| Schedule of Significant Expense Categories by Segment |
The table below summarizes the significant expense categories regularly reviewed by the CODM for the three and six months ended June 30, 2025 and 2024 (in thousands): | | | | | | | | | | | | | | | Three Months Ended
June 30, | | Six Months Ended
June 30, | | | 2025 | | 2024 | | 2025 | | 2024 | Collaboration revenues | | $ | — | | $ | 9,197 | | $ | 3,729 | | $ | 12,594 | Less: | | | | | | | | | | | | | Research and development, excluding facilities, personnel, depreciation and amortization expenses | | | 1,499 | | | 7,643 | | | 3,027 | | | 17,834 | General and administrative, excluding facilities and personnel expenses, depreciation and amortization expenses | | | 2,836 | | | 4,070 | | | 5,257 | | | 7,726 | Facilities expense | | | 656 | | | 1,794 | | | 1,755 | | | 3,426 | Personnel expense | | | 787 | | | 6,311 | | | 8,141 | | | 12,840 | Depreciation, amortization and interest on finance and sale-leaseback lease liabilities | | | 38 | | | 1,153 | | | 750 | | | 2,338 | Other segment items(a) | | | 3,958 | | | (612) | | | 3,839 | | | (1,430) | Net loss | | $ | (9,774) | | $ | (11,162) | | $ | (19,040) | | $ | (30,140) |
| (a) | “Other segment items” includes loss on sale of held for sale assets, loss on abandonment of operating lease right-of-use assets, and other income, net. |
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The table below summarizes the significant expense categories regularly reviewed by the CODM for the years ended December 31, 2024 and 2023: | | | | | | | | | Years Ended | | | December 31, | | | 2024 | | 2023 | Collaboration revenues | | $ | 19,632 | | $ | 14,919 | Less: | | | | | | | Research and development, excluding facilities, personnel, depreciation and amortization expenses | | | 33,147 | | | 45,905 | General and administrative, excluding facilities and personnel expenses, depreciation and amortization expenses | | | 14,829 | | | 19,118 | Facilities expense | | | 5,917 | | | 7,671 | Personnel expense | | | 24,564 | | | 27,324 | Depreciation, amortization and interest on finance and sale-leaseback lease liabilities | | | 3,894 | | | 3,984 | Other segment items(a) | | | (2,242) | | | (2,204) | Net loss | | $ | (60,477) | | $ | (86,879) |
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| Schedule of Dilutive Securities |
The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares of common stock outstanding, as they would be anti-dilutive: | | | | | | | June 30, | | | 2025 | | 2024 | Stock options | | 6,420,876 | | 8,685,238 |
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The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares of common stock outstanding, as they would be anti-dilutive: | | | | | | | December 31, | | | 2024 | | 2023 | Stock options | | 7,746,991 | | 6,023,370 |
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