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          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/MitocarexTransactionDetailsNarrative" id="MitocarexTransactionDetailsNarrative">
          <link:definition>999059 - Disclosure - MITOCAREX TRANSACTION (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfPropertyPlantAndEquipmentDetails" id="ScheduleOfPropertyPlantAndEquipmentDetails">
          <link:definition>999060 - Disclosure - SCHEDULE OF PROPERTY PLANT AND EQUIPMENT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/PropertyAndEquipmentNetDetailsNarrative" id="PropertyAndEquipmentNetDetailsNarrative">
          <link:definition>999061 - Disclosure - PROPERTY AND EQUIPMENT, NET (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfFairValueConversionDetails" id="ScheduleOfFairValueConversionDetails">
          <link:definition>999062 - Disclosure - SCHEDULE OF FAIR VALUE CONVERSION (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfEquityInvestmentDetails" id="ScheduleOfEquityInvestmentDetails">
          <link:definition>999063 - Disclosure - SCHEDULE OF EQUITY INVESTMENT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/InvestmentInNonconsolidatedAffiliateDetailsNarrative" id="InvestmentInNonconsolidatedAffiliateDetailsNarrative">
          <link:definition>999064 - Disclosure - INVESTMENT IN NONCONSOLIDATED AFFILIATE (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/InvestmentAndLoanToSolterraDetailsNarrative" id="InvestmentAndLoanToSolterraDetailsNarrative">
          <link:definition>999065 - Disclosure - INVESTMENT AND LOAN TO SOLTERRA (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/SolarPhotovolaicJointVentureProjectDetailsNarrative" id="SolarPhotovolaicJointVentureProjectDetailsNarrative">
          <link:definition>999066 - Disclosure - SOLAR PHOTOVOLAIC JOINT VENTURE PROJECT (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ConsolidatedEntityDetailsNarrative" id="ConsolidatedEntityDetailsNarrative">
          <link:definition>999067 - Disclosure - A CONSOLIDATED ENTITY (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfOtherLiabilitiesDetails" id="ScheduleOfOtherLiabilitiesDetails">
          <link:definition>999068 - Disclosure - SCHEDULE OF OTHER LIABILITIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfWarrantAssumptionsUsedDetails" id="ScheduleOfWarrantAssumptionsUsedDetails">
          <link:definition>999069 - Disclosure - SCHEDULE OF WARRANT ASSUMPTIONS USED (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/CommitmentAndContingentLiabilitiesDetailsNarrative" id="CommitmentAndContingentLiabilitiesDetailsNarrative">
          <link:definition>999070 - Disclosure - COMMITMENT AND CONTINGENT LIABILITIES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfOperatingLeaseCostDetails" id="ScheduleOfOperatingLeaseCostDetails">
          <link:definition>999071 - Disclosure - SCHEDULE OF OPERATING LEASE COST (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeaseDetails" id="ScheduleOfSupplementalCashFlowInformationRelatedToOperatingLeaseDetails">
          <link:definition>999072 - Disclosure - SCHEDULE OF SUPPLEMENTAL CASH FLOW INFORMATION RELATED TO OPERATING LEASE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSupplementalBalanceSheetInformationRelatedToOperatingLeasesDetails" id="ScheduleOfSupplementalBalanceSheetInformationRelatedToOperatingLeasesDetails">
          <link:definition>999073 - Disclosure - SCHEDULE OF SUPPLEMENTAL BALANCE SHEET INFORMATION RELATED TO OPERATING LEASES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfMinimumLeasePaymentsUnderNon-CancelableLeasesDetails" id="ScheduleOfMinimumLeasePaymentsUnderNon-CancelableLeasesDetails">
          <link:definition>999074 - Disclosure - SCHEDULE OF MINIMUM LEASE PAYMENTS UNDER NON- CANCELABLE LEASES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/LeasesDetailsNarrative" id="LeasesDetailsNarrative">
          <link:definition>999075 - Disclosure - LEASES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetailsParenthetical" id="ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetailsParenthetical">
          <link:definition>999076 - Disclosure - SCHEDULE OF TRANSACTIONS AND BALANCES WITH RELATED PARTIES (Details) (Parenthetical)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/CommonStockAndWarrantsDetailsNarrative" id="CommonStockAndWarrantsDetailsNarrative">
          <link:definition>999077 - Disclosure - COMMON STOCK AND WARRANTS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfEstimatedFairValueOfOptionsGrantedDetails" id="ScheduleOfEstimatedFairValueOfOptionsGrantedDetails">
          <link:definition>999078 - Disclosure - SCHEDULE OF ESTIMATED FAIR VALUE OF OPTIONS GRANTED (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfEstimatedFairValueOfOptionsGrantedDetailsParenthetical" id="ScheduleOfEstimatedFairValueOfOptionsGrantedDetailsParenthetical">
          <link:definition>999079 - Disclosure - SCHEDULE OF ESTIMATED FAIR VALUE OF OPTIONS GRANTED (Details) (Parenthetical)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfStockOptionActivityDetails" id="ScheduleOfStockOptionActivityDetails">
          <link:definition>999080 - Disclosure - SCHEDULE OF STOCK OPTION ACTIVITY (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/StockOptionsDetailsNarrative" id="StockOptionsDetailsNarrative">
          <link:definition>999081 - Disclosure - STOCK OPTIONS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfCostOfSalesDetails" id="ScheduleOfCostOfSalesDetails">
          <link:definition>999082 - Disclosure - SCHEDULE OF COST OF SALES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfResearchAndDevelopmentExpensesDetails" id="ScheduleOfResearchAndDevelopmentExpensesDetails">
          <link:definition>999083 - Disclosure - SCHEDULE OF RESEARCH AND DEVELOPMENT EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSellingAndMarketingExpensesDetails" id="ScheduleOfSellingAndMarketingExpensesDetails">
          <link:definition>999084 - Disclosure - SCHEDULE OF SELLING AND MARKETING EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfGeneralAndAdministrativeExpensesDetails" id="ScheduleOfGeneralAndAdministrativeExpensesDetails">
          <link:definition>999085 - Disclosure - SCHEDULE OF GENERAL AND ADMINISTRATIVE EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfFinancingExpensesNetDetails" id="ScheduleOfFinancingExpensesNetDetails">
          <link:definition>999086 - Disclosure - SCHEDULE OF FINANCING EXPENSES NET (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfIncomeTaxExpensesDetails" id="ScheduleOfIncomeTaxExpensesDetails">
          <link:definition>999087 - Disclosure - SCHEDULE OF INCOME TAX EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" id="ScheduleOfDeferredTaxAssetsAndLiabilitiesDetails">
          <link:definition>999088 - Disclosure - SCHEDULE OF DEFERRED TAX ASSETS AND LIABILITIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/IncomeTaxDetailsNarrative" id="IncomeTaxDetailsNarrative">
          <link:definition>999089 - Disclosure - INCOME TAX (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfBasicAndDilutedLossPerShareDetails" id="ScheduleOfBasicAndDilutedLossPerShareDetails">
          <link:definition>999090 - Disclosure - SCHEDULE OF BASIC AND DILUTED LOSS PER SHARE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetails" id="ScheduleOfTransactionsAndBalancesWithRelatedPartiesDetails">
          <link:definition>999091 - Disclosure - SCHEDULE OF TRANSACTIONS AND BALANCES WITH RELATED PARTIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/RelatedPartiesDetailsNarrative" id="RelatedPartiesDetailsNarrative">
          <link:definition>999092 - Disclosure - RELATED PARTIES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfInformationRelatedToOperationsOfReportableOperatingSegmentsDetails" id="ScheduleOfInformationRelatedToOperationsOfReportableOperatingSegmentsDetails">
          <link:definition>999093 - Disclosure - SCHEDULE OF INFORMATION RELATED TO OPERATIONS OF REPORTABLE OPERATING SEGMENTS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfInformationOnSalesByGeographicDistributionDetails" id="ScheduleOfInformationOnSalesByGeographicDistributionDetails">
          <link:definition>999094 - Disclosure - SCHEDULE OF INFORMATION ON SALES BY GEOGRAPHIC DISTRIBUTION (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfSalesToCustomersDetails" id="ScheduleOfSalesToCustomersDetails">
          <link:definition>999095 - Disclosure - SCHEDULE OF SALES TO CUSTOMERS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfInformationOnLongLivedAssetsDetails" id="ScheduleOfInformationOnLongLivedAssetsDetails">
          <link:definition>999096 - Disclosure - SCHEDULE OF INFORMATION ON LONG LIVED ASSETS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/SegmentReportingDetailsNarrative" id="SegmentReportingDetailsNarrative">
          <link:definition>999097 - Disclosure - SEGMENT REPORTING (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/ScheduleOfFairValueOfLevels3AssetsDetails" id="ScheduleOfFairValueOfLevels3AssetsDetails">
          <link:definition>999098 - Disclosure - SCHEDULE OF FAIR VALUE OF THE LEVELS 3 ASSETS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
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        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/SubsequentEventsDetailsNarrative" id="SubsequentEventsDetailsNarrative">
          <link:definition>999099 - Disclosure - SUBSEQUENT EVENTS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfEstimatedFairValueOfWarrantSharesDetails" id="ScheduleOfEstimatedFairValueOfWarrantSharesDetails">
          <link:definition>999100 - Disclosure - SCHEDULE OF ESTIMATED FAIR VALUE OF WARRANT SHARES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/CreditFacilityDetailsNarrative" id="CreditFacilityDetailsNarrative">
          <link:definition>999101 - Disclosure - CREDIT FACILITY (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://n2off.com/role/ScheduleOfEstimatedFairValueOfWarrantSharesAssumptionsDetails" id="ScheduleOfEstimatedFairValueOfWarrantSharesAssumptionsDetails">
          <link:definition>999102 - Disclosure - SCHEDULE OF ESTIMATED FAIR VALUE OF WARRANT SHARES ASSUMPTIONS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://n2off.com/role/DiscontinuedOperationsDetailsNarrative" id="DiscontinuedOperationsDetailsNarrative">
          <link:definition>999103 - Disclosure - DISCONTINUED OPERATIONS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:linkbaseRef xlink:type="simple" xlink:href="nito-20250630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Presentation Links" />
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        <link:linkbaseRef xlink:type="simple" xlink:href="nito-20250630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links" />
        <link:linkbaseRef xlink:type="simple" xlink:href="nito-20250630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Definition Links" />
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    <element id="NITO_ComprehensiveIncomeLossNetOfTax" name="ComprehensiveIncomeLossNetOfTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IssuanceOfSharesForYaaranExchangeAgreementInValue" name="IssuanceOfSharesForYaaranExchangeAgreementInValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IssuanceOfSharesForYaaranExchangeAgreementInShares" name="IssuanceOfSharesForYaaranExchangeAgreementInShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StockIssuedDuringPeriodValueTransactionsWithNoncontrollingInterests" name="StockIssuedDuringPeriodValueTransactionsWithNoncontrollingInterests" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IssuanceOfSharesForPrivateInvestmentInPublicEquityPipeAgreement" name="IssuanceOfSharesForPrivateInvestmentInPublicEquityPipeAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IssuanceOfSharesForPrivateInvestmentInPublicEquityPipeAgreementShares" name="IssuanceOfSharesForPrivateInvestmentInPublicEquityPipeAgreementShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StockIssuedDuringPeriodValueExercisingWarrants" name="StockIssuedDuringPeriodValueExercisingWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StockIssuedDuringPeriodSharesExercisingWarrants" name="StockIssuedDuringPeriodSharesExercisingWarrants" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StockIssuedDuringPeriodValueDeconsolidationOfNtwoOffLtd" name="StockIssuedDuringPeriodValueDeconsolidationOfNtwoOffLtd" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProfitLossForThePeriod" name="ProfitLossForThePeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GainFromStandbyEquityPurchaseAgreementI" name="GainFromStandbyEquityPurchaseAgreementI" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ExpensesFromStandbyEquityPurchaseAgreementIIAndPromissoryNote" name="ExpensesFromStandbyEquityPurchaseAgreementIIAndPromissoryNote" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_InterestOnLoan" name="InterestOnLoan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ChangeInFairValueOfLoans" name="ChangeInFairValueOfLoans" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ChangeInFairValueOfCreditFacilityLiability" name="ChangeInFairValueOfCreditFacilityLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ChangeInFairValueOfPIPESWarrantLiability" name="ChangeInFairValueOfPIPESWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GainLossOnInvestment" name="GainLossOnInvestment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IncreaseDecreaseInInterestIncomeFromSolarProject" name="IncreaseDecreaseInInterestIncomeFromSolarProject" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IncreaseDecreaseInExchangeRateDifferencesOnOperatingLeases" name="IncreaseDecreaseInExchangeRateDifferencesOnOperatingLeases" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IncreaseDecreaseInOperatingLeaseExpense" name="IncreaseDecreaseInOperatingLeaseExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IncreaseDecreaseInOperatingLeaseAssets" name="IncreaseDecreaseInOperatingLeaseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PaymentsToInvestmentInBatteryStorageProjects" name="PaymentsToInvestmentInBatteryStorageProjects" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PaymentsOnLoansGantedOrSolarPVJointVentureProject" name="PaymentsOnLoansGantedOrSolarPVJointVentureProject" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromSaleOfSubsidiaryNetOfCashDisposed" name="ProceedsFromSaleOfSubsidiaryNetOfCashDisposed" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromPIPEAgreement" name="ProceedsFromPIPEAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromStandbyEquityPurchaseAgreementNet" name="ProceedsFromStandbyEquityPurchaseAgreementNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CashPaidDuringYearAbstract" name="CashPaidDuringYearAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_TerminationOfLeaseLiability" name="TerminationOfLeaseLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_InitialRecognitionOfOperatingLeaseLiabilityAndCorrespondingRightofuseAsset" name="InitialRecognitionOfOperatingLeaseLiabilityAndCorrespondingRightofuseAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ReclassificationOfWarrantLiabilitiesToEquityUponExerciseOfWarrants" name="ReclassificationOfWarrantLiabilitiesToEquityUponExerciseOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IssuanceOfSharesForFutureCreditLine" name="IssuanceOfSharesForFutureCreditLine" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IssuanceOfSharesForFutureServices" name="IssuanceOfSharesForFutureServices" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IssuanceOfSharesForCommitmentFee" name="IssuanceOfSharesForCommitmentFee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_RecognitionOfPrepaidWarrantCostsAndCorrespondingWarrantLiability" name="RecognitionOfPrepaidWarrantCostsAndCorrespondingWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureMitocarexTransactionAbstract" name="DisclosureMitocarexTransactionAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_MitocarexTransactionDisclosureTextBlock" name="MitocarexTransactionDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureInvestmentAndLoanToSolterraAbstract" name="DisclosureInvestmentAndLoanToSolterraAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_InvestmentAndLoanToSolterraDisclosureTextBlock" name="InvestmentAndLoanToSolterraDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureSolarPhotovolaicJointVentureProjectAbstract" name="DisclosureSolarPhotovolaicJointVentureProjectAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_SolarPhotovolaicJointVentureProjectDisclosureTextBlock" name="SolarPhotovolaicJointVentureProjectDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureConsolidatedEntityAbstract" name="DisclosureConsolidatedEntityAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ConsolidationEntityTextBlock" name="ConsolidationEntityTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureLeasesAbstract" name="DisclosureLeasesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureCostOfSalesAbstract" name="DisclosureCostOfSalesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CostOfSalesTextBlock" name="CostOfSalesTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureSellingAndMarketingExpensesAbstract" name="DisclosureSellingAndMarketingExpensesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_SellingAndMarketingExpenseDisclosureTextBlock" name="SellingAndMarketingExpenseDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DisclosureGeneralAndAdministrativeExpensesAbstract" name="DisclosureGeneralAndAdministrativeExpensesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GeneralAndAdministrativeExpensesTextBlock" name="GeneralAndAdministrativeExpensesTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CreditFacilityPolicyTextBlock" name="CreditFacilityPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProjectAssetsPolicyTextBlock" name="ProjectAssetsPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_RoyaltyBearingGrantsPolicyTextBlock" name="RoyaltyBearingGrantsPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfPropertyPlantAndEquipmentDepreciationRatesTableTextBlock" name="ScheduleOfPropertyPlantAndEquipmentDepreciationRatesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfWarrantAssumptionsUsedTableTextBlock" name="ScheduleOfWarrantAssumptionsUsedTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfSupplementalBalanceSheetInformationRealtedToOperatingLeasesTableTextBlock" name="ScheduleOfSupplementalBalanceSheetInformationRealtedToOperatingLeasesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfCostOfSalesTableTextBlock" name="ScheduleOfCostOfSalesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfSellingAndMarketingExpenseTableTextBlock" name="ScheduleOfSellingAndMarketingExpenseTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfGeneralAndAdministrativeExpensesTableTextBlock" name="ScheduleOfGeneralAndAdministrativeExpensesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfFinancingExpensesNetTableTextBlock" name="ScheduleOfFinancingExpensesNetTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ScheduleOfEstimatedFairValueOfWarrantAssumptionsUsedTableTextBlock" name="ScheduleOfEstimatedFairValueOfWarrantAssumptionsUsedTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StockPurchaseWarrantsLiabilityFairValueDisclosure" name="StockPurchaseWarrantsLiabilityFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_WarrantLiabilitiesFairValueDisclosure" name="WarrantLiabilitiesFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CreditFacilityFairValueDisclosure" name="CreditFacilityFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueOfShareIssuedUnderSettlementAgreement" name="FairValueOfShareIssuedUnderSettlementAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisInvestmentInSolterra" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisInvestmentInSolterra" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GainOnMarketableSecurities" name="GainOnMarketableSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ChangesInFairValueOfAssets" name="ChangesInFairValueOfAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisCreditFacilityToPlantify" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisCreditFacilityToPlantify" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGrantedToSolterra" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGrantedToSolterra" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGrantedToSolarProject" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGrantedToSolarProject" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGrantedToMitoCareX" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLoansGrantedToMitoCareX" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisShareIssuedUnderSettlementAgreementInExchangeForInvestment" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisShareIssuedUnderSettlementAgreementInExchangeForInvestment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CumulativeResearchAndDevelopmentGrantsReceived" name="CumulativeResearchAndDevelopmentGrantsReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GrantOfRestrictedStockPercentage" name="GrantOfRestrictedStockPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromSaleOfPropertyPlantAndEquipmentCost" name="ProceedsFromSaleOfPropertyPlantAndEquipmentCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_EquitySecuritiesFvNiMeasurementInputTerm" name="EquitySecuritiesFvNiMeasurementInputTerm" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GrossLoss" name="GrossLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_IncreaseInPercentageOfOwnership" name="IncreaseInPercentageOfOwnership" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DebtInstrumentInvestmentRate" name="DebtInstrumentInvestmentRate" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ImpairmentLoss" name="ImpairmentLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueOfInvestment" name="FairValueOfInvestment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DescriptionForNetProfitFormSales" name="DescriptionForNetProfitFormSales" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ShareCapitalPercentage" name="ShareCapitalPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ExchangeCapitalForSharePrice" name="ExchangeCapitalForSharePrice" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_RoyaltyDescription" name="RoyaltyDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PercentageOfNetRevenues" name="PercentageOfNetRevenues" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_MaximumCompensationPercentageOfGrossProfit" name="MaximumCompensationPercentageOfGrossProfit" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PercentageOfConsultants" name="PercentageOfConsultants" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ReimbursementExpenses" name="ReimbursementExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_SuccessFeesGrossProceedsPercentage" name="SuccessFeesGrossProceedsPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_SuccessFeesPercentage" name="SuccessFeesPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_SuccessFees" name="SuccessFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_LesseeOperatingAdditionalLeaseTermOfContract" name="LesseeOperatingAdditionalLeaseTermOfContract" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdditionalPaymentsForRent" name="AdditionalPaymentsForRent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_MonthlyConsultancyFee" name="MonthlyConsultancyFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ExercisePriceDescription" name="ExercisePriceDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ConsultantFees" name="ConsultantFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfStockIssued" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfStockIssued" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CashFee" name="CashFee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PurchaseAgreementPercentage" name="PurchaseAgreementPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdvanceNotice" name="AdvanceNotice" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdvanceOrAcquiringPaymentDescription" name="AdvanceOrAcquiringPaymentDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_PurchaseAgreementDescription" name="PurchaseAgreementDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdvancesDiscountPercentage" name="AdvancesDiscountPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_StructuringFee" name="StructuringFee" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FinancingExpenses" name="FinancingExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DebtInstrumentDefaultInterestRatePercentage" name="DebtInstrumentDefaultInterestRatePercentage" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromStandbyEquityPurchaseAgreement" name="ProceedsFromStandbyEquityPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_NoncashGainOnCarryingAmountOfWarrantLiabilities" name="NoncashGainOnCarryingAmountOfWarrantLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ChangeInFairValueOfRemainingWarrantLiabilities" name="ChangeInFairValueOfRemainingWarrantLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueOfRemainingWarrantLiabilities" name="FairValueOfRemainingWarrantLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValue" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DoubtfulDebt" name="DoubtfulDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ChangeInFairValueOfMarketableSecurities" name="ChangeInFairValueOfMarketableSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_InterestOnLoans" name="InterestOnLoans" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_BankChargesAndOtherFinanceExpensesNet" name="BankChargesAndOtherFinanceExpensesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FinancingIncomeNet" name="FinancingIncomeNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_DeferredTaxOperatingLeaseLiabilities" name="DeferredTaxOperatingLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_GeneralAndAdministrativeExpenses" name="GeneralAndAdministrativeExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_CommonStockOutstandingPercentage" name="CommonStockOutstandingPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AnnualFees" name="AnnualFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProfessionalServices" name="ProfessionalServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FinancingExpensesIncomeNet" name="FinancingExpensesIncomeNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_LongLivedAssets" name="LongLivedAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ConcentrationRiskPercentage" name="ConcentrationRiskPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_AdditionsDuringPeriodLiabilitiesFairValueDisclosure" name="AdditionsDuringPeriodLiabilitiesFairValueDisclosure" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_LiabilitiesFairValueDisclosureSettlements" name="LiabilitiesFairValueDisclosureSettlements" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_LiabilitiesFairValueDisclosureChangesInFairValue" name="LiabilitiesFairValueDisclosureChangesInFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_WarrantsAndRightsOutstandingMaturityDateDescription" name="WarrantsAndRightsOutstandingMaturityDateDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_FairValueOfWarrants" name="FairValueOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="NITO_ProceedsFromCashPartiallyOffset" name="ProceedsFromCashPartiallyOffset" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
