v3.25.3
UNAUDITED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Cash flows from operating activities    
Net loss $ (161,885) $ (166,295)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 11,789 8,285
Amortization of discount on investment securities (6,091) (8,472)
Share-based compensation expense 13,016 17,509
Royalty financing agreement interest expense, net of interest paid 29,209 33,107
Deferred tax expense 1,979 1,573
Changes in fair value of contingent consideration 5,293 (2,032)
Changes in fair value of liability related to pre-funded warrants 5,722  
Unrealized foreign exchange gains, net (24,534) (5,726)
Allowance for inventory write-downs   6,297
Other items, net (3,013) (2,460)
Changes in operating assets and liabilities:    
Accounts receivable, prepaid expenses, and other current assets and receivables 2,880 (5,764)
Inventories   (3,876)
Accounts payable (1,648) (512)
Income tax payable 7,568 167
Accrued expenses, other liabilities, and operating leases 19,321 (1,685)
Net cash used in operating activities (100,394) (129,884)
Cash flows from investing activities    
Proceeds on maturity of debt securities 337,195 480,806
Investment in debt securities (217,124) (279,586)
Divestment of commercial manufacturing facility   (8,300)
Purchases of property, plant, and equipment (320) (3,328)
Net cash generated from investing activities 119,751 189,592
Cash flows generated from / (used in) financing activities    
Proceeds from follow-on public offerings of ordinary shares, net of issuance costs 380,737  
Proceeds from issuance of pre-funded warrants, net of issuance costs 23,499  
Proceeds from issuance of ordinary shares related to employee stock options and purchase plans 8,713 81
Repayment of long-term debt   (53,050)
Net cash generated from / (used in) financing activities 412,949 (52,969)
Currency effect on cash, cash equivalents and restricted cash 5,914 1,796
Net increase in cash, cash equivalents and restricted cash 438,220 8,535
Cash, cash equivalents and restricted cash at beginning of period 160,329 244,544
Cash, cash equivalents and restricted cash at the end of period 598,549 253,079
Cash and cash equivalents 597,056 251,626
Restricted cash related to leasehold and other deposits 1,493 1,453
Total cash, cash equivalents and restricted cash 598,549 253,079
Supplemental cash flow disclosures:    
Cash paid for interest (16,659) (16,892)
Non-cash decrease in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment $ (54) $ (673)