SHARE-BASED COMPENSATION (Tables)
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12 Months Ended |
Dec. 31, 2025 |
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| Share-Based Payment Arrangement [Abstract] |
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| Schedule of Balances by Plan |
As of December 31, 2025, the Company had the following balances by plan: | | | | | | | | | | | | | | | | | | | | | Restricted Stock Units Outstanding | | Stock Options Outstanding | | | | Shares Available for Issuance | | Inducement Awards | — | | | 7,751,302 | | | | | — | | | 2020 Plan | — | | | 51,188 | | | | | — | | | 2016 Plan | 1,064,375 | | | 6,666,137 | | | | | 10,247,537 | | | | | | | | | | | Total | 1,064,375 | | | 14,468,627 | | | | | 10,247,537 | |
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| Schedule of Restricted Stock Units |
A summary of RSU activity is as follows: | | | | | | | | | | | | | RSUs | | Weighted-Average Grant Date Fair Value per Share | Outstanding at December 31, 2024 | 314,075 | | | $ | 15.51 | | | Granted | 921,478 | | | $ | 15.52 | | | Vested | (95,617) | | | $ | 15.63 | | | Forfeited | (75,561) | | | $ | 15.48 | | Outstanding at December 31, 2025 | 1,064,375 | | | $ | 15.51 | |
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| Schedule of Stock Option Activity |
A summary of common stock option activity is as follows: | | | | | | | | | | | | | | | | | | | | | | | | | Number of Options | | Weighted-Average Exercise Price Per Share | | Weighted-Average Remaining Contractual Term
(years) | | Aggregate Intrinsic Value
(in thousands) | | Outstanding as of December 31, 2024 | 11,348,519 | | | $ | 18.11 | | | 7.9 | | $ | 37,138 | | | Granted | 6,271,027 | | | 16.32 | | | | | | | Exercised | (811,970) | | | 14.84 | | | | | | | Forfeited | (770,843) | | | 20.51 | | | | | | | Expired | (1,568,106) | | | 23.33 | | | | | | | Outstanding as of December 31, 2025 | 14,468,627 | | | $ | 16.82 | | | 8.4 | | $ | 209,090 | | | Exercisable as of December 31, 2025 | 5,032,644 | | | $ | 17.74 | | | 7.8 | | $ | 69,057 | |
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| Schedule of Fair Value Assumptions for Stock Options |
The fair value was determined by the Black-Scholes option pricing model using the following weighted-average assumptions: | | | | | | | | | | | | | | | | | | | Year Ended
December 31, | | 2025 | | 2024 | | 2023 | | Expected term, in years | 5.0 | | 5.1 | | 5.6 | | Expected volatility | 83 | % | | 88 | % | | 90 | % | | Risk-free interest rate | 3.9 | % | | 4.3 | % | | 4.3 | % | | Expected dividend yield | — | % | | — | % | | — | % | | Weighted average exercise price | $ | 16.32 | | | $ | 16.45 | | | $ | 21.61 | |
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| Schedule of Allocation of Share-based Compensation Expense |
Share-based compensation related to all equity awards issued pursuant to the Equity Incentive Plans, the Inducement Awards and for estimated shares to be issued under the ESPP for the purchase periods active during each respective period is included in the consolidated statements of operations and comprehensive loss as follows: | | | | | | | | | | | | | | | | | | | | | | | | | Year Ended
December 31, | | | | | | 2025 | | 2024 | | 2023 | | | | | | (in thousands) | | Research and development | | | | | $ | 21,514 | | | $ | 22,345 | | | $ | 16,220 | | | Selling, general and administrative | | | | | 22,789 | | | 19,805 | | | 50,952 | | | Total share-based compensation expense | | | | | $ | 44,303 | | | $ | 42,150 | | | $ | 67,172 | |
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