Share-based Compensation - Summary of Share-Based Compensation Expense (Details) - USD ($) $ in Thousands |
3 Months Ended | 9 Months Ended | ||
|---|---|---|---|---|
Sep. 30, 2025 |
Sep. 30, 2024 |
Sep. 30, 2025 |
Sep. 30, 2024 |
|
| Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] | ||||
| Compensation expense recognized | $ 7,194 | $ 8,453 | $ 23,026 | $ 25,218 |
| Stock options | ||||
| Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] | ||||
| Compensation expense recognized | 6,568 | 5,722 | 19,590 | 16,929 |
| Restricted share awards and units | ||||
| Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] | ||||
| Compensation expense recognized | 626 | 2,731 | 3,436 | 8,289 |
| Research and development | ||||
| Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] | ||||
| Compensation expense recognized | 3,298 | 3,642 | 11,570 | 11,373 |
| General and administrative | ||||
| Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] | ||||
| Compensation expense recognized | $ 3,896 | $ 4,811 | $ 11,456 | $ 13,845 |