v3.25.3
Consolidated Statements of Shareholders' Equity - USD ($)
$ in Thousands
Total
Underwriter Offering
ATM Program
Ordinary Shares
Ordinary Shares
Underwriter Offering
Ordinary Shares
ATM Program
Additional paid-in capital
Additional paid-in capital
Underwriter Offering
Additional paid-in capital
ATM Program
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2023       98,774,827              
Beginning balance at Dec. 31, 2023 $ 236,244     $ 273     $ 987,423     $ 1,493 $ (752,945)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares, net of issuance costs (in shares)         29,932,626 1,250,000          
Issuance of ordinary shares, net of issuance costs   $ 349,980 $ 9,655   $ 76 $ 3   $ 349,904 $ 9,652    
Stock option exercises (in shares)       1,054,246              
Stock option exercises 6,311     $ 2     6,309        
Share-based compensation expense 25,218           25,218        
Vesting of ordinary shares (in shares)       1,055,535              
Vesting of ordinary shares 0     $ 3     (3)        
Shares withheld to pay employee withholding tax on share-based compensation (in shares)       (408,131)              
Shares withheld to pay employee withholding tax on share-based compensation (4,445)           (4,445)        
Foreign currency translation adjustments (498)                 (498)  
Unrealized gain on available for sale securities, net of tax 2,390                 2,390  
Reclassification adjustment for realized net gain on available for sale marketable securities included in net loss, net of tax (1,290)                 (1,290)  
Net loss (124,428)                   (124,428)
Ending balance (in shares) at Sep. 30, 2024       131,659,103              
Ending balance at Sep. 30, 2024 499,137     $ 357     1,374,058     2,095 (877,373)
Beginning balance (in shares) at Jun. 30, 2024       113,177,764              
Beginning balance at Jun. 30, 2024 286,965     $ 309     1,119,868     1,595 (834,807)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares, net of issuance costs (in shares)         17,542,372            
Issuance of ordinary shares, net of issuance costs   $ 242,708     $ 45     $ 242,663      
Stock option exercises (in shares)       751,810              
Stock option exercises 4,664     $ 2     4,662        
Share-based compensation expense 8,453           8,453        
Vesting of ordinary shares (in shares)       292,384              
Vesting of ordinary shares 0     $ 1     (1)        
Shares withheld to pay employee withholding tax on share-based compensation (in shares)       (105,227)              
Shares withheld to pay employee withholding tax on share-based compensation (1,587)           (1,587)        
Foreign currency translation adjustments (412)                 (412)  
Unrealized gain on available for sale securities, net of tax 912                 912  
Net loss (42,566)                   (42,566)
Ending balance (in shares) at Sep. 30, 2024       131,659,103              
Ending balance at Sep. 30, 2024 $ 499,137     $ 357     1,374,058     2,095 (877,373)
Beginning balance (in shares) at Dec. 31, 2024 132,631,587     132,631,587              
Beginning balance at Dec. 31, 2024 $ 401,545     $ 359     1,385,675     4,213 (988,702)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Issuance of ordinary shares, net of issuance costs (in shares)           372,538          
Issuance of ordinary shares, net of issuance costs     $ 6,109     $ 1     $ 6,108    
Stock option exercises (in shares) 1,087,469     1,087,469              
Stock option exercises $ 6,995     $ 3     6,992        
Share-based compensation expense 23,026           23,026        
Vesting of ordinary shares (in shares)       514,982              
Vesting of ordinary shares 0     $ 1     (1)        
Shares withheld to pay employee withholding tax on share-based compensation (in shares)       (185,427)              
Shares withheld to pay employee withholding tax on share-based compensation (3,119)           (3,119)        
Foreign currency translation adjustments 855                 855  
Unrealized gain on available for sale securities, net of tax 319                 319  
Reclassification adjustment for realized net gain on available for sale marketable securities included in net loss, net of tax (2,787)                    
Net loss $ (131,369)                   (131,369)
Ending balance (in shares) at Sep. 30, 2025 134,421,149     134,421,149              
Ending balance at Sep. 30, 2025 $ 301,574     $ 364     1,418,681     2,600 (1,120,071)
Beginning balance (in shares) at Jun. 30, 2025       133,913,556              
Beginning balance at Jun. 30, 2025 344,919     $ 363     1,408,145     1,591 (1,065,180)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Stock option exercises (in shares)       495,143              
Stock option exercises 3,468     $ 1     3,467        
Share-based compensation expense 7,194           7,194        
Vesting of ordinary shares (in shares)       19,664              
Shares withheld to pay employee withholding tax on share-based compensation (in shares)       (7,214)              
Shares withheld to pay employee withholding tax on share-based compensation (125)           (125)        
Foreign currency translation adjustments 691                 691  
Unrealized gain on available for sale securities, net of tax 318                 318  
Net loss $ (54,891)                   (54,891)
Ending balance (in shares) at Sep. 30, 2025 134,421,149     134,421,149              
Ending balance at Sep. 30, 2025 $ 301,574     $ 364     $ 1,418,681     $ 2,600 $ (1,120,071)