UNAUDITED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands |
3 Months Ended | 9 Months Ended | ||
|---|---|---|---|---|
Sep. 30, 2025 |
Sep. 30, 2024 |
Sep. 30, 2025 |
Sep. 30, 2024 |
|
| Total revenues | $ 3,701 | $ 2,287 | $ 10,530 | $ 21,898 |
| Operating expenses: | ||||
| Cost of license revenues | (398) | (264) | (1,251) | (648) |
| Cost of contract manufacturing revenues | (757) | (17,060) | ||
| Research and development expenses | (34,366) | (30,595) | (105,889) | (104,942) |
| Selling, general and administrative expenses | (19,438) | (11,575) | (43,846) | (41,279) |
| Total operating expenses | (54,202) | (43,191) | (150,986) | (163,929) |
| Other income | 1,510 | 2,591 | 12,413 | 5,950 |
| Other expense | (2,044) | (1,915) | (6,188) | (2,385) |
| Loss from operations | (51,035) | (40,228) | (134,231) | (138,466) |
| Interest income | 3,503 | 4,866 | 11,154 | 17,179 |
| Interest expense | (16,721) | (16,611) | (47,421) | (48,865) |
| Foreign currency (losses) / gains, net | (428) | 7,564 | 25,382 | 5,430 |
| Other non-operating losses, net | (7,222) | (7,222) | ||
| Loss before income tax expense | (71,903) | (44,409) | (152,338) | (164,722) |
| Income tax (expense) / benefit | (8,626) | 31 | (9,547) | (1,573) |
| Net loss | (80,529) | (44,378) | (161,885) | (166,295) |
| Other comprehensive loss: | ||||
| Foreign currency translation gains / (losses), net | 158 | (415) | (5,945) | (3,252) |
| Defined benefit pension gain, net of taxes | 37 | 107 | ||
| Total comprehensive loss | $ (80,371) | $ (44,756) | $ (167,830) | $ (169,440) |
| Loss per ordinary share - basic | ||||
| Basic net loss per ordinary share | $ (1.38) | $ (0.91) | $ (2.9) | $ (3.42) |
| Loss per ordinary share - diluted | ||||
| Diluted net loss per ordinary share | $ (1.38) | $ (0.91) | $ (2.9) | $ (3.42) |
| Weighted average shares - basic | 58,516,415 | 48,718,533 | 55,880,318 | 48,576,339 |
| Weighted average shares - diluted | 58,516,415 | 48,718,533 | 55,880,318 | 48,576,339 |
| License revenues | ||||
| Total revenues | $ 3,582 | $ 2,111 | $ 10,411 | $ 5,182 |
| Contract manufacturing revenues | ||||
| Total revenues | 6,114 | |||
| Collaboration revenues | ||||
| Total revenues | $ 119 | $ 176 | $ 119 | $ 10,602 |
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- Definition The amount of cost of contract manufacturing revenues incurred during the reporting period. No definition available.
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- Definition Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Total costs of sales and operating expenses for the period. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- References No definition available.
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- Definition The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- References No definition available.
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- Definition Amount, before tax, of realized and unrealized gain (loss) from foreign currency transaction. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount of income (loss) from continuing operations, including income (loss) from equity method investments, before deduction of income tax expense (benefit), and income (loss) attributable to noncontrolling interest. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of interest expense classified as nonoperating. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount before accretion (amortization) of purchase discount (premium) of interest income on nonoperating securities. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- References No definition available.
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- Definition The net result for the period of deducting operating expenses from operating revenues. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount, after tax and reclassification adjustment, of (increase) decrease in accumulated other comprehensive income for defined benefit plan, attributable to parent. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount after tax and reclassification adjustments of gain (loss) on foreign currency translation adjustments, foreign currency transactions designated and effective as economic hedges of a net investment in a foreign entity and intra-entity foreign currency transactions that are of a long-term-investment nature, attributable to parent entity. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- References No definition available.
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- Definition Amount of expense classified as other. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of revenue and income classified as other. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of income (expense) related to nonoperating activities, classified as other. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition The average number of shares or units issued and outstanding that are used in calculating diluted EPS or earnings per unit (EPU), determined based on the timing of issuance of shares or units in the period. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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