v3.25.3
Segment Information
 9 Months Ended
Sep. 30, 2025
Segment Reporting [Abstract]  
Segment Information Segment Information
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company with a mission to discover, develop and ultimately deliver medicines that are transformational for patients. The Company’s ability to generate recurring product revenue and to become profitable will depend upon the ability to successfully develop, obtain regulatory approval and commercialize any current and future product candidates.
The Company manages the business as one segment. Its operating results are regularly reviewed by the Company’s Chief Executive Officer, who is the chief operating decision-maker (“CODM”), based on available financial information prepared on a consolidated basis. The CODM evaluates its performance based primarily on research and development efforts and the results of clinical trials. The CODM also utilizes the Company’s long-range plan as a strategic tool to allocate resources according to the Company’s strategic objectives. The consolidated net loss is used to monitor budget versus actual results in assessing segment performance and the allocation of resources. Assets provided to the CODM are consistent with those reported on the Consolidated Balance Sheets with particular emphasis on the Company’s available liquidity, including its cash, cash equivalents and investments.
The following table presents reportable segment loss, including significant expenses regularly provided to the CODM, attributable to the Company’s reportable segment for the nine months ended September 30, 2025 and September 30, 2024 (in thousands):
Three Months Ended
September 30, 2025		Three Months Ended
September 30, 2024		Nine Months Ended
September 30, 2025		Nine Months Ended
September 30, 2024
License and other revenue$— $— $15,000 $— 
Less:
OX2R agonist program expenses
(35,562)(11,744)(88,336)(26,696)
LockBody program expenses
(3,441)(2,815)(8,624)(9,081)
Discontinued R&D program expenses585 (16,165)(3,524)(44,784)
Other R&D expenses:
Personnel expenses¹(7,370)(4,393)(19,749)(14,893)
Research tax incentives9,321 5,500 18,055 18,895 
Other preclinical and clinical development expenses(1,798)(644)(3,999)(1,438)
General and administrative expenses¹(8,331)(7,691)(25,017)(23,260)
Share-based compensation(7,194)(8,453)(23,026)(25,218)
Interest and investment income
3,765 3,340 16,035 9,171 
Interest expense(2,890)(2,557)(8,651)(7,611)
Other segment items²(1,810)3,664 2,808 2,281 
Income tax expense
(166)(608)(2,341)(1,794)
Consolidated net loss$(54,891)$(42,566)$(131,369)$(124,428)
¹ Excludes share-based compensation
² Other segment items includes non-operating income (expenses), net