v3.25.4
Share-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2025
Share-Based Payment Arrangement [Abstract]  
Schedule of Share-based Compensation Expense Related to Share Options, RSUs, PSRUs and Grants Under ESPP
Share-based compensation expense related to RSUs, PRSUs, share options and grants under our ESPP was as follows (in thousands):
Year Ended December 31,
202520242023
Selling, general and administrative$186,622 $158,570 $146,942 
Research and development86,480 74,673 64,847 
Cost of product sales18,031 14,802 15,052 
Total share-based compensation expense, pre-tax291,133 248,045 226,841 
Income tax benefit from share-based compensation expense(51,810)(40,552)(40,015)
Total share-based compensation expense, net of tax$239,323 $207,493 $186,826 
Schedule of RSU and PRSU Activity
The following table summarizes information as of December 31, 2025 and activity during 2025 related to our RSUs:
Number of RSUs (In thousands)Weighted-
Average
Grant-Date
Fair Value		Weighted-
Average
Remaining
Contractual
Term (Years)		Aggregate
Intrinsic
Value
(In thousands)
Outstanding at January 1, 20254,033 $133.60 
RSUs granted2,261 139.80 
RSUs released(1,464)140.28 
RSUs forfeited(424)132.38 
Outstanding at December 31, 20254,406 $134.68 1.3$749,044 
The following table summarizes information as of December 31, 2025 and activity during 2025 related to our PRSUs:
Number of PRSUs (In thousands)Weighted-
Average
Grant-Date
Fair Value		Weighted-
Average
Remaining
Contractual
Term (Years)		Aggregate
Intrinsic
Value
(In thousands)
Outstanding at January 1, 2025781 $150.82 
PRSUs granted334 168.75 
PRSUs released(154)171.37 
PRSUs forfeited(172)161.31 
Outstanding at December 31, 2025789 $152.16 1.5$134,181 
Schedule of Information and Activity Related to Share Option Plans Activity
The following table summarizes information as of December 31, 2025 and activity during 2025 related to our share option plans:
Shares
Subject to
Outstanding
Options
(In thousands)		Weighted-
Average
Exercise
Price		Weighted-
Average
Remaining
Contractual
Term (Years)		Aggregate
Intrinsic
Value
(In thousands)
Outstanding at January 1, 20252,158 $139.79 
Options exercised(658)134.51 
Options expired(340)167.80 
Outstanding at December 31, 20251,160 $134.57 3.0$41,403 
Vested and exercisable at December 31, 20251,160 $134.57 3.0$41,403 
The following table summarizes information as of December 31, 2025 and activity during 2025 related to our nominal strike price options:
Shares
Subject to
Outstanding
Options
(In thousands)		Weighted-
Average
Exercise
Price		Weighted-
Average
Remaining
Contractual
Term (Years)		Aggregate
Intrinsic
Value
(In thousands)
Outstanding at January 1, 202519 $0.02 
Options exercised(10)0.02 
Outstanding at December 31, 20259 $0.02 4.8$1,496 
Vested and exercisable at December 31, 20259 $0.02 4.8$1,496