFinancialAssets_303826be-f634-499d-bf52-fef13738b919" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_4fc18cb6-73e2-46b8-9b2e-7cecf4b64b70" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_InterestBearingLoansAndBorrowings_a6c596cf-1c32-4796-88d1-228fab638bcf" xlink:href="bntx-20241231.xsd#bntx_InterestBearingLoansAndBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_4fc18cb6-73e2-46b8-9b2e-7cecf4b64b70" xlink:to="loc_bntx_InterestBearingLoansAndBorrowings_a6c596cf-1c32-4796-88d1-228fab638bcf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinancialLiabilities_db7b2340-6301-42f7-bd1c-42e338a66c0f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_4fc18cb6-73e2-46b8-9b2e-7cecf4b64b70" xlink:to="loc_ifrs-full_OtherFinancialLiabilities_db7b2340-6301-42f7-bd1c-42e338a66c0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherPayables_5cd6a04b-f646-4477-b958-de538c6c6e0a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_4fc18cb6-73e2-46b8-9b2e-7cecf4b64b70" xlink:to="loc_ifrs-full_TradeAndOtherPayables_5cd6a04b-f646-4477-b958-de538c6c6e0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination_cfa5a798-2528-4dbf-97fd-a8756c6b58a5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_4fc18cb6-73e2-46b8-9b2e-7cecf4b64b70" xlink:to="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination_cfa5a798-2528-4dbf-97fd-a8756c6b58a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_5a396a75-62ad-479b-ac1c-6c766549d95c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LeaseLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_4fc18cb6-73e2-46b8-9b2e-7cecf4b64b70" xlink:to="loc_ifrs-full_LeaseLiabilities_5a396a75-62ad-479b-ac1c-6c766549d95c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialLiabilities_12d94df2-4571-499d-850a-34f560a93a5c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DerivativeFinancialLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_4fc18cb6-73e2-46b8-9b2e-7cecf4b64b70" xlink:to="loc_ifrs-full_DerivativeFinancialLiabilities_12d94df2-4571-499d-850a-34f560a93a5c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/InventoriesSummaryofInventoriesDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#InventoriesSummaryofInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/InventoriesSummaryofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_07b6f3aa-49dd-4bc3-92a2-2b577fb6c1b0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Inventories"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies_9258a50e-783e-4518-8bf4-9c300f90fe5b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_07b6f3aa-49dd-4bc3-92a2-2b577fb6c1b0" xlink:to="loc_ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies_9258a50e-783e-4518-8bf4-9c300f90fe5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinishedGoods_267e9d50-abbe-417b-9fab-1a29280e49fb" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinishedGoods"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_07b6f3aa-49dd-4bc3-92a2-2b577fb6c1b0" xlink:to="loc_ifrs-full_FinishedGoods_267e9d50-abbe-417b-9fab-1a29280e49fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WorkInProgress_b6ed43b8-20fe-4329-bbc0-bc8f231266e1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_WorkInProgress"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_07b6f3aa-49dd-4bc3-92a2-2b577fb6c1b0" xlink:to="loc_ifrs-full_WorkInProgress_b6ed43b8-20fe-4329-bbc0-bc8f231266e1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#OtherNonFinancialAssetsSummaryofOtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialAssets_1f7011fc-d53b-464b-bf2d-ce6b8e64b5b9" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNonfinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialAssets_b2c953b5-c95e-42db-9af7-b8d3174d524d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentNonfinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_1f7011fc-d53b-464b-bf2d-ce6b8e64b5b9" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialAssets_b2c953b5-c95e-42db-9af7-b8d3174d524d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_b12b54fa-17d6-4ce9-bdd7-bad485dd428b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_1f7011fc-d53b-464b-bf2d-ce6b8e64b5b9" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_b12b54fa-17d6-4ce9-bdd7-bad485dd428b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails_1" xlink:type="simple" xlink:href="bntx-20241231.xsd#OtherNonFinancialAssetsSummaryofOtherAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialAssets_6de98de2-9ef5-49ed-8255-4d42c3172abf" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNonfinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherCurrentAssetsOther_7a0ec52a-e7b6-48ec-b7b7-504f937bbf8c" xlink:href="bntx-20241231.xsd#bntx_OtherCurrentAssetsOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_6de98de2-9ef5-49ed-8255-4d42c3172abf" xlink:to="loc_bntx_OtherCurrentAssetsOther_7a0ec52a-e7b6-48ec-b7b7-504f937bbf8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpense_35765d74-d9ad-4abd-837e-1aef235f95f2" xlink:href="bntx-20241231.xsd#bntx_DeferredExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_6de98de2-9ef5-49ed-8255-4d42c3172abf" xlink:to="loc_bntx_DeferredExpense_35765d74-d9ad-4abd-837e-1aef235f95f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentPrepaymentsRelatedToServiceContracts_32db77f4-8dd9-429d-a23e-5d225672c70d" xlink:href="bntx-20241231.xsd#bntx_CurrentPrepaymentsRelatedToServiceContracts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_6de98de2-9ef5-49ed-8255-4d42c3172abf" xlink:to="loc_bntx_CurrentPrepaymentsRelatedToServiceContracts_32db77f4-8dd9-429d-a23e-5d225672c70d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ShareBasedPaymentsSummaryofExpenseRecognizedforEmployeeServicesReceivedDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#ShareBasedPaymentsSummaryofExpenseRecognizedforEmployeeServicesReceivedDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ShareBasedPaymentsSummaryofExpenseRecognizedforEmployeeServicesReceivedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_1da2005d-a94e-4ac4-a461-1855bffbe345" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_3fd5360e-3e6d-4c0c-88ce-0513b4b69523" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_1da2005d-a94e-4ac4-a461-1855bffbe345" xlink:to="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_3fd5360e-3e6d-4c0c-88ce-0513b4b69523" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_d197b0dd-b873-4ad5-89c9-53529b3061df" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_1da2005d-a94e-4ac4-a461-1855bffbe345" xlink:to="loc_ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_d197b0dd-b873-4ad5-89c9-53529b3061df" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ProvisionsProvisionsDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#ProvisionsProvisionsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ProvisionsProvisionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Provisions_92781334-9848-48e6-add0-be82954d65b8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Provisions"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherProvisions_ac968288-7959-46fc-a0d5-25c00929abd4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_92781334-9848-48e6-add0-be82954d65b8" xlink:to="loc_ifrs-full_OtherProvisions_ac968288-7959-46fc-a0d5-25c00929abd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermOnerousContractsProvision_11cd88ce-8510-42b5-bd73-722359180c7e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ShorttermOnerousContractsProvision"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_92781334-9848-48e6-add0-be82954d65b8" xlink:to="loc_ifrs-full_ShorttermOnerousContractsProvision_11cd88ce-8510-42b5-bd73-722359180c7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LegalProceedingsProvision_7086af38-117a-4066-abb2-b5ee28c20f12" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LegalProceedingsProvision"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_92781334-9848-48e6-add0-be82954d65b8" xlink:to="loc_ifrs-full_LegalProceedingsProvision_7086af38-117a-4066-abb2-b5ee28c20f12" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ProvisionsProvisionsDetails_1" xlink:type="simple" xlink:href="bntx-20241231.xsd#ProvisionsProvisionsDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ProvisionsProvisionsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Provisions_bd7f2565-dff8-4eeb-b751-0ffa8a175fe8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Provisions"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_551cfda4-f758-4bce-9183-77ce741d984c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_bd7f2565-dff8-4eeb-b751-0ffa8a175fe8" xlink:to="loc_ifrs-full_CurrentProvisions_551cfda4-f758-4bce-9183-77ce741d984c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_9820f990-f875-4d6b-95dc-ac51ddf33db0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_bd7f2565-dff8-4eeb-b751-0ffa8a175fe8" xlink:to="loc_ifrs-full_NoncurrentProvisions_9820f990-f875-4d6b-95dc-ac51ddf33db0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialLiabilities_8821c702-3ae6-40bd-ac47-81c0bf4dc07f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNonfinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_dc1a3134-9637-4017-a235-6bd13ca8143b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentNonfinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_8821c702-3ae6-40bd-ac47-81c0bf4dc07f" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_dc1a3134-9637-4017-a235-6bd13ca8143b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_04e81f33-fcdb-45f4-8248-951002cbf95d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_8821c702-3ae6-40bd-ac47-81c0bf4dc07f" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_04e81f33-fcdb-45f4-8248-951002cbf95d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails_1" xlink:type="simple" xlink:href="bntx-20241231.xsd#OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialLiabilities_e0a3454b-f4f8-4657-aa2d-fd3535365867" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNonfinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GovernmentGrants_655c40b8-8c7c-4352-94a3-dc7fcc671c88" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GovernmentGrants"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_e0a3454b-f4f8-4657-aa2d-fd3535365867" xlink:to="loc_ifrs-full_GovernmentGrants_655c40b8-8c7c-4352-94a3-dc7fcc671c88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesFromWageTaxesAndSocialSecuritiesExpenses_a4860c96-179d-401c-aad1-cd22b682376d" xlink:href="bntx-20241231.xsd#bntx_LiabilitiesFromWageTaxesAndSocialSecuritiesExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_e0a3454b-f4f8-4657-aa2d-fd3535365867" xlink:to="loc_bntx_LiabilitiesFromWageTaxesAndSocialSecuritiesExpenses_a4860c96-179d-401c-aad1-cd22b682376d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherLiabilitiesOther_63da51bb-428d-4a49-9108-ca57918f3576" xlink:href="bntx-20241231.xsd#bntx_OtherLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_e0a3454b-f4f8-4657-aa2d-fd3535365867" xlink:to="loc_bntx_OtherLiabilitiesOther_63da51bb-428d-4a49-9108-ca57918f3576" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesForEmployeeBenefits_4ca6b075-0fa8-4ed4-8cb7-d0d97c794dc9" xlink:href="bntx-20241231.xsd#bntx_LiabilitiesForEmployeeBenefits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_e0a3454b-f4f8-4657-aa2d-fd3535365867" xlink:to="loc_bntx_LiabilitiesForEmployeeBenefits_4ca6b075-0fa8-4ed4-8cb7-d0d97c794dc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_528ceb53-1ee9-4200-ad40-ba707537a9ac" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_e0a3454b-f4f8-4657-aa2d-fd3535365867" xlink:to="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_528ceb53-1ee9-4200-ad40-ba707537a9ac" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_a780cce4-088f-4dd9-8c0b-409a02405245" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LeaseLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLeaseLiabilities_4f7578bc-551d-4d7a-a8bd-ac338eaac454" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_LeaseLiabilities_a780cce4-088f-4dd9-8c0b-409a02405245" xlink:to="loc_ifrs-full_CurrentLeaseLiabilities_4f7578bc-551d-4d7a-a8bd-ac338eaac454" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLeaseLiabilities_867c6e89-9ad7-4d86-baed-daa5ac262733" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_LeaseLiabilities_a780cce4-088f-4dd9-8c0b-409a02405245" xlink:to="loc_ifrs-full_NoncurrentLeaseLiabilities_867c6e89-9ad7-4d86-baed-daa5ac262733" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_eaaf12fa-ab15-47ed-911b-ae80b0fcbf9e" xlink:href="bntx-20241231.xsd#bntx_LeaseExpensesRecognizedInProfitOrLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepreciationRightofuseAssets_cb0da474-5c69-4546-98fa-27fb54d0439b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DepreciationRightofuseAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_eaaf12fa-ab15-47ed-911b-ae80b0fcbf9e" xlink:to="loc_ifrs-full_DepreciationRightofuseAssets_cb0da474-5c69-4546-98fa-27fb54d0439b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ExpenseRelatingToShortTermLeasesAndLeasesOfLowValueAssetsForWhichRecognitionExemptionHasBeenUsed_e23a96dd-0032-4cd1-b7c2-c883d8cde72e" xlink:href="bntx-20241231.xsd#bntx_ExpenseRelatingToShortTermLeasesAndLeasesOfLowValueAssetsForWhichRecognitionExemptionHasBeenUsed"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_eaaf12fa-ab15-47ed-911b-ae80b0fcbf9e" xlink:to="loc_bntx_ExpenseRelatingToShortTermLeasesAndLeasesOfLowValueAssetsForWhichRecognitionExemptionHasBeenUsed_e23a96dd-0032-4cd1-b7c2-c883d8cde72e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_909232f0-d09c-46f0-8e51-023156e4d713" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_eaaf12fa-ab15-47ed-911b-ae80b0fcbf9e" xlink:to="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_909232f0-d09c-46f0-8e51-023156e4d713" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensation_834ae997-1a8e-4280-b3ef-7c8ca1706ab3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensation"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment_2e3d44ad-610e-445d-ac31-4de578f76c19" xlink:href="bntx-20241231.xsd#bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_834ae997-1a8e-4280-b3ef-7c8ca1706ab3" xlink:to="loc_bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment_2e3d44ad-610e-445d-ac31-4de578f76c19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_e56032b9-7ed8-4398-8faf-bd81f1199ebf" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_834ae997-1a8e-4280-b3ef-7c8ca1706ab3" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_e56032b9-7ed8-4398-8faf-bd81f1199ebf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_7728c77e-98b0-4416-9305-d5b17106b296" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_834ae997-1a8e-4280-b3ef-7c8ca1706ab3" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_7728c77e-98b0-4416-9305-d5b17106b296" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationFixedCompensation_61ccc172-2330-42f0-9180-10c294ebdc54" xlink:href="bntx-20241231.xsd#bntx_KeyManagementPersonnelCompensationFixedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_834ae997-1a8e-4280-b3ef-7c8ca1706ab3" xlink:to="loc_bntx_KeyManagementPersonnelCompensationFixedCompensation_61ccc172-2330-42f0-9180-10c294ebdc54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationOtherVariableCompensation_ce5a23ca-6ad6-466f-bd9a-20e6955a6f03" xlink:href="bntx-20241231.xsd#bntx_KeyManagementPersonnelCompensationOtherVariableCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_834ae997-1a8e-4280-b3ef-7c8ca1706ab3" xlink:to="loc_bntx_KeyManagementPersonnelCompensationOtherVariableCompensation_ce5a23ca-6ad6-466f-bd9a-20e6955a6f03" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails" xlink:type="simple" xlink:href="bntx-20241231.xsd#RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasesFromRelatedPartyTransactions_5aaf934d-251e-490f-b861-99ddfc3d44ce" xlink:href="bntx-20241231.xsd#bntx_PurchasesFromRelatedPartyTransactions"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_2bcd9bfb-da82-4d4b-924d-5bbde0c533ed" xlink:href="bntx-20241231.xsd#bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_PurchasesFromRelatedPartyTransactions_5aaf934d-251e-490f-b861-99ddfc3d44ce" xlink:to="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_2bcd9bfb-da82-4d4b-924d-5bbde0c533ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions_f16c67a3-b9ee-405d-8ab2-2882be5a2892" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_bntx_PurchasesFromRelatedPartyTransactions_5aaf934d-251e-490f-b861-99ddfc3d44ce" xlink:to="loc_ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions_f16c67a3-b9ee-405d-8ab2-2882be5a2892" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
