SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Significant Accounting Policies [Text Block]
Stephen Mahoney [Member]
Stephen Mahoney
Statistical Measurement [Domain]
Statistical Measurement [Domain]
Marketable Securities
Investment, Policy [Policy Text Block]
Schedule of Debt Securities, Available-for-sale
Debt Securities, Available-for-Sale [Table Text Block]
Operating lease, liability, current, statement of financial position [Extensible List]
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Award Timing Predetermined
Award Timing Predetermined [Flag]
Entity File Number
Entity File Number
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Net deferred tax assets before valuation allowance
Deferred Tax Assets, Net, Before Valuation Allowance
Deferred Tax Assets, Net, Before Valuation Allowance
Valuation Approach and Technique [Domain]
Valuation Approach and Technique [Domain]
Debt and Debt Issuance Costs And Liability Related to the Sale of Future Revenue
Debt, Policy [Policy Text Block]
Debt instrument, face amount, fourth tranche
Debt Instrument, Face Amount, Fourth Tranche
Debt Instrument, Face Amount, Fourth Tranche
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
2024 Public Offering
2024 Public Offering [Member]
2024 Public Offering
Tabular List, Table
Tabular List [Table Text Block]
Recently Issued Accounting Standard Updates
New Accounting Pronouncements, Policy [Policy Text Block]
Accounts payable
Increase (Decrease) in Accounts Payable
Weighted-average share price (in dollars per share)
Sale Of Stock, Weighted Average Share Price
Sale Of Stock, Weighted Average Share Price
Commercial milestone payments
Collaboration Arrangement, Commercial Milestone Payment, Intellectual Property Rights Development, Maximum
Collaboration Arrangement, Commercial Milestone Payment, Intellectual Property Rights Development, Maximum
Research and development credit
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
License revenue
License
License [Member]
Gross Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Long-term debt, net
Secured Long-Term Debt, Noncurrent
Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Beginning balance (in shares)
Ending balance (in shares)
Class of Warrant or Right, Outstanding
Net loss per share, basic (in dollars per share)
Earnings Per Share, Basic
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Liabilities:
Liabilities, Fair Value Disclosure [Abstract]
Fairmount Funds Management
Fairmount Funds Management [Member]
Fairmount Funds Management
Stock-based expense
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Total deferred tax assets
Deferred Tax Assets, Gross
Stock, Class of Stock [Table]
Stock, Class of Stock [Table]
Tax benefit
Share-Based Payment Arrangement, Exercise of Option, Tax Benefit
Measurement Input, Discount Rate
Measurement Input, Discount Rate [Member]
Schedule of Segment Reporting Information, by Segment
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Issuance of common stock upon vesting of restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Issuance of common stock for cash under employee stock purchase plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
ATM Agreement
At-The-Market Offering [Member]
At-the-market Offering [Member]
July 1, 2024 through December 15, 2024
Debt Covenant Period Two [Member]
Debt Covenant Period Two
Schedule of Derivative Liabilities at Fair Value
Schedule of Derivative Liabilities at Fair Value [Table Text Block]
Area of property
Area of Real Estate Property
Measurement Input Type [Domain]
Measurement Input Type [Domain]
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Zenas BioPharma
Zenas BioPharma [Member]
Zenas BioPharma
Share-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Operating lease liability derecognized
Operating Lease, Liability, Current Derecognized
Operating Lease, Liability, Current Derecognized
Options to purchase common stock
Share-Based Payment Arrangement, Option [Member]
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Research and Development
Research and Development Expense, Policy [Policy Text Block]
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Percent
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Total stockholders’ equity
Beginning balance
Ending balance
Equity, Attributable to Parent
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Other comprehensive income (loss):
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Insider Trading Policies and Procedures [Line Items]
Total share-based compensation expense
Share-based compensation expense (see Note 12)
Share-Based Payment Arrangement, Expense
Schedule of Components of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Issuance of stock, net of issuance cost (in shares)
Stock Issued During Period, Shares, New Issues
Current assets:
Assets, Current [Abstract]
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Total liabilities and stockholders’ equity
Liabilities and Equity
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Fair Value, Recurring
Fair Value, Recurring [Member]
Number of Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Concentrations of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Liabilities and Stockholders’ Equity
Liabilities and Equity [Abstract]
State and Local Jurisdiction
State and Local Jurisdiction [Member]
Cover [Abstract]
Cover [Abstract]
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Going Concern
Going Concern, Policy [Policy Text Block]
Going Concern [Policy Text Block]
Maximum
Maximum [Member]
Exercisable (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Accrued interest
Unrecognized Tax Benefits, Interest on Income Taxes Accrued
Schedule of Future Lease Payments under Noncancelable Leases
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Pay vs Performance Disclosure [Line Items]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Issuance of common stock upon exercises of warrants
Stock Issued During Period, Value, Warrants Exercised, Value
Stock Issued During Period, Value, Warrants Exercised, Value
Total discounted lease liabilities
Operating Lease, Liability
Retirement Benefits [Abstract]
Series B Convertible Preferred Stock
Series B Convertible Preferred Stock
Series B convertible preferred stock, as converted to shares of common stock
Series B Preferred Stock [Member]
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Issuance of common stock under license agreement (in shares)
Stock Issued During Period, Shares, Issued for Services
PURCHASE AND SALE OF THE REVENUE PARTICIPATION RIGHT
Purchase And Sale Of Revenue Participation Right [Text Block]
Purchase And Sale Of Revenue Participation Right
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Debt Covenant Period [Domain]
Debt Covenant Period [Domain]
Debt Covenant Period [Domain]
Entity Shell Company
Entity Shell Company
Other liabilities
Other Liabilities, Noncurrent
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-Term Debt Instruments [Table]
Proceeds from sale of future revenue
Proceeds from Issuance of Debt
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Exercised (in dollars per share)
Class of Warrant or Right, Exercised In Period, Weighted Average Grant Date Fair Value
Class of Warrant or Right, Exercised In Period, Weighted Average Grant Date Fair Value
Operating loss subject to expiration
Operating Loss Carryforwards, Subject To Expiration
Operating Loss Carryforwards, Subject To Expiration
Sale of Future Revenue, Royalty Payments, Tier 3
Sale of Future Revenue, Royalty Payments, Tier 3 [Member]
Sale of Future Revenue, Royalty Payments, Tier 3
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Company Selected Measure Amount
Company Selected Measure Amount
2028
Lessee, Operating Lease, Liability, to be Paid, Year Three
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Expired (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Measurement Input Type [Axis]
Measurement Input Type [Axis]
Name
Measure Name
Number of underlying shares (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights, Net
Class of Warrant or Right, Number of Securities Called by Warrants or Rights, Net
Schedule of Allocation of Share-based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Secured Debt
Secured Debt [Member]
Operating lease liabilities, short-term
Operating Lease, Liability, Current
Class of Stock [Line Items]
Class of Stock [Line Items]
Document Fiscal Period Focus
Document Fiscal Period Focus
Award Timing Method
Award Timing Method [Text Block]
Paragon Therapeutics
Paragon Therapeutics [Member]
Paragon Therapeutics
Furniture and fixtures
Furniture and Fixtures [Member]
Award Type [Axis]
Award Type [Axis]
Number
Class of Warrant or Right, Activity [Roll Forward]
Class of Warrant or Right, Activity [Roll Forward]
Long-term debt, net
Long-Term Debt
Total assets
Assets
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Subtotal
Equity-classified Warrants [Member]
Equity-classified Warrants [Member]
Share-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Trading Symbol
Trading Symbol
2029
Lessee, Operating Lease, Liability, to be Paid, Year Four
Vested (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
2025 Employee Stock Purchase Plan
2025 Employee Stock Purchase Plan [Member]
2025 Employee Stock Purchase Plan
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Income Taxes
Income Tax, Policy [Policy Text Block]
Entity Address, City or Town
Entity Address, City or Town
Cash flows from operating activities:
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Research and development credit
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Other items
Segment Reporting, Other Segment Item, Amount
Net deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Statement of Income Location, Balance [Domain]
Statement of Income Location, Balance [Domain]
Restricted Stock Units Outstanding
Restricted stock units
Restricted Stock Units (RSUs) [Member]
Measurement of Credit Losses
Credit Loss, Financial Instrument [Policy Text Block]
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Assets:
Assets, Fair Value Disclosure [Abstract]
Entity Emerging Growth Company
Entity Emerging Growth Company
Reportable Segment
Reportable Segment [Member]
Reportable Segment
2028
Long-Term Debt, Maturity, Year Three
Research and development
Research and Development Expense (Excluding Acquired in Process Cost)
Impairment charges
Impairment, Long-Lived Asset, Held-for-Use
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Right-of-use asset obtained in exchange for new lease liability
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Maximum interest rate (in percent)
Debt Instrument, Interest Rate, Maximum
Debt Instrument, Interest Rate, Maximum
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Stock options outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member]
Total revenues
License revenue
Revenue from Contract with Customer, Including Assessed Tax
Unamortized debt issuance costs
Debt Issuance Costs, Net
Significant Other Observable Inputs (Level 2)
Fair Value, Inputs, Level 2 [Member]
Document Financial Statement Error Correction [Flag]
Document Financial Statement Error Correction [Flag]
Change in fair value of derivative liability
Change in fair value
Derivative, Gain (Loss) on Derivative, Net
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
Aggregate limitation on utilization of certain net operating losses and credits
Tax Credit Carryforward, Limitations On Use, Amount
Tax Credit Carryforward, Limitations On Use, Amount
Lessee, Operating Lease, Liability, to be Paid [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Sale of Future Revenue, Royalty Payments, Tier 1
Sale of Future Revenue, Royalty Payments, Tier 1 [Member]
Sale of Future Revenue, Royalty Payments, Tier 1
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Plan Name [Axis]
Plan Name [Axis]
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
PEO
PEO [Member]
Lease Contractual Term [Domain]
Lease Contractual Term [Domain]
Proceeds from issuance of long-term debt, net
Proceeds from Issuance of Secured Debt
Interest income
Investment Income, Interest
Debt Covenant Period [Axis]
Debt Covenant Period [Axis]
Debt Covenant Period
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Issuance of common stock upon exercises of stock options
Stock Issued During Period, Value, Stock Options Exercised
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member]
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Accumulated Deficit
Retained Earnings [Member]
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Income Tax Jurisdiction [Axis]
Income Tax Jurisdiction [Axis]
RSUs
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Effective interest rate (in percent)
Debt Instrument, Interest Rate, Effective Percentage
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Restatement Determination Date
Restatement Determination Date
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Income Statement [Abstract]
Income Statement [Abstract]
Cash and cash equivalents
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Effective income tax rate
Income Tax Expense (Benefit)
2025 Public Offering
2025 Public Offering [Member]
2025 Public Offering
Basis spread (in percent)
Debt Instrument, Basis Spread on Variable Rate
Sale of Stock [Domain]
Sale of Stock [Domain]
Sale of Stock [Domain]
Derivative liability
Derivative Liability, Noncurrent
Issuance costs
Debt And Derivative Liability, Issuance Costs
Debt And Derivative Liability, Issuance Costs
Convertible preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Pension Adjustments Service Cost
Pension Adjustments Service Cost [Member]
Segment selling, general and administrative expense
Selling, General And Administrative Expense, Excluding Share-Based Compensation Expense
Selling, General And Administrative Expense, Excluding Share-Based Compensation Expense
Issued February 2020
Equity-classified Warrants, Issued February 2020 [Member]
Equity-classified Warrants, Issued February 2020 [Member]
Beneficial ownership (in percent)
Class of Warrant or Right, Conversion, Percentage Of Ownership
Class of Warrant or Right, Conversion, Percentage Of Ownership
Product and Service [Domain]
Product and Service [Domain]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Property and equipment, gross
Property, Plant and Equipment, Gross
Cash, cash equivalents and short-term investments
Cash, Cash Equivalents, and Short-Term Investments
Issuance of common stock upon the conversion of convertible preferred stock
Conversion of Stock, Amount Issued
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Total liabilities
Liabilities, Fair Value Disclosure
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Convertible Preferred Stock
Stockholders' Equity, Policy [Policy Text Block]
September 2024 Underwritten Offering
September 2024 Underwritten Offering [Member]
September 2024 Underwritten Offering
Amortization expense relating to operating lease right-of-use assets
Operating Lease, Right-of-Use Asset, Periodic Reduction
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
Proceeds from issuance of common stock upon exercise of stock options
Proceeds from Stock Options Exercised
City Area Code
City Area Code
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
All Trading Arrangements
All Trading Arrangements [Member]
Equity Awards Adjustments, Footnote
Equity Awards Adjustments, Footnote [Text Block]
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Total accrued liabilities
Total accrued liabilities
Accrued Liabilities, Current
Other adjustments
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Restricted stock units outstanding (in shares)
Nonvested beginning balance (in shares)
Nonvested ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
ImmunoGen, Inc
ImmunoGen, Inc [Member]
ImmunoGen, Inc
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Tax credit write off
Tax Credit Carryforward, Write Off
Tax Credit Carryforward, Write Off
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Line Items]
Cash flows from investing activities:
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Unrecognized share-based compensation costs related to stock options
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Defined contribution plan, employer matching contribution, percent of match
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Clinical Trial and Nonclinical Study Accruals
Clinical Trials And Nonclinical Study Accruals [Policy Text Block]
Clinical Trials and Pre-clinical Study Accruals [Policy Text Block]
Proceeds from sales of short-term investments
Proceeds from Sale of Debt Securities, Available-for-Sale
Estimated useful lives (in years)
Property, Plant and Equipment, Useful Life
Convertible preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Schedule of Fair Value Assumptions for Stock Options
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Selling, general and administrative
Selling, General and Administrative Expenses [Member]
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
PEO Total Compensation Amount
PEO Total Compensation Amount
Long-term Debt, Type [Axis]
Long-Term Debt, Type [Axis]
Money market funds
Money Market Funds [Member]
Derivative liability, measurement input
Derivative Liability, Measurement Input
Lease Contractual Term [Axis]
Lease Contractual Term [Axis]
Numerator:
Net Income (Loss) Available to Common Stockholders, Diluted [Abstract]
Equity Components [Axis]
Equity Components [Axis]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Auditor Name
Auditor Name
Issuance of common stock under license agreement
Stock Issued During Period, Value, Issued for Services
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Liability related to the sale of future revenue, net
Other Long-Term Debt, Noncurrent
Operating lease right-of-use asset derecognized
Operating Lease, Right-Of-Use Asset Derecognized
Operating Lease, Right-Of-Use Asset Derecognized
Number of reportable segments
Number of Reportable Segments
Lab equipment
Equipment [Member]
Expired (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Supplemental disclosure of cash flow information
Supplemental Cash Flow Information [Abstract]
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Other Performance Measure, Amount
Other Performance Measure, Amount
Weighted-Average Exercise Price Per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
U.S. agency and treasury securities
US Treasury and Government [Member]
Payment of debt issuance costs
Payments of Debt Issuance Costs
Entity Address, State or Province
Entity Address, State or Province
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Cashless exercises (in shares)
Class of Warrant or Right, Cashless Exercises
Class of Warrant or Right, Cashless Exercises
Total current liabilities
Liabilities, Current
Amount
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Over-Allotment Option
Over-Allotment Option [Member]
Sale of Future Revenue, Royalty Payments, Tier 4
Sale of Future Revenue, Royalty Payments, Tier 4 [Member]
Sale of Future Revenue, Royalty Payments, Tier 4
Derivative Instrument [Axis]
Derivative Instrument [Axis]
Individual:
Individual [Axis]
Expense incurred related to defined contribution 401(k) plan
Defined Contribution Plan, Cost
Vesting [Axis]
Vesting [Axis]
Fair Value Measurements
Fair Value of Financial Instruments, Policy [Policy Text Block]
Income Tax Jurisdiction [Domain]
Income Tax Jurisdiction [Domain]
Document Annual Report
Document Annual Report
Research and development
Research and Development Expense [Member]
Viridian Merger
Viridian Merger [Member]
Viridian Merger
Kissei Pharmaceutical Co., Ltd
Kissei Pharmaceutical Co., Ltd [Member]
Kissei Pharmaceutical Co., Ltd
Net cash used in investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Conditional payments, sales achievement threshold
Debt Instrument, Conditional Payments, Sales Achievement Threshold
Debt Instrument, Conditional Payments, Sales Achievement Threshold
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member]
Interest paid
Interest Paid, Excluding Capitalized Interest, Operating Activity
Document Fiscal Year Focus
Document Fiscal Year Focus
Basis of Presentation and Principles of Consolidation
Basis of Accounting, Policy [Policy Text Block]
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Noncontrolling interest ownership (in percent)
Subsidiary, Ownership Percentage, Noncontrolling Owner
IRC § 174 capitalized costs
Deferred Tax Asset, In-Process Research and Development
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Potential royalty payments
Collaborative Arrangement, Potential Royalty Payments, Maximum
Collaborative Arrangement, Potential Royalty Payments, Maximum
Entity Interactive Data Current
Entity Interactive Data Current
Plan Name [Domain]
Plan Name [Domain]
Marketable securities:
Short-Term Investments [Abstract]
Conditional payments
Debt Instrument, Conditional Payments
Debt Instrument, Conditional Payments
Remaining weighted-average period (in years)
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Operating lease right-of-use asset, net
Deferred Tax Assets, Operating Lease, Right-of-Use Asset, Net
Deferred Tax Assets, Operating Lease, Right-of-Use Asset, Net
Issuance of common stock upon exercises of stock options (in shares)
Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Equity [Abstract]
Equity [Abstract]
Revenue Recognition and Liability Related to the Sale of Future Revenue
Revenue from Contract with Customer [Policy Text Block]
Exercisable (Aggregate Intrinsic Value)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Schedule of Balances by Plan
Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block]
Derivative Liability
Derivatives, Policy [Policy Text Block]
SEGMENT INFORMATION
Segment Reporting Disclosure [Text Block]
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Expired (in shares)
Class Of Warrant Or Right, Expired In Period
Class Of Warrant Or Right, Expired In Period
Debt instrument, face amount, third tranche
Debt Instrument, Face Amount, Third Tranche
Debt Instrument, Face Amount, Third Tranche
Property, Plant and Equipment, Type [Axis]
Long-Lived Tangible Asset [Axis]
Class of Warrant or Right [Table]
Class of Warrant or Right [Table]
Stockholders’ deficit
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Ownership [Domain]
Ownership [Domain]
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
Commitments and Contingencies [Table]
Commitments and Contingencies [Table]
Commitments and Contingencies [Table]
Operating Lease Right-of-Use Assets and Liabilities
Lessee, Leases [Policy Text Block]
Selling, general and administrative
Selling, General and Administrative Expense
Accrued outsourced clinical and nonclinical studies
Accrued Outsourced Clinical and Nonclinical Studies, Current
Accrued Outsourced Clinical and Nonclinical Studies, Current
Depreciation and amortization
Depreciation, Depletion and Amortization
Other assets
Other Assets, Noncurrent
Accrued interest payable
Interest Payable, Current
Entity Central Index Key
Entity Central Index Key
PEO Name
PEO Name
Schedule of Future Principal Payments of Debt
Schedule of Maturities of Long-Term Debt [Table Text Block]
Aggregate offering
Sale of Stock, Consideration Received on Transaction
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
Comprehensive loss:
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Arrangement Duration
Trading Arrangement Duration
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Segment Reporting Information, by Segment [Table]
Initial Vesting Period
Share-Based Payment Arrangement, Tranche One [Member]
Deferred revenue, current - related party
Contract with Customer, Liability, Current
Computer hardware and software
Computer Equipment [Member]
MARKETABLE SECURITIES AND FAIR VALUE MEASUREMENTS
Financial Instruments Disclosure [Text Block]
Segments [Axis]
Segments [Axis]
Weighted-average exercise price (in dollars per share)
Beginning balance (in dollars per share)
Ending balance (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Prepaid expenses, other current assets and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Exercise Price
Award Exercise Price
Elegrobart
Elegrobart [Member]
Elegrobart
Entity Filer Category
Entity Filer Category
Class of Stock [Domain]
Class of Stock [Domain]
Class of Stock [Domain]
Local Phone Number
Local Phone Number
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
Unrecognized share-based compensation costs
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Federal statutory income tax rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
SHARE-BASED COMPENSATION
Share-Based Payment Arrangement [Text Block]
Assets
Assets [Abstract]
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Vesting [Domain]
Vesting [Domain]
Debt Instrument [Axis]
Debt Instrument [Axis]
Forfeited (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Deferred tax assets:
Deferred Tax Assets, Net [Abstract]
Stockholders’ equity:
Equity, Attributable to Parent [Abstract]
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member]
Vesting (in percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Entity Address, Address Line One
Entity Address, Address Line One
Issued April 2017
Liability-Classified Warrants, Issued April 2017 [Member]
Liability-Classified Warrants, Issued April 2017 [Member]
Accumulated Other Comprehensive Income (Loss)
AOCI Attributable to Parent [Member]
Interest rate (in percent)
Debt Instrument, Interest Rate, Stated Percentage
Long term lease obligation
Operating Lease, Liability, Noncurrent
Entity Voluntary Filers
Entity Voluntary Filers
Issuance of common stock upon the conversion of convertible preferred stock (in shares)
Stock Issued During Period, Shares, Conversion of Convertible Securities
Valuation allowance percent
Deferred Tax Asset, Valuation Allowance, Percent
Deferred Tax Asset, Valuation Allowance, Percent
Number of performance obligations
Collaborative Arrangement, Number Of Performance Obligations
Collaborative Arrangement, Number Of Performance Obligations
Exercised (in shares)
Class of Warrant or Right, Exercised in Period
Class of Warrant or Right, Exercised in Period
Ownership [Axis]
Ownership [Axis]
Fair Value as of Grant Date
Award Grant Date Fair Value
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Entity Registrant Name
Entity Registrant Name
Weighted-Average Exercise Price
Class of Warrant or Right Weighted Average Exercise Price [Roll Forward]
Class of Warrant or Right Weighted Average Exercise Price [Roll Forward]
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
Net operating loss carryforwards
Operating Loss Carryforwards
March 2025 ATM Agreement
March 2025 ATM Agreement [Member]
March 2025 ATM Agreement
Schedule of Components of The Amended Term Loan
Schedule of Long-Term Debt Instruments
Schedule of Long-Term Debt Instruments [Table Text Block]
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Veligrotug
Veligrotug [Member]
Veligrotug
Title and Position [Domain]
Title and Position [Domain]
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Sale of Future Revenue, Agreed Upon Financial Terms
Sale of Future Revenue, Agreed Upon Financial Terms [Member]
Sale of Future Revenue, Agreed Upon Financial Terms
Term fee at maturity (in percent)
Debt Instrument, Principal Amount, Term Fee At Maturity
Debt Instrument, Principal Amount, Term Fee At Maturity
Issuance costs
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Total cash equivalents and marketable securities
Assets, Fair Value Disclosure
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
Counterparty Name [Domain]
Counterparty Name [Domain]
2027
Lessee, Operating Lease, Liability, to be Paid, Year Two
Number of operating segments
Number of Operating Segments
Accretion and amortization of available-for-sale securities
Accretion (Amortization) of Discounts and Premiums, Investments
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward [Line Items]
Outstanding (Weighted Average Remaining Contractual Term)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Remeasurement of right-of-use asset and lease liability for lease modifications
Remeasurement Of Operating Lease Right-Of-Use Assets For Lease Modifications
Remeasurement Of Operating Lease Right-Of-Use Assets For Lease Modifications
Schedule of Components of Accrued Liabilities
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Granted (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Title
Trading Arrangement, Individual Title
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Restatement Determination Date:
Restatement Determination Date [Axis]
Non-PEO NEO
Non-PEO NEO [Member]
Outstanding (Aggregate Intrinsic Value)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Through December 15, 2023
Debt Covenant Period One [Member]
Debt Covenant Period One
Issuance of long-term debt
Notes Issued
Issuance of common stock under employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Sale of Stock [Axis]
Sale of Stock [Axis]
Sale of Stock [Axis]
Chief Executive Officer And Chief Financial Officer
Former Executive Officers [Member]
Former Executive Officers
Gross Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Name
Trading Arrangement, Individual Name
Award Type [Domain]
Award Type [Domain]
2026
Lessee, Operating Lease, Liability, to be Paid, Year One
Equity Awards Adjustments
Equity Awards Adjustments [Member]
Leasehold improvements
Leasehold Improvements [Member]
Other non cash items
Other Noncash Income (Expense)
Pension Benefits Adjustments, Footnote
Pension Benefits Adjustments, Footnote [Text Block]
Massachusetts Lease
Massachusetts Lease [Member]
Massachusetts Lease
Compensation Amount
Outstanding Recovery Compensation Amount
Principal amount
Debt Instrument, Face Amount
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Sale of Future Revenue, Royalty Payments, Tier 2
Sale of Future Revenue, Royalty Payments, Tier 2 [Member]
Sale of Future Revenue, Royalty Payments, Tier 2
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
Accrued outsourced manufacturing
Accrued Outsourced Manufacturing, Current
Accrued Outsourced Manufacturing, Current
Convertible Preferred Stock
Preferred Stock [Member]
Warrants
Warrants Policy [Policy Text Block]
Warrants Policy
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Name
Awards Close in Time to MNPI Disclosures, Individual Name
ACCRUED LIABILITIES
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Outstanding beginning balance (in dollars per share)
Outstanding ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Denominator:
Weighted Average Number of Shares Outstanding Reconciliation [Abstract]
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Employee Stock
Employee Stock [Member]
Debt instrument, face amount, fifth tranche
Debt Instrument, Face Amount, Fifth Tranche
Debt Instrument, Face Amount, Fifth Tranche
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Defined contribution plan, employer matching contribution, percent of employees' gross pay
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Revenues:
Revenues [Abstract]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Issuance of common stock upon conversion of convertible preferred stock
Stock Issued During Period, Value, Conversion of Convertible Securities
Share-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Sale of Future Revenue, Milestone And Marketing Approval
Sale of Future Revenue, Milestone And Marketing Approval [Member]
Sale of Future Revenue, Milestone And Marketing Approval
Accumulated other comprehensive income (loss)
Accumulated Other Comprehensive Income (Loss), Net of Tax
2026
Long-Term Debt, Maturity, Year One
Financial Instruments [Domain]
Financial Instruments [Domain]
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Sale of Future Revenue
Sale of Future Revenue [Member]
Sale of Future Revenue
Auditor Firm ID
Auditor Firm ID
Segments [Domain]
Segments [Domain]
Statement of Income Location, Balance [Axis]
Statement of Income Location, Balance [Axis]
2030
Long-Term Debt, Maturity, Year Five
Operating lease, annual base rent
Operating Lease, Annual Base Rent
Operating Lease, Annual Base Rent
Aggregate Pension Adjustments Service Cost
Aggregate Pension Adjustments Service Cost [Member]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Seth Harmon [Member]
Seth Harmon
Minimum
Minimum [Member]
Less: accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Net Loss per Share
Earnings Per Share, Policy [Policy Text Block]
Company Selected Measure Name
Company Selected Measure Name
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-Sale
DEBT
Debt Disclosure [Text Block]
Preferred stock
Preferred Stock, Value, Issued
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Accounts payable
Accounts Payable, Current
Deferred tax liabilities:
Deferred Tax Liabilities, Net [Abstract]
Proceeds from the issuance of common stock for cash under employee stock purchase plan
Proceeds from Stock Plans
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
2016 Plan
2016 Employee Stock Purchase Plan [Member]
2016 Employee Stock Purchase Plan
Issuance costs allocated to derivative liability
Derivative Liability, Issuance Costs
Derivative Liability, Issuance Costs
All Executive Categories
All Executive Categories [Member]
Schedule of Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Common stock, $0.01 par value; 200,000,000 shares authorized; 101,826,500 and 80,994,046 shares issued and outstanding as of December 31, 2025 and 2024, respectively
Common Stock, Value, Issued
Expired (in dollars per share)
Class Of Warrant Or Right, Expired In Period, Weighted Average Grant Date Fair Value
Class Of Warrant Or Right, Expired In Period, Weighted Average Grant Date Fair Value
Third Party Collaborator
Third Party Collaborator [Member]
Third Party Collaborator
COMMITMENTS AND CONTINGENCIES
Commitments and Contingencies Disclosure [Text Block]
Subsequent Vesting Period
Share-Based Payment Arrangement, Tranche Two [Member]
Title and Position [Axis]
Title and Position [Axis]
Weighted-average shares outstanding, diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Segment Information
Segment Reporting, Policy [Policy Text Block]
Commitments and contingencies (Note 9)
Commitments and Contingencies
Fair value options vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Derivative [Table]
Derivative [Table]
Entity Small Business
Entity Small Business
2020 Plan
2020 Plan [Member]
2020 Plan
Payment of issuance costs
Payments of Stock Issuance Costs
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Convertible preferred stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Preferred Stock, Shares Outstanding
Document Transition Report
Document Transition Report
Underlying Securities
Award Underlying Securities Amount
Total deferred tax assets, net
Deferred Tax Assets, Net
Extinguishment of long-term debt
Notes Reduction
Equity Component [Domain]
Equity Component [Domain]
Document Period End Date
Document Period End Date
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
INCOME TAXES
Income Tax Disclosure [Text Block]
Research and development costs
Research And Development Expense, Excluding Share-Based Compensation Expense
Research And Development Expense, Excluding Share-Based Compensation Expense
Accrued end-of-term fees
Accrued Debt, Fees
Accrued Debt, Fees
Sales royalties threshold
Debt Instrument, Royalty Payments Threshold
Debt Instrument, Royalty Payments Threshold
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Common stock, vote per share
Common Stock, Vote per Share
Common Stock, Vote per Share
Collaboration revenue - related parties
Collaboration
Collaboration [Member]
Collaboration [Member]
Operating lease, liability, noncurrent, statement of financial position [Extensible List]
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Exercisable (Weighted Average Remaining Contractual Term)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
January 2024 Underwritten Offering
January 2024 Underwritten Offering [Member]
January 2024 Underwritten Offering
Collaborative arrangement, rights and licenses fee
Collaborative Arrangement, Rights And Licenses Fee
Collaborative Arrangement, Rights And Licenses Fee
Accruals and reserves
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
RETIREMENT BENEFIT PLAN
Defined Contribution Plan [Text Block]
Document Type
Document Type
Significant Unobservable Inputs (Level 3)
Fair Value, Inputs, Level 3 [Member]
NET LOSS PER SHARE
Earnings Per Share [Text Block]
Name
Outstanding Recovery, Individual Name
Additional paid-in capital
Additional Paid in Capital
Product and Service [Axis]
Product and Service [Axis]
Asset Acquisition [Domain]
Asset Acquisition [Domain]
Derivative Contract [Domain]
Derivative Contract [Domain]
Proceeds from the issuance of common stock
Proceeds from the issuance of Series B convertible preferred stock in offerings
Proceeds from Issuance of Common Stock
Sale of Future Revenue, Net Sales Achievement
Sale of Future Revenue, Net Sales Achievement [Member]
Sale of Future Revenue, Net Sales Achievement
All Individuals
All Individuals [Member]
Long-term Debt, Type [Domain]
Long-Term Debt, Type [Domain]
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Name
Forgone Recovery, Individual Name
Expiration period (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Total current assets
Assets, Current
Statistical Measurement [Axis]
Statistical Measurement [Axis]
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member]
Other Liabilities Disclosure [Abstract]
Other Liabilities Disclosure [Abstract]
Colorado Lease
Colorado Lease [Member]
Colorado Lease
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Purchase price of common stock, fair market value (in percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Intrinsic value of stock options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Sale of Future Revenue, Milestone
Sale of Future Revenue, Milestone [Member]
Sale of Future Revenue, Milestone
Accelerated vesting costs
Share-Based Payment Arrangement, Accelerated Cost
Private Placement
Private Placement [Member]
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Audit Information [Abstract]
Audit Information
Collaboration arrangement, future developments milestone payment obligation
Collaboration Arrangement, Future Developments Milestone Payment Obligation
Collaboration Arrangement, Future Developments Milestone Payment Obligation
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Acquired October 2020
Equity-classified Warrants, Acquired October 2020 [Member]
Equity-classified Warrants, Acquired October 2020
Available-for-sale securities, term (less than) (in months)
Debt Securities, Available-for-Sale, Term
Total other comprehensive income (loss)
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Current liabilities:
Liabilities, Current [Abstract]
Weighted average remaining contractual term and Aggregate intrinsic value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Accrued milestone payment
Accrued Milestone Payment, Current
Accrued Milestone Payment, Current
Total operating expenses
Operating Expenses
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
Quoted Prices in Active Markets (Level 1)
Fair Value, Inputs, Level 1 [Member]
Tax credits
Deferred Tax Assets, Tax Credit Carryforwards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Start-up costs and amortized costs
Deferred Tax Assets, Tax Deferred Expense, Start-up Costs and Amortized Costs
Deferred Tax Assets, Tax Deferred Expense, Start-up Costs and Amortized Costs
Accrued liabilities and other liabilities
Increase (Decrease) in Accrued Liabilities
Net loss per share, diluted (in dollars per share)
Earnings Per Share, Diluted
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Title of 12(b) Security
Title of 12(b) Security
Supplemental disclosure of non-cash investing and financing activities
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Debt instrument, number of tranches
Debt Instrument, Number Of Tranches
Debt Instrument, Number Of Tranches
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Shares sold (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Non-cash interest expense
Paid-in-Kind Interest
Warrants to purchase common stock
Common Stock Warrants [Member]
Common Stock Warrants [Member]
Earnings Per Share [Abstract]
Earnings Per Share [Abstract]
DESCRIPTION OF THE BUSINESS
Business Description and Basis of Presentation [Text Block]
Total other income, net
Nonoperating Income (Expense)
Commission fee (in percent)
Sale of Stock, Commission Fee, Percentage of Gross Sale Proceeds
Sale of Stock, Commission Fee, Percentage of Gross Sale Proceeds
Auditor Location
Auditor Location
Schedule of Potentially Dilutive Securities
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Tax credit carryforward amount
Tax Credit Carryforward, Amount
Marketable securities
Debt Securities, Available-for-Sale, Current
Debt instrument, face amount, first tranche
Debt Instrument, Face Amount, First Tranche
Debt Instrument, Face Amount, First Tranche
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Domestic Tax Jurisdiction
Domestic Tax Jurisdiction [Member]
Weighted average exercise price (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Collaboration arrangement, maximum milestone payments
Collaboration Arrangement, Maximum Milestone Payments
Collaboration Arrangement, Maximum Milestone Payments
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Tax Credit Carryforward [Axis]
Tax Credit Carryforward [Axis]
Exercised (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Award Timing Disclosures [Line Items]
Sale of future revenues
Deferred Tax Assets, Sale Of Future Revenues
Deferred Tax Assets, Sale Of Future Revenues
Gross proceeds outstanding
Total
Long-Term Debt, Gross
Granted (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Accrued compensation and related benefits
Employee-related Liabilities, Current
Measurement Frequency [Domain]
Measurement Frequency [Domain]
PROPERTY AND EQUIPMENT
Property, Plant and Equipment Disclosure [Text Block]
Total undiscounted lease liabilities
Lessee, Operating Lease, Liability, to be Paid
Lessee, operating lease, renewal term (in years)
Lessee, Operating Lease, Renewal Term
Unrealized gain (loss) on available-for-sale securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
CAPITAL STOCK
WARRANTS
Equity [Text Block]
Limitations on use (in percent)
Operating Loss Carryforwards, Limitations On Use, Percent
Operating Loss Carryforwards, Limitations On Use, Percent
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Sales royalties, percentage
Debt Instrument, Royalty Payments, Percentage
Debt Instrument, Royalty Payments, Percentage
Expiration Date
Trading Arrangement Expiration Date
Other accrued liabilities
Other Accrued Liabilities, Current
Schedule of Effective Income Tax Rate Reconciliation
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Vesting (in percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Other adjustments
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Segment Reporting Information [Line Items]
Segment Reporting Information [Line Items]
Sale of Future Revenue, Marketing Approval
Sale of Future Revenue, Marketing Approval [Member]
Sale of Future Revenue, Marketing Approval
Convertible preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Adoption Date
Trading Arrangement Adoption Date
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Tax Credit Carryforward [Table]
Tax Credit Carryforward [Table]
Series A Convertible Preferred Stock
Series A Convertible Preferred Stock
Series A convertible preferred stock, as converted to shares of common stock
Series A Preferred Stock [Member]
Entity Current Reporting Status
Entity Current Reporting Status
Lessee, operating lease, term of contract (in years)
Lessee, Operating Lease, Term of Contract
Derivative [Line Items]
Derivative [Line Items]
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Loss from operations
Operating Income (Loss)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Federal statutory income tax rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Allocation of net loss
Net Income (Loss) Attributable To Parent, Allocation
Net Income (Loss) Attributable To Parent, Allocation
Financial Instrument [Axis]
Financial Instrument [Axis]
Proceeds from the issuance of Series B convertible preferred stock in offerings
Proceeds from Issuance of Convertible Preferred Stock
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member]
Executive Category:
Executive Category [Axis]
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
State income taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Other expense, net
Other expense, net
Other Operating Income (Expense), Net
Operating lease expenses
Operating Leases, Operating Expense
Operating Leases, Operating Expense
Plan modification costs
Share-Based Payment Arrangement, Plan Modification, Incremental Cost
Valuation, Market Approach
Valuation, Market Approach [Member]
Proceeds from issuance of long-term debt, net
Proceeds from Issuance of Long-Term Debt
Class of Stock [Axis]
Class of Stock [Axis]
Class of Stock [Axis]
Current Fiscal Year End Date
Current Fiscal Year End Date
Number of securities called by each warrant or right (in shares)
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Expected term, in years
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Remaining contractual life (in years)
Class of Warrant or Right, Remaining Term
Class of Warrant or Right, Remaining Term
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member]
Debt instrument, face amount, second tranche
Debt Instrument, Face Amount, Second Tranche
Debt Instrument, Face Amount, Second Tranche
Payables and Accruals [Abstract]
Payables and Accruals [Abstract]
Weighted-Average Grant Date Fair Value per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Shares available for issuance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Statement [Table]
Statement [Table]
Derivative Liability [Roll Forward]
Derivative Liability [Roll Forward]
Derivative Liability
Derivative liability
Initial fair value of derivative liability
Initial fair value of derivative liability
Carrying value as of December 31, 2025
Derivative Liability
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table]
Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table]
COLLABORATION AND LICENSE AGREEMENTS
Collaborative Arrangement Disclosure [Text Block]
Cash flows from financing activities:
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Nontaxable or nondeductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Weighted average fair value per option (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Shares issued in exchange for rights granted (in shares)
Collaborative Arrangement, Shares Issued For Rights Granted
Collaborative Arrangement, Shares Issued For Rights Granted
Equity Awards Adjustments, Excluding Value Reported in Compensation Table
Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member]
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Milestone payments
Collaboration Arrangement, Potential Milestone Payment, Maximum
Collaboration Arrangement, Potential Milestone Payment, Maximum
Cash equivalents:
Cash and Cash Equivalents [Abstract]
Unrecognized tax benefits
Unrecognized Tax Benefits
Antidilutive securities (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Amendment Flag
Amendment Flag
Sale of stock price (in dollars per share)
Sale of Stock, Price Per Share
2027
Long-Term Debt, Maturity, Year Two
Unrealized gains/losses
Deferred Tax Assets, Investments
Termination Date
Trading Arrangement Termination Date
Net cash provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Measure:
Measure [Axis]
Valuation Approach and Technique [Axis]
Valuation Approach and Technique [Axis]
Operating lease, weighted average incremental borrowing rate (in percent)
Operating Lease, Weighted Average Discount Rate, Percent
Schedule of Stock Option Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
September 2022 ATM Agreement
September 2022 ATM Agreement [Member]
September 2022 ATM Agreement
Schedule of Warrants
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Property, Plant and Equipment, Type [Domain]
Long-Lived Tangible Asset [Domain]
Issuance of common stock upon vesting of restricted stock units
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Weighted-average shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Future developments milestone payments
Collaboration Arrangement, Milestone Payment, Intellectual Property Rights Development, Maximum
Collaboration Arrangement, Milestone Payment, Intellectual Property Rights Development, Maximum
Schedule of Basic And Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Exercisable (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Segment Reporting [Abstract]
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
Income tax penalties and interest expense
Income Tax Examination, Penalties and Interest Expense
Debt Disclosure [Abstract]
Debt Disclosure [Abstract]
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Other income (expense), net:
Nonoperating Income (Expense) [Abstract]
Entity Tax Identification Number
Entity Tax Identification Number
Federal and state tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Asset Acquisition [Axis]
Asset Acquisition [Axis]
Issuance of common stock under license agreement
Issuance of Stock and Warrants for Services or Claims
Realized gains in available for sale securities
Debt Securities, Available-for-Sale, Realized Gain (Loss)
Document Financial Statement Restatement Recovery Analysis [Flag]
Document Financial Statement Restatement Recovery Analysis [Flag]
Beginning balance (in dollars per share)
Ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Term fee (in percent)
Debt Instrument, Principal Amount, Term Fee
Debt Instrument, Principal Amount, Term Fee
Lease remaining term (in months)
Operating Lease, Weighted Average Remaining Lease Term
2029
Long-Term Debt, Maturity, Year Four
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Inducement Awards
Inducement Grants [Member]
Inducement Grants
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Entity Public Float
Entity Public Float
Commitments and Contingencies [Line Items]
Commitments and Contingencies [Line Items]
Commitments and Contingencies [Line Items]
Value of shares issued in exchange for rights granted
Collaborative Arrangement, Value Of Shares Issued For Rights Granted
Collaborative Arrangement, Value Of Shares Issued For Rights Granted
Interest expense
Interest expense
Interest Expense, Nonoperating
Trading Arrangement:
Trading Arrangement [Axis]
Total Shareholder Return Amount
Total Shareholder Return Amount
Insider Trading Arrangements [Line Items]
Proceeds from the exercise of warrants
Proceeds from Issuance of Warrants
Security Exchange Name
Security Exchange Name
Forfeited (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Collaborative arrangement, upfront fee payment
Collaborative Arrangement, Upfront Fee Payment
Collaborative Arrangement, Upfront Fee Payment
Total liabilities
Liabilities
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Issuance of common stock upon exercise of warrants (in shares)
Stock Issued During Period, Value, Warrants Exercised, Shares
Stock Issued During Period, Value, Warrants Exercised, Shares
Nontaxable or nondeductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount
Pension Adjustments Prior Service Cost
Pension Adjustments Prior Service Cost [Member]
Proceeds from issuance of common stock in offerings
Proceeds from Issuance Initial Public Offering
Maturities of marketable securities
Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale
Operating expenses:
Operating Expenses [Abstract]
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
Collaborative arrangement, rights and obligations, milestone payments
Collaborative Arrangement, Rights And Obligations, Milestone Payment
Collaborative Arrangement, Rights And Obligations, Milestone Payment
Enable Injections
Enable Injections [Member]
Enable Injections
Thomas Beetham [Member]
Thomas Beetham
Issuance of stock, net of issuance cost
Stock Issued During Period, Value, New Issues
Hercules Capital, Inc
Hercules Term Loan [Member]
Hercules Term Loan
Statement [Line Items]
Statement [Line Items]
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
Counterparty Name [Axis]
Counterparty Name [Axis]
Schedule of Restricted Stock Units
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Research and experimentation tax carryforward
Research Tax Credit Carryforward [Member]
Additional shares authorized for plan (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Common Stock
Common Stock [Member]
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Fair Value
Marketable securities
Debt Securities, Available-for-Sale
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name [Domain]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Non-NEOs
Non-NEOs [Member]
Corporate paper and bonds
Corporate Debt Securities [Member]
Net increase (decrease) in cash and cash equivalents
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Payment of issuance costs associated with sale of future revenue
Payment Of Issuance Costs, Sale Of Future Revenue
Payment Of Issuance Costs
Accrued professional fees
Accrued Professional Fees, Current