License agreements (Additional Information) (Detail) - USD ($) $ in Thousands |
12 Months Ended | ||
|---|---|---|---|
Feb. 10, 2022 |
Dec. 31, 2024 |
Dec. 31, 2023 |
|
| License Agreement [Line Items] | |||
| Common stock, issued | 14,856,309 | 1,407,753 | |
| Research And Development Expense | $ 41,364 | $ 36,966 | |
| Harvard Agreement [Member] | |||
| License Agreement [Line Items] | |||
| Common stock, issued | 227,486 | ||
| License Agreements Payments Description | (1) annual maintenance fees ranging from the low five digits to the low six digits during the term of the License Agreement (through the first commercial sale of a royalty-bearing product); (2) royalty payments as a percentage in the low single digits of the annual net sales that the Company generates from products that utilize the license technology (“Licensed Products”) and royalty payments as a percentage in the low single digits of the annual net sales that the Company generates from know-how enabled product licenses (“Know-How Enabled Products”) and (3) a percentage between 10-20% of all non-royalty income received by the Company under sublicenses, strategic partnerships and know-how enabled product licenses that utilize the license technology | ||
| Stock Issued During Period Value | $ 400 | ||
| Research And Development Expense | $ 400 | 200 | |
| Amount Due to Related Party | $ 0 | $ 0 | |
| One-time license fee | $ 170,000 | ||