<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:17440b85-cbe3-402e-9cda-81d51da10d35,g:fab9bf19-639d-4d92-ad99-268b1e844e1d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.abivax.com/role/UNAUDITEDINTERIMCONDENSEDCONSOLIDATEDSTATEMENTSOFFINANCIALPOSITION" xlink:type="simple" xlink:href="abvx-20250930.xsd#UNAUDITEDINTERIMCONDENSEDCONSOLIDATEDSTATEMENTSOFFINANCIALPOSITION"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/UNAUDITEDINTERIMCONDENSEDCONSOLIDATEDSTATEMENTSOFFINANCIALPOSITION" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_d66396d2-8b2b-489a-b59c-c7ebb368a1c5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_191705a3-42f6-4164-8f1c-71d384dcd77b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Goodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_d66396d2-8b2b-489a-b59c-c7ebb368a1c5" xlink:to="loc_ifrs-full_Goodwill_191705a3-42f6-4164-8f1c-71d384dcd77b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_9ed1b375-ff4d-4e7d-b802-e5f83817dc30" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_d66396d2-8b2b-489a-b59c-c7ebb368a1c5" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_9ed1b375-ff4d-4e7d-b802-e5f83817dc30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipmentIncludingRightofuseAssets_eef06c0c-e811-4e81-a79d-d474fb2b189e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipmentIncludingRightofuseAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_d66396d2-8b2b-489a-b59c-c7ebb368a1c5" xlink:to="loc_ifrs-full_PropertyPlantAndEquipmentIncludingRightofuseAssets_eef06c0c-e811-4e81-a79d-d474fb2b189e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialAssets_fa8a95d5-3018-4242-9b09-6a9157373e04" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentFinancialAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_d66396d2-8b2b-489a-b59c-c7ebb368a1c5" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialAssets_fa8a95d5-3018-4242-9b09-6a9157373e04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_dda449e7-f9e6-465c-aa09-ed3b4095a5f3" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_d66396d2-8b2b-489a-b59c-c7ebb368a1c5" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_dda449e7-f9e6-465c-aa09-ed3b4095a5f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_aa017e95-0ccc-4754-a050-74b68dfb952e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_a944820d-0c05-45b9-a795-b7da65fe75fc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_aa017e95-0ccc-4754-a050-74b68dfb952e" xlink:to="loc_ifrs-full_CurrentAssets_a944820d-0c05-45b9-a795-b7da65fe75fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_1eab92b6-cc38-4391-b4d0-d11cf5c522cf" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_aa017e95-0ccc-4754-a050-74b68dfb952e" xlink:to="loc_ifrs-full_NoncurrentAssets_1eab92b6-cc38-4391-b4d0-d11cf5c522cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_fb2bd4df-33b1-4de5-ae85-97d4530602c5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialAssets_6cf56a50-e0e1-45a6-bcbf-5dc9a7ca450f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentFinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_fb2bd4df-33b1-4de5-ae85-97d4530602c5" xlink:to="loc_ifrs-full_OtherCurrentFinancialAssets_6cf56a50-e0e1-45a6-bcbf-5dc9a7ca450f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_dc0f034d-a853-4934-a415-d34babc300fe" xlink:href="abvx-20250930.xsd#abvx_CurrentReceivablesAndCurrentPrepaidExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_fb2bd4df-33b1-4de5-ae85-97d4530602c5" xlink:to="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_dc0f034d-a853-4934-a415-d34babc300fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_996912cb-0851-44bf-b623-a407a35d6832" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_fb2bd4df-33b1-4de5-ae85-97d4530602c5" xlink:to="loc_ifrs-full_CashAndCashEquivalents_996912cb-0851-44bf-b623-a407a35d6832" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_e36348e5-9389-4527-932c-1e8566e36258" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentBorrowingsAndCurrentPortionOfOtherNoncurrentBorrowings_20e104aa-12e3-41da-8b58-b325717a312e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentBorrowingsAndCurrentPortionOfOtherNoncurrentBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_e36348e5-9389-4527-932c-1e8566e36258" xlink:to="loc_ifrs-full_OtherCurrentBorrowingsAndCurrentPortionOfOtherNoncurrentBorrowings_20e104aa-12e3-41da-8b58-b325717a312e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentPortionOfNonCurrentConvertibleLoansNotes_0f9e177e-ddbc-4681-aba4-e38d484215d8" xlink:href="abvx-20250930.xsd#abvx_CurrentPortionOfNonCurrentConvertibleLoansNotes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_e36348e5-9389-4527-932c-1e8566e36258" xlink:to="loc_abvx_CurrentPortionOfNonCurrentConvertibleLoansNotes_0f9e177e-ddbc-4681-aba4-e38d484215d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_090af80f-70be-4830-8edd-dee081e501c1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentDerivativeFinancialLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_e36348e5-9389-4527-932c-1e8566e36258" xlink:to="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_090af80f-70be-4830-8edd-dee081e501c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherShorttermProvisions_ca87043f-2b43-437f-9359-c55086d1cd03" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherShorttermProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_e36348e5-9389-4527-932c-1e8566e36258" xlink:to="loc_ifrs-full_OtherShorttermProvisions_ca87043f-2b43-437f-9359-c55086d1cd03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_bc0e9c8b-22ce-4847-a541-7245732520e7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_e36348e5-9389-4527-932c-1e8566e36258" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_bc0e9c8b-22ce-4847-a541-7245732520e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentTaxAndEmployeeBenefitLiabilities_e963b6b5-2680-43ab-8005-ebe702523f1d" xlink:href="abvx-20250930.xsd#abvx_CurrentTaxAndEmployeeBenefitLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_e36348e5-9389-4527-932c-1e8566e36258" xlink:to="loc_abvx_CurrentTaxAndEmployeeBenefitLiabilities_e963b6b5-2680-43ab-8005-ebe702523f1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_79420df6-542a-443b-9920-c6214890c3d0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_6ab74beb-9276-439c-9022-80f41526ea8d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentProvisionsForEmployeeBenefits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_79420df6-542a-443b-9920-c6214890c3d0" xlink:to="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_6ab74beb-9276-439c-9022-80f41526ea8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherLongtermProvisions_e68d2af2-e9d9-43c7-84ef-7b5210fb8d76" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherLongtermProvisions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_79420df6-542a-443b-9920-c6214890c3d0" xlink:to="loc_ifrs-full_OtherLongtermProvisions_e68d2af2-e9d9-43c7-84ef-7b5210fb8d76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentPortionOfOtherNoncurrentBorrowings_68ba90bc-2c72-4543-8679-41f00f344049" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentPortionOfOtherNoncurrentBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_79420df6-542a-443b-9920-c6214890c3d0" xlink:to="loc_ifrs-full_NoncurrentPortionOfOtherNoncurrentBorrowings_68ba90bc-2c72-4543-8679-41f00f344049" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_NonCurrentConvertibleLoansNotes_23338035-c056-4495-bb26-9e26ff567270" xlink:href="abvx-20250930.xsd#abvx_NonCurrentConvertibleLoansNotes"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_79420df6-542a-443b-9920-c6214890c3d0" xlink:to="loc_abvx_NonCurrentConvertibleLoansNotes_23338035-c056-4495-bb26-9e26ff567270" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentDerivativeFinancialLiabilities_eb6207de-cf93-4113-8aec-180f43751aa4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentDerivativeFinancialLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_79420df6-542a-443b-9920-c6214890c3d0" xlink:to="loc_ifrs-full_NoncurrentDerivativeFinancialLiabilities_eb6207de-cf93-4113-8aec-180f43751aa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_NonCurrentRoyaltyCertificates_53624e38-f43f-42b7-a989-71a13662fa1b" xlink:href="abvx-20250930.xsd#abvx_NonCurrentRoyaltyCertificates"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_79420df6-542a-443b-9920-c6214890c3d0" xlink:to="loc_abvx_NonCurrentRoyaltyCertificates_53624e38-f43f-42b7-a989-71a13662fa1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_b06bbf68-37d0-4818-bda5-abf5f84a473e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_d54c29e7-42b1-4bf7-8905-3da6a81e6fa8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_b06bbf68-37d0-4818-bda5-abf5f84a473e" xlink:to="loc_ifrs-full_IssuedCapital_d54c29e7-42b1-4bf7-8905-3da6a81e6fa8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_0db4f587-b4b0-43b2-83ae-aeae668209a1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SharePremium"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_b06bbf68-37d0-4818-bda5-abf5f84a473e" xlink:to="loc_ifrs-full_SharePremium_0db4f587-b4b0-43b2-83ae-aeae668209a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_9cdda937-110c-4db5-bd28-5aae107ee414" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_b06bbf68-37d0-4818-bda5-abf5f84a473e" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_9cdda937-110c-4db5-bd28-5aae107ee414" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarningsExcludingProfitLossForReportingPeriod_5845ec30-d4d0-4ba0-9a3f-67ead11d5686" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RetainedEarningsExcludingProfitLossForReportingPeriod"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_b06bbf68-37d0-4818-bda5-abf5f84a473e" xlink:to="loc_ifrs-full_RetainedEarningsExcludingProfitLossForReportingPeriod_5845ec30-d4d0-4ba0-9a3f-67ead11d5686" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarningsProfitLossForReportingPeriod_482b5c84-90bd-479e-965c-c16911267c3d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RetainedEarningsProfitLossForReportingPeriod"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_b06bbf68-37d0-4818-bda5-abf5f84a473e" xlink:to="loc_ifrs-full_RetainedEarningsProfitLossForReportingPeriod_482b5c84-90bd-479e-965c-c16911267c3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_755a4e94-e9df-4eca-8541-6ab11feb99ee" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_4d35b64d-32a3-40b9-80b5-63b5810114d8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_755a4e94-e9df-4eca-8541-6ab11feb99ee" xlink:to="loc_ifrs-full_Equity_4d35b64d-32a3-40b9-80b5-63b5810114d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_170ec138-f53d-4791-aa47-ac115a355707" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_755a4e94-e9df-4eca-8541-6ab11feb99ee" xlink:to="loc_ifrs-full_NoncurrentLiabilities_170ec138-f53d-4791-aa47-ac115a355707" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_65cd4ec9-17a5-4c8e-a0da-bbbd477e2c91" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_755a4e94-e9df-4eca-8541-6ab11feb99ee" xlink:to="loc_ifrs-full_CurrentLiabilities_65cd4ec9-17a5-4c8e-a0da-bbbd477e2c91" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFLOSS" xlink:type="simple" xlink:href="abvx-20250930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFLOSS"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFLOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_ab84971f-3d58-4592-bc46-89d59eee639e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_0fc7bcda-b7dc-43fb-92a1-f068829c00f6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_ab84971f-3d58-4592-bc46-89d59eee639e" xlink:to="loc_ifrs-full_FinanceCosts_0fc7bcda-b7dc-43fb-92a1-f068829c00f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_4b02fc01-4b00-497e-a9d6-395294635187" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_ab84971f-3d58-4592-bc46-89d59eee639e" xlink:to="loc_ifrs-full_FinanceIncome_4b02fc01-4b00-497e-a9d6-395294635187" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueAndOperatingIncome_9eef4257-526f-4f4b-92d9-1dd27aebb64f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueAndOperatingIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherIncome_741cc750-af25-4fd4-a6c5-3a0bddb915bd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueAndOperatingIncome_9eef4257-526f-4f4b-92d9-1dd27aebb64f" xlink:to="loc_ifrs-full_OtherIncome_741cc750-af25-4fd4-a6c5-3a0bddb915bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_c5c87a8a-ac4d-44df-a73c-1348c781b092" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_974af610-9df7-4be6-b0ad-a05964ba2f87" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_c5c87a8a-ac4d-44df-a73c-1348c781b092" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_974af610-9df7-4be6-b0ad-a05964ba2f87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_c614c582-711e-4b82-b7de-3c0fdcb16449" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_c5c87a8a-ac4d-44df-a73c-1348c781b092" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_c614c582-711e-4b82-b7de-3c0fdcb16449" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_4f7e09b2-35ca-4aec-ab6b-39f1260e01a8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueAndOperatingIncome_71a69d94-c21e-4ace-bd98-c2e97b538c5c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueAndOperatingIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_4f7e09b2-35ca-4aec-ab6b-39f1260e01a8" xlink:to="loc_ifrs-full_RevenueAndOperatingIncome_71a69d94-c21e-4ace-bd98-c2e97b538c5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_be7de9c2-20a7-4df6-ab7c-e10bf7684afc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OperatingExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_4f7e09b2-35ca-4aec-ab6b-39f1260e01a8" xlink:to="loc_ifrs-full_OperatingExpense_be7de9c2-20a7-4df6-ab7c-e10bf7684afc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_82b13b5b-ce87-4461-aa8d-d3ad4db99597" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OperatingExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_d3de42b1-4d88-42ab-9897-8b0d3e8c989f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_82b13b5b-ce87-4461-aa8d-d3ad4db99597" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_d3de42b1-4d88-42ab-9897-8b0d3e8c989f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_c363eccc-bfc7-4e7a-96ef-740f7cd73518" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_82b13b5b-ce87-4461-aa8d-d3ad4db99597" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_c363eccc-bfc7-4e7a-96ef-740f7cd73518" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SalesAndMarketingExpense_50581153-0de8-4b02-8570-241e7dd3347f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SalesAndMarketingExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_82b13b5b-ce87-4461-aa8d-d3ad4db99597" xlink:to="loc_ifrs-full_SalesAndMarketingExpense_50581153-0de8-4b02-8570-241e7dd3347f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_f7dd497f-b1c1-4e65-b69d-4b3619233590" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_8c10ef4a-d452-45a4-a0ec-03dbca87210c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_f7dd497f-b1c1-4e65-b69d-4b3619233590" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_8c10ef4a-d452-45a4-a0ec-03dbca87210c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_1749a7d6-0e1a-473a-8de2-ee0ee7aa4d75" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_f7dd497f-b1c1-4e65-b69d-4b3619233590" xlink:to="loc_ifrs-full_FinanceIncomeCost_1749a7d6-0e1a-473a-8de2-ee0ee7aa4d75" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="abvx-20250930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_936597f3-e5d0-40ba-8b73-7954e574f7eb" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_5ea3fbd7-54c4-4c7d-b488-a90107007dca" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_936597f3-e5d0-40ba-8b73-7954e574f7eb" xlink:to="loc_ifrs-full_ProfitLoss_5ea3fbd7-54c4-4c7d-b488-a90107007dca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_9d6efba3-e020-4e42-9497-4ca98e0f79ff" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_936597f3-e5d0-40ba-8b73-7954e574f7eb" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_9d6efba3-e020-4e42-9497-4ca98e0f79ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_dc6ad4bb-f99c-483b-85b2-58b3b7f71138" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_38f4af9a-d2d3-4dc1-86af-58e5b5b5bd4a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_dc6ad4bb-f99c-483b-85b2-58b3b7f71138" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_38f4af9a-d2d3-4dc1-86af-58e5b5b5bd4a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_71f0aa4e-545c-42cd-a857-2101b206df05" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_020eb1a9-16d2-4c37-b027-16b9aefbbdbc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_71f0aa4e-545c-42cd-a857-2101b206df05" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_020eb1a9-16d2-4c37-b027-16b9aefbbdbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_4771a245-0c37-433d-80ee-e5b26383daab" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_71f0aa4e-545c-42cd-a857-2101b206df05" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_4771a245-0c37-433d-80ee-e5b26383daab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_55940f9c-7ba0-4e15-964f-ad53fd258eca" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_52602bee-5053-41cd-8299-28670a045eb1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_55940f9c-7ba0-4e15-964f-ad53fd258eca" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_52602bee-5053-41cd-8299-28670a045eb1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="abvx-20250930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_6c246ac4-573b-432b-95ba-af643642468e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_9f273514-531d-4fce-863c-e8c6f3b2552d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_6c246ac4-573b-432b-95ba-af643642468e" xlink:to="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_9f273514-531d-4fce-863c-e8c6f3b2552d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_bd5f46e2-ba6f-4f73-a4c5-63599dc51429" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_6c246ac4-573b-432b-95ba-af643642468e" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_bd5f46e2-ba6f-4f73-a4c5-63599dc51429" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_91024467-83b0-4f80-9e3b-fdb93d580bff" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_49c82822-e77f-47ad-a414-a89ad88ba008" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_91024467-83b0-4f80-9e3b-fdb93d580bff" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_49c82822-e77f-47ad-a414-a89ad88ba008" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_a307d834-54d8-4ad4-8588-27bec188ddd8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_91024467-83b0-4f80-9e3b-fdb93d580bff" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_a307d834-54d8-4ad4-8588-27bec188ddd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_AdjustmentsForIncreaseDecreaseInTaxAndSocialSecurityLiabilities_73d654fd-6671-41c0-a5a7-564202c03d87" xlink:href="abvx-20250930.xsd#abvx_AdjustmentsForIncreaseDecreaseInTaxAndSocialSecurityLiabilities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_91024467-83b0-4f80-9e3b-fdb93d580bff" xlink:to="loc_abvx_AdjustmentsForIncreaseDecreaseInTaxAndSocialSecurityLiabilities_73d654fd-6671-41c0-a5a7-564202c03d87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_AdjustmentsForIncreaseDecreaseInProvisionsDeferredIncomeAndOtherLiabilities_6a853f4e-3380-4005-867e-96a83c94844f" xlink:href="abvx-20250930.xsd#abvx_AdjustmentsForIncreaseDecreaseInProvisionsDeferredIncomeAndOtherLiabilities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_91024467-83b0-4f80-9e3b-fdb93d580bff" xlink:to="loc_abvx_AdjustmentsForIncreaseDecreaseInProvisionsDeferredIncomeAndOtherLiabilities_6a853f4e-3380-4005-867e-96a83c94844f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_94b86fae-dcd7-4de6-9221-34b3192ed1a2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_bc03a91c-8779-43c8-806e-70fa3e9245aa" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_94b86fae-dcd7-4de6-9221-34b3192ed1a2" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_bc03a91c-8779-43c8-806e-70fa3e9245aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_PaymentsForAdvancesReimbursedMadeToContractResearchOrganizations_a219703c-6dde-4c63-8c33-a38e899016b3" xlink:href="abvx-20250930.xsd#abvx_PaymentsForAdvancesReimbursedMadeToContractResearchOrganizations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_94b86fae-dcd7-4de6-9221-34b3192ed1a2" xlink:to="loc_abvx_PaymentsForAdvancesReimbursedMadeToContractResearchOrganizations_a219703c-6dde-4c63-8c33-a38e899016b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CashPaymentsForDeposits_b1789bd1-cfcf-4d05-8545-60882db921f3" xlink:href="abvx-20250930.xsd#abvx_CashPaymentsForDeposits"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_94b86fae-dcd7-4de6-9221-34b3192ed1a2" xlink:to="loc_abvx_CashPaymentsForDeposits_b1789bd1-cfcf-4d05-8545-60882db921f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_ProceedsFromReimbursementsOfDeposits_d684fb7a-04ce-4deb-92f6-b5710d045323" xlink:href="abvx-20250930.xsd#abvx_ProceedsFromReimbursementsOfDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_94b86fae-dcd7-4de6-9221-34b3192ed1a2" xlink:to="loc_abvx_ProceedsFromReimbursementsOfDeposits_d684fb7a-04ce-4deb-92f6-b5710d045323" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsInvestingActivities_2be53cce-a6c1-4189-a28d-5e876e9e2d5c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestReceivedClassifiedAsInvestingActivities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_94b86fae-dcd7-4de6-9221-34b3192ed1a2" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsInvestingActivities_2be53cce-a6c1-4189-a28d-5e876e9e2d5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_9d08574e-a289-4681-95f8-8fc6ce2a2a9b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_94b86fae-dcd7-4de6-9221-34b3192ed1a2" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_9d08574e-a289-4681-95f8-8fc6ce2a2a9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_ac59e2e4-d720-4962-9fe7-d8c5080bc1ae" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_ifrs-full_ProfitLoss_ac59e2e4-d720-4962-9fe7-d8c5080bc1ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_706f16ae-2845-43fd-bf78-830af70f7797" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_706f16ae-2845-43fd-bf78-830af70f7797" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_ca9d5fdc-2188-4353-8110-d1cbb55600b8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_ca9d5fdc-2188-4353-8110-d1cbb55600b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_6321c266-c123-459c-95c9-8505cb8fe031" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_6321c266-c123-459c-95c9-8505cb8fe031" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_AdjustmentsForNetGainOnSaleOfTreasuryShares_00dde036-750b-423e-90ff-caa65a4ee031" xlink:href="abvx-20250930.xsd#abvx_AdjustmentsForNetGainOnSaleOfTreasuryShares"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_abvx_AdjustmentsForNetGainOnSaleOfTreasuryShares_00dde036-750b-423e-90ff-caa65a4ee031" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_AdjustmentsForOtherFinanceCosts_0f898d2a-d21f-4272-836a-53ea2bb7f45d" xlink:href="abvx-20250930.xsd#abvx_AdjustmentsForOtherFinanceCosts"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_abvx_AdjustmentsForOtherFinanceCosts_0f898d2a-d21f-4272-836a-53ea2bb7f45d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_AdjustmentsForOtherFinanceIncome_93c6fd3e-e151-4c53-b6f0-e956380d323a" xlink:href="abvx-20250930.xsd#abvx_AdjustmentsForOtherFinanceIncome"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_abvx_AdjustmentsForOtherFinanceIncome_93c6fd3e-e151-4c53-b6f0-e956380d323a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_AdjustmentsForUnwindingOfDiscountRelatedToConditionalAdvances_12808c28-a4bb-43d9-9697-fab6048fe3f0" xlink:href="abvx-20250930.xsd#abvx_AdjustmentsForUnwindingOfDiscountRelatedToConditionalAdvances"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_abvx_AdjustmentsForUnwindingOfDiscountRelatedToConditionalAdvances_12808c28-a4bb-43d9-9697-fab6048fe3f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_8b50b4f0-7e41-4155-acb0-76335081ef9c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForFairValueGainsLosses"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_8b50b4f0-7e41-4155-acb0-76335081ef9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_AdjustmentsForForgivenessOfCovid19ConditionalAdvances_99849a79-b5ee-47de-b459-4bf867cf30b3" xlink:href="abvx-20250930.xsd#abvx_AdjustmentsForForgivenessOfCovid19ConditionalAdvances"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_abvx_AdjustmentsForForgivenessOfCovid19ConditionalAdvances_99849a79-b5ee-47de-b459-4bf867cf30b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_037189d9-f054-4564-9a6e-9b49e78bee6f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_17ec23c3-42dc-4f40-8de2-5257c00d8274" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_037189d9-f054-4564-9a6e-9b49e78bee6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingShares_28007b1d-ca45-4383-940c-f9d0bcb2faef" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromIssuingShares"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_ifrs-full_ProceedsFromIssuingShares_28007b1d-ca45-4383-940c-f9d0bcb2faef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_PaymentsForProceedsFromShareIssueRelatedCostsCredit_8d7fc660-82cf-4d74-bf51-ad0f87da626f" xlink:href="abvx-20250930.xsd#abvx_PaymentsForProceedsFromShareIssueRelatedCostsCredit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_abvx_PaymentsForProceedsFromShareIssueRelatedCostsCredit_8d7fc660-82cf-4d74-bf51-ad0f87da626f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_NetProceedsFromNonConvertibleLoansNotes_4ffa26a6-df91-4c6a-918a-18cb5a1b1c9b" xlink:href="abvx-20250930.xsd#abvx_NetProceedsFromNonConvertibleLoansNotes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_abvx_NetProceedsFromNonConvertibleLoansNotes_4ffa26a6-df91-4c6a-918a-18cb5a1b1c9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromExerciseOfWarrants_dda5fdee-7258-4edc-8905-2fce001da9fd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromExerciseOfWarrants"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_ifrs-full_ProceedsFromExerciseOfWarrants_dda5fdee-7258-4edc-8905-2fce001da9fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_RepaymentsOfNonConvertibleLoansNotes_6deeac00-b106-4e1c-8cbe-187d45968b8e" xlink:href="abvx-20250930.xsd#abvx_RepaymentsOfNonConvertibleLoansNotes"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_abvx_RepaymentsOfNonConvertibleLoansNotes_6deeac00-b106-4e1c-8cbe-187d45968b8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_RepaymentsOfConvertibleLoansNotes_47f7c8de-6b1a-4278-a5d4-f45d2d50bb54" xlink:href="abvx-20250930.xsd#abvx_RepaymentsOfConvertibleLoansNotes"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_abvx_RepaymentsOfConvertibleLoansNotes_47f7c8de-6b1a-4278-a5d4-f45d2d50bb54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_RepaymentsOfPGE_9b6c359c-098c-48a6-8765-d15f0d5b5f79" xlink:href="abvx-20250930.xsd#abvx_RepaymentsOfPGE"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_abvx_RepaymentsOfPGE_9b6c359c-098c-48a6-8765-d15f0d5b5f79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSaleOrIssueOfTreasuryShares_27c16fa6-0015-4d2e-8e7f-7a740de6331e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromSaleOrIssueOfTreasuryShares"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_ifrs-full_ProceedsFromSaleOrIssueOfTreasuryShares_27c16fa6-0015-4d2e-8e7f-7a740de6331e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_RepaymentsOfConditionalAdvances_6f4c57db-364f-4170-92f9-0602cad648ea" xlink:href="abvx-20250930.xsd#abvx_RepaymentsOfConditionalAdvances"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_abvx_RepaymentsOfConditionalAdvances_6f4c57db-364f-4170-92f9-0602cad648ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_2e2e1b4e-f8d8-4ce0-9237-132d1691f028" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_2e2e1b4e-f8d8-4ce0-9237-132d1691f028" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_5e0e0b5a-4e24-4b22-9569-a8718df15e4f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestPaidClassifiedAsFinancingActivities"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_5e0e0b5a-4e24-4b22-9569-a8718df15e4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_9896274a-fa95-49e0-ab94-3cc0a4d5dc02" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fce00fd6-60c1-4b81-89d3-635665a9dd53" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_9896274a-fa95-49e0-ab94-3cc0a4d5dc02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_571ae95e-f071-434f-bb60-4f501e7c39fd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_9f197bce-b090-45d7-9145-a01d462d8846" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_571ae95e-f071-434f-bb60-4f501e7c39fd" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_9f197bce-b090-45d7-9145-a01d462d8846" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_822fa5e2-3544-412a-80c7-f47ff0e5555c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_571ae95e-f071-434f-bb60-4f501e7c39fd" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_822fa5e2-3544-412a-80c7-f47ff0e5555c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_680daea5-e0ec-4253-a6c0-1712329c60dd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_571ae95e-f071-434f-bb60-4f501e7c39fd" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_680daea5-e0ec-4253-a6c0-1712329c60dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_167d457d-e064-4fde-980d-bbaabee3af89" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_571ae95e-f071-434f-bb60-4f501e7c39fd" xlink:to="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_167d457d-e064-4fde-980d-bbaabee3af89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_RevaluationOfCashEquivalentsMeasuredAtFairValue_5edc76b7-3806-4eaf-9e21-4c6ac27cf303" xlink:href="abvx-20250930.xsd#abvx_RevaluationOfCashEquivalentsMeasuredAtFairValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_571ae95e-f071-434f-bb60-4f501e7c39fd" xlink:to="loc_abvx_RevaluationOfCashEquivalentsMeasuredAtFairValue_5edc76b7-3806-4eaf-9e21-4c6ac27cf303" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/OtherfinancialassetsDisclosureofotherfinancialassetsDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#OtherfinancialassetsDisclosureofotherfinancialassetsDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/OtherfinancialassetsDisclosureofotherfinancialassetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialAssets_f3a41111-d703-4619-9c76-55b37270090c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentFinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_NonCurrentAdvancesToCROContracts_51f83635-d438-41e1-a6bd-e01cb7267987" xlink:href="abvx-20250930.xsd#abvx_NonCurrentAdvancesToCROContracts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNoncurrentFinancialAssets_f3a41111-d703-4619-9c76-55b37270090c" xlink:to="loc_abvx_NonCurrentAdvancesToCROContracts_51f83635-d438-41e1-a6bd-e01cb7267987" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LongtermDeposits_69f4d001-64ec-4293-b497-21bc6e929c39" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LongtermDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNoncurrentFinancialAssets_f3a41111-d703-4619-9c76-55b37270090c" xlink:to="loc_ifrs-full_LongtermDeposits_69f4d001-64ec-4293-b497-21bc6e929c39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_OtherNonCurrentMiscellaneousFinancialAssets_7b4c1119-1b2e-430d-af65-6a565f9562bc" xlink:href="abvx-20250930.xsd#abvx_OtherNonCurrentMiscellaneousFinancialAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNoncurrentFinancialAssets_f3a41111-d703-4619-9c76-55b37270090c" xlink:to="loc_abvx_OtherNonCurrentMiscellaneousFinancialAssets_7b4c1119-1b2e-430d-af65-6a565f9562bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialAssets_3710e0cd-6666-4fab-adf4-5fc65163c2f7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentFinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentAdvancesToCROContracts_1d7251f4-9073-4814-be22-add859ad40a6" xlink:href="abvx-20250930.xsd#abvx_CurrentAdvancesToCROContracts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentFinancialAssets_3710e0cd-6666-4fab-adf4-5fc65163c2f7" xlink:to="loc_abvx_CurrentAdvancesToCROContracts_1d7251f4-9073-4814-be22-add859ad40a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentReceivablesFromCitibank_28175570-272c-4291-bdef-a2264bf5013c" xlink:href="abvx-20250930.xsd#abvx_CurrentReceivablesFromCitibank"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentFinancialAssets_3710e0cd-6666-4fab-adf4-5fc65163c2f7" xlink:to="loc_abvx_CurrentReceivablesFromCitibank_28175570-272c-4291-bdef-a2264bf5013c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermDepositsNotClassifiedAsCashEquivalents_9850b268-4e20-4163-b326-131fb626608a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ShorttermDepositsNotClassifiedAsCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentFinancialAssets_3710e0cd-6666-4fab-adf4-5fc65163c2f7" xlink:to="loc_ifrs-full_ShorttermDepositsNotClassifiedAsCashEquivalents_9850b268-4e20-4163-b326-131fb626608a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/OtherreceivablesandassetsDisclosureofotherreceivablesandotherassetsDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#OtherreceivablesandassetsDisclosureofotherreceivablesandotherassetsDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/OtherreceivablesandassetsDisclosureofotherreceivablesandotherassetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_9c6446e8-fee4-4b13-bbcf-a151d03cfef6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_NonCurrentPrepaidExpenses_9bc12ccb-d96a-4634-8886-101362cd2b9c" xlink:href="abvx-20250930.xsd#abvx_NonCurrentPrepaidExpenses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_9c6446e8-fee4-4b13-bbcf-a151d03cfef6" xlink:to="loc_abvx_NonCurrentPrepaidExpenses_9bc12ccb-d96a-4634-8886-101362cd2b9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_565beb24-612f-4dfc-80c4-45f093faaf96" xlink:href="abvx-20250930.xsd#abvx_CurrentReceivablesAndCurrentPrepaidExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentResearchTaxCreditReceivables_f4b42ef7-7b1d-484a-a3d7-e6d7787ac247" xlink:href="abvx-20250930.xsd#abvx_CurrentResearchTaxCreditReceivables"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_565beb24-612f-4dfc-80c4-45f093faaf96" xlink:to="loc_abvx_CurrentResearchTaxCreditReceivables_f4b42ef7-7b1d-484a-a3d7-e6d7787ac247" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentValueAddedTaxReceivables_8068a7d2-8e65-481b-8712-4237ec52bc26" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentValueAddedTaxReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_565beb24-612f-4dfc-80c4-45f093faaf96" xlink:to="loc_ifrs-full_CurrentValueAddedTaxReceivables_8068a7d2-8e65-481b-8712-4237ec52bc26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPrepaidExpenses_d64c4ae5-37e3-4d2b-b4b5-9b7239279093" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentPrepaidExpenses"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_565beb24-612f-4dfc-80c4-45f093faaf96" xlink:to="loc_ifrs-full_CurrentPrepaidExpenses_d64c4ae5-37e3-4d2b-b4b5-9b7239279093" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentReceivablesForEmployeeBenefits_69a4d1ae-ac7d-4de4-a213-7cf6dae2966f" xlink:href="abvx-20250930.xsd#abvx_CurrentReceivablesForEmployeeBenefits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_565beb24-612f-4dfc-80c4-45f093faaf96" xlink:to="loc_abvx_CurrentReceivablesForEmployeeBenefits_69a4d1ae-ac7d-4de4-a213-7cf6dae2966f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentReceivablesFromCreditNotes_36796719-41cc-4e11-b14e-570729c8c3bf" xlink:href="abvx-20250930.xsd#abvx_CurrentReceivablesFromCreditNotes"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_565beb24-612f-4dfc-80c4-45f093faaf96" xlink:to="loc_abvx_CurrentReceivablesFromCreditNotes_36796719-41cc-4e11-b14e-570729c8c3bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAssets_25194bfd-f64f-470a-90a3-3840c8916579" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_268681ce-2c3f-40fb-84a9-2d7deb4e349c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_25194bfd-f64f-470a-90a3-3840c8916579" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_268681ce-2c3f-40fb-84a9-2d7deb4e349c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_bfcd56e3-02ec-43c0-8efa-85de68c7739e" xlink:href="abvx-20250930.xsd#abvx_CurrentReceivablesAndCurrentPrepaidExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherAssets_25194bfd-f64f-470a-90a3-3840c8916579" xlink:to="loc_abvx_CurrentReceivablesAndCurrentPrepaidExpenses_bfcd56e3-02ec-43c0-8efa-85de68c7739e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/CashandcashequivalentsDisclosureofcompositionofcashandcashequivalentsDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#CashandcashequivalentsDisclosureofcompositionofcashandcashequivalentsDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/CashandcashequivalentsDisclosureofcompositionofcashandcashequivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_2b66523f-5e9d-419c-942c-b6b91a5b02f8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashEquivalents_8e2cb241-ac43-4125-9f35-89b6d75761d2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_2b66523f-5e9d-419c-942c-b6b91a5b02f8" xlink:to="loc_ifrs-full_CashEquivalents_8e2cb241-ac43-4125-9f35-89b6d75761d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Cash_837a2e5a-0645-43c0-960d-e64cf9190080" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Cash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_2b66523f-5e9d-419c-942c-b6b91a5b02f8" xlink:to="loc_ifrs-full_Cash_837a2e5a-0645-43c0-960d-e64cf9190080" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/SharebasedpaymentsDisclosureofbreakdownofthecompensationexpensesDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#SharebasedpaymentsDisclosureofbreakdownofthecompensationexpensesDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/SharebasedpaymentsDisclosureofbreakdownofthecompensationexpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_95ffd515-7369-4a86-9d85-d13f41f222cc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpenseFromSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_1d1335cc-07df-4586-89cd-a96bf64d2abf" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_95ffd515-7369-4a86-9d85-d13f41f222cc" xlink:to="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_1d1335cc-07df-4586-89cd-a96bf64d2abf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_ExpenseFromEquitySettledShareBasedPaymentTransactionsSocialTaxes_ef61183b-9e31-422c-97be-a4b61e365d4c" xlink:href="abvx-20250930.xsd#abvx_ExpenseFromEquitySettledShareBasedPaymentTransactionsSocialTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_95ffd515-7369-4a86-9d85-d13f41f222cc" xlink:to="loc_abvx_ExpenseFromEquitySettledShareBasedPaymentTransactionsSocialTaxes_ef61183b-9e31-422c-97be-a4b61e365d4c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/FinancialliabilitiesDisclosureoffinancialliabilitiesbreakdownDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#FinancialliabilitiesDisclosureoffinancialliabilitiesbreakdownDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/FinancialliabilitiesDisclosureoffinancialliabilitiesbreakdownDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_b59425ad-2d38-406d-89b3-200f23f23f9f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilities_48615456-46ef-4295-8b77-1cd2fd524899" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentFinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_b59425ad-2d38-406d-89b3-200f23f23f9f" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilities_48615456-46ef-4295-8b77-1cd2fd524899" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilities_e18207b7-96d9-4176-a512-fe2d6754880f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_b59425ad-2d38-406d-89b3-200f23f23f9f" xlink:to="loc_ifrs-full_CurrentFinancialLiabilities_e18207b7-96d9-4176-a512-fe2d6754880f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/FinancialliabilitiesDisclosureofremainingcontractualmaturitiesoffinancialliabilitiesDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#FinancialliabilitiesDisclosureofremainingcontractualmaturitiesoffinancialliabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/FinancialliabilitiesDisclosureofremainingcontractualmaturitiesoffinancialliabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_85f2fb39-2e92-4713-8bed-8fdc6bc7798a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_ConvertibleLoansNotes_ec88847b-b575-4d34-bf8b-0d2c394cb386" xlink:href="abvx-20250930.xsd#abvx_ConvertibleLoansNotes"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_85f2fb39-2e92-4713-8bed-8fdc6bc7798a" xlink:to="loc_abvx_ConvertibleLoansNotes_ec88847b-b575-4d34-bf8b-0d2c394cb386" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Borrowings_89f24a6d-ad56-461f-9908-b5e18bca26c6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Borrowings"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_85f2fb39-2e92-4713-8bed-8fdc6bc7798a" xlink:to="loc_ifrs-full_Borrowings_89f24a6d-ad56-461f-9908-b5e18bca26c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_NonCurrentRoyaltyCertificates_4d152dbf-202c-4fd8-8f0b-bc8e83eb521c" xlink:href="abvx-20250930.xsd#abvx_NonCurrentRoyaltyCertificates"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_85f2fb39-2e92-4713-8bed-8fdc6bc7798a" xlink:to="loc_abvx_NonCurrentRoyaltyCertificates_4d152dbf-202c-4fd8-8f0b-bc8e83eb521c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_9b5bcb6f-e760-4902-9f94-a0b5e86500ad" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LeaseLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_85f2fb39-2e92-4713-8bed-8fdc6bc7798a" xlink:to="loc_ifrs-full_LeaseLiabilities_9b5bcb6f-e760-4902-9f94-a0b5e86500ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialLiabilities_c75d527e-fc48-4b24-bc63-cd1184827086" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DerivativeFinancialLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_85f2fb39-2e92-4713-8bed-8fdc6bc7798a" xlink:to="loc_ifrs-full_DerivativeFinancialLiabilities_c75d527e-fc48-4b24-bc63-cd1184827086" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_FinancialLiabilitiesUndiscountedCashFlows_6f0f290a-0bb9-43c4-8c16-a76461328f29" xlink:href="abvx-20250930.xsd#abvx_FinancialLiabilitiesUndiscountedCashFlows"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_ConvertibleLoansNotesUndiscountedCashFlows_9331ad1e-7879-4f0d-860e-2cb9d8c1785a" xlink:href="abvx-20250930.xsd#abvx_ConvertibleLoansNotesUndiscountedCashFlows"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_FinancialLiabilitiesUndiscountedCashFlows_6f0f290a-0bb9-43c4-8c16-a76461328f29" xlink:to="loc_abvx_ConvertibleLoansNotesUndiscountedCashFlows_9331ad1e-7879-4f0d-860e-2cb9d8c1785a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BankBorrowingsUndiscountedCashFlows_19821c5c-9f44-43b2-aa89-236c9cd24d1b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_BankBorrowingsUndiscountedCashFlows"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_FinancialLiabilitiesUndiscountedCashFlows_6f0f290a-0bb9-43c4-8c16-a76461328f29" xlink:to="loc_ifrs-full_BankBorrowingsUndiscountedCashFlows_19821c5c-9f44-43b2-aa89-236c9cd24d1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_RoyaltyCertificatesUndiscountedCashFlows_bf6bb015-b14b-4c2e-8aff-7405d2f2e1ff" xlink:href="abvx-20250930.xsd#abvx_RoyaltyCertificatesUndiscountedCashFlows"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_FinancialLiabilitiesUndiscountedCashFlows_6f0f290a-0bb9-43c4-8c16-a76461328f29" xlink:to="loc_abvx_RoyaltyCertificatesUndiscountedCashFlows_bf6bb015-b14b-4c2e-8aff-7405d2f2e1ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GrossLeaseLiabilities_b6f99b23-56f9-422b-b235-f24d4729c0f5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GrossLeaseLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_FinancialLiabilitiesUndiscountedCashFlows_6f0f290a-0bb9-43c4-8c16-a76461328f29" xlink:to="loc_ifrs-full_GrossLeaseLiabilities_b6f99b23-56f9-422b-b235-f24d4729c0f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialLiabilitiesUndiscountedCashFlows_3b6d317f-de49-4ccc-8625-9a2eb3fa7e92" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DerivativeFinancialLiabilitiesUndiscountedCashFlows"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_FinancialLiabilitiesUndiscountedCashFlows_6f0f290a-0bb9-43c4-8c16-a76461328f29" xlink:to="loc_ifrs-full_DerivativeFinancialLiabilitiesUndiscountedCashFlows_3b6d317f-de49-4ccc-8625-9a2eb3fa7e92" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/PayablesandothercurrentliabilitiesDisclosureofbreakdownoftradeandotherpayablesDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#PayablesandothercurrentliabilitiesDisclosureofbreakdownoftradeandotherpayablesDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/PayablesandothercurrentliabilitiesDisclosureofbreakdownoftradeandotherpayablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_935851d8-a73d-4b27-b48b-59ea1684ab6c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_cb5f4455-919e-45d6-b38c-bc4c8429886b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_TradeAndOtherCurrentPayables_935851d8-a73d-4b27-b48b-59ea1684ab6c" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_cb5f4455-919e-45d6-b38c-bc4c8429886b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AccrualsClassifiedAsCurrent_16a2685a-413d-4435-9e8e-d47f57adaad1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AccrualsClassifiedAsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_TradeAndOtherCurrentPayables_935851d8-a73d-4b27-b48b-59ea1684ab6c" xlink:to="loc_ifrs-full_AccrualsClassifiedAsCurrent_16a2685a-413d-4435-9e8e-d47f57adaad1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentPayables_409d7161-b08a-4065-9b18-6394d4b1713f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_TradeAndOtherCurrentPayables_935851d8-a73d-4b27-b48b-59ea1684ab6c" xlink:to="loc_ifrs-full_OtherCurrentPayables_409d7161-b08a-4065-9b18-6394d4b1713f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/PayablesandothercurrentliabilitiesDisclosureoftaxandemployeerelatedpayablesDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#PayablesandothercurrentliabilitiesDisclosureoftaxandemployeerelatedpayablesDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/PayablesandothercurrentliabilitiesDisclosureoftaxandemployeerelatedpayablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentTaxAndEmployeeBenefitLiabilities_497879f0-3f1e-4377-85d6-5e2a420a71fa" xlink:href="abvx-20250930.xsd#abvx_CurrentTaxAndEmployeeBenefitLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPayablesOnSocialSecurityAndTaxesOtherThanIncomeTax_bc6ac94d-401e-4ae7-8c2f-b59b75928ce9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentPayablesOnSocialSecurityAndTaxesOtherThanIncomeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentTaxAndEmployeeBenefitLiabilities_497879f0-3f1e-4377-85d6-5e2a420a71fa" xlink:to="loc_ifrs-full_CurrentPayablesOnSocialSecurityAndTaxesOtherThanIncomeTax_bc6ac94d-401e-4ae7-8c2f-b59b75928ce9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_CurrentPayablesOnOtherTaxAndRelatedPayments_9653b551-c698-451c-84d5-82b9109ec02b" xlink:href="abvx-20250930.xsd#abvx_CurrentPayablesOnOtherTaxAndRelatedPayments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentTaxAndEmployeeBenefitLiabilities_497879f0-3f1e-4377-85d6-5e2a420a71fa" xlink:to="loc_abvx_CurrentPayablesOnOtherTaxAndRelatedPayments_9653b551-c698-451c-84d5-82b9109ec02b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermEmployeeBenefitsAccruals_37590853-421a-4579-a1c3-577bc5f40e69" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ShorttermEmployeeBenefitsAccruals"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abvx_CurrentTaxAndEmployeeBenefitLiabilities_497879f0-3f1e-4377-85d6-5e2a420a71fa" xlink:to="loc_ifrs-full_ShorttermEmployeeBenefitsAccruals_37590853-421a-4579-a1c3-577bc5f40e69" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/OperatingincomeDisclosureofbreakdownofoperatingincomeDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#OperatingincomeDisclosureofbreakdownofoperatingincomeDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/OperatingincomeDisclosureofbreakdownofoperatingincomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherIncome_b1d0be4d-da4e-42f8-b60a-42603adbc9fe" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_IncomeFromResearchTaxCredit_16cc9031-4888-4c0e-8676-f086d4f783c1" xlink:href="abvx-20250930.xsd#abvx_IncomeFromResearchTaxCredit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_b1d0be4d-da4e-42f8-b60a-42603adbc9fe" xlink:to="loc_abvx_IncomeFromResearchTaxCredit_16cc9031-4888-4c0e-8676-f086d4f783c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromGovernmentGrants_12975898-7d85-4b21-90c5-00faec48d246" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueFromGovernmentGrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_b1d0be4d-da4e-42f8-b60a-42603adbc9fe" xlink:to="loc_ifrs-full_RevenueFromGovernmentGrants_12975898-7d85-4b21-90c5-00faec48d246" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_MiscellaneousOtherOperatingIncomeIncludingAdjustments_da2bde76-9ac5-4ff7-a073-821db07756c3" xlink:href="abvx-20250930.xsd#abvx_MiscellaneousOtherOperatingIncomeIncludingAdjustments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_b1d0be4d-da4e-42f8-b60a-42603adbc9fe" xlink:to="loc_abvx_MiscellaneousOtherOperatingIncomeIncludingAdjustments_da2bde76-9ac5-4ff7-a073-821db07756c3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/OperatingexpensesDisclosureofresearchanddevelopmentexpensesDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#OperatingexpensesDisclosureofresearchanddevelopmentexpensesDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/OperatingexpensesDisclosureofresearchanddevelopmentexpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_ecc48165-acc1-4074-a24a-61731cab7a45" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OperatingExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_SubContractingStudiesAndResearchExpenses_fe64c650-0e3f-4f76-87f4-86920d4d0c86" xlink:href="abvx-20250930.xsd#abvx_SubContractingStudiesAndResearchExpenses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_ecc48165-acc1-4074-a24a-61731cab7a45" xlink:to="loc_abvx_SubContractingStudiesAndResearchExpenses_fe64c650-0e3f-4f76-87f4-86920d4d0c86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EmployeeBenefitsExpense_c80b95e0-f75d-4706-a1f9-6ef982272854" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EmployeeBenefitsExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_ecc48165-acc1-4074-a24a-61731cab7a45" xlink:to="loc_ifrs-full_EmployeeBenefitsExpense_c80b95e0-f75d-4706-a1f9-6ef982272854" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfessionalFeesExpense_c248a7e8-685d-431f-a84c-2723ba7b7378" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfessionalFeesExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_ecc48165-acc1-4074-a24a-61731cab7a45" xlink:to="loc_ifrs-full_ProfessionalFeesExpense_c248a7e8-685d-431f-a84c-2723ba7b7378" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_IntellectualPropertyFees_ce8b3160-8566-47f9-9bad-cd32157530b6" xlink:href="abvx-20250930.xsd#abvx_IntellectualPropertyFees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_ecc48165-acc1-4074-a24a-61731cab7a45" xlink:to="loc_abvx_IntellectualPropertyFees_ce8b3160-8566-47f9-9bad-cd32157530b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_1e3642d8-13c5-4a40-bd29-ea11c766dd25" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_ecc48165-acc1-4074-a24a-61731cab7a45" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_1e3642d8-13c5-4a40-bd29-ea11c766dd25" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abivax.com/role/FinancialgainlossDisclosureofnetfinancialincomelossDetails" xlink:type="simple" xlink:href="abvx-20250930.xsd#FinancialgainlossDisclosureofnetfinancialincomelossDetails"/>
  <link:calculationLink xlink:role="http://www.abivax.com/role/FinancialgainlossDisclosureofnetfinancialincomelossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnBonds_630f4f4f-7303-4095-80e7-25b8537f9044" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseOnBonds"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_ifrs-full_InterestExpenseOnBonds_630f4f4f-7303-4095-80e7-25b8537f9044" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnDebtInstrumentsIssued_e29c3d9e-0a85-497f-aef6-6497c346f85a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseOnDebtInstrumentsIssued"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_ifrs-full_InterestExpenseOnDebtInstrumentsIssued_e29c3d9e-0a85-497f-aef6-6497c346f85a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnBorrowings_37457d90-de5b-43c0-b1fc-681e09f7c9a3" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseOnBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_ifrs-full_InterestExpenseOnBorrowings_37457d90-de5b-43c0-b1fc-681e09f7c9a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_InterestExpenseOnRoyaltyCertificates_74875589-a753-4c10-862e-fd3e5a2d04aa" xlink:href="abvx-20250930.xsd#abvx_InterestExpenseOnRoyaltyCertificates"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_abvx_InterestExpenseOnRoyaltyCertificates_74875589-a753-4c10-862e-fd3e5a2d04aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_46b2777c-5bfc-4f00-94bb-391a71d060ad" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_46b2777c-5bfc-4f00-94bb-391a71d060ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LossesOnChangeInFairValueOfDerivatives_d95af9e5-76c7-4dfa-96a5-ca39d9a1bed4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LossesOnChangeInFairValueOfDerivatives"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_ifrs-full_LossesOnChangeInFairValueOfDerivatives_d95af9e5-76c7-4dfa-96a5-ca39d9a1bed4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_LossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_432f6a36-ac32-45cf-bd70-73814a8cc6f4" xlink:href="abvx-20250930.xsd#abvx_LossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_abvx_LossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_432f6a36-ac32-45cf-bd70-73814a8cc6f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_LossesOnFinancialLiabilitiesAtAmortizedCost_8fd26d60-1c0e-462a-8e3b-98c4669e3496" xlink:href="abvx-20250930.xsd#abvx_LossesOnFinancialLiabilitiesAtAmortizedCost"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_abvx_LossesOnFinancialLiabilitiesAtAmortizedCost_8fd26d60-1c0e-462a-8e3b-98c4669e3496" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_TransactionCosts_aa31ad99-f360-4d52-93a9-5d974bd50659" xlink:href="abvx-20250930.xsd#abvx_TransactionCosts"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_abvx_TransactionCosts_aa31ad99-f360-4d52-93a9-5d974bd50659" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_ForeignExchangeLosses_3590e4a0-7a22-497d-8507-75c156bfe508" xlink:href="abvx-20250930.xsd#abvx_ForeignExchangeLosses"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_abvx_ForeignExchangeLosses_3590e4a0-7a22-497d-8507-75c156bfe508" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinanceCost_019b09a9-1599-79c9-ba9d-f6c57eea19f6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherFinanceCost"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_85dd31aa-a6eb-435e-996a-2a90ed4e9403" xlink:to="loc_ifrs-full_OtherFinanceCost_019b09a9-1599-79c9-ba9d-f6c57eea19f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_a04fc847-a620-473b-bfbd-e50785714c60" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromInterest_326d160a-df6f-42bf-9b87-d60d877045cb" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueFromInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_a04fc847-a620-473b-bfbd-e50785714c60" xlink:to="loc_ifrs-full_RevenueFromInterest_326d160a-df6f-42bf-9b87-d60d877045cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsOnChangeInFairValueOfDerivatives_2bf99293-35a6-4be9-85bb-7ffe3affefda" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GainsOnChangeInFairValueOfDerivatives"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_a04fc847-a620-473b-bfbd-e50785714c60" xlink:to="loc_ifrs-full_GainsOnChangeInFairValueOfDerivatives_2bf99293-35a6-4be9-85bb-7ffe3affefda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_GainsOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_a66d5387-5921-4cb6-8002-f5efc9f71711" xlink:href="abvx-20250930.xsd#abvx_GainsOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_a04fc847-a620-473b-bfbd-e50785714c60" xlink:to="loc_abvx_GainsOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_a66d5387-5921-4cb6-8002-f5efc9f71711" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_UnwindingEffectOfDiscountRelatedToAdvancesMadeToCROs_4bb97853-dfbe-4f5c-92a4-8831d1265b22" xlink:href="abvx-20250930.xsd#abvx_UnwindingEffectOfDiscountRelatedToAdvancesMadeToCROs"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_a04fc847-a620-473b-bfbd-e50785714c60" xlink:to="loc_abvx_UnwindingEffectOfDiscountRelatedToAdvancesMadeToCROs_4bb97853-dfbe-4f5c-92a4-8831d1265b22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abvx_GainsArisingFromRecognitionOfFinancialLiabilities_e049bffd-73ed-4b27-9b77-08a1e0a61ec4" xlink:href="abvx-20250930.xsd#abvx_GainsArisingFromRecognitionOfFinancialLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_a04fc847-a620-473b-bfbd-e50785714c60" xlink:to="loc_abvx_GainsArisingFromRecognitionOfFinancialLiabilities_e049bffd-73ed-4b27-9b77-08a1e0a61ec4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ForeignExchangeGain_231391d9-a088-4e0f-9936-4b8fc7278caa" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ForeignExchangeGain"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_a04fc847-a620-473b-bfbd-e50785714c60" xlink:to="loc_ifrs-full_ForeignExchangeGain_231391d9-a088-4e0f-9936-4b8fc7278caa" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
