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        <link:definition>9955517 - Disclosure - Trade and Other Receivables (Tables)</link:definition>
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        <link:definition>9955518 - Disclosure - Financial Assets - Current (Tables)</link:definition>
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        <link:definition>9955519 - Disclosure - Cash and Cash Equivalents (Tables)</link:definition>
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        <link:definition>9955520 - Disclosure - Share Capital and Share Premium (Tables)</link:definition>
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        <link:definition>9955523 - Disclosure - Other Operating Income (Tables)</link:definition>
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        <link:definition>9955524 - Disclosure - Segment Reporting (Tables)</link:definition>
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        <link:definition>9955525 - Disclosure - Research and Development Expenses (Tables)</link:definition>
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  <xs:element id="argx_LonzaAndFujifilmMember" abstract="true" name="LonzaAndFujifilmMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_IfrsTypeOfArrangementAndNonArrangementTransactionsAxis" abstract="true" name="IfrsTypeOfArrangementAndNonArrangementTransactionsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="argx_IfrsTypeOfArrangementAndNonArrangementTransactionsDomain" abstract="true" name="IfrsTypeOfArrangementAndNonArrangementTransactionsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_EfgartigimodMember" abstract="true" name="EfgartigimodMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_CommitmentsLineItems" abstract="true" name="CommitmentsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="argx_FutureMilestonePaymentsAllTargets" abstract="false" name="FutureMilestonePaymentsAllTargets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="argx_NumberOnNominatedTargetUnderAgreement" abstract="false" name="NumberOnNominatedTargetUnderAgreement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="argx_AuditorsRemunerationTable" abstract="true" name="AuditorsRemunerationTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="argx_EYAccountantsB.V.Member" abstract="true" name="EYAccountantsB.V.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_AuditorsRemunerationLineItems" abstract="true" name="AuditorsRemunerationLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="argx_AuditorsRemunerationAuditRelatedExpenses" abstract="false" name="AuditorsRemunerationAuditRelatedExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="argx_ARGENXBVSubsidiaryMember" abstract="true" name="ARGENXBVSubsidiaryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_NumberOfSubsidiaries" abstract="false" name="NumberOfSubsidiaries" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="argx_ARGENXSEMember" abstract="true" name="ARGENXSEMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxBeneluxB.V.Member" abstract="true" name="ArgenxBeneluxB.V.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ARGENXUSINCMember" abstract="true" name="ARGENXUSINCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxAustraliaPty.LtdMember" abstract="true" name="ArgenxAustraliaPty.LtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxAustriaServicesGmbHMember" abstract="true" name="ArgenxAustriaServicesGmbHMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxBrasilProdutosFarmaceuticosLtdaMember" abstract="true" name="ArgenxBrasilProdutosFarmaceuticosLtdaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxCanadaIncMember" abstract="true" name="ArgenxCanadaIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ARGENXFRANCESASMember" abstract="true" name="ARGENXFRANCESASMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ARGENXGERMANYGMBHMember" abstract="true" name="ARGENXGERMANYGMBHMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxItalyMember" abstract="true" name="ArgenxItalyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ARGENXJAPANKKMember" abstract="true" name="ARGENXJAPANKKMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxNetherlandsB.vMember" abstract="true" name="ArgenxNetherlandsB.vMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxSpainS.l.Member" abstract="true" name="ArgenxSpainS.l.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxSpainS.L.SucursalEmPortugalMember" abstract="true" name="ArgenxSpainS.L.SucursalEmPortugalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxSwitzerlandS.A.Member" abstract="true" name="ArgenxSwitzerlandS.A.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_ArgenxUKLtd.Member" abstract="true" name="ArgenxUKLtd.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_BroteioPharmaB.V.Member" abstract="true" name="BroteioPharmaB.V.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
