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<!-- Creation Date :2026-03-19T19:48:42.1431+00:00 -->
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          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:label="dei_EntityEmergingGrowthCompany"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinancialAssetsAtFairValueThroughProfitOrLoss" xlink:label="ifrs-full_FinancialAssetsAtFairValueThroughProfitOrLoss"/>
          <link:loc xlink:type="locator" xlink:href="clls-20251231.xsd#clls_IncomeTaxAuthoritiesDomain" xlink:label="clls_IncomeTaxAuthoritiesDomain"/>
          <link:loc xlink:type="locator" xlink:href="clls-20251231.xsd#clls_ReserachTaxCreditReceivableCurrent" xlink:label="clls_ReserachTaxCreditReceivableCurrent"/>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CarryforwardsThatCanBeOffsetAgainstFutureTaxableProfitPercentageProfitExceedingLimit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Carryforwards That Can Be Offset Against Future Taxable Profit, Percentage Profit Exceeding Limit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CarryforwardsThatCanBeOffsetAgainstFutureTaxableProfitPercentageProfitExceedingLimit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carryforwards limit that can be offset against future taxable profit, additional percentage of profit exceeding the limit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialAssetsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of financial assets [table]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtAmortisedCost_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounting category amortized cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtAmortisedCost_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Financial liabilities at amortised cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentPrepaidExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current prepaid expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentPrepaidExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Prepaid expenses and other prepayments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfOutstandingBalancesWithRelatedPartiesExplanatoryTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of outstanding balances with related parties explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfOutstandingBalancesWithRelatedPartiesExplanatoryTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of outstanding balances with related parties explanatory [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfOutstandingBalancesWithRelatedPartiesExplanatoryTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of outstanding balances with related parties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SalesOfNon-CurrentFinancialAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Sales of non-current financial assets, classified as investing activities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SalesOfNon-CurrentFinancialAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sales of Non-Current Financial Assets, Classified as Investing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SalesOfNon-CurrentFinancialAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Sales of non-current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SalesOfNon-CurrentFinancialAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Sales of non-current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ReserveOfExchangeDifferencesOnTranslation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reserve of exchange differences on translation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ReserveOfExchangeDifferencesOnTranslation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Currency translation adjustment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashRepaymentsOfAdvancesAndLoansFromRelatedParties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash repayments of advances and loans from related parties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashRepaymentsOfAdvancesAndLoansFromRelatedParties_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loan principal payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LandAndBuildingsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Land and buildings [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LandAndBuildingsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Land and Buildings [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueOfSiaDerivativeInstrument_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gain in fair value of SIA derivative instrument.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueOfSiaDerivativeInstrument_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain in Fair Value of SIA Derivative Instrument</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueOfSiaDerivativeInstrument_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain in Fair Value of SIA Derivative Instrument</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueOfSiaDerivativeInstrument_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Gain in fair value of SIA derivative instrument</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AstraZenecaIrelandMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Astra Zeneca Ireland [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AstraZenecaIrelandMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Astra Zeneca Ireland [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReclassificationAdjustmentsOnIntangibleAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reclassification adjustments on intangible assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReclassificationAdjustmentsOnIntangibleAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reclassification Adjustments On Intangible Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReclassificationAdjustmentsOnIntangibleAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reclassification</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research and development expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research and development expenses [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research and Development Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TopOfRangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Top of range [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TopOfRangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Top of Range [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through effect of changes in foreign exchange rates, liabilities arising from financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Currency translation adjustment financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other current assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Current Assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Incorporation, State or Country Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberTwentyEightTwoThousandSixteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">October twenty eight two thousand sixteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberTwentyEightTwoThousandSixteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">October twenty eight two thousand sixteen [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberTwentyEightTwoThousandSixteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">10/28/2016 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberEightThousAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">November Eight Thous and Twenty Two</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberEightThousAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">November Eight Thous and Twenty Two [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberEightThousAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">11/08/2022 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyNinethousandtwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March Twenty NineThousandTwenty Two</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyNinethousandtwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">03/29/2022 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ActuarialAssumptionOfDiscountRates_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Actuarial assumption of discount rates</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ActuarialAssumptionOfDiscountRates_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedDividendsWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Expected dividends warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedDividendsWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected Dividends Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedDividendsWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected dividends</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsValuationMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrants valuation method.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsValuationMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants Valuation Method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsValuationMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Valuation method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfSensitivityAnalysisOfFairValueMeasurementToChangesInUnobservableInputsAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of sensitivity analysis of fair value measurement to changes in unobservable inputs, assets [text block]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCurrentReportingStatus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Current Reporting Status</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOptionsOrWarrantsExercisedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of options or warrants exercised in share based payment arrangement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOptionsOrWarrantsExercisedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of options/warrants exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashAndCashEquivalentsFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashAndCashEquivalentsFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and cash equivalents from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashAndCashEquivalentsFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cash and cash equivalents from continuing operations.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through share-based payment transactions, equity</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberTwentyFifthTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">November Twenty Fifth Two Thousand And Twenty One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberTwentyFifthTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">November twenty fifth two thousand and twenty one.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberTwentyFifthTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">11/25/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EffectsOfProfitAndLossAndEquityNetOfTaxAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Effects Of Profit And Loss And Equity Net Of Tax [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EffectsOfProfitAndLossAndEquityNetOfTaxAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Effects of profit and loss and equity net of tax.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of property, plant and equipment [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Classes of property, plant and equipment [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxReceivableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Income tax receivable current.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxReceivableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income Tax Receivable Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxReceivableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income tax receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments of lease liabilities, classified as financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Payments on lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Payments of lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDecreaseInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of decrease in salary increase rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDecreaseInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Decrease In Salary Increase Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDecreaseInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of decrease in salary increase rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gains (losses) recognised in profit or loss including exchange differences, fair value measurement, assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total gains (losses) recognised in profit or loss including exchange differences, fair value measurement, assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss in fair value recognized in profit and loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInOtherIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in other income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInOtherIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Other Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInOtherIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in other income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfExercisableShareOptionsForfeitedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Exercisable Share Options Forfeited In Share Based Payment Arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfExercisableShareOptionsForfeitedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of exercisable share options forfeited in share based payment arrangement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfExercisableShareOptionsForfeitedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Option exercisable, forfeited or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialInstitutionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Institution [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial investment agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Investment Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial Investment Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementOneAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement one.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementOneAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreement One [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfFinancialAssetsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of financial assets [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Period Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Fiscal Period Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfVotingRight_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Description of voting right.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfVotingRight_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description of voting right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfVotingRight_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Voting right description</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfShareholdingDilutedOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage Of Shareholding Diluted Of Merged Entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfShareholdingDilutedOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Shareholding Diluted Of Merged Entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfShareholdingDilutedOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage Of Shareholding Diluted Of Merged Entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfShareholdingDilutedOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Percentage of shareholding diluted of merged entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfIntangibleAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about intangible assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityShellCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Shell Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativesByNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Derivatives by name.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativesByNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Derivatives By Name [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) investing activities, continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) investing activities, continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash flows provided by (used in) investing activities of continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingPeriodShare-BasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Vesting Period, Share-based Payment Arrangements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingPeriodShare-BasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Vesting period, share-based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingPeriodShare-BasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vesting period, years</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInForeignExchangeGains_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Foreign Exchange Gains</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInForeignExchangeGains_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in foreign exchange gains.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInForeignExchangeGains_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in foreign exchange gains</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Purchase of other long-term assets, classified as investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Acquisition of non-current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Purchase of other long-term assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SpotForeignExchangeRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Spot foreign exchange rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SpotForeignExchangeRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Spot foreign exchange rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantAndRefundableAdvanceAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Grant And Refundable Advance Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantAndRefundableAdvanceAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Grant And Refundable Advance Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantAndRefundableAdvanceAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant and refundable advance agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantAndRefundableAdvanceAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Grant and Refundable Advance Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpenseByNatureTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">This table concepts are used to disclose the amount of expenses aggregated according to their nature (for example, depreciation, purchases of materials, transport costs, employee benefits and advertising costs), and not reallocated among functions within the entity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpenseByNatureTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expense By Nature [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpenseByNatureTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expense By Nature [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash flows provided by (used in) financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementStrategyAndGovernanceAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management, Strategy, and Governance [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementPositionsOrCommitteesResponsibleReportToBoardFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskBoardOfDirectorsOversightTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Board of Directors Oversight [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentProvisionsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non current provisions used during the period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentProvisionsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Current Provisions Used During the Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentProvisionsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non current provisions Amounts used during period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ContractualCommitments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Contractual commitments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ContractualCommitments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Contractual commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ContractualCommitments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassACommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class A common stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassACommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class A Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassACommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class A Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssueOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issue of equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssueOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Capital increase of Cellectis</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssueOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital increase</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other current financial assets (deposits)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JointCollaborationAndResearchAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Joint collaboration and research agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JointCollaborationAndResearchAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Joint collaboration and research agreement [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JointCollaborationAndResearchAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Joint Collaboration and Research Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BorrowingExtendedPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Extended period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BorrowingExtendedPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Borrowing extended period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BorrowingExtendedPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Borrowing extended period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Effect of exchange rate changes on cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Effect of exchange rate changes on cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of reconciliation of liabilities arising from financing activities [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsMayFifteenthAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Call Options May Fifteenth And Twenty Twenty Six [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsMayFifteenthAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Call options may fifteenth and twenty twenty six.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsMayFifteenthAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Call options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreement [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassesOfCommitmentsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Classes of commitments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassesOfCommitmentsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of commitments [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Finance costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceCosts_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Financial expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceCosts_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Total Financial expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash flows provided by (used in) financing activities of continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) financing activities, continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) financing activities, continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativeInstrumentsFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Instruments Fair Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativeInstrumentsFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Derivative instruments fair value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ImpactOfDeconsolidationOfFinancialStatementsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Impact Of Deconsolidation Of Financial Statements [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ImpactOfDeconsolidationOfFinancialStatementsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Impact of deconsolidation of financial statements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ImpactOfDeconsolidationOfFinancialStatementsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Impact of Deconsolidation on Group's Financial Statements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2025Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Capital Evolution 2025.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2025Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Capital Evolution 2025 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AccrualsAndDeferredIncomeIncludingContractLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accruals and deferred income including contract liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AccrualsAndDeferredIncomeIncludingContractLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accruals and deferred income including contract liabilities [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFilerCategory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Filer Category</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BasicEarningsLossPerShareFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Basic net income (loss) attributable to shareholders of Cellectis per share ($ /share) from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BasicEarningsLossPerShareFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basic net income (loss) attributable to shareholders of Cellectis from discontinued operations, per share ($ /share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BasicEarningsLossPerShareFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Basic net income (loss) attributable to shareholders of Cellectis from discontinued operations, per share ($ /share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInTaxBenefitArisingFromPermanentDifferences_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in tax benefit arising from permanent differences.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInTaxBenefitArisingFromPermanentDifferences_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) In Tax Benefit Arising From Permanent Differences</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInTaxBenefitArisingFromPermanentDifferences_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Permanent differences</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfExpectedTermOfShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description Of Expected Term Of Share Options Granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfExpectedTermOfShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The expected term of the options (in years) at grant date used to calculate the fair value of share options granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfExpectedTermOfShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected term (in years)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current financial liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current financial liabilities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current Financial Liabilities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NotLaterThanOneYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Not later than one year [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NotLaterThanOneYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Less than One Year [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingPeriodForShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vesting period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingPeriodForShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Vesting Period For Share Based Payment Arrangements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingPeriodForShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Describes whether the instruments granted in share-based payment arrangements vest in instalments over a specified period (aka graded vesting) or vest all at once on a specified date (aka cliff vesting).</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperatingExpensesAndOtherOperatingIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Operating (expenses) and other operating income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperatingExpensesAndOtherOperatingIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating (expenses) and other operating income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperatingExpensesAndOtherOperatingIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total operating expenses and other operating income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndServerance_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of provisions for employee litigation and serverance.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndServerance_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions for employee litigation and serverance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndServerance_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Employee litigation and severance, Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndServerance_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Employee litigation and severance, Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InterestAccrued_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Interest accrued.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InterestAccrued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest Accrued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InterestAccrued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interests accrued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InterestIncomeOnCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Interest income on cash, cash equivalents and financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InterestIncomeOnCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest income on cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InterestIncomeOnCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income from cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other provision for charges used during the period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Provision for Charges Used During The Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other provision for charges, Amounts used during the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SegmentsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segments [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfIntangibleAssetsAndGoodwillDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of intangible assets and goodwill [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NotionalAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Notional amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDeferredTaxesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of deferred taxes [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDeferredTaxesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Deferred Tax Assets and Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Financial liabilities at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Financial liabilities at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Book value on the statement of financial position</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Book value on the statement of financial position</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DilutedEarningsLossPerShareFromDiscontinuedOperationsAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Diluted earnings loss per share from discontinued operations attributable to ordinary equity holders of parent entity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DilutedEarningsLossPerShareFromDiscontinuedOperationsAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Diluted Earnings Loss Per Share From Discontinued Operations Attributable To Ordinary Equity Holders Of Parent Entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DilutedEarningsLossPerShareFromDiscontinuedOperationsAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Diluted net income (loss) attributable to shareholders of Cellectis per share ($ /share) from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CostOfSales_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Cost of revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CostOfSales_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cost of sales</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CostOfSales_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Cost of revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of expected volatility amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Of Expected Volatility Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Fair value in $ thousands</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmountToBeRepaid_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount to be repaid.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmountToBeRepaid_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amount to be repaid</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskThirdPartyOversightAndIdentificationProcessesFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConditionalAdvancesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Conditional Advances.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConditionalAdvancesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Conditional Advances [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutFairValueSharePriceTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of detailed information about fair value share price explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutFairValueSharePriceTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Detailed Information About Fair Value Share Price [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutFairValueSharePriceTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of Initial Investment Agreement at Initial Recognition Date Determined on Basis of Share Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheCWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Tranche C Warrants [Member].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheCWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tranche C Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementThirdPartyEngagedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Third Party Engaged [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancingTaxReceivblePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financing Tax Receivble Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancingTaxReceivblePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financing Tax Receivble Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancingTaxReceivblePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing tax receivble percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Cash and cash equivalents at the end of the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Cash and cash equivalents at the beginning of the year</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit (loss) from operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Operating income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Operating income (loss) before tax</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisS.a.Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cellectis S.A. [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateGuarantedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">State guaranted loan.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateGuarantedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">State Guaranted Loan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentPortionOfState-GuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-Current Portion of State-Guaranteed Loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentPortionOfState-GuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-Current Portion of State-Guaranteed Loan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentPortionOfState-GuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Non-Current Portion of State-Guaranteed Loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AccrualsAndDeferredIncomeIncludingContractLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accruals and deferred income including contract liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tax expense (income) at applicable tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Theoretical tax benefit (expense)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">ASSETS</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TradeReceivablesAndOtherCurrentAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The entire disclosure of trade receivables and other current assets Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TradeReceivablesAndOtherCurrentAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trade receivables and other current assets Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TradeReceivablesAndOtherCurrentAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trade receivables and other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_SegmentGeographicalDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Geographical [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gains on change in fair value of derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain on change in fair value measurement recognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Gain on change in fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Gain on fair value measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of transactions between related parties [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Comprehensive income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total Comprehensive income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure Of Number And Weighted Average Exercise Prices Of Share Options and Awards [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Number And Weighted Average Exercise Prices Of Share Options and Awards [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure Of Number And Weighted Average Exercise Prices Of Share Options and Awards [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income taxes paid (refund), classified as operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Income tax received (paid)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromSaleOfPreferredShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from sale of preferred shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromSaleOfPreferredShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Sale Of Preferred Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromSaleOfPreferredShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from sale of preferred shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConversionOfNotesReceivableIntoTradeReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Conversion of notes receivable into trade receivable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConversionOfNotesReceivableIntoTradeReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Conversion Of Notes Receivable Into Trade Receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConversionOfNotesReceivableIntoTradeReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Conversion of notes receivable into trade receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditFinancingsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research tax credit financings.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditFinancingsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Financings [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditFinancingsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research Tax Credit Financings [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentLiabilities1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other current liabilities1.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentLiabilities1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Current Liabilities 1- [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentLiabilities1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Current Liabilities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLossCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial liabilities at fair value through profit or loss, category [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLossCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Liabilities at Fair Value through Profit or Loss, Category [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PensionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Pension.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PensionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Pension [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PensionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pension [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredRevenues_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred revenues.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredRevenues_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred revenues</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredRevenues_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred revenues and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredRevenues_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Deferred revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentForDecreaseIncreaseInTradeReceivablesAndOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Adjustment for decrease (increase) in trade receivables and other current assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentForDecreaseIncreaseInTradeReceivablesAndOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustment for Decrease (Increase) in Trade Receivables and Other Current Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentForDecreaseIncreaseInTradeReceivablesAndOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease (increase) in trade receivables and other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Share Options Exercisable Granted In Share Based Payment Arrangements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of share options exercisable granted in share based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Option exercisable, granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Consolidated operations [table].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Consolidated operations [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consolidated operations [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValuesPerOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair values per options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValuesPerOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair values per options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValuesPerOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value per options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CarryingAmountMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Carrying amount [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CarryingAmountMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carrying amount [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_UsefulLifeMeasuredAsPeriodOfTimePropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Useful life measured as period of time, property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provisions for employee litigation and severance other comprehensive income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions For Employee Litigation And Severance Other Comprehensive Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Employee litigation and severance, OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OfficeEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Office equipment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OfficeEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Office Equipment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OfficeEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Office and laboratory equipment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfExpectedTermsOfYearsShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Description of expected terms of years share options granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfExpectedTermsOfYearsShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description of expected terms of years share options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfExpectedTermsOfYearsShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected term (in years)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_CurrencyAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Currency [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Total fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Total Fair Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Expected volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseOnLoanInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase Decrease on loan interest.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseOnLoanInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease on loan interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseOnLoanInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase on loans interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ServierMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Servier [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ServierMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Servier</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityNetOfTaxWeakeningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Net Of Tax Weakening [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityNetOfTaxWeakeningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity net of tax weakening.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityNetOfTaxWeakeningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weakening</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2024Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Capital evolution 2024.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2024Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Capital Evolution 2024 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2024Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital Evolution 2024 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Intangible Assets [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Intangible assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementStrategyAndGovernanceTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management, Strategy, and Governance [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilityAssetOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel">Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilityAssetOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel">Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilityAssetOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net defined benefit liability (asset)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilityAssetOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Net defined benefit liability (asset) at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilityAssetOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Net defined benefit liability (asset) at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Intangible assets other than goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Intangible assets other than goodwill at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Intangible assets other than goodwill at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Intangible assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total intangible assets other than goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RevenueFromPerformanceObligationsSatisfiedOrPartiallySatisfiedInPreviousPeriods_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue from performance obligations satisfied or partially satisfied in previous periods</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RevenueFromPerformanceObligationsSatisfiedOrPartiallySatisfiedInPreviousPeriods_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenue from performance obligations satisfied or partially satisfied in previous periods</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AccrualsAndDeferredIncomeIncludingContractLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accruals and deferred income including contract liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AccrualsAndDeferredIncomeIncludingContractLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accruals And Deferred Income Including Contract Liabilities [Line Items]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentShellCompanyReport_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Shell Company Report</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsCreditsAndNetOperatingLossCarryforwards_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credits and net operating loss carryforwards</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmountPlusFivePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of expected volatility amount plus five percentage.</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmountPlusFivePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected volatility +5%</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JuneTwentySixThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">June twenty six thousand and twenty four.</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromIssueOfShareCapitalAndOtherEquityInstrumentsAfterDeductionOfTransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from issue of share capital and other equity instruments after deduction of transaction costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromIssueOfShareCapitalAndOtherEquityInstrumentsAfterDeductionOfTransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from issue of share capital and other equity instruments after deduction of transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNonCurrentRestrictedCashDueToReclassificationInCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in non current restricted cash due to reclassification in current assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNonCurrentRestrictedCashDueToReclassificationInCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Non Current Restricted Cash Due To Reclassification In Current Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNonCurrentRestrictedCashDueToReclassificationInCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in restricted cash due to reclassification in current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AttributionOfExpensesByNatureToTheirFunctionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Attribution of expenses by nature to their function [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanTrancheBMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">European Investment Bank Loan Tranche B.</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExerciseOfShareWarrantsAndEmployeeWarrantsShares_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Exercise of share warrants, employee warrants, stock-options and free-shares vesting, shares</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Foreign currencies</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfNonadjustingEventsAfterReportingPeriodLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of non-adjusting events after reporting period [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BpifranceMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Bpifrance.</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProportionOfOwnershipInterestInSubsidiary_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Ownership interest</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LicenseAgreementWithServierMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">License agreement with Servier.</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Revenue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Revenue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total revenues</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AllocationOfPriorPeriodGainLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Allocation of prior period gain (loss)</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialAssetsAndLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of financial assets and liabilities table.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialAssetsAndLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Financial Assets And Liabilities [Table]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Call options february twenty fifth two thousand and twenty six.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Call options</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash flows provided by (used in) operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesRightOfUseAssetsAndOtherLeasesRelatedEffects_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Liabilities Right Of Use Assets And Other Leases Related Effects</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesRightOfUseAssetsAndOtherLeasesRelatedEffects_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax liabilities right of use assets and other leases related effects.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesRightOfUseAssetsAndOtherLeasesRelatedEffects_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Right-of-use assets and other leases-related effects</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanTrancheAMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">European Investment Bank Loan Tranche A.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanTrancheAMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">European Investment Bank Loan - Tranche A [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfFinancialAssetsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of financial assets [axis]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Liabilities at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Liabilities at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Liabilities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredExpensesAndOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred expenses and other current assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredExpensesAndOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Expenses And Other Current Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredExpensesAndOtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred expenses and other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherOperatingExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other operating expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherOperatingExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Operating Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherOperatingExpenses_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Other operating expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfNetDefinedBenefitLiabilityAssetAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of net defined benefit liability (asset) [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedLifeOfDerivativePlusOneMonth_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair value of expected life of derivative plus one month</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedLifeOfDerivativePlusOneMonth_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of expected life of derivative plus one month.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedLifeOfDerivativePlusOneMonth_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected life of derivative +1 month</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current assets or disposal groups classified as held for sale</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Assets held for sale</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentProvisionsOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non Current provisions other comprehensive income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentProvisionsOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Current provisions other comprehensive income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentProvisionsOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non current provisions OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfScopeOfConsolidationAndNonConsolidatedEntitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of Scope of consolidation and non-consolidated entities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfScopeOfConsolidationAndNonConsolidatedEntitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Scope Of Consolidation and Non-Consolidated Entities [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInPurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease in purchases and external expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInPurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in purchases and external expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Transaction costs disbursed in cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Transaction costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Transaction Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactionsEquityAndOtherIfrsAdjustments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease increase through tax on sharebased payment transactions equity and other IFRS adjustments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactionsEquityAndOtherIfrsAdjustments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease Increase Through Tax On Sharebased Payment Transactions Equity And Other IFRS Adjustments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactionsEquityAndOtherIfrsAdjustments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share-based compensation &amp; other IFRS adjustments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProvisionsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ApplicableTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Theoretical group tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ApplicableTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Applicable tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ApplicableTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Applicable tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutBreakdownOfRightOfUseAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure Of Detailed Information About Breakdown Of Right Of Use Assets Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutBreakdownOfRightOfUseAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Detailed Information About Breakdown Of Right Of Use Assets Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutBreakdownOfRightOfUseAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure Of Detailed Information About Breakdown Of Right Of Use Assets Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityWellKnownSeasonedIssuer_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Well-known Seasoned Issuer</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInTheNumberOfSharesGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In The Number Of Shares Granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInTheNumberOfSharesGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in the number of shares granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInTheNumberOfSharesGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in the number of shares granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustFourTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">August Four Two Thousand Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustFourTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">August four two thousand twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustFourTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">8/4/2025 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNetDefinedBenefitLiabilityInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in net defined benefit liability in discount rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNetDefinedBenefitLiabilityInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Net Defined Benefit Liability In Discount Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNetDefinedBenefitLiabilityInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in net defined benefit liability in discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ImpairmentLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Impairment loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ImpairmentLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Impairment of assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheAAndTrancheBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tranche A And Tranche B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheAAndTrancheBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Tranche A and Tranche B warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NetForeignExchangeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net foreign exchange loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NetForeignExchangeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net foreign exchange loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NetForeignExchangeLoss_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Foreign exchange losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConvertibleNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Convertible Notes</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConvertibleNotesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Convertible Notes [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOperatingAndReportableSegments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of operating and reportable segments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOperatingAndReportableSegments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Operating and Reportable Segments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOperatingAndReportableSegments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of operating and reportable segments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNonCurrentDeposits_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in non current deposits.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNonCurrentDeposits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Non Current Deposits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNonCurrentDeposits_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in non current deposits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialAssetsAndCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current financial assets and cash and cash equivalent.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialAssetsAndCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Financial Assets And Cash And Cash Equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialAssetsAndCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Current financial assets and cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current deferred income including current contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred income and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total Deferred revenue and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Deferred revenues and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdditionsOtherThanThroughBusinessCombinationsPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additions other than through business combinations, property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdditionsOtherThanThroughBusinessCombinationsPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DiscontinuedOperationsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Discontinued operations [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DiscontinuedOperationsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discontinued operations [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MiscellaneousOtherOperatingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Miscellaneous other operating expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MiscellaneousOtherOperatingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other operating expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberOneThreeTwoThousandTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">October one three two thousand twenty one</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberOneThreeTwoThousandTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">October one three two thousand twenty one [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberOneThreeTwoThousandTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">10/13/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in research and development expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease in Research and Development Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in research and development expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeLossMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Income loss.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeLossMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income (loss) [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of share capital, reserves and other equity interest [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfFairMarketValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Fair Market Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfFairMarketValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of fair market value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfFairMarketValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of market value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about property, plant and equipment [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of detailed information about property, plant and equipment [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseForFinancialLiabilitiesNotAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest expense for financial liabilities not at fair value through profit or loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseForFinancialLiabilitiesNotAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest on financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseForFinancialLiabilitiesNotAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Interest on financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLiabilitiesOtherMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current liabilities other [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLiabilitiesOtherMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current liabilities other.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFifthTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March fifth two thousand and twenty one tranch one [Member].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFifthTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Fifth Two Thousand And Twenty One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFifthTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">03/05/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BorrowingsByNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Borrowings by name [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfIntangibleAssetsAndGoodwillAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of intangible assets and goodwill [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfIntangibleAssetsAndGoodwillAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Classes of intangible assets and goodwill [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsForfeitedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of other equity instruments forfeited in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsForfeitedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Option outstanding, forfeited, cancelled or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressPostalZipCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Postal Zip Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonRecognitionOfDeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Recognition Of Deferred Tax Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonRecognitionOfDeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non recognition of deferred tax assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonRecognitionOfDeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Non-recognition of deferred tax assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfRelatedPartiesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Categories of related parties [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="stpr_NC_lbl" xlink:role="http://www.xbrl.org/2003/role/label">NORTH CAROLINA</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="stpr_NC_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Raleigh, North Carolina [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementPaymentReallocated_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Collaboration Agreement Payment Reallocated.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementPaymentReallocated_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaboration Agreement Payment Reallocated</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementPaymentReallocated_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaboration agreement payment reallocated</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MajorCustomersAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Major customers [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CopyrightsPatentsAndOtherIndustrialPropertyRightsServiceAndOperatingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Patents [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CopyrightsPatentsAndOtherIndustrialPropertyRightsServiceAndOperatingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Copyrights, patents and other industrial property rights, service and operating rights [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskRoleOfManagementTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Role of Management [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentRestrictedCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current restricted cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentRestrictedCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentRestrictedCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Short term restricted cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightofuseAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Right-of-use assets [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightofuseAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Right-of-Use Asset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromCollaborationAgreements_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of revenue from collaboration agreements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromCollaborationAgreements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue From Collaboration Agreements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromCollaborationAgreements_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaboration agreements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromCollaborationAgreements_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Collaboration agreements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromCollaborationAgreements_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Revenue from collaboration agreements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RetainedEarningsProfitLossForReportingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retained earnings, profit (loss) for reporting period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RetainedEarningsProfitLossForReportingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cellectis, Inc. [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cellectis Inc [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cellectis [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Cellectis, Inc. [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfVotingRights_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of voting rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfVotingRights_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of voting rights.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfVotingRights_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of voting rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Address Line One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateOperatingLossCarryforwardsExpirationYear_lbl" xlink:role="http://www.xbrl.org/2003/role/label">State Operating Loss Carryforwards Expiration Year</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateOperatingLossCarryforwardsExpirationYear_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">State operating loss carryforwards expiration year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateOperatingLossCarryforwardsExpirationYear_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">State operating loss carryforwards expiration year</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncontrollingInterestsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-controlling interests [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncontrollingInterestsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non controlling Interests [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskMateriallyAffectedOrReasonablyLikelyToMateriallyAffectRegistrantFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmendmentAgreementOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Amendment agreement one.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmendmentAgreementOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Agreement One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmendmentAgreementOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amendment Agreement One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueByNatureExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of revenue by nature explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueByNatureExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of revenue by nature explanatory [table text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueByNatureExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenues by Nature</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ValuationMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The method used to estimate the fair value of an asset or a liability.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ValuationMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Valuation Method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ValuationMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Valuation method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAndGoodwillGross_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Intangible assets and goodwill gross.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAndGoodwillGross_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Intangible assets and goodwill gross</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAndGoodwillGross_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gross value at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwentyFourTwoThousandAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May Twenty Four Two Thousand and Twenty Two [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwentyFourTwoThousandAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May Twenty Four Two Thousand and Twenty Two.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwentyFourTwoThousandAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">05/24/2022 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanFiveYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Later than five years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanFiveYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">More than Five Years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsGrantDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrants grant date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsGrantDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants Grant Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsGrantDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskBoardCommitteeOrSubcommitteeResponsibleForOversightTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Ordinary shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total number of shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Number of shares to be issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_UnobservableInputsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Unobservable inputs [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromSaleOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from sale of ordinary shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromSaleOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Sale Of Ordinary Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromSaleOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from sale of ordinary shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromSaleOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Proceeds received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecemberNineteenTwoThousandAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">12/19/2022 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecemberNineteenTwoThousandAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">December Nineteen Two Thousand and Twenty Two [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecemberNineteenTwoThousandAndTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">December Nineteen Two Thousand and Twenty Two.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfIncomeTaxExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of income tax [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfIncomeTaxExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Income Tax</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalentsInSubsidiaryOrBusinessesAcquiredOrDisposed2013_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and cash equivalents in subsidiary or businesses acquired or disposed</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalentsInSubsidiaryOrBusinessesAcquiredOrDisposed2013_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Calyxt's cash and cash equivalents disposed of</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseDueToRevenueRecognitionContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The decrease in contract liability balances resulting from the transfer of goods or services to customers.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseDueToRevenueRecognitionContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease due to Revenue Recognition, Contract Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseDueToRevenueRecognitionContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease due to revenue recognition</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_ContactPersonnelFaxNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Contact Personnel Fax Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentySevenTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March twenty seven two thousand fifteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentySevenTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March twenty seven two thousand fifteen [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentySevenTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">3/27/2015 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DevelopmentMilestoneReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Development milestone received.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DevelopmentMilestoneReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Development milestone received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Exercise Price Of Share Options Additional Shares Due To May Twenty Twenty Four Sharebased Payment Arrangement 2019</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Weighted Average Exercise Price Of Share Options Additional Shares Due To May Twenty Twenty Four Sharebased Payment Arrangement 2019</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, additional shares due to May 2024 modification</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PercentageOfEntitysRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PercentageOfEntitysRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of entity's revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OperatingExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OperatingExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Operating expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OperatingExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Total operating expenses and other operating income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EstimatedFairValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Estimated fair value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EstimatedFairValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Estimated Fair Value [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EstimatedFairValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimated Fair Value [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightsPreferencesAndRestrictionsAttachingToClassOfShareCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Rights, preferences and restrictions attaching to class of share capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightsPreferencesAndRestrictionsAttachingToClassOfShareCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Conversion ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightsPreferencesAndRestrictionsAttachingToClassOfShareCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Conversion ratio description</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StockOption1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock option.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StockOption1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Option 1 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StockOption1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock options [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsExercisableForfeitedOrExpiredInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Weighted average exercise price of share options exercisable forfeited or expired in share based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsExercisableForfeitedOrExpiredInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Exercise Price Of Share Options Exercisable Forfeited Or Expired In Share Based Payment Arrangements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsExercisableForfeitedOrExpiredInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted- average exercise price per share, forfeited or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsExercisableForfeitedOrExpiredInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Weighted- average exercise price per share, forfeited or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Cash flows provided by (used in) investment activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of material accounting policy information [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounting principles</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of other current liabilities [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseIncomeNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Interest cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseIncomeNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in net defined benefit liability (asset) resulting from interest expense (income)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialAssetsAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current financial assets at fair value through profit or loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialAssetsAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current financial assets at fair value through profit or loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialAssetsAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditLitigationsAccrual_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research tax credit litigations accrual</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditLitigationsAccrual_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Litigations Accrual</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditLitigationsAccrual_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research tax credit litigations accrual.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskProcessForInformingBoardCommitteeOrSubcommitteeResponsibleForOversightTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BottomOfRangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Bottom of range [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BottomOfRangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Bottom of Range [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughChangesInForeignExchangeRatesContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase (decrease) in contract liability balances resulting from changes in foreign exchange rates.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughChangesInForeignExchangeRatesContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) Through Changes in Foreign Exchange Rates, Contract Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughChangesInForeignExchangeRatesContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenue from positive foreign exchange impact, partially offset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MiscellaneousOtherOperatingIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Miscellaneous other operating income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MiscellaneousOtherOperatingIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other operating income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLossesExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Federal R&amp;D tax credits, expiration period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLossesExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research and Development Tax Credits, Tax Effect of Tax Losses, Expiration Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLossesExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research and development tax credits, tax effect of tax losses, expiration period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CytoviaAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cytovia agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CytoviaAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cytovia Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CytoviaAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cytovia Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionMayThirteenthTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Put Option May Thirteenth Two Thousand And Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionMayThirteenthTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Put option may thirteenth two thousand and twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionMayThirteenthTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Put options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ContinuingAndDiscontinuedOperationsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Continuing and discontinued operations [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provision for tax litigation additions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provision For Tax Litigation Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provision for tax litigation, Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GeographicalAreasAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Geographical areas [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GeographicalAreasAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Geographical areas [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInWorkingCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in working capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInWorkingCapital_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Change in working capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Financial Assets [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentFinancialAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current Financial Assets [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Borrowings_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Borrowings_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Borrowings_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AggregateCreditFacility_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Aggregate credit facility.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AggregateCreditFacility_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Aggregate credit facility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfVotingEquityInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of voting equity interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfVotingEquityInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of voting equity interest.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementOneDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement one.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementOneDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreement One [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfBasisOfConsolidationAndMaterialAccountingPolicyInformationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of basis of consolidation and material accounting policy information explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfBasisOfConsolidationAndMaterialAccountingPolicyInformationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Basis Of Consolidation And Material Accounting Policy Information Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfBasisOfConsolidationAndMaterialAccountingPolicyInformationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basis for preparation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Collaboration agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaboration Agreement [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentPortionOfState-GuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current Portion of State-Guaranteed Loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentPortionOfState-GuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Portion of State-Guaranteed Loan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantInvestmentsInAssociatesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Associates [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashReceivedRelatedToIncreaseDecreaseInWorkingCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashReceivedRelatedToIncreaseDecreaseInWorkingCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash received related to increase (decrease) in working capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashReceivedRelatedToIncreaseDecreaseInWorkingCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cash received related to increase (decrease) in working capital.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantDateAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Grant Date [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantDateAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Grant date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAAndBPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class A and B Preferred Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAAndBPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class A and B Preferred Shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAAndBPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class A and B Preferred Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedTermBankDepositMaturityPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fixed term bank deposit maturity period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedTermBankDepositMaturityPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fixed Term Bank Deposit Maturity Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedTermBankDepositMaturityPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fixed term bank deposit, maturity period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperatingExpenseAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Operating expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperatingExpenseAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Expense [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperatingExpenseAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RetainedEarningsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retained earnings [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RetainedEarningsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retained Earnings (Deficit) [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DepreciationAmortisationAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Depreciation, amortisation and impairment loss (reversal of impairment loss) recognised in profit or loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DepreciationAmortisationAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Depreciation &amp; impairment expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DepreciationAmortisationAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total depreciation, amortisation and impairment loss (reversal of impairment loss) recognised in profit or loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DepreciationAmortisationAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Depreciation &amp; impairment expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatility_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The expected volatility of the share price used to calculate the fair value of the share options granted. Expected volatility is a measure of the amount by which a price is expected to fluctuate during a period. The measure of volatility used in option pricing models is the annualized standard deviation of the continuously compounded rates of return on the share over a period of time.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatility_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected Volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFinStmtErrorCorrectionFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Financial Statement Error Correction [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfFinancialAssetsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Categories of financial assets [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesAndLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Liabilities And Lease Debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesAndLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financial liabilities and lease debts.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesAndLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total Financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyFourTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March twenty four two thousand fifteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyFourTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March twenty four two thousand fifteen [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyFourTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">3/24/2015 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsForfeited_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Fair Value At Measurement Date Other Equity Instruments Forfeited</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsForfeited_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The weighted average fair value at the measurement date of other equity instruments (ie other than share options) expired or forfeited in a share-based payment arrangement. [Refer: Weighted average [member]"</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsForfeited_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, Cancelled</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueInstrumentRemeasured_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Instrument Remeasured</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueInstrumentRemeasured_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value instrument remeasured.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ShareIssuancePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share issuance price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ShareIssuancePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Issuance Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ShareIssuancePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share issuance price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Receivables1Abstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Receivables.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Receivables1Abstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Receivables1 [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Put Options February Twenty Fifth Two Thousand And Twenty Six [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Put options february twenty fifth two thousand and twenty six.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Put options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionOfReversalTaxLitigation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provision Of Reversal Tax Litigation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionOfReversalTaxLitigation_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provision of reversal tax litigation.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionOfReversalTaxLitigation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provision of reversal tax litigation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromIssueOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from issue of ordinary shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromIssueOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise stock option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Tranche A Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheAWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tranche A Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfRevenueExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of revenue [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of subsidiaries [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RelatedPartyTransactionsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related party transactions [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_OwnershipDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Ownership [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Fiscal Year End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current Fiscal Year End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentAssetsOtherThanAssetsOrDisposalGroupsClassifiedAsHeldForSaleOrAsHeldForDistributionToOwners_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current assets other than non-current assets or disposal groups classified as held for sale or as held for distribution to owners</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentAssetsOtherThanAssetsOrDisposalGroupsClassifiedAsHeldForSaleOrAsHeldForDistributionToOwners_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherOperatingIncome1_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other operating income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherOperatingIncome1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Operating Income1</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherOperatingIncome1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other operating income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInInterestIncomeFromCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase Decrease in interest income from cash, cash equivalents and financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInInterestIncomeFromCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease in interest income from cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInInterestIncomeFromCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease /increase in income from cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromDiscontinuedOperationsAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit (loss) from discontinued operations attributable to ordinary equity holders of parent entity, used in calculating basic earnings per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromDiscontinuedOperationsAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net income (loss) attributable to shareholders of Cellectis from discontinued operations (in thousands)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditLitigationSettled_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Litigation Settled</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditLitigationSettled_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research Tax Credit Litigation Settled</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditLitigationSettled_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research tax credit litigation settled</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AstraZenecaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Astra Zeneca.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AstraZenecaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Astra Zeneca [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AstraZenecaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">AstraZeneca [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseOnBankLoansAndOverdrafts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest expense on EIB loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseOnBankLoansAndOverdrafts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest expense on bank loans and overdrafts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseByNatureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expenses by nature [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseByNatureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in cash and cash equivalents, discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">(Decrease) increase in cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherNoncurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other non-current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherNoncurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MaturityByGrantDateDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maturity by Grant Date [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MaturityByGrantDateDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Maturity by grant date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MaturityByGrantDateDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant Date [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityInvestmentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity investments [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule Of Cash Flow Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Cash Flow Statement Of Discontinued Operations [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Cash Flow Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfImpairmentLossAndReversalOfImpairmentLossAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of impairment loss and reversal of impairment loss [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) investing activities, discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net cash flows provided by (used in) investing activities of discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) investing activities, discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfFinancialLiabilitiesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of financial liabilities [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInPersonnelExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in personnel expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInPersonnelExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Personnel Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInPersonnelExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in personnel expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AccumulatedTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated tax losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AccumulatedTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated Tax Losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AccumulatedTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accumulated tax losses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnShare-BasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income Tax effect on share-based compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnShare-BasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Income tax effect on share-based compensation.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnShare-BasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Tax effect on share-based compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherNonCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other non-current financial liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherNonCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other non-current financial liabilities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherNonCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Non-Current Financial Liabilities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JulyTwentyTwoThousandAndTwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">July Twenty Two Thousand and Twenty [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JulyTwentyTwoThousandAndTwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">July twenty two thousand and twenty.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JulyTwentyTwoThousandAndTwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">07/20/2020 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_StatementGeographicalAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Geographical [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassOfWarrantsOrRightAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrants Or Right [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementTwoAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement two</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementTwoAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreement Two [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenueAndContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Adjustments for increase (decrease) in deferred revenue and contract liabilities to reconcile profit (loss) to net cash flows provided by (used in) operating activities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenueAndContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments For Increase Decrease In Deferred Revenue And Contract Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenueAndContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">(Decrease) increase in deferred revenues and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncomeCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Finance income (cost)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncomeCost_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net financial gain (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncomeCost_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net Financial gain (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncomeCost_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net Financial gain (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncomeCost_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Net Financial gain (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_KeyManagementPersonnelCompensationShareBasedPaymentsInShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Key management personnel compensation share based payments in shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_KeyManagementPersonnelCompensationShareBasedPaymentsInShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Key management personnel compensation share based payments in shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_KeyManagementPersonnelCompensationShareBasedPaymentsInShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Key management personnel compensation, share-based payments in shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-adjusting events after reporting period [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of trade and other receivables [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Trade Receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInForeignExchangeGainsLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in foreign exchange gains (losses)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInForeignExchangeGainsLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in foreign exchange gains losses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInForeignExchangeGainsLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Foreign Exchange Gains Losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueAndOtherIncomeExplanatoryTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of revenue and other income explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueAndOtherIncomeExplanatoryTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Revenue And Other Income Explanatory [TableTextBlock]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueAndOtherIncomeExplanatoryTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenues By Country of Origin and Other Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfFinancialLiabilitiesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of financial liabilities [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInAccrualsForPersonnelRelatedExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in accruals for personnel related expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInAccrualsForPersonnelRelatedExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Accruals for Personnel Related Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInAccrualsForPersonnelRelatedExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in accruals for personnel related expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsExpiredInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of other equity instruments expired in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsExpiredInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of instruments voided</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsExpiredInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Number of instruments voided</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of expected impact of initial application of new standards or interpretations [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of changes in accounting estimates [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfFreeSharesVested_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Free shares Vested</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfFreeSharesVested_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of free shares vested.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharePriceWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share price warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharePriceWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Price Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharePriceWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShorttermDepositsNotClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Short-term deposits, not classified as cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShorttermDepositsNotClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShorttermDepositsNotClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Deposit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageChangeSensistivity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage change sensistivity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageChangeSensistivity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Change Sensistivity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageChangeSensistivity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage change sensistivity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesAcceleratedDepreciationOfAssetsForTaxPurposes_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Liabilities Accelerated Depreciation Of Assets For Tax Purposes</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesAcceleratedDepreciationOfAssetsForTaxPurposes_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax liabilities accelerated depreciation of assets for tax purposes.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesAcceleratedDepreciationOfAssetsForTaxPurposes_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accelerated depreciation of assets for tax purposes</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SeptemberFiveThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">September Five Thousand And Twenty Four [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SeptemberFiveThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">September five thousand and twenty four.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SeptemberFiveThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">09/05/2024 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current lease debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current lease debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current Lease Debts [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateShareOptionsGrantedPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Weighted average fair value at measurement date share options granted per share.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateShareOptionsGrantedPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Fair Value at Measurement Date Share Options Granted Per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateShareOptionsGrantedPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Weighted-Average fair values of warrants granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateShareOptionsGrantedPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average fair values of stock options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmountConvertibleNoteDueAndPayableInFullCash_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount convertible note due and payable in full cash.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmountConvertibleNoteDueAndPayableInFullCash_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amount Convertible Note Due and Payable in Full Cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmountConvertibleNoteDueAndPayableInFullCash_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Amount of convertible note due and payable in full cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of Provisions for employee litigation and severance additions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions for employee litigation and severance additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Employee litigation and severance, Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JointResearchAndCollaborationAgreementInitialInvestmentAgreementSubsequentInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Joint research and collaboration agreement, initial investment agreement, subsequent investment agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JointResearchAndCollaborationAgreementInitialInvestmentAgreementSubsequentInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Joint Research And Collaboration Agreement Initial Investment Agreement Subsequent Investment Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JointResearchAndCollaborationAgreementInitialInvestmentAgreementSubsequentInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">AZ JRCA, IIA and SIA [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total non-current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RetirementAge_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Retirement age.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RetirementAge_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retirement Age</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RetirementAge_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retirement age</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Fair value of pre funded warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDetailedInformationAboutFinancialInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about financial instruments [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDetailedInformationAboutFinancialInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial assets and liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreeementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement Axis and License.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreeementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreeement [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfLiabilitiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of liabilities [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestPaidClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest paid, classified as financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestPaidClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestPaidClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Interest paid on financial debt</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestPaidClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Interest paid</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueOfForeignExchangeDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gain in fair value of foreign exchange derivatives.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueOfForeignExchangeDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain In Fair Value Of Foreign Exchange Derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueOfForeignExchangeDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain in fair value of foreign exchange derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsForfeitedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Weighted average exercise price per share, cancelled, forfeited or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsForfeitedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, forfeited or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsForfeitedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Weighted average exercise price per share, cancelled, forfeited or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsForfeitedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average exercise price per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PastServiceCostNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in net defined benefit liability (asset) resulting from past service cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PastServiceCostNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Past service cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnrealizedGainsLossesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unrealized Gains Losses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnrealizedGainsLossesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Unrealized Gains Losses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnrealizedGainsLossesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Unrealized Gains Losses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NetDeferredTaxLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net deferred tax liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NetDeferredTaxLiabilities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Net deferred tax liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCashStockBasedCompensationExpenseDueToChangeInRatioConversion_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-Cash Stock Based Compensation Expense Due To Change In Ratio Conversion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCashStockBasedCompensationExpenseDueToChangeInRatioConversion_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-cash stock based compensation expense due to change in ratio conversion.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCashStockBasedCompensationExpenseDueToChangeInRatioConversion_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional stock-based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RangeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Range [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RangeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Range [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other comprehensive income that will not be reclassified to profit or loss net of tax from continuing operations.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income That Will Not Be Reclassified To Profit Or Loss Net Of Tax From Continuing Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Other comprehensive income (loss) that will not be reclassified subsequently to income or loss from continued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsAccumulatedTaxLossCarryforwardsAndFederalResearchAndDevelopmentTaxCredits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred tax assets accumulated tax loss carryforwards and federal research and development tax credits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsAccumulatedTaxLossCarryforwardsAndFederalResearchAndDevelopmentTaxCredits_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax assets accumulated tax loss carryforwards and federal research and development tax credits.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsAccumulatedTaxLossCarryforwardsAndFederalResearchAndDevelopmentTaxCredits_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred tax assets related to accumulated tax loss carryforwards and federal R&amp;D tax credits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOffsettingOfFinancialLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of offsetting of financial liabilities [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOffsettingOfFinancialLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of offsetting of financial liabilities [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOffsettingOfFinancialLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Disclosure of offsetting of financial liabilities [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfExercisableShareOptionsExercisedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Exercisable Share Options Exercised In Share Based Payment Arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfExercisableShareOptionsExercisedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of exercisable share options exercised in share based payment arrangement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfExercisableShareOptionsExercisedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Option exercisable, exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Option Outstanding, exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares, Vested</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Forfeited or Expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Warrants outstanding, exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Option outstanding, exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) investing activities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash flows from investment activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharesEntitlementPerOption_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Shares entitlement per option.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharesEntitlementPerOption_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Shares Entitlement per Option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharesEntitlementPerOption_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share entitlement per option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberfivetwothousandtwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">NovemberFiveTwoThousandTwenty [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberfivetwothousandtwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">11/05/2020 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberfivetwothousandtwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Novemberfivetwothousandtwenty Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SegmentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segments [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherSubsidiesAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">other subsidies amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherSubsidiesAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Subsidies Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherSubsidiesAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other subsidies and other</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JuneTwentySixTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">06/26/2023 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JuneTwentySixTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">June Twenty Six Two Thousand And Twenty Three [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JuneTwentySixTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">June twenty six two thousand and twenty three.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberElevenTwoThousandSeventeenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">October eleven two thousand seventeen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberElevenTwoThousandSeventeenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">October eleven two thousand seventeen [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberElevenTwoThousandSeventeenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">10/11/2017 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease (increase) in trade receivables and other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for decrease (increase) in trade and other receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Discontinued Operations [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discontinued Operations [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisableInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average exercise price of share options exercisable in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisableInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Weighted- average exercise price per share, ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisableInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Weighted- average exercise price per share, beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeAndOtherReceivablesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trade and other receivables [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInIncomeFromCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase decrease in Income from cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInIncomeFromCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in Income from cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInIncomeFromCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase (decrease) in Income from cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit (loss), attributable to ordinary equity holders of parent entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net income (loss) attributable to shareholders of Cellectis (in thousands)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToOrdinaryEquityHoldersOfParentEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Profit (loss), attributable to ordinary equity holders of parent entity, used in calculating basic earnings per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of financial liabilities [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Calyxt Inc.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Calyxt Inc [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Calyxt Inc. [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestReceivedClassifiedAsOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest received, classified as operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestReceivedClassifiedAsOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial liabilities, at fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Fair value of financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTermsAndConditionsOfSharebasedPaymentArrangementTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of terms and conditions of share-based payment arrangement [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTermsAndConditionsOfSharebasedPaymentArrangementTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of terms and conditions of share-based payment arrangement [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesEntitledPerOption_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of shares entitled per option.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesEntitledPerOption_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Shares Entitled Per Option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesEntitledPerOption_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share entitlement per option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesEntitledPerOption_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share entitlement per warrant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLoansReceivedAndCurrentPortionOfNoncurrentLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current loans received and current portion of non-current loans received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLoansReceivedAndCurrentPortionOfNoncurrentLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current liability of loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfFinancialLiabilitiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of financial liabilities [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfFinancialLiabilitiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Classes of financial liabilities [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfInstrumentsOtherEquityInstrumentsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of other equity instruments granted in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfInstrumentsOtherEquityInstrumentsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Option outstanding, granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfInstrumentsOtherEquityInstrumentsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number shares granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EarningsPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings per share [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EarningsPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Basic / Diluted net income (loss) per share attributable to shareholders of Cellectis</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseAgreementTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Lease agreement term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseAgreementTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease Agreement Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseAgreementTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lease agreement term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of current financial assets and cash and cash equivalents.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Current Financial Assets And Cash And Cash Equivalents [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of current financial assets and cash and cash equivalents [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAttributableToOwnersOfParentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity attributable to owners of parent [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAttributableToOwnersOfParentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Attributable to Shareholders of Cellectis [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesAmountsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provisions for retirement indemnities amounts used during the period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesAmountsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions For Retirement Indemnities Amounts Used During The Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesAmountsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retirement indemnities , Amounts used during the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfitAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Annual limit to carryforwards use against future taxable profit amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfitAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Annual Limit To Carryforwards Use Against Future Taxable Profit Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfitAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Annual limit to carryforwards use against future taxable profit amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfIntangibleAssetsOtherThanGoodwillDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of intangible assets other than goodwill [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutAssumptionsUsedAndValuationResultsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of information about assumptions used and valuation results.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutAssumptionsUsedAndValuationResultsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of information about assumptions used and valuation results [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutAssumptionsUsedAndValuationResultsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Assumptions Used and Estimated Fair Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_UnobservableInputsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Unobservable inputs [domain]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainLossOnFairValueMeasurement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain Loss on Fair Value Measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainLossOnFairValueMeasurement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gain loss on fair value measurement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditSubsidyAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Subsidy Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditSubsidyAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research tax credit subsidy amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditSubsidyAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research tax credit subsidy</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research tax credit.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research tax credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Fair Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Advances_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Advances received, representing contract liabilities for performance obligations satisfied at point in time</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Advances_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Conditional advance</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnChangeInFairValueOfFinancialInstruments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income Tax effect on change in fair value of financial instruments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnChangeInFairValueOfFinancialInstruments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Income Tax effect on change in fair value of financial instruments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfBreakdownOfRightOfUseAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of Breakdown Of Right Of Use Assets [Abstract].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfBreakdownOfRightOfUseAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Breakdown Of Right Of Use Assets [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeReclassificationAdjustmentOnDeconsolidationOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other comprehensive income, reclassification adjustment on deconsolidation of merged entity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeReclassificationAdjustmentOnDeconsolidationOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other comprehensive income, reclassification adjustment on deconsolidation of merged entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeReclassificationAdjustmentOnDeconsolidationOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">OCI Reclassification pursuant to Calyxt's deconsolidation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of property, plant and equipment [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyTwoTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Twenty Two Two Thousand And Twenty Three [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyTwoTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March twenty two two thousand and twenty three.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchTwentyTwoTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">03/22/2023 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Comprehensive income, attributable to owners of parent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Attributable to shareholders of Cellectis</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total comprehensive income, attributable to owners of parent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForFinanceIncomeCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for finance income (cost)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForFinanceIncomeCost_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Net financial loss (gain)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDisaggregationOfRevenueFromContractsWithCustomersExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of disaggregation of revenue from contracts with customers [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDisaggregationOfRevenueFromContractsWithCustomersExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenues by Nature</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberSixTwoThousandNineteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">November Six Two Thousand Nineteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberSixTwoThousandNineteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">November Six Two Thousand Nineteen [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberSixTwoThousandNineteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">11/06/2019 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Milestone [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperationBetweenShareholder_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operation between shareholder</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperationBetweenShareholder_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Operation between shareholder.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OperationBetweenShareholder_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operation between shareholders</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Consolidated operations.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Consolidated operations [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cellectis.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cellectis [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cellectis [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Cellectis [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentDerivativeFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current derivative financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentDerivativeFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExercisePriceShareOptionsGranted2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exercise price, share options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExercisePriceShareOptionsGranted2019_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of basis of consolidation [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Information concerning the Group's Consolidated Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Scope of consolidation and non-consolidated entities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDetailedInformationAboutPropertyPlantAndEquipmentExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about property, plant and equipment [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDetailedInformationAboutPropertyPlantAndEquipmentExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Details of Property, Plant and Equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of impairment of assets [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Impairment tests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AuditorFirmId_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Auditor Firm ID</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OptionVestingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Option vesting period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OptionVestingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Option Vesting Period</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseOptionToExtendLeaseAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Lease option to extend lease agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseOptionToExtendLeaseAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease Option To Extend Lease Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseOptionToExtendLeaseAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lease option to extend lease agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseOptionToExtendLeaseAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Lease option to extend lease agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsOtherThanGoodwillEstimatedUsefulLife_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Intangible assets other than goodwill estimated useful life.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsOtherThanGoodwillEstimatedUsefulLife_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Intangible Assets Other than Goodwill Estimated Useful Life</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsOtherThanGoodwillEstimatedUsefulLife_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimated useful lives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TermsOfRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Terms of repayment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TermsOfRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Terms of Repayment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TermsOfRepayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Terms of repayment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypesOfWarrantsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Types of warrants [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypesOfWarrantsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of warrants [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsRevaluationsOfFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revaluations of financial assets</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsRevaluationsOfFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax assets revaluations of financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfAssumptionsUsedToEstimateFairValueOfWarrantsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of assumption used to estimate fair value of warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfAssumptionsUsedToEstimateFairValueOfWarrantsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Assumptions Used to Estimate Fair Value of Warrants [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfAssumptionsUsedToEstimateFairValueOfWarrantsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of assumptions Weighted-average Fair Values of Warrants Granted and Assumptions Used for Black-Scholes Option Pricing Model</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditFinancingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research Tax Credit financing</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditFinancingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Financing [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of reconciliation of liabilities arising from financing activities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesFromOtherTaxableDifferences_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Deferred tax liabilities from other taxable differences</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialInstitutionAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Institution [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of financial liabilities [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WagesAndSalaries_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Wages and salaries</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentServiceCostNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Current service cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentServiceCostNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase in net defined benefit liability (asset) resulting from current service cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneAchievementRelatedToDosingOfFirstSubjectInPhaseIMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Milestone achievement related to dosing of first subject in phase I.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneAchievementRelatedToDosingOfFirstSubjectInPhaseIMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Milestone Achievement Related to Dosing of First Subject in Phase I [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneAchievementRelatedToDosingOfFirstSubjectInPhaseIMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Milestone Achievement Related to Dosing of First Subject in Phase I [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SummaryOfCashAndCashEquivalentsAndCurrentFinancialAssetsDenominatedInUnitedStatesDollarsAffectedEquityAndProfitOrLossTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Summary Of Cash And Cash equivalents And Current Financial Assets Denominated In United States Dollars Affected Equity And Profit Or Loss [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SummaryOfCashAndCashEquivalentsAndCurrentFinancialAssetsDenominatedInUnitedStatesDollarsAffectedEquityAndProfitOrLossTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Summary of cash and cash equivalents and current financial assets denominated in united states dollars affected equity and profit or loss.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SummaryOfCashAndCashEquivalentsAndCurrentFinancialAssetsDenominatedInUnitedStatesDollarsAffectedEquityAndProfitOrLossTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Cash, Cash Equivalents and Current Financial Assets Denominated in US Dollars Affected Profit or Loss and Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research tax credit receivable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research tax credit receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Research tax credit receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAndLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity and liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAndLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAPreferredSharesWithSingleVotingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class A Preferred shares with single voting rights [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAPreferredSharesWithSingleVotingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class A Preferred shares with single voting rights.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAPreferredSharesWithSingleVotingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class A Preferred shares with single voting rights [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of information about consolidated and non-consolidated structured entities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Information About Consolidated And Non-consolidated Structured Entities [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ForeignExchangeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Foreign exchange loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ForeignExchangeLoss_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Foreign exchange loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ForeignExchangeLoss_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Foreign exchange losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ForeignExchangeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Foreign exchange loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdditionsToRightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additions to right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdditionsToRightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement Axis</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreement [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementPositionsOrCommitteesResponsibleTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Positions or Committees Responsible [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfAntidilutiveInstrumentsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of antidilutive instruments [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfAnalysisOfSingleAmountOfDiscontinuedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of analysis of single amount of discontinued operations [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities included in disposal groups classified as held for sale</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Liabilities related to asset held for sale</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingOfFreeSharesAndStockOptionExercisesValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Vesting Of Free Shares And Stock Option Exercises Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingOfFreeSharesAndStockOptionExercisesValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase (decrease) in shareholders' equity through the issue of equity instruments resulting from the vesting of free shares and the exercises of stock-options granted to employees and directors in share-based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VestingOfFreeSharesAndStockOptionExercisesValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of share warrants, employee warrants, stock-options and free-shares vesting, amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Finance income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinanceIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Financial income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentInformationLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Information [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForSharebasedPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for share-based payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForSharebasedPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expenses related to share-based payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForSharebasedPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Adjustments for share-based payments, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PaymentsForShareIssueCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Transactions costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PaymentsForShareIssueCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments for share issue costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOfEquityInstrumentGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOfEquityInstrumentGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Type of equity instrument granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOfEquityInstrumentGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Type of equity instrument granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityLessFivePercentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Expected volatility less five percent.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityLessFivePercentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected Volatility Less Five Percent [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityLessFivePercentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected volatility -5% [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-current financial liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current financial liabilities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other non current financial liabilities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantExpirationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant expiration date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantExpirationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Expiration Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantExpirationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expiration date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantUnobservableInputLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Significant unobservable input, liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantUnobservableInputLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of grant and refundable advance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementUpfrontPaymentReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Collaboration agreement upfront payment received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementUpfrontPaymentReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaboration Agreement Upfront Payment Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementUpfrontPaymentReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaboration agreement, upfront payment received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Non current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskProcessForInformingManagementOrCommitteesResponsibleTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit from deconsolidation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income (loss) from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income (loss) from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net loss for the period from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provisions for retirement indemnities other comprehensive income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions For Retirement Indemnities Other Comprehensive Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retirement Indemnities , OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDebtRepaymentTerms_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of debt repayment terms</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDebtRepaymentTerms_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of debt repayment terms</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The risk-free rate represents the interest an investor would expect from an absolutely risk-free investment over a specified period of time.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Risk Free Interest Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Risk-free interest rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Risk free rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentRegistrationStatement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Registration Statement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other comprehensive income, before tax, gains (losses) on remeasurements of defined benefit plans</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total other comprehensive income, before tax, gains (losses) on remeasurements of defined benefit plans</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Actuarial gains (losses)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CapitalRequirementsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Capital requirements [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CapitalRequirementsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital requirements [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativeInstrumentsMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Instruments Maturity Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativeInstrumentsMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Derivative instruments maturity date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provisions for retirement indemnities additions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions For Retirement Indemnities Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retirement indemnities , Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClinicalAndRdAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Clinical And Rd Agreements Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClinicalAndRdAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Clinical And RD Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClinicalAndRdAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Clinical &amp; Research and Development agreements [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredIncomeIncludingContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred income including contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredIncomeIncludingContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred income and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredIncomeIncludingContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total deferred income and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfShareCapitalDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of share capital [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LongtermDeposits_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deposit and financial investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LongtermDeposits_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Non-current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LongtermDeposits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deposit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CompanySharePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The fair value of the Company's common shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CompanySharePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Company share price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CompanySharePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingEIBWarrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financial liabilities excluding EIB warrant liability.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingEIBWarrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Liabilities Excluding EIB Warrant Liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingEIBWarrantLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Financial liabilities excluding EIB warrant liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cibus shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cibus shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cibus Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProfitAndLossWeakeningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit And Loss Weakening [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProfitAndLossWeakeningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Profit and loss weakening.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProfitAndLossWeakeningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weakening</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-RecurringGainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-Recurring Gains (Losses) On Financial Assets At Fair Value Through Profit Or Loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-RecurringGainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-recurring gains (losses) on financial assets at fair value through profit or loss.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-RecurringGainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-recurring gain (loss) in fair value measurement before derecognition</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_BusinessContactMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Business Contact [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DefinedBenefitPlansDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Defined benefit plans [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalUpfrontPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Total upfront payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalUpfrontPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Total upfront payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of share-based payment arrangements [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-cash stock-based compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share-based payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfProvisionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of provisions [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfProvisionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustfivetwothousandtwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">AugustFiveTwoThousandTwenty [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustfivetwothousandtwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">08/05/2020 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustfivetwothousandtwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Augustfivetwothousandtwenty Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfIntangibleAssetsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about intangible assets [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTermsAndConditionsOfSharebasedPaymentArrangementAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of terms and conditions of share-based payment arrangement [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expense from share-based payment transactions with employees</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share based payment expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share-based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Non-cash stock based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reserve of exchange differences on translation [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Currency Translation Adjustment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="country_US_lbl" xlink:role="http://www.xbrl.org/2003/role/label">UNITED STATES</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="country_US_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">United States [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="country_US_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">US</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SocialSecurityContributionsOnStockOptionGrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Social security contributions on stock option grants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SocialSecurityContributionsOnStockOptionGrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Social Security Contributions On Stock Option Grants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SocialSecurityContributionsOnStockOptionGrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Social charges on stock option grants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfShareCapitalAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of share capital [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfShareCapitalAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Classes of share capital [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfSharebasedPaymentArrangementsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of share-based payment arrangements [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VariableConsiderationAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Variable consideration amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VariableConsiderationAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Variable consideration amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VariableConsiderationAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable consideration amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughTransferBetweenRetainedEarningsIntoSharePremium_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) through transfer between retained earnings into share premium.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughTransferBetweenRetainedEarningsIntoSharePremium_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease Through Transfer Between Retained Earnings Into Share Premium</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughTransferBetweenRetainedEarningsIntoSharePremium_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase (decrease) through transfer between retained earnings into share premium</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StepUpInterestRatePercentageOnNotesReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Step up interest rate percentage on notes receivable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StepUpInterestRatePercentageOnNotesReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Step Up Interest Rate Percentage On Notes Receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StepUpInterestRatePercentageOnNotesReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Step up interest rate percentage on notes receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOrdinarySharesReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of ordinary shares received.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOrdinarySharesReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Ordinary Shares Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfOrdinarySharesReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of common stock received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmountLessFivePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of expected volatility amount less five percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmountLessFivePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value of Expected Volatility Amount Less Five Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityAmountLessFivePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected volatility -5%</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProportionOfOwnershipInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proportion of ownership interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProportionOfOwnershipInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proportion of Ownership Interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProportionOfOwnershipInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proportion of ownership interest.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProportionOfOwnershipInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Ownership interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MajorCustomersDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Major customers [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VolatilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VolatilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Volatility [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VolatilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Volatility.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisposalsOfRightOfUseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Disposal</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisposalsOfRightOfUseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disposals of right of use assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisposalsOfRightOfUseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposals Of Right Of Use Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisposalsOfRightOfUseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disposals of right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialAssetsAndLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of financial assets and liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialAssetsAndLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Financial Assets And Liabilities [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialAssetsAndLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of financial assets and liabilities [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShareIssueRelatedCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share issue related cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShareIssueRelatedCost_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShareIssueRelatedCost_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share issuance related cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShareIssueRelatedCost_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShareIssueRelatedCost_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Transaction costs related to capital increase</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfSensitivityOfTheDerivativeFairValueToTheExpectedLifeOfTheDerivativeTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Sensitivity of the derivative fair value to the expected life of the derivative [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfSensitivityOfTheDerivativeFairValueToTheExpectedLifeOfTheDerivativeTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of sensitivity of the derivative fair value to the expected life of the derivative.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfSensitivityOfTheDerivativeFairValueToTheExpectedLifeOfTheDerivativeTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Sensitivity of Derivative Fair Value to Expected Life of Derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit (loss), attributable to owners of parent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Attributable to shareholders of Cellectis</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income (loss) attributable to shareholders of Cellectis</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Other financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfFinancingTaxReceivableRelatedToResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The percentage of the certain Research Tax Credit Receivables subject to a prefinancing.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfFinancingTaxReceivableRelatedToResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of financing tax receivable related to research tax credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NoncurrentFinancialLiabilitiesAndNoncurrentLeaseDebtsProceedsFromDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Noncurrent Financial Liabilities and Noncurrent Lease Debts Proceeds from Debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NoncurrentFinancialLiabilitiesAndNoncurrentLeaseDebtsProceedsFromDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Noncurrent financial liabilities and noncurrent lease debts proceeds from debts.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NoncurrentFinancialLiabilitiesAndNoncurrentLeaseDebtsProceedsFromDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from new debts non-current financial liabilities and non-current lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseOnLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest expense on lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestExpenseOnLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Interest on lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNonCurrentFinancialAssetsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Non-current Financial Assets Explanatory [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNonCurrentFinancialAssetsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The enitre disclosure of non-current financial assets explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNonCurrentFinancialAssetsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current financial assets and Other non-current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherExpenseByNature_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other expenses, by nature</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherExpenseByNature_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherExpenseByNature_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Other</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherExpenseByNature_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Other expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity attributable to owners of parent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAttributableToOwnersOfParent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total shareholders' equity - Group Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CapitalCommitmentsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Capital commitments [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Deposit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayFourTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May Four Two Thousand And Twenty Three [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayFourTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May four two thousand and twenty three</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayFourTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">05/04/2023 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComputerSoftwareMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Computer Software [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComputerSoftwareMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Computer software [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SoftwareAndPatentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Software and patents.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SoftwareAndPatentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Software And Patents [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SoftwareAndPatentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Software and Patents [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentSecuredBankLoansReceivedAndCurrentPortionOfNoncurrentSecuredBankLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current secured bank loans received and current portion of non-current secured bank loans received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentSecuredBankLoansReceivedAndCurrentPortionOfNoncurrentSecuredBankLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionJulyEleventhTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Put Option July Eleventh Two Thousand And Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionJulyEleventhTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Put option july eleventh two thousand and twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionJulyEleventhTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Put options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Entity [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenuesAndContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Adjustments for increase decrease in deferred revenues and contract liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenuesAndContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for increase decrease in deferred revenues and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenuesAndContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in deferred revenues and contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NameOfAssociate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Name of associate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NameOfAssociate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Name of associate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialFairValueOfLoan_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial fair value of loan.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialFairValueOfLoan_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Fair Value Of Loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialFairValueOfLoan_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial fair value of the loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskMateriallyAffectedOrReasonablyLikelyToMateriallyAffectRegistrantTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provision for tax litigation member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provision For Tax Litigation [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provision for tax litigation [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInNonCashStockBasedCompensationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in non-cash stock based compensation expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInNonCashStockBasedCompensationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Non-cash Stock Based Compensation Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInNonCashStockBasedCompensationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in non-cash stock-based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInNonCashStockBasedCompensationExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Decrease in non-cash stock based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeconsolidationOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deconsolidation of merged entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeconsolidationOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deconsolidation of merged entity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeconsolidationOfMergedEntity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss of control over Calyxt</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInSellingGeneralAndAdministrativeExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase In Selling General And Administrative Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInSellingGeneralAndAdministrativeExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Selling General And Administrative Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInSellingGeneralAndAdministrativeExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in selling, general and administrative expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisBiologicsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cellectis biologics, Inc.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisBiologicsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cellectis Biologics Inc [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisBiologicsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cellectis Biologics, Inc. [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementExpertiseOfManagementResponsibleTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Expertise of Management Responsible [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LossInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Loss in financial expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LossInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Loss in financial expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LicenseAndCollaborationAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">License and Collaboration Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LicenseAndCollaborationAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">License and Collaboration Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LicenseAndCollaborationAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">License and Collaboration Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SellingGeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Selling, general and administrative expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SellingGeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total selling, general and administrative expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SellingGeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Selling, general and administrative expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SellingGeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Total selling, general and administrative expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AprilTwentyFourTwoThousandNineteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">04/24/2019 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AprilTwentyFourTwoThousandNineteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">April Twenty Four Two Thousand Nineteen [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AprilTwentyFourTwoThousandNineteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">April twenty four two thousand nineteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativesByNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Derivatives by name.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativesByNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Derivatives By Name [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinanceAdvance_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Finance Advance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinanceAdvance_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Finance Advance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinanceAdvance_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Finance advance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SharePremium_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share premium</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SharePremium_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Premiums related to the share capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of events after reporting period [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsequent events</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisableInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Option exercisable, beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisableInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of share options exercisable in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsExercisableInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Option exercisable, ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwelveTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May Twelve Two Thousand and Twenty One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwelveTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May Twelve Two Thousand and Twenty One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwelveTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">05/12/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SensitivityOfDerivativeFairValueToExpectedLifePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Sensitivity of derivative fair value to expected life period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SensitivityOfDerivativeFairValueToExpectedLifePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sensitivity of derivative fair value to expected life period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SensitivityOfDerivativeFairValueToExpectedLifePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Sensitivity of derivative fair value to expected life period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceReversal_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of provisions for employee litigation and severance reversal.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceReversal_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions for employee litigation and severance reversal</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceReversal_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Employee litigation and severance, Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfEstimationOfRetirementIndemnityToEmployeeExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of estimation of retirement indemnity to employee explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfEstimationOfRetirementIndemnityToEmployeeExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of estimation of retirement indemnity to employee explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfEstimationOfRetirementIndemnityToEmployeeExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Estimation of Retirement Indemnity to Employee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixturesFittingsAndOtherEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fixtures, fittings and other equipment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixturesFittingsAndOtherEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fixtures, Fittings and Other Equipment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AcquisitionRelatedRightToLicence_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Acquisition Related Right To Licence</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AcquisitionRelatedRightToLicence_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Acquisition related right to licence.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AcquisitionRelatedRightToLicence_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Acquisition related right to licence</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementMilestonePaymentsPlusTieredRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaboration Agreement Milestone Payments Plus Tiered Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementMilestonePaymentsPlusTieredRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Collaboration agreement milestone payments plus tiered royalties.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementMilestonePaymentsPlusTieredRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Milestone payments for tiered royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConditionalAdvances_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Conditional advances.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConditionalAdvances_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Conditional Advances</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConditionalAdvances_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Conditional advances</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOutstandingShareOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of share options outstanding in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOutstandingShareOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Option outstanding, ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOutstandingShareOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Option outstanding, beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, City or Town</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesWithADoubleVotingRight_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares with double voting rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesWithADoubleVotingRight_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Shares With A Double Voting Right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesWithADoubleVotingRight_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of Shares with a Double Voting Right.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Expected volatility warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected Volatility Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughNetExchangeDifferencesIntangibleAssetsAndGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through net exchange differences, intangible assets and goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughNetExchangeDifferencesIntangibleAssetsAndGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Translation adjustments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ContinuingOperationsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Continuing operations, unless line item indicates otherwise [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationConcerningGroupsConsolidatedOperartionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of Information concerning groups consolidated operartions explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationConcerningGroupsConsolidatedOperartionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Information concerning Groups Consolidated Operartions Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationConcerningGroupsConsolidatedOperartionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Information concerning the Group's Consolidated Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentValueAddedTaxReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current value added tax receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentValueAddedTaxReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">VAT receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TaxAndSocialReceivablesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Tax (other than income tax and value added tax) and social receivables current.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TaxAndSocialReceivablesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tax and social receivables current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TaxAndSocialReceivablesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Tax and social receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total non-current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_SecurityExchangeName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Security Exchange Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerecognitionOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease through derecognition of derivative.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerecognitionOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Derecognition of Derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerecognitionOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Derecognition of AZ SIA derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerecognitionOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Derecognition of AZ derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_ContactPersonnelName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Contact Personnel Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other current financial liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentFinancialLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Current Financial Liabilities [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesGross_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Liabilities Gross</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesGross_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax liabilities gross.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxLiabilitiesGross_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Deferred tax liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsAndGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Intangible assets and goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsAndGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total intangible assets and goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsAndGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IntangibleAssetsAndGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInPersonnelExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Personnel Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInPersonnelExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease In Personnel Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInPersonnelExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in personnel expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfChangesInAccountingEstimatesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of changes in accounting estimates [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LevelsOfFairValueHierarchyAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Levels of fair value hierarchy [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionForCurrentProvision_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Addition for current provision.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionForCurrentProvision_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Addition For Current Provision</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionForCurrentProvision_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current provision additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashInForeignCurrenciesPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash in foreign currencies percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashInForeignCurrenciesPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cash in foreign currencies percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfWarrantGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of warrant granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfWarrantGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MeasurementDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfAdditionalSharesDueToChangeInConversationRatioExercisableOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Additional Shares Due to Change in Conversation Ratio, Exercisable Options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfAdditionalSharesDueToChangeInConversationRatioExercisableOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The number of additional potential shares due to change in conversation ratio of exercisable options in share-based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfAdditionalSharesDueToChangeInConversationRatioExercisableOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Option exercisable, change in coversion ratios</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AverageLifeOfOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Average life of options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AverageLifeOfOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Average Life of Options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AverageLifeOfOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Average life of options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrincipalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Principal.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrincipalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Principal [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassesOfCommitmentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Classes of commitments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassesOfCommitmentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of commitments [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfClassesOfShareCapitalLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of classes of share capital [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfClassesOfShareCapitalLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of classes of share capital [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashAndCashEquivalentsFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and cash equivalents from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashAndCashEquivalentsFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cash and cash equivalents from discontinued operations.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashAndCashEquivalentsFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanOneYearAndNotLaterThanThreeYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Later than one year and not later than three years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanOneYearAndNotLaterThanThreeYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">1-3 years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SIACashProceeds_lbl" xlink:role="http://www.xbrl.org/2003/role/label">SIA cash proceeds</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SIACashProceeds_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">SIA cash proceeds.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredTaxLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred tax liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredTaxLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current deferred tax liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredTaxLiabilities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Deferred tax liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_StatementOfChangesInEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of changes in equity [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Annual Limit To Carryforwards Use Against Future Taxable Profit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfit_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Annual Limit to carryforwards use against future taxable profit.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Annual Limit to carryforwards use against future taxable profit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net income (loss) for the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net Loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonVotingRightsPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Voting Rights Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonVotingRightsPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non voting rights period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonVotingRightsPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non voting rights period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LicenceFeeIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Licence fee income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LicenceFeeIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Licenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule Of Cash Flow Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Cash Flow Statement Of Discontinued Operations [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ForeignExchangeGain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Foreign exchange gain</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ForeignExchangeGain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Foreign exchange gains</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashOnHand_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash on hand</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashOnHand_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and bank accounts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Period End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Period End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Other current financial assets (deposits)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DebtSecuritiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt securities [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBPrefereredSharesWithNoVotingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class B Preferered shares with no voting rights [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBPrefereredSharesWithNoVotingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class B Preferered shares with no voting rights.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBPrefereredSharesWithNoVotingRightsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class B Preferered shares with no voting rights [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantInvestmentsInAssociatesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Associates [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_IcfrAuditorAttestationFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">ICFR Auditor Attestation Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfRelatedPartiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Categories of related parties [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfRelatedPartiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Categories of related parties [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinanceIncomeExpenseAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Finance income expense [abstract].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinanceIncomeExpenseAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Finance income expense [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfNonadjustingEventsAfterReportingPeriodTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of non-adjusting events after reporting period [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfTradeReceivablesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of trade receivables [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfTradeReceivablesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of trade receivables.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustSevenThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">08/07/2024 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustSevenThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">August Seven Thousand And Twenty Four [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AugustSevenThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">August seven thousand and twenty four.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of detailed information about current financial assets and cash and cash equivalents explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Detailed Information About Current Financial Assets And Cash And Cash Equivalents Explanatory [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Current Financial Assets and Cash and Cash Equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SignificantUnobservableInputProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Significant unobservable input, Probability of transaction completion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SignificantUnobservableInputProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Significant unobservable input, Probability of transaction completion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SignificantUnobservableInputProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Probability of transaction completion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfChangesInAccountingEstimatesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of changes in accounting estimates [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredRevenueIncludingUpfrontPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred revenue including upfront payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredRevenueIncludingUpfrontPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Revenue Including Upfront Payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredRevenueIncludingUpfrontPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred revenue including upfront payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial litigation.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Commercial litigation [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial litigation [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInInterestExpenseOnLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in interest expense on lease liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInInterestExpenseOnLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease in Interest Expense on Lease Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInInterestExpenseOnLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease / Increase in interest expense on lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInInterestExpenseOnLeaseLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Increase / (Decrease) in interest expense on lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOneNovemberNineTwoThousandTwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Type One November Nine Two Thousand Twenty [Member].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOneNovemberNineTwoThousandTwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Type One November Nine Two Thousand Twenty [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOneNovemberNineTwoThousandTwentyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">09/11/2020 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Other income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">External other income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PersonnelExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Personnel expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PersonnelExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Personnel Expenses [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PersonnelExpensesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Personnel Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial assets, at fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalCurrentFinancialLiabilitiesAndLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Total current financial liabilities and lease debts.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalCurrentFinancialLiabilitiesAndLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Total Current Financial Liabilities And Lease Debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalCurrentFinancialLiabilitiesAndLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total current financial liabilities and current lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalCurrentFinancialLiabilitiesAndLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current financial liabilities and current lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssuedCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issued capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssuedCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total issued capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssuedCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsOutsideScopeOfIFRS7Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial assets outside scope of IFRS 7, class [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InvesteeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Investee.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InvesteeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investee [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average fair value at measurement date other equity instruments outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The weighted average fair value at the measurement date of outstanding equity instruments other than share options. [Refer: Weighted average [member]].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Weighted average exercise price per share, beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Weighted average exercise price per share, ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeTaxExpenseContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income tax</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeTaxExpenseContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Effective tax expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeTaxExpenseContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total tax expense (income)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeTaxExpenseContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Tax income (expense)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeTaxExpenseContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Effective tax benefit (expense)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Consolidated operations [line items].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Consolidated operations [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConsolidatedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consolidated operations [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BPIRefundableAdvanceAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">BPI Refundable Advance Agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BPIRefundableAdvanceAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">BPI Refundable Advance Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PropertyPlantAndEquipmentAccumulatedDepreciationAmortisationAndImpairment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Property, plant and equipment, accumulated depreciation, amortisation and impairment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PropertyPlantAndEquipmentAccumulatedDepreciationAmortisationAndImpairment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Property, plant and equipment, accumulated depreciation, amortisation and impairment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PropertyPlantAndEquipmentAccumulatedDepreciationAmortisationAndImpairment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated depreciation and impairment at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseThroughFinancingCashFlowsInterestPaymentLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The decrease in liabilities arising from financing activities resulting from interest payments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseThroughFinancingCashFlowsInterestPaymentLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease Through Financing Cash Flows (Interest Payment), Liabilities Arising from Financing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseThroughFinancingCashFlowsInterestPaymentLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest paid financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfScheduleOfOffBalanceSheetCommitmentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of schedule of off-balance sheet commitments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfScheduleOfOffBalanceSheetCommitmentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Schedule of Off-balance Sheet Commitments Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfScheduleOfOffBalanceSheetCommitmentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Off-balance Sheet Commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RevenueAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionJulyEleventhTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Call Option July Eleventh Two Thousand And Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionJulyEleventhTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Call option july eleventh two thousand and twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionJulyEleventhTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Call options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ForeignExchangeRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Foreign exchange rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ForeignExchangeRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Foreign exchange rate [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ForeignExchangeRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Foreign exchange rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayFifteenTwoThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May Fifteen Two Thousand And Twenty Four [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayFifteenTwoThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May Fifteen Two Thousand And Twenty Four</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayFifteenTwoThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">05/15/2024 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Contract liabilities at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Contract liabilities at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred revenues</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure Of Number And Weighted Average Exercise Prices Of Share Options and awards [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Number And Weighted Average Exercise Prices Of Share Options and awards [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure Of Number And Weighted Average Exercise Prices Of Share Options and awards [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilityMaturity_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financial liability maturity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilityMaturity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Liability Maturity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilityMaturity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial liability maturity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementStrategyAndGovernanceLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management, Strategy, and Governance [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfFinancialLiabilitiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of financial liabilities [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusGlobalLlcMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cibus global LLC.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusGlobalLlcMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cibus Global LLC [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusGlobalLlcMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cibus Global [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfImpairmentLossAndReversalOfImpairmentLossTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of impairment loss and reversal of impairment loss [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Warrant1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Warrant1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant1 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Warrant1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryThirtyTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">January Thirty Two Thousand Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryThirtyTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">January thirty two thousand twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryThirtyTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">1/30/2025 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ValuationTechniquesUsedInFairValueMeasurementDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Valuation techniques used in fair value measurement [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Milestone received.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Milestone Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Milestone received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentPayables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other current payables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentPayables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReversalOfCurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reversal of current provisions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReversalOfCurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reversal Of Current Provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReversalOfCurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current provisions Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxExchangeDifferencesOnTranslation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other comprehensive income, before tax, exchange differences on translation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxExchangeDifferencesOnTranslation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Currency translation adjustment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxExchangeDifferencesOnTranslation_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Other comprehensive income, before tax, exchange differences on translation of foreign operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfFinancialAssetsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of financial assets [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LossesOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Losses on change in fair value of derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LossesOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Losses on change in fair value of derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LossesOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Loss on fair value measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberThirtyTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">November Thirty Two Thousand and Twenty One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberThirtyTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">November Thirty Two Thousand and Twenty One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberThirtyTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">09/30/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfMaturitiesOfFinancialLiabilitiesExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Maturities Of Financial Liabilities Explanatory [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfMaturitiesOfFinancialLiabilitiesExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of maturities of financial liabilities explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfMaturitiesOfFinancialLiabilitiesExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Remaining contractual maturities of financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected dividend as percentage, share options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected dividends</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="currency_AllCurrenciesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">All Currencies [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in net defined benefit liability in salary increase rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Net Defined Benefit Liability In Salary Increase Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease of net defined benefit liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfPreferredShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in number of preferred shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfPreferredShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Number Of Preferred Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfPreferredShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital increase by issuance of preference shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInFinancialIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in financial income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInFinancialIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Financial Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughTransfersPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through transfers, property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughTransfersPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reclassification</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughTransfersPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Reclassification</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassOfWarrantsOrRightDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrants Or Right [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredTaxAssetsAndLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred tax assets and liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInFairValueOfEuropenInvestmentBank_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Fair Value of Europen Investment Bank</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInFairValueOfEuropenInvestmentBank_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of europen investment bank.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="stpr_NY_lbl" xlink:role="http://www.xbrl.org/2003/role/label">NEW YORK</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="stpr_NY_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">New York [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cibus, Inc.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CibusIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cibus Inc [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit (loss) from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Income (loss) from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Income (loss) from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net (loss) income for the period from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income tax effect on revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Income tax effect on revenue.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxEffectOnRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Tax effect on revenue recognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfProvisionsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of other provisions [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsConsiderationReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Discontinued Operations Consideration Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsConsiderationReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Discontinued operations, consideration received.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsConsiderationReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Consideration received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityNetOfTaxStrengtheningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Strengthening</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityNetOfTaxStrengtheningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Net Of Tax Strengthening [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityNetOfTaxStrengtheningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity net of tax strengthening.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfNoncurrentFinancialAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Categories of non-current financial assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfPresentationCurrencyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Description of presentation currency explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfPresentationCurrencyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description Of Presentation Currency Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfPresentationCurrencyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Currency of the financial statements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentSubsidiesReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of current grant receivables.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentSubsidiesReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current subsidies receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentSubsidiesReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsidies receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFileNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity File Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fixed interest rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fixed Interest Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Annual rate of discounting</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalResearchPlansUnderTheAZJRCAOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional Research Plans under the AZ JRCA One.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalResearchPlansUnderTheAZJRCAOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Research Plans under the AZ JRCA One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalResearchPlansUnderTheAZJRCAOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional Research Plans under the AZ JRCA One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreasedInBaseRentForSettingTheAmountOfDeposit_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increased in base rent for setting the amount of deposit.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreasedInBaseRentForSettingTheAmountOfDeposit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increased In Base Rent For Setting The Amount Of Deposit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreasedInBaseRentForSettingTheAmountOfDeposit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increased in base rent for setting the amount of deposit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionMayThirteenthTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Call option May Thirteenth Two Thousand And Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionMayThirteenthTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Call option may thirteenth two thousand and twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionMayThirteenthTwoThousandAndTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Call options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Fair Value At Measurement Date Other Equity Instrument Granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Weighted average fair value at measurement date other equity instrument granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CoverAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfPotentiallyDilutiveInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Share Warrants and Non-employee Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfPotentiallyDilutiveInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of potentially dilutive instruments explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfPotentiallyDilutiveInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of potentially dilutive instruments [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Purchases and external expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Purchases And External Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchases and external expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchases and external expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeasedEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Leased equipment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeasedEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Leased Equipment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeasedEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leased Equipment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrants issued.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDeferredIncomeAndContractLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of deferred income and contract liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDeferredIncomeAndContractLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Deferred Income and Contract Liabilities Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassOfSharesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassOfSharesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of shares [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InvesteeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Investee.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InvesteeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investee [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfQuantitativeInformationAboutRightofuseAssetsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of quantitative information about right-of-use assets [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfIncreaseInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of increase in salary increase rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfIncreaseInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Increase In Salary Increase Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfIncreaseInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of increase in salary increase rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchThreeThousandTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March Three Thousand Twenty Two [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchThreeThousandTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Three Thousand Twenty Two [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchThreeThousandTwentyTwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">03/03/2022 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInEmployeeBenefitsExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Employee Benefits Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInEmployeeBenefitsExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease In Employee Benefits Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInEmployeeBenefitsExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in stock-based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentLeaseLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-current Lease Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentLeaseLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current Lease Liabilities [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentLeaseLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Non Current Lease Debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementsExtendedMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreements Extended Maturity Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementsExtendedMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreements Extended Maturity Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementsExtendedMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Agreements extended maturity date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentFixedTermBankDepositsIncludingAccruedInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-current fixed term bank deposits including accrued interests.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentFixedTermBankDepositsIncludingAccruedInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current Fixed term Bank Deposits including Accrued Interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentFixedTermBankDepositsIncludingAccruedInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current fixed term bank deposits including accrued interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_USDollarMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Us Dollar [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_USDollarMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Us Dollar [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_USDollarMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">US Dollar</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of expected volatility percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Of Expected Volatility Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfExpectedVolatilityPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of expected volatility percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Level1OfFairValueHierarchyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Level 1 of fair value hierarchy [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Level1OfFairValueHierarchyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Level 1 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantUnobservableInputAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Significant unobservable input, assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantUnobservableInputAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Rate at maturity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfRelatedPartyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of related party [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfRelatedPartyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related parties and other major shareholders</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CarryingAmountAccumulatedDepreciationAmortisationAndImpairmentAndGrossCarryingAmountAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Carrying amount, accumulated depreciation, amortisation and impairment and gross carrying amount [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CarryingAmountAccumulatedDepreciationAmortisationAndImpairmentAndGrossCarryingAmountAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carrying amount, accumulated depreciation, amortisation and impairment and gross carrying amount [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberSevenTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">November Seven Two Thousand Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberSevenTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">November seven two thousand twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberSevenTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">11/7/2025 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfFinancialLiabilitiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Categories of financial liabilities [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFourteenTwoThousandSixteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March fourteen two thousand sixteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFourteenTwoThousandSixteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March fourteen two thousand sixteen [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFourteenTwoThousandSixteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">3/14/2016 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisSaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cellectis SA.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisSaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cellectis SA [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfVestingRequirementsForSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description of vesting requirements for share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfVestingRequirementsForSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Vesting conditions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfVestingRequirementsForSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vesting period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of financial assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of financial assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfInputsUsedInFairValueMeasurementLiabilitiesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The description of inputs used in the fair value measurement of liabilities. Inputs are the assumptions that market participants would use when pricing the liability, including assumptions about risk such as the risk inherent in a particular valuation technique used to measure fair value (such as a pricing model) and the risk inherent in the inputs to the valuation technique.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfInputsUsedInFairValueMeasurementLiabilitiesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description of inputs used in fair value measurement, liabilities [Table text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfInputsUsedInFairValueMeasurementLiabilitiesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of assumptions and results of the warrant valuation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryTwentyFourTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">January Twenty Four Two Thousand And Twenty Three [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryTwentyFourTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">January twenty four two thousand and twenty three.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryTwentyFourTwoThousandAndTwentyThreeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">01/24/2023 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInWagesAndSalaries_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in wages and salaries.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInWagesAndSalaries_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Wages and Salaries</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInWagesAndSalaries_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase (decrease) in wages and salaries</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TradePayablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Trade payables.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TradePayablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trade Payables [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TradePayablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trade Payables [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsMayFifteenthAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Put Options May Fifteenth And Twenty Twenty Six [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsMayFifteenthAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Put options may fifteenth and twenty twenty six.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsMayFifteenthAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Put options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of number and weighted average exercise prices of share options [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Information on Stock Option Activity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProfitAndLossStrengtheningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit And Loss Strengthening [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProfitAndLossStrengtheningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Profit and loss strengthening.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProfitAndLossStrengtheningMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Strengthening</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TextBlock1Abstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Text Block [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TextBlock1Abstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Text block1 [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TextBlock1Abstract_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Text block1 [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of current financial assets and cash and cash equivalents explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of current financial assets and cash and cash equivalents explanatory [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current financial assets and Cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfEarningsPerShareExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of earnings per share [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfEarningsPerShareExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Earnings per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ITLicensingAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">IT Licensing agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ITLicensingAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">IT Licensing agreement [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ITLicensingAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">IT Licensing Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentFixedTermBankDepositsMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-current fixed term bank deposits maturity date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentFixedTermBankDepositsMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-Current Fixed Term Bank Deposits Maturity Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_Non-CurrentFixedTermBankDepositsMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current fixed term bank deposits maturity date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other provision for charges additions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Provision For Charges Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other provision for charges, Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LiabilityAssetOfDefinedBenefitPlansReclassification_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Liability asset of defined benefit plans reclassification.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LiabilityAssetOfDefinedBenefitPlansReclassification_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liability Asset Of Defined Benefit Plans reclassification</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LiabilityAssetOfDefinedBenefitPlansReclassification_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reclassification/CTA</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfMethodOfSettlementForSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description of method of settlement for share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfMethodOfSettlementForSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of shares outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance at end, Number of shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance at beginning, Number of shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares ordinary outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_OwnershipAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Ownership [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsidiesReceivablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Subsidies receivables.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsidiesReceivablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsidies receivables [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsidiesReceivablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsidies Receivables [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Option outstanding, additional shares due to May 2024 modification</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Share Options Additional Shares Due To May Twenty Twenty Four Share Based Payment Arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of share options additional shares due to May Twenty Twenty Four share based payment arrangement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTermsAndConditionsOfSharebasedPaymentArrangementLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of terms and conditions of share-based payment arrangement [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTermsAndConditionsOfSharebasedPaymentArrangementLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of terms and conditions of share-based payment arrangement [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTermsAndConditionsOfSharebasedPaymentArrangementLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Assumptions and results of the warrants valuation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other current financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Current investment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provision for tax litigation used during the period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provision for Tax Litigation Used During The Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provision for tax litigation, Amounts used during the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtAmortisedCostCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial liabilities at amortised cost, category [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtAmortisedCostCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Liabilities at Amortised Cost, Category [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOtherCurrentAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of other current assets [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOtherCurrentAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Other Current Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughNetExchangeDifferencesPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through net exchange differences, property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughNetExchangeDifferencesPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Translation adjustments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtFairValueThroughProfitOrLossCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial assets at fair value through profit or loss, category [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtFairValueThroughProfitOrLossCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Assets at Fair Value Through Profit or Loss, Category [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfOtherReceivablesPrepaymentsAndOtherCurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of other receivables, prepayments and other current asset.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfOtherReceivablesPrepaymentsAndOtherCurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Other Receivables Prepayments and Other Current Assets [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutProvisionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of detailed information about provisions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutProvisionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Detailed Information About Provisions [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutProvisionsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Details of Provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProportionOfOwnershipInterestsHeldByNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proportion of ownership interests held by non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProportionOfOwnershipInterestsHeldByNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-controlling shareholders interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CapitalRequirementsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Capital requirements [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OptionLifeShareOptionGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Option Life Share Option Granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OptionLifeShareOptionGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The option life of share option granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OptionLifeShareOptionGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Option life, share option granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueProbabilityOfTransactionCompletionPlusTwoPercent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair value probability of transaction completion plus two percent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueProbabilityOfTransactionCompletionPlusTwoPercent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value probability of transaction completion plus two percent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueProbabilityOfTransactionCompletionPlusTwoPercent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Probability of transaction completion +2%</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other provision for charges reversals.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Provision For Charges Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other provision for charges, Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementProcessesIntegratedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Processes Integrated [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (Decrease) In Research Tax Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Research Tax Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease In Research Tax Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInResearchTaxCredit_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Increase (decrease) in research tax credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Risk free interest rate, share options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Risk-free interest rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentTransitionReport_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Transition Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeSharesAndStockOptionExercises_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Number Of Ordinary Shares Issued Due To Vesting Of Free Shares And Stock Option Exercises</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeSharesAndStockOptionExercises_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase in the number of ordinary shares issued due to vesting of free shares and exercise of stock options granted to employees and directors in share-based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeSharesAndStockOptionExercises_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of share warrants, employee warrants, stock-options and free-shares vesting, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfTaxableIncomeSubjectToAnnualLimitation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Taxable Income Subject to Annual Limitation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfTaxableIncomeSubjectToAnnualLimitation_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of taxable income subject to annual limitation.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfTaxableIncomeSubjectToAnnualLimitation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of taxable income subject to annual limitation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNonCurrentFinancialLiabilitiesAndNonCurrentLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Total non-current financial liabilities and non-current lease debts.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNonCurrentFinancialLiabilitiesAndNonCurrentLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Total Non current Financial Liabilities And Non current Lease Debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNonCurrentFinancialLiabilitiesAndNonCurrentLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total non-current financial liabilities and non-current lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNonCurrentFinancialLiabilitiesAndNonCurrentLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Non-current financial liabilities and non-current lease debts, Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNonCurrentFinancialLiabilitiesAndNonCurrentLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Non-current financial liabilities and non-current lease debts, Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNonCurrentFinancialLiabilitiesAndNonCurrentLeaseDebts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total non-current financial liabilities and non-current lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncomeStatementAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit or loss [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfAnalysisOfSingleAmountOfDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of analysis of single amount of discontinued operations [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_StatementOfFinancialPositionAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of financial position [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RoyaltyExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Royalty expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RoyaltyExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Royalty expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrepaidExpensesAndOtherCurrentAssetsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Prepaid expenses and other current assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrepaidExpensesAndOtherCurrentAssetsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Expenses and Other Current Assets [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrepaidExpensesAndOtherCurrentAssetsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Prepaid expenses and other current assets [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionsDeletionsOtherThanThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionsDeletionsOtherThanThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additions deletions other than through business combinations intangible assets other than goodwill.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionsDeletionsOtherThanThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additions Deletions Other Than Through Business Combinations Intangible Assets Other Than Goodwill</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionsDeletionsOtherThanThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additions to intangible assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_NoTradingSymbolFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">No Trading Symbol Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SellingGeneralAndAdministrativeExpenses1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Selling general and administrative expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SellingGeneralAndAdministrativeExpenses1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Selling General And Administrative Expenses 1 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SellingGeneralAndAdministrativeExpenses1Member_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Selling, General and Administrative Expenses [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other comprehensive income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total other comprehensive income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Other comprehensive income (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ApprovalOfResearchPlanDevelopementMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Approval of research plan developement milestone payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ApprovalOfResearchPlanDevelopementMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Approval of research plan developement milestone payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProportionOfOwnershipInterestInAssociate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proportion of ownership interest in associate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProportionOfOwnershipInterestInAssociate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Ownership interest in associate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProportionOfOwnershipInterestInAssociate_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Percentage of share capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwentyEightTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">May Twenty Eight Two Thousand and Twenty One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwentyEightTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">May Twenty Eight Two Thousand and Twenty One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MayTwentyEightTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">05/28/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfAssetsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of assets [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RetirementIndemnitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Retirement indemnities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RetirementIndemnitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retirement Indemnities [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RetirementIndemnitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retirement Indemnities [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsGrantedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average exercise price of share options granted in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsGrantedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedLifeOfDerivativeEstimatedByManagement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair value expected life of derivative estimated by management</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedLifeOfDerivativeEstimatedByManagement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value expected life of derivative estimated by management.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedLifeOfDerivativeEstimatedByManagement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected life of derivative estimated by management</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash flows provided by (used in) operating activities of continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) operating activities, continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) operating activities, continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentProvisionsOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current provisions other comprehensive income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentProvisionsOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Provisions Other Comprehensive Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentProvisionsOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current provisions OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComponentsOfEquityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Components of equity [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComponentsOfEquityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Components of equity [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfAntidilutiveInstrumentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of antidilutive instruments [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in research and development expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase in Research and Development Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in research and development expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SellingGeneralAndAdministrativeExpenseMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Selling, general and administrative expense [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SellingGeneralAndAdministrativeExpenseMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Selling General and Administrative Expense [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for gain (loss) on disposals, property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Net loss (income) on disposals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) operations before changes in working capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Operating cash flows before change in working capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BasicEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Basic earnings (loss) per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BasicEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basic net income (loss) attributable to shareholders of Cellectis per share ( $ /share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BasicEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total basic earnings (loss) per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BasicEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Basic net income (loss) attributable to shareholders of Cellectis, per share ($ /share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementProcessesIntegratedTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Processes Integrated [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInDepreciationAndAmortizationExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase In Depreciation And Amortization Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInDepreciationAndAmortizationExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Depreciation And Amortization Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInDepreciationAndAmortizationExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in depreciation and amortization expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AtFairValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">At fair value [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AtFairValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provisions for retirement indemnities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions For Retirement Indemnities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Retirement indemnities , Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Retirement indemnities , Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LegalAndFinanceExternalSupportMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Legal and Finance External Support [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LegalAndFinanceExternalSupportMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Legal and Finance External Support.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfSharesInAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Of Shares In Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfSharesInAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of shares in amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfSharesInAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfDerivativeInstrumentsWarrantGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of derivative instruments warrant granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfDerivativeInstrumentsWarrantGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Derivative Instruments Warrant Granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfDerivativeInstrumentsWarrantGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OfficeAndLaboratoryEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Office and Laboratory equipment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OfficeAndLaboratoryEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Office and Laboratory equipment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OfficeAndLaboratoryEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Office and laboratory equipment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReallocatedProceedsFromSaleOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reallocated proceeds from sale of ordinary shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReallocatedProceedsFromSaleOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reallocated Proceeds From Sale Of Ordinary Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReallocatedProceedsFromSaleOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reallocated proceeds from sale of ordinary shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForRealizedForeignExchangeLossesGains_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Adjustments for realized foreign exchange losses gains.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForRealizedForeignExchangeLossesGains_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments For Realized Foreign Exchange Losses Gains</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForRealizedForeignExchangeLossesGains_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Realized foreign exchange gain (loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDerivativeFairValueProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of derivative fair value probability of transaction completion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDerivativeFairValueProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of derivative fair value probability of transaction completion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDerivativeFairValueProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of derivative fair value probability of transaction completion.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Purchase of intangible assets, classified as investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Acquisition of intangible assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Purchase of intangible assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfWarrantsIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of warrants issued.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfWarrantsIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Warrants Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfWarrantsIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of warrants issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for depreciation and amortisation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amortization and depreciation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Adjustments for depreciation and amortisation expense, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AttributionOfExpensesByNatureToTheirFunctionAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Attribution of expenses by nature to their function [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Provisions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Provisions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Provisions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Provisions_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain in Financial Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gain in financial expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain in financial expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentTradeReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current trade receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentTradeReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trade receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentTradeReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total net value of trade receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentTradeReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Total net value of trade receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsMayTwentySixAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Call Options May Twenty Six And Twenty Twenty Six [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsMayTwentySixAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Call options may twenty six and twenty twenty six .</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CallOptionsMayTwentySixAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Call options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialFairValueAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial fair value amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialFairValueAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Fair Value Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialFairValueAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial fair value amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MaturityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maturity [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities arising from financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Financial liabilities and lease debts, Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Financial liabilities and lease debts, Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnderlyingStockPriceAtGrantDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share price used as input to the option pricing model to calculate the fair value of share options granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnderlyingStockPriceAtGrantDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Underlying Stock Price at Grant Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnderlyingStockPriceAtGrantDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Underlying stock price at grant date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) financing activities, discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net cash flows provided by (used in) financing activities of discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net cash flows provided by (used in) financing activities of discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) financing activities, discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeasedPremisesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Leased premises.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeasedPremisesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Leased Premises [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeasedPremisesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leased Premises [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Year Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Fiscal Year Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedProbabilityOfTransactionCompletionEstimatedByManagement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair value expected probability of transaction completion estimated by management</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedProbabilityOfTransactionCompletionEstimatedByManagement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value expected probability of transaction completion estimated by management.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedProbabilityOfTransactionCompletionEstimatedByManagement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected probability of transaction completion estimated by management</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInPurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Purchases And External Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInPurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase In Purchases And External Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInPurchasesAndExternalExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in purchases and external expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InvestmentAccountedForUsingEquityMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investments accounted for using equity method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InvestmentAccountedForUsingEquityMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total investments accounted for using equity method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InvestmentAccountedForUsingEquityMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity investment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OrdinarySharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Ordinary shares [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OrdinarySharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share Capital Ordinary Shares [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OrdinarySharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MaturityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maturity [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MaturityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maturity [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpirationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Expiration Date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpirationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expiration Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpirationDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expiration date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLeaseLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current Lease Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLeaseLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Lease Liabilities [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentLeaseLiabilitiesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Current Lease Debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SpotSharePricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Spot Share Price Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SpotSharePricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Spot share price per share.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SpotSharePricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Spot share price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average number of ordinary shares outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average number of outstanding shares, used to calculate basic net result per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageShares_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutDeferredIncomeAndContractLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of detailed information about deferred income and contract liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutDeferredIncomeAndContractLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Detailed Information About Deferred Income And Contract Liabilities Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutDeferredIncomeAndContractLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Details of Deferred Income and Contract Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashCashAndCashEquivalentsAndCurrentAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cash cash and cash equivalents and current assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashCashAndCashEquivalentsAndCurrentAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Cash and Cash equivalents and current assets [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CashCashAndCashEquivalentsAndCurrentAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash Cash and Cash Equivalents and Current Assets [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromIssuingSharesNetOfIssuanceCost_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in share capital of Cellectis after deduction of transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromIssuingSharesNetOfIssuanceCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Issuing Shares, Net Of Issuance Cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromIssuingSharesNetOfIssuanceCost_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from issuing shares, net of issuance cost.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsFromIssuingSharesNetOfIssuanceCost_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Increase in share capital from financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GeographicalAreasDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Geographical areas [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfContingentLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of contingent liabilities [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainsLossesOnChangeInFairValueOfInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gains (Losses) On Change In Fair Value Of Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainsLossesOnChangeInFairValueOfInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gains (losses) on change in fair value of investments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainsLossesOnChangeInFairValueOfInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain (loss) on change in fair value of our investment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingEIBWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financial liabilities, excluding EIB warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingEIBWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Liabilities, Excluding EIB Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingEIBWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial liabilities, excluding EIB warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">(Decrease) increase in cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">(Decrease) increase in cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net increase (decrease) in cash and cash equivalents after effect of exchange rate changes</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInFinancialInvestmentsGain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in financial investments gain.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInFinancialInvestmentsGain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease in financial investments gain</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfExpensesByNatureExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of expenses by nature [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfExpensesByNatureExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Details of Operating Expenses by Nature</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromDisposalOfNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from disposal of non-current assets or disposal groups classified as held for sale and discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromDisposalOfNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consideration received in cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConvertibleNoteNominalAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Convertible note nominal amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConvertibleNoteNominalAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Convertible Note Nominal Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ConvertibleNoteNominalAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Convertible note nominal amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of current financial assets and cash and cash equivalents.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Current Financial Assets and Cash and Cash Equivalents [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Current Financial Assets and Cash and Cash Equivalents [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Level3OfFairValueHierarchyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Level 3 of fair value hierarchy [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Level3OfFairValueHierarchyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Level 3 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsLossesOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gains (losses) on change in fair value of derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsLossesOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net gains (losses) on change in fair value of derivatives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GainsLossesOnChangeInFairValueOfDerivatives_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss on fair value measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinanceLeaseReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current finance lease receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentFinanceLeaseReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Finance lease receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AttributableProfitLossFromDeconsolidation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Attributable Profit Loss From Deconsolidation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AttributableProfitLossFromDeconsolidation_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Attributable profit loss from deconsolidation.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AttributableProfitLossFromDeconsolidation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Profit from deconsolidation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantInvestmentsInSubsidiariesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsidiaries [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SignificantInvestmentsInSubsidiariesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsidiaries [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughChangesInForeignExchangeRatesNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Foreign exchange differences</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughChangesInForeignExchangeRatesNetDefinedBenefitLiabilityAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in net defined benefit liability (asset) resulting from changes in foreign exchange rates, net defined benefit liability (asset)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EstimationOfRetirementIndemnityToEmployeeSocialSecurityContributionsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Estimation of retirement indemnity to employee social security contributions percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EstimationOfRetirementIndemnityToEmployeeSocialSecurityContributionsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Estimation of retirement indemnity to employee social security contributions percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EstimationOfRetirementIndemnityToEmployeeSocialSecurityContributionsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">% social security contributions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfLiabilitiesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of liabilities [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non current lease debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non current lease debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non Current Lease Debts [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GrossCarryingAmountMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gross carrying amount [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GrossCarryingAmountMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gross value [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_GrossCarryingAmountMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Gross Value [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtAmortisedCostCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial assets at amortised cost, category [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtAmortisedCostCategoryMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Assets at Amortised Cost, Category [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsExercisedOrVestedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of other equity instruments exercised or vested in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsExercisedOrVestedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Number of free shares vested</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VotingAgreementWithCibusMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Voting agreement with cibus.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VotingAgreementWithCibusMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Voting Agreement with Cibus [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_VotingAgreementWithCibusMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Voting Agreement with Cibus [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReinvoicingToAzIrelandOfResearchCostsRechargeableMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reinvoicing to AZ Ireland of research costs rechargeable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReinvoicingToAzIrelandOfResearchCostsRechargeableMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reinvoicing to AZ Ireland of Research Costs Rechargeable [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReinvoicingToAzIrelandOfResearchCostsRechargeableMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reinvoicing to AZ Ireland of Research Costs Rechargeable [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsequentInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Subsequent investment agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsequentInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Investment Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsequentInvestmentAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsequent Investment Agreement (SIA) [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutShareBasedPaymentArrangementsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Discolsure of Detailed Information About Share based Payment Arrangements [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutShareBasedPaymentArrangementsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about share based payment arrangements [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutShareBasedPaymentArrangementsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of assumptions Vesting Details</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AverageEffectiveTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Average effective tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AverageEffectiveTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Effective tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AverageEffectiveTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Effective income tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AverageEffectiveTaxRate_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Effective tax rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average exercise price of share options exercised in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Weighted average exercise price per share, exercised/vested</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestRateMeasurementInputMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Interest rate, measurement input [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_InterestRateMeasurementInputMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest Rate, Measurement Input [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharePriceOfWarrant_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share price of warrant.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharePriceOfWarrant_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Price Of Warrant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharePriceOfWarrant_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share price (in euros)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharePriceOfWarrant_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherAdjustmentsForNoncashItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other adjustments for non-cash items</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherAdjustmentsForNoncashItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other non-cash items</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherAdjustmentsForNoncashItems_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Other non-cash transactions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) operating activities, discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net cash flows provided by (used in) operating activities of discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Net cash flows from (used in) operating activities, discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfFinancialAssetsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Categories of financial assets [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageGrantDateFairValueOfOtherEquityInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of number and weighted average grant date fair value of other equity Instruments Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfNumberAndWeightedAverageGrantDateFairValueOfOtherEquityInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The disclosure of the number and weighted average grant date fair value of other equity instruments (i.e. other than share options) in share-based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of subsidiaries [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2023Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Capital evolution 2023.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2023Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Capital Evolution 2023 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CapitalEvolution2023Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital Evolution 2023 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedTermBankDepositIncludingAccruedInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fixed term bank deposit including accrued interest.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedTermBankDepositIncludingAccruedInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fixed Term Bank Deposit Including Accrued Interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FixedTermBankDepositIncludingAccruedInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fixed term bank deposit including accrued interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of fair value of financial instruments [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Financial Assets and Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsForfeitedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of share options forfeited in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsForfeitedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Option outstanding, forfeited, cancelled or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provision for tax litigation, Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provision For Tax Litigation Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provision for tax litigation, Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipmentByOperatingLeaseStatusDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Property, plant and equipment by operating lease status [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">LIABILITIES</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) financing activities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash flows from financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule Of Cash Flow Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Cash Flow Statement Of Discontinued Operations [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAConvertiblePreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class A convertible preferred shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAConvertiblePreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class A convertible preferred shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAConvertiblePreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">"Class A" Convertible Preferred Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAConvertiblePreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Class A" Convertible Preferred Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PreferenceSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preference shares [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PreferenceSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Preferrence Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfIntangibleAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of intangible assets [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfIntangibleAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Intangible assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RangeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Range [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativeInstrumentsExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Instruments Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DerivativeInstrumentsExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Derivative instruments exercise price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfPropertyPlantAndEquipmentEstimatedUsefulLivesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Property Plant and Equipment Estimated Useful Lives</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfPropertyPlantAndEquipmentEstimatedUsefulLivesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Property, Plant and Equipment Estimated Useful Lives [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfPropertyPlantAndEquipmentEstimatedUsefulLivesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of property, plant and equipment estimated useful lives.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialDerivativeDerecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financial derivative derecognized.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialDerivativeDerecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial Derivative Derecognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialDerivativeDerecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Financial derivative derecognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_StatementOfChangesInEquityLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of changes in equity [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_Security12bTitle_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Title of 12(b) Security</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CarryingAmountAndValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Carrying value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CarryingAmountAndValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Carrying Amount and value [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CarryingAmountAndValueMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carrying Value [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrimeraTherapeuticsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Primera therapeutics, Inc.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrimeraTherapeuticsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Primera Therapeutics Inc [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrimeraTherapeuticsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Primera Therapeutics, Inc. [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsGrantedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of share options granted in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsGrantedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of equity instruments granted in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfShareOptionsGrantedInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Option outstanding, granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditNonCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research tax credit non-current financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditNonCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Non-current Financial Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditNonCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research tax credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditNonCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Research tax credit receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RetainedEarningsExcludingProfitLossForReportingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retained earnings, excluding profit (loss) for reporting period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RetainedEarningsExcludingProfitLossForReportingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Retained earnings (deficit)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedFinancialLiabilitiesAndLeaseDebtsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The entire disclosure in details of financial liabilities and lease debts.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedFinancialLiabilitiesAndLeaseDebtsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Detailed Financial Liabilities and Lease Debts Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedFinancialLiabilitiesAndLeaseDebtsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeReceivablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trade receivables [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeReceivablesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trade Receivables [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Weighted average exercise price of share options exercisable granted in share based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Exercise Price Of Share Options Exercisable Granted In Share Based Payment Arrangements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageExercisePriceOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted- average exercise price per share, granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForCharges_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other provision for charges.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForCharges_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Provision For Charges</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForCharges_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Other provision for charges, Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForCharges_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Other provision for charges, Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForCharges_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other provision for charges, Biginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SecuredBankLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Secured bank loans received</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfOtherProvisionsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of other provisions [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total increase (decrease) in financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseInFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentInformationTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Information [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_LegalEntityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Legal Entity [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_LegalEntityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Legal Entity [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsFromOtherDeductibleDifferences_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets From Other Deductible Differences</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsFromOtherDeductibleDifferences_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax assets from other deductible differences.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsFromOtherDeductibleDifferences_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred tax assets from other deductible differences</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOtherProvisionsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of other provisions [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provision for tax litigation other comprehensive income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provision For Tax Litigation Other Comprehensive Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionForTaxLitigationOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provision for tax litigation, OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateAndLocalTaxAuthorityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">State and local tax authority.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateAndLocalTaxAuthorityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">State And Local Tax Authority [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase in number of ordinary shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in number of ordinary shares issued.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital increase, Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about property, plant and equipment [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Calyxt.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Calyxt [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Calyxt [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfContingentLiabilitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of contingent liabilities [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalCurrentFinancialLiabilitiesAndCurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Total Current Financial Liabilities and Current Lease Debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalCurrentFinancialLiabilitiesAndCurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Total Current Financial Liabilities and Current Lease Debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Current provisions Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Current provisions beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipmentByOperatingLeaseStatusAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Property, plant and equipment by operating lease status [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PropertyPlantAndEquipmentByOperatingLeaseStatusAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property, plant and equipment by operating lease status [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FreeSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Free shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FreeSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Free Shares [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FreeSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Free Shares [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SocialSecurityContributionsIncludingPriorPeriodAdjustments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Social Security Contributions Including Prior Period Adjustments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SocialSecurityContributionsIncludingPriorPeriodAdjustments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Social Security Contributions Including Prior Period Adjustments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SocialSecurityContributionsIncludingPriorPeriodAdjustments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Social charges on stock option grants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SocialSecurityContributionsIncludingPriorPeriodAdjustments_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Social charges on stock option grants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of expected impact of initial application of new standards or interpretations [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of changes in accounting estimates [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsCapitalizationOfResearchAndDevelopmentExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Capitalization Of Research And Development Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsCapitalizationOfResearchAndDevelopmentExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax assets capitalization of research and development expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsCapitalizationOfResearchAndDevelopmentExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capitalization of R&amp;D expenses under SEC 174 rule</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Profit (loss), attributable to non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Attributable to non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProfitLossAttributableToNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net income (loss) attributable to NCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Milestone [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestoneAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Milestone [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialInstrumentsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about financial instruments [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of reconciliation of liabilities arising from financing activities [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of reconciliation of movements of liabilities to cash flows arising from financing liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_TradingSymbol_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trading Symbol</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfFinancialAssetsMeasuredAtAmortisedCostClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Purchase of financial assets measured at amortised cost, classified as investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfFinancialAssetsMeasuredAtAmortisedCostClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Acquisition of current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonExecutiveEmployeesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non Executive Employees.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonExecutiveEmployeesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Executive Employees [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentDerivativeInstrumentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-current derivative instruments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentDerivativeInstrumentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current derivative instruments [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentDerivativeInstrumentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current Derivative Instruments (EIB warrants) [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IssuancePricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issuance Price Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IssuancePricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Issuance price per share.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IssuancePricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance price per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentProvisionsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current provisions used during the period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentProvisionsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Provisions Used During the Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentProvisionsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current provisions Amounts used during the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class B Preferred Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class B Preferred Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class B Preferred Shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageSharesAndAdjustedWeightedAverageSharesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average ordinary shares used in calculating basic and diluted earnings per share [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageSharesAndAdjustedWeightedAverageSharesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares used for computing</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubleaseStartTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sublease Start Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubleaseStartTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Sublease start term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubleaseStartTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Sublease start term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BuildingsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Buildings [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BuildingsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Building lease [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Federal R&amp;D tax credits, tax loss carryforwards</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research and Development Tax Credits, Tax Effect of Tax Losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research and development tax credits, tax effect of tax losses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DepreciationRightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Depreciation, right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DepreciationRightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Depreciation, right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DepreciationRightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Depreciation &amp; impairment expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfDerivativeInstrumentsPutAndCallOptionsTableTextBlpck_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Derivative Instruments Put And Call Options [Table Text Blpck]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfDerivativeInstrumentsPutAndCallOptionsTableTextBlpck_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of derivative instruments put and call options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfDerivativeInstrumentsPutAndCallOptionsTableTextBlpck_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of derivative instruments put and call options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialLiabilitiesAndLeaseDebtsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of financial liabilities and lease debts.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialLiabilitiesAndLeaseDebtsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of financial liabilities and lease debts explanatory [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfFinancialLiabilitiesAndLeaseDebtsExplanatoryTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Detail of financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule Of Income Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Income Statement Of Discontinued Operations [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughChangesInFairValuesLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through changes in fair values, liabilities arising from financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughChangesInFairValuesLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-cash change in fair value financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBConvertiblePreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class B convertible preferred shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBConvertiblePreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class B convertible preferred shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassBConvertiblePreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class B" Convertible Preferred Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityInvestment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity investment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityInvestment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity investment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityInvestment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity investment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Tranche B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TrancheBWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tranche B Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DefinedBenefitPlansAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Defined benefit plans [axis]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Risk Free Rate [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Risk Free Rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Risk-Free Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FederalTaxAuthorityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Federal tax authority.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FederalTaxAuthorityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Federal Tax Authority [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfClassesOfShareCapitalTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of classes of share capital [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfClassesOfShareCapitalTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of classes of share capital [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LaboratoryEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Laboratory equipment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LaboratoryEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Laboratory Equipment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LaboratoryEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Laboratory Equipment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsLeasesLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Leases Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsLeasesLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax assets leases liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsLeasesLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leases liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsExercisableInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of other equity instruments exercisable in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsExercisableInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of exercisable warrants and stock options as of 12/31/2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditsFinancingArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credits Financing Arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditsFinancingArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research tax credits financing arrangement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInForeignExchangeLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase Decrease In Foreign Exchange Losses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInForeignExchangeLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Foreign Exchange Losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInForeignExchangeLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase/ Decrease in foreign exchange losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SeptemberEightTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">September eight two thousand fifteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SeptemberEightTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">September eight two thousand fifteen [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SeptemberEightTwoThousandFifteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">9/8/2015 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EffectiveInterestRateOfLoan_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Effective interest rate of loan.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EffectiveInterestRateOfLoan_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Effective Interest Rate of Loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EffectiveInterestRateOfLoan_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Effective interest rate of loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfOtherEquityInstrumentsExercisableInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average exercise price of other equity instruments exercisable in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfOtherEquityInstrumentsExercisableInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise price per option / warrant in Euros</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentDerivativeFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current derivative financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentDerivativeFinancialLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current derivative financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Key management personnel compensation, short-term employee benefits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase in the number of ordinary shares issued due to vesting of free shares granted to employees and directors in share-based payment arrangements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Number Of Ordinary Shares Issued Due To Vesting Of Free Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vesting of free shares granted to employees and directors, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeShares_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Shares issued to the benefit of employees related free share plans</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisIncAndCellectisBiologicsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cellectis, Inc. and Cellectis Biologics, Inc. [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CellectisIncAndCellectisBiologicsIncMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cellectis, inc. and cellectis biologics, inc.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AddressTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Address Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughReclassificationBetweenCurrentAndNon-CurrentLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase (decrease) in liabilities arising from financing activities resulting from reclassifications between current and non-current activities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughReclassificationBetweenCurrentAndNon-CurrentLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) Through Reclassification Between Current and Non-Current, Liabilities Arising from Financing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughReclassificationBetweenCurrentAndNon-CurrentLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reclassifications financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RestrictedShareUnitsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Restricted share units [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RestrictedShareUnitsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted Stock Unit Awards [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LicenceOfPatentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Licence Of Patents [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LicenceOfPatentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Licence of patents.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LicenceOfPatentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">License of Patents [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentAnnualReport_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Annual Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInPurchasesExternalExpensesAndOther_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in purchases, external expenses and other.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInPurchasesExternalExpensesAndOther_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Purchases, External Expenses and Other</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInPurchasesExternalExpensesAndOther_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase (decrease) in purchases, external expenses and other</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInPurchasesExternalExpensesAndOther_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Decrease in purchases, external expenses and other</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxAuthoritiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income Tax Authorities [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncomeTaxAuthoritiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Income Tax Authorities [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentAccruedLiabilitiesForPersonnelRelatedExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Current accrued liabilities for personnel related expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentAccruedLiabilitiesForPersonnelRelatedExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current accrued liabilities for personnel related expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CurrentAccruedLiabilitiesForPersonnelRelatedExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accruals for personnel related expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeAndOtherPayablesToTradeSuppliers_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trade payables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeAndOtherPayablesToTradeSuppliers_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trade payables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeAndOtherPayablesToTradeSuppliers_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Trade payables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shareholders' equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionUsedIncludingProvisionForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provision Used Including Provision for Employee Benefits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionUsedIncludingProvisionForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provision used including provision for employee benefits.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionUsedIncludingProvisionForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Amounts used during the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BorrowingsByNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Borrowings by name [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of probability of transaction completion.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Probability of Transaction Completion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfProbabilityOfTransactionCompletion_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of probability of transaction completion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfIntangibleAssetsOtherThanGoodwillAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of intangible assets other than goodwill [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExerciseOfShareWarrantsAndEmployeeWarrantsAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exercise of share warrants and employee warrants amount.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExerciseOfShareWarrantsAndEmployeeWarrantsAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exercise of share warrants and employee warrants amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExerciseOfShareWarrantsAndEmployeeWarrantsAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of share warrants, employee warrants, stock-options and free-shares, amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExerciseOfShareWarrantsAndEmployeeWarrantsAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Exercise of share warrants, employee warrants, stock-options and free-shares vesting</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ConstructionInProgressMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Construction in progress [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ConstructionInProgressMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Assets Under Construction [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughOtherNon-CashMovementsLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase (decrease) in liabilities arising from financing activities resulting from other non-cash changes.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughOtherNon-CashMovementsLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) Through Other Non-Cash Movements, Liabilities Arising from Financing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughOtherNon-CashMovementsLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other non-cash movements financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Of Derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of derivative.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value measurement of derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of financial liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfIntangibleAssetsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about intangible assets [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityPlusFivePercentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Expected volatility plus five percent.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityPlusFivePercentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected Volatility Plus Five Percent [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedVolatilityPlusFivePercentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected volatility +5% [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentAccountingStandard_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Accounting Standard</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RevenueThatWasIncludedInContractLiabilityBalanceAtBeginningOfPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue that was included in contract liability balance at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RevenueThatWasIncludedInContractLiabilityBalanceAtBeginningOfPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenue that was included in contract liability balance at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfCommitmentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of commitments [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfCommitmentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfCommitmentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Off-balance sheet commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Assets at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Assets at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">TOTAL ASSETS</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrepaidExpensesAndOtherCurrentAssetsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Prepaid Expenses and Other Current Assets [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrepaidExpensesAndOtherCurrentAssetsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Expenses and Other Current Assets [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PrepaidExpensesAndOtherCurrentAssetsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Prepaid Expenses and Other Current Assets [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReversalOfNonCurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reversal of non current provisions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReversalOfNonCurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reversal Of Non Current Provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReversalOfNonCurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non current provisions Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressesAddressTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Addresses, Address Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashAndCashEquivalentsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and cash equivalents [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeInterestRateWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The implied yield currently available on zero-coupon government issues of the country in whose currency the exercise price for share options granted is expressed.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeInterestRateWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Risk Free Interest Rate Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RiskFreeInterestRateWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Risk free rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TaxEffectOfTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tax effect of tax losses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TaxEffectOfTaxLosses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credits and net operating loss carryforwards</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutOtherCurrentLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of detailed information about other current liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutOtherCurrentLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about other current liabilities [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedInformationAboutOtherCurrentLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Other Current Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForGoingConcernExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Description of accounting policy for going concern explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForGoingConcernExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description Of Accounting Policy For Going Concern Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForGoingConcernExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Going concern</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsOutstandingInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of other equity instruments outstanding in share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsOutstandingInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Number of outstanding instruments as of 12/31/2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NumberOfOtherEquityInstrumentsOutstandingInSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Number of outstanding instruments as of 01/01/2025</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnusedProvisionsReversedIncludingEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Unused provisions reversed including employee benefits.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnusedProvisionsReversedIncludingEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Unused Provisions Reversed Including Employee Benefits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_UnusedProvisionsReversedIncludingEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Pension, Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInTradeAccountPayableAndOtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Adjustments for increase (decrease) in trade account payable and other current liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInTradeAccountPayableAndOtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments For Increase (Decrease) In Trade Account Payable And other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForIncreaseDecreaseInTradeAccountPayableAndOtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">(Decrease) increase in trade payables and other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInProvisionsThroughOtherComprehensiveIncomeIncludingProvisionsForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in provisions through other comprehensive income including provisions for employee benefits.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInProvisionsThroughOtherComprehensiveIncomeIncludingProvisionsForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Provisions through Other Comprehensive Income Including Provisions for Employee Benefits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ChangeInProvisionsThroughOtherComprehensiveIncomeIncludingProvisionsForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOtherProvisionsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of other provisions [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PerformanceStockUnitMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Performance Stock Unit.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PerformanceStockUnitMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Performance Stock Unit [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PerformanceStockUnitMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Performance Stock Unit [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComponentsOfEquityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Components of equity [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of share-based payment arrangements [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Types of share-based payment arrangements [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LossInFairValueMeasurement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Loss in fair value measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LossInFairValueMeasurement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Loss in fair value measurement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherSubsidiesReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other subsidies receivables.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherSubsidiesReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Subsidies Receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherSubsidiesReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other subsidies</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughNetExchangeDifferencesRightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through net exchange differences, right-of-use assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughNetExchangeDifferencesRightofuseAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Translation adjustments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ParValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Par value per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ParValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Nominal value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ParValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Par value per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ParValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Subscription/ Spot share price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">European Investment Bank Loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">European Investment Bank Loan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">European Investment Bank Loan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">European Investment Bank Credit Facility [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherOperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other operating income (expense)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherOperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other operating income (expenses)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherOperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Other operating income and (expense)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Weighted average exercise price per share, ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Weighted average exercise price per share, beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average exercise price per share, cancelled, forfeited or expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of cash and cash equivalents [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Details of Cash and Cash Equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueMeasurement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain in fair value measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GainInFairValueMeasurement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gain in fair value measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MinimumRevenueToBeAchieved_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Minimum revenue to be achieved.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MinimumRevenueToBeAchieved_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Minimum revenue to be achieved</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PreferredSharesConversionRatio_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Shares Conversion Ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PreferredSharesConversionRatio_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Preferred shares, conversion ratio.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PreferredSharesConversionRatio_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Conversion ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementProcessesForAssessingIdentifyingAndManagingThreatsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsPensionCommitments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pension commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsPensionCommitments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax assets pension commitments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsPensionCommitments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred tax assets pension commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DeferredTaxAssetsPensionCommitments_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Pension commitments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxExchangeDifferencesOnTranslationOtherThanTranslationOfForeignOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other comprehensive income, before tax, exchange differences on translation, other than translation of foreign operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherComprehensiveIncomeBeforeTaxExchangeDifferencesOnTranslationOtherThanTranslationOfForeignOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Currency translation adjustment generated by the parent company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity awards.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity awards [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EquityAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity awards [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfQuantitativeInformationAboutRightofuseAssetsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of quantitative information about right-of-use assets [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustedWeightedAverageShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average number of ordinary shares used in calculating diluted earnings per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustedWeightedAverageShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AdjustedWeightedAverageShares_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Weighted average number of outstanding shares, net of effects of dilutive potential ordinary shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of revenue.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Revenue [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Revenue [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantRefundableAdvanceReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Grant Refundable Advance Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantRefundableAdvanceReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Grant refundable advance received.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GrantRefundableAdvanceReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grand refundable advance received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AverageLifeOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Average Life Options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AverageLifeOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Average life options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AverageLifeOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Average life of options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredIncomeOtherThanContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred income other than contract liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredIncomeOtherThanContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other deferred income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JuneTwentyThreeTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">June Twenty Three Two Thousand Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JuneTwentyThreeTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">June twenty three two thousand twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JuneTwentyThreeTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">6/23/2025 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current assets [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentAssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current assets</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestonePaymentFor10Candidate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Milestone payment for 10 candidate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MilestonePaymentFor10Candidate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Milestone Payment For 10 Candidate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current trade payables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trade payables</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedLifeOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected life of derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedLifeOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected life of derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedLifeOfDerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Expected life of derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDiscontinuedOperationsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of discontinued operations [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDiscontinuedOperationsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial litigation other comprehensive income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Litigation Other Comprehensive Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial litigation, OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DilutedEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Diluted earnings (loss) per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DilutedEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Diluted net income (loss) attributable to shareholders of Cellectis per share ( $ /share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DilutedEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total diluted earnings (loss) per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DilutedEarningsLossPerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Diluted net income (loss) attributable to shareholders of Cellectis, per share ($ /share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of reconciliation of liabilities arising from financing activities [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CytoviaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cytovia.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CytoviaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cytovia [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="country_FR_lbl" xlink:role="http://www.xbrl.org/2003/role/label">FRANCE</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="country_FR_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">France [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="country_FR_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">FRANCE</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentVested_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Fair Value At Measurement Date Other Equity Instrument Vested</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentVested_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The weighted average fair value at the measurement date of other equity instruments (ie other than share options) vested in a share-based payment arrangement. [Refer: Weighted average [member]".</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentVested_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average exercise price per share, Vested</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDefinedBenefitPlansAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of defined benefit plans [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityVoluntaryFilers_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Voluntary Filers</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtAmortisedCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial assets at amortised cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssetsAtAmortisedCost_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounting category amortized cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentPortionOfNoncurrentLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current portion of non-current loans received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentPortionOfNoncurrentLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non current liability of loan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentPortionOfNoncurrentLoansReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Conditional advances</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_StatementOfChangesInEquityTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of changes in equity [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAndGoodwillAccumulatedDepreciationAndImpairment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Intangible assets and goodwill accumulated depreciation and impairment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAndGoodwillAccumulatedDepreciationAndImpairment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Intangible assets and goodwill accumulated depreciation and impairment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IntangibleAssetsAndGoodwillAccumulatedDepreciationAndImpairment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated depreciation and impairment at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseCashCashEquiventAndCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) cash, cash equivent and current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseCashCashEquiventAndCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) cash, cash equivent and current financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseCashCashEquiventAndCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total cash, cash equivent and current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfTradeReceivablesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of trade receivables [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfTradeReceivablesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of trade receivables.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="cyd_CybersecurityRiskManagementPositionsOrCommitteesResponsibleFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cybersecurity Risk Management Positions or Committees Responsible [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfFinancialAssetsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of financial assets [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CountryRegion_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Country Region</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provisions for retirement indemnities reversals.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions For Retirement Indemnities Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForRetirementIndemnitiesReversals_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retirement Indemnities , Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassOfSharesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class Of Shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassOfSharesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Shares [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ValuationTechniquesUsedInFairValueMeasurementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Valuation techniques used in fair value measurement [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in contract liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Contract Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in deferred revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GauranteedBorrowingAmountPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gauranteed borrowing amount percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GauranteedBorrowingAmountPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gauranteed Borrowing Amount Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_GauranteedBorrowingAmountPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Guaranteed borrowing amount, percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShorttermDepositsClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Short-term deposits, classified as cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShorttermDepositsClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and bank accounts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ShorttermDepositsClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Fixed bank deposits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementExtendedPeriodMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreement extended period [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementExtendedPeriodMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement extended period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementExtendedPeriodMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Agreement Extended Period [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForTransactionsWithAstraZeneaExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Description of accounting policy for transactions with AstraZenea explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForTransactionsWithAstraZeneaExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description Of Accounting Policy For Transactions With AstraZenea Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForTransactionsWithAstraZeneaExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounting treatment of transactions with AstraZeneca</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_StatementOfComprehensiveIncomeAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of comprehensive income [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisposalsAndRetirementsPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposals and retirements, property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisposalsAndRetirementsPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Disposal</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisposalsAndRetirementsPropertyPlantAndEquipment_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Total disposals and retirements, property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DepreciationAndAmortizationExpensesInclusiveRightOfUseAmortization_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Depreciation And Amortization Expenses Inclusive Right Of Use Amortization</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DepreciationAndAmortizationExpensesInclusiveRightOfUseAmortization_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Depreciation And Amortization Expenses Inclusive Right Of Use Amortization</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DepreciationAndAmortizationExpensesInclusiveRightOfUseAmortization_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Depreciation and amortization expenses (incl. right of use amortization)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Common Stock, Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ItLicensingAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">It licensing agreements member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ItLicensingAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">It Licensing Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ItLicensingAgreementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">IT Licensing Agreements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SharePremiumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share premium [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_SharePremiumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Premiums Related to Share Capital [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Equity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Equity_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance at end of year</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Equity_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Equity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total shareholders' equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfPotentialOrdinarySharesIssuedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Potential Ordinary Shares Issued In Share Based Payment Arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfPotentialOrdinarySharesIssuedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of potential ordinary shares issued in share based payment arrangement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfPotentialOrdinarySharesIssuedInShareBasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum of shares to be issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanTrancheCMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">European Investment Bank Loan Tranche C.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankLoanTrancheCMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">European Investment Bank Loan - Tranche C [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfPropertyPlantAndEquipmentDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of property, plant and equipment [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNon-CurrentFinancialLiabilitiesAndNon-CurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Total Non-Current Financial Liabilities and Non-Current Lease Debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TotalNon-CurrentFinancialLiabilitiesAndNon-CurrentLeaseDebtsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Total Non-Current Financial Liabilities and Non-Current Lease Debts [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfNetDefinedBenefitLiabilityAssetExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of net defined benefit liability (asset) [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfNetDefinedBenefitLiabilityAssetExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Net Defined Benefit Liability and Components</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfGovernmentGrantsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of government grants [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfGovernmentGrantsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Subsidies Receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFinancialIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease (increase) in financial income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFinancialIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Financial Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFinancialIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease /increase in financial income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentFinancialAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-current financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentFinancialAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current financial assets [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NonCurrentFinancialAssetsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current Financial Assets [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RemainingContractualLifeOfOption_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Remaining contractual life of option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RemainingContractualLifeOfOption_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Remaining Contractual Life Of Option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RemainingContractualLifeOfOption_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Contractual life of options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueProbabilityOfTransactionCompletionLessTwoPercent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair value probability of transaction completion less two percent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueProbabilityOfTransactionCompletionLessTwoPercent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair Value Probability of transaction completion less two percent.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueProbabilityOfTransactionCompletionLessTwoPercent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Probability of transaction completion -2%</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FollowOnOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Follow on Offering Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FollowOnOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Follow on offering.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from borrowings, classified as financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Secured Borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromProductsServices_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of revenue from products and services.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromProductsServices_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Revenue From Products Services</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_RevenueFromProductsServices_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Products &amp; services</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MiscellaneousCurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Miscellaneous current liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PercentageOfVotingEquityInterestsAcquired_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of voting equity interests acquired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PercentageOfVotingEquityInterestsAcquired_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of voting rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PercentageOfVotingEquityInterestsAcquired_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Voting rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share-based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expense from share-based payment transactions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total expense from share-based payment transactions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Non current provisions Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Non current provisions beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentProvisions_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total non-current provisions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfIncreaseInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of increase in discount rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfIncreaseInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Increase In Discount Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfIncreaseInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of increase in discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease (increase) in financial Expenses.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Financial Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFinancialExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease /increase in financial Expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherFinanceCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other finance cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherFinanceCost_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Other financial expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AccumulatedImpairmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated impairment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfCashGeneratingUnit_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of cash generating unit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfCashGeneratingUnit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of cash generating unit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfCashGeneratingUnit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of cash generating unit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule Of Income Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Income Statement Of Discontinued Operations [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Income Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComputerEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Computer equipment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComputerEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">IT Equipment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherFinanceIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other finance income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfCandidateProductsForNovelCellAndGeneTherapy_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of candidate products for novel cell and gene therapy.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfCandidateProductsForNovelCellAndGeneTherapy_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Candidate Products For Novel Cell And Gene Therapy</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfCandidateProductsForNovelCellAndGeneTherapy_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of candidate products for novel cell and gene therapy</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalResearchPlansUnderTheAZJRCATwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional Research Plans under the AZ JRCA Two.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalResearchPlansUnderTheAZJRCATwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Research Plans under the AZ JRCA Two [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalResearchPlansUnderTheAZJRCATwoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional Research Plans under the AZ JRCA Two [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PriorServiceCostsAmendmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prior service costs amendment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PriorServiceCostsAmendmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Prior service costs amendment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about property, plant and equipment [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of detailed information about property, plant and equipment [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfPropertyPlantAndEquipmentTable_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Details of Property, Plant and Equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryTwentyFiveThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">January Twenty Five Thousand And Twenty Four [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryTwentyFiveThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">January twenty five thousand and twenty four.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_JanuaryTwentyFiveThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">01/25/2024 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CityAreaCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">City Area Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalProvisionsIncludingProvisionsForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Provisions including Provisions for Employee Benefits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalProvisionsIncludingProvisionsForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional provisions including provisions for employee benefits.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalProvisionsIncludingProvisionsForEmployeeBenefits_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AccumulatedDepreciationAmortisationAndImpairmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated depreciation, amortisation and impairment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AccumulatedDepreciationAmortisationAndImpairmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated depreciation and impairment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_AccumulatedDepreciationAmortisationAndImpairmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Accumulated Depreciation and Impairment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmericanDepositorySharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">American depository shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmericanDepositorySharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">American Depository Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AmericanDepositorySharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">ADR [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TechnicalEquipmentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Technical equipments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TechnicalEquipmentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Technical Equipments [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TechnicalEquipmentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Technical Equipment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpirationPeriodOfStockOptionPlan_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Expiration period of stock option plan.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpirationPeriodOfStockOptionPlan_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expiration Period of Stock Option Plan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpirationPeriodOfStockOptionPlan_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock option expire, years</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForDecreaseIncreaseInSubsidiesAndTaxReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Adjustments for decrease (increase) in subsidies and tax receivables to reconcile profit (loss) to net cash flows provided by (used in) operating activities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForDecreaseIncreaseInSubsidiesAndTaxReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments for Decrease (Increase) in Subsidies and Tax Receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdjustmentsForDecreaseIncreaseInSubsidiesAndTaxReceivables_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease (increase) in subsidies and tax receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfSensitivityAnalysisOnTheExpectedVolatilityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of sensitivity analysis on the expected volatility [table text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfSensitivityAnalysisOnTheExpectedVolatilityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of sensitivity analysis on the expected volatility explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfSensitivityAnalysisOnTheExpectedVolatilityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of sensitivity analysis on the expected volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfAccountingPolicyForChangesInAccountingEstimatesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of accounting policy for changes in accounting estimates explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfAccountingPolicyForChangesInAccountingEstimatesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of accounting policy for changes in accounting estimates explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfAccountingPolicyForChangesInAccountingEstimatesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Use of judgment, estimates and assumptions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AuditorName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Auditor Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInOtherOperatingIncomeExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Other Operating Income (Expenses)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInOtherOperatingIncomeExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in other operating income (expenses).</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInOtherOperatingIncomeExpenses_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in other operating income (expenses)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceAmountsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of provisions for employee litigation and severance, amounts used during the period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceAmountsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions for employee litigation and severance amounts used during the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeveranceAmountsUsedDuringThePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Employee litigation and severance, Amounts used during the period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharesReceivableOnConversionOfWarrantsAsAPercentageOfSharesEntitlementOnConversionOnNotesReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Shares receivable on conversion of warrants as a percentage of shares entitlement on conversion on notes receivable.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharesReceivableOnConversionOfWarrantsAsAPercentageOfSharesEntitlementOnConversionOnNotesReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Shares Receivable On Conversion Of Warrants As A Percentage Of Shares Entitlement On Conversion On Notes Receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SharesReceivableOnConversionOfWarrantsAsAPercentageOfSharesEntitlementOnConversionOnNotesReceivable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares receivable on conversion of warrants as a percentage of shares entitlement on conversion of notes receivable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DateOfGrantOfSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Date of grant of share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DateOfGrantOfSharebasedPaymentArrangement_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Purchase of property, plant and equipment, classified as investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Acquisition of property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Purchase of property, plant and equipment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNon-CurrentRestrictedCash_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in non-current restricted cash.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNon-CurrentRestrictedCash_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease in Non-Current Restricted Cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNon-CurrentRestrictedCash_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in non-current restricted cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research and development expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Research and development expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Total research and development expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Repayments of borrowings, classified as financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Decrease in borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Repayments of borrowings</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfAnalysisOfSingleAmountOfDiscontinuedOperationsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of analysis of single amount of discontinued operations [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedDividendAsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The percentage of an expected dividend used to calculate the fair value of share options granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedDividendAsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected Dividend As Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpectedDividendAsPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected dividends</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total non-current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_StatementOfCashFlowsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of cash flows [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">European investment bank warrants [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">European investment bank warrants [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EuropeanInvestmentBankWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">European Investment Bank Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseRemainingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Lease remaining period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseRemainingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease Remaining Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseRemainingPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lease remaining period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationsReversal_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of commercial litigations reversal.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationsReversal_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Commercial litigations reversal</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationsReversal_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial litigation, Reversals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule Of Income Statement Of Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Income Statement Of Discontinued Operations [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Income Statement Of Discontinued Operations [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FunctionalCurrencyPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Functional currency percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FunctionalCurrencyPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Functional Currency Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FunctionalCurrencyPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Currency denominated percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MaximumNumberOfExclusiveLicenseForProductCandidates_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum number of exclusive license for product candidates.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MaximumNumberOfExclusiveLicenseForProductCandidates_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maximum Number Of Exclusive License For Product Candidates</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MaximumNumberOfExclusiveLicenseForProductCandidates_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum number of exclusive license for product candidates</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentRestrictedCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-current restricted cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncurrentRestrictedCashAndCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialTermForSelectionOfCandidateProducts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial term for selection of candidate products.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialTermForSelectionOfCandidateProducts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Term For Selection Of Candidate Products</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_InitialTermForSelectionOfCandidateProducts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial term for selection of candidate products</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AprilThirteenTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">April Thirteen Two Thousand and Twenty One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AprilThirteenTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">April Thirteen Two Thousand and Twenty One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AprilThirteenTwoThousandAndTwentyOneMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">04/13/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedLifeOfDerivativeLessOneMonth_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair value expected life of derivative less one month</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedLifeOfDerivativeLessOneMonth_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value expected life of derivative less one month.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueExpectedLifeOfDerivativeLessOneMonth_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected life of derivative -1 month</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of ordinary shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Of Ordinary Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueOfOrdinaryShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of ordinary shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BorrowingsInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Borrowings, interest rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BorrowingsInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_BorrowingsInterestRate_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Fixed interest rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other provision for charges member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Provision For Charges [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other provision for charges [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfAssetsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Classes of assets [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ClassesOfAssetsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Classes of assets [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFourthTwoThousandAndTwentyOnememberMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March Fourth Two Thousand and Twenty One [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFourthTwoThousandAndTwentyOnememberMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Fourth Two Thousand and Twenty One Member [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchFourthTwoThousandAndTwentyOnememberMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">03/04/2021 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberFourThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">11/04/2024 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberFourThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">November Four Thousand And Twenty Four [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NovemberFourThousandAndTwentyFourMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">November four thousand and twenty four.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NetDeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net deferred tax assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NetDeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net deferred tax assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NonadjustingEventsAfterReportingPeriodDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-adjusting events after reporting period [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseLiabilitiesDiscontinuedOperation_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Lease liabilities discontinued operation.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseLiabilitiesDiscontinuedOperation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease Liabilities Discontinued Operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_LeaseLiabilitiesDiscontinuedOperation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lease liabilities discontinued operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsidiesReceivablesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsidies receivables current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsidiesReceivablesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Subsidies receivables current.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubsidiesReceivablesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total subsidies receivables</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EmployeeLitigationAndSeveranceMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Employee litigation and severance.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EmployeeLitigationAndSeveranceMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Employee litigation and severance [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_EmployeeLitigationAndSeveranceMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Employee Litigation and Severance [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_NoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOfEquityInstrumentsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Type of equity instruments granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypeOfEquityInstrumentsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Type of equity instruments granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class A Preferred Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class A Preferred Shares [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ClassAPreferredSharesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class A Preferred Shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash flows from (used in) operating activities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash flows from operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueSIADerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueSIADerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value SIA Derivative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueSIADerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value SIA derivative.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValueSIADerivative_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expected volatility, share options granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Expected volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtAtmProgramMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Calyxt Atm Program Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtAtmProgramMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Calyxt ATM Program [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CalyxtAtmProgramMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Calyxt ATM Program [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInCapitalFromOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in capital from operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInCapitalFromOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in capital from operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInCapitalFromOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in capital from operating activities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressCountry_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Country</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other provision for charges other comprehensive income.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Provision For Charges Other Comprehensive Income</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherProvisionForChargesOtherComprehensiveIncome_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other provision for charges, OCI</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNetDefinedBenefitLiabilityInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in net defined benefit liability in discount rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNetDefinedBenefitLiabilityInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Decrease In Net Defined Benefit Liability In Discount Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecreaseInNetDefinedBenefitLiabilityInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in net defined benefit liability in discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchThirteenTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">March Thirteen Two Thousand Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchThirteenTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">March thirteen two thousand twenty five</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_MarchThirteenTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">3/13/2025 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LeaseholdImprovementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Leasehold improvements [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LeaseholdImprovementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leasehold Improvements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationsAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of commercial litigations additions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationsAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Litigations Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CommercialLitigationsAdditions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial litigation, Additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease /increase in cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase decrease in cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInCashCashEquivalentsAndFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in cash, cash equivalents and financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Level2OfFairValueHierarchyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Level 2 of fair value hierarchy [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_Level2OfFairValueHierarchyMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Level 2 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of information about consolidated and non-consolidated structured entities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure Of Information About Consolidated And Non-consolidated Structured Entities [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of Information about Consolidated and Non-consolidated Structured Entities [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberEightTwoThousandEighteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">October eight two thousand eighteen.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberEightTwoThousandEighteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">October eight two thousand eighteen [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OctoberEightTwoThousandEighteenMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">10/08/2018 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EarningsPerShareExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings per share [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EarningsPerShareExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Earnings per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDetailedInformationAboutIntangibleAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Details Information About Intangible Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfDetailedInformationAboutIntangibleAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed information about intangible assets [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Comprehensive income, attributable to non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total comprehensive income, attributable to non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Attributable to non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubscriptionPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subscription price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubscriptionPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subscription Price Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubscriptionPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Subscription price per share.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExecutiveEmployeesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Executive employees.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExecutiveEmployeesMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Executive Employees [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_KeyManagementPersonnelNoncashStockbasedCompensationExpenseRecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Key management personnel non-cash stock-based compensation expense recognized.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_KeyManagementPersonnelNoncashStockbasedCompensationExpenseRecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Key management personnel non-cash stock-based compensation expense recognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_KeyManagementPersonnelNoncashStockbasedCompensationExpenseRecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Key management personnel non-cash stock-based compensation expense recognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AuditorLocation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Auditor Location</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BuildingsAndOtherOutsideImprovementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Buildings and other outside improvements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BuildingsAndOtherOutsideImprovementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Buildings And Other Outside Improvements [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BuildingsAndOtherOutsideImprovementsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Buildings and Other Outside Improvements [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeverance_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Provisions For Employee Litigation and Severance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeverance_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Provisions for employee litigation and severance.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeverance_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Employee litigation and severance, Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeverance_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Employee litigation and severance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProvisionsForEmployeeLitigationAndSeverance_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Employee litigation and severance, Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecemberNineTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">December Nine Two Thousand Twenty Five [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecemberNineTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">December nine two thousand twenty five.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DecemberNineTwoThousandTwentyFiveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">12/9/2025 [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherNoncurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other non-current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherNoncurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other non-current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherNoncurrentAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Other non-current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReclassificationInCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Decrease in Reclassification current financial assets.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReclassificationInCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reclassification In Current Financial Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ReclassificationInCurrentFinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in reclassification current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Fair Value of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in fair value of warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInFairValueOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in fair value of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase in net defined benefit liability in salary increase rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase In Net Defined Benefit Liability In Salary Increase Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase of net defined benefit liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingTradesPayableAndOtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Financial liabilities excluding trades payable and other current liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingTradesPayableAndOtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial liabilities excluding trades payable and other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FinancialLiabilitiesExcludingTradesPayableAndOtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BPIAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">B P I Agreement [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BPIAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">B P I Agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BPIAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">BPI Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionForNonCurrentProvision_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Addition for non current provision.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionForNonCurrentProvision_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Addition For Non Current Provision</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionForNonCurrentProvision_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non current provisions additions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpenseByNatureLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Line items represent concepts included in a table. These concepts are used to disclose the amount of expenses aggregated according to their nature (for example, depreciation, purchases of materials, transport costs, employee benefits and advertising costs), and not reallocated among functions within the entity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpenseByNatureLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Expense by Nature [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ExpenseByNatureLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expense by nature [line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Collaboration agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_CollaborationAgreementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaboration Agreement [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MajorComponentsOfTaxExpenseIncomeAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Major components of tax expense (income) [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred tax assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred tax assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DeferredTaxAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Deferred tax assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of subsidiaries [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromSalesOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from sales of investments other than investments accounted for using equity method</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ProceedsFromSalesOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Sale of current financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_CategoriesOfFinancialLiabilitiesDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Categories of financial liabilities [domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of revenue [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of revenue [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfRevenueLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of revenue [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypesOfWarrantsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Types of warrants [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TypesOfWarrantsDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Types of warrants [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of transactions between related parties [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount represents the research tax credit income for the period. The research tax credit is a French tax credit calculated based on our claimed amount of eligible research and development expenses in France. It can be offset against French corporate income tax due and the portion in excess (if any) may be refunded at the end of a three fiscal-year period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research Tax Credit Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research tax credit subsidy</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ResearchTaxCreditAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Research Tax Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FurnitureFixturesAndOfficeEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Furniture fixtures and office equipment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FurnitureFixturesAndOfficeEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Furniture Fixtures and Office Equipment [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FurnitureFixturesAndOfficeEquipmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Office Furniture [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityInteractiveDataCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Interactive Data Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValuePerOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value per options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValuePerOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Per Options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValuePerOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value per options (in euros per share)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_FairValuePerOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Fair value per options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BankDepositsNotClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Bank deposits, not classified as cash equivalents.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BankDepositsNotClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Bank Deposits Not Classified As Cash Equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_BankDepositsNotClassifiedAsCashEquivalents_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Bank deposits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalManufacturingActivitiesToSupportRDPipelineMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Manufacturing Activities to Support R&amp;D Pipeline [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AdditionalManufacturingActivitiesToSupportRDPipelineMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional Manufacturing Activities to Support R&amp;D Pipeline.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInAccrualsForPersonnelRelatedExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in accruals for personnel related expense.</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInAccrualsForPersonnelRelatedExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in accruals for personnel related expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInForeignExchangeGains_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase (decrease) in foreign exchange gains.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseInForeignExchangeGains_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) in foreign exchange gains</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedFinancialLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The entire disclosure in details of financial liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedFinancialLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of detailed financial liabilities explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfDetailedFinancialLiabilitiesExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial liabilities at fair value through profit or loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total financial liabilities at fair value through profit or loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialLiabilitiesAtFairValueThroughProfitOrLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfImpairmentLossAndReversalOfImpairmentLossLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of impairment loss and reversal of impairment loss [line items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DepreciationImpairmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Depreciation &amp; Impairment Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DepreciationImpairmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Depreciation &amp; impairment expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DepreciationImpairmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Depreciation &amp; impairment expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_ChangesInDeferredTaxLiabilityAssetAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Changes in deferred tax liability (asset) [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_MeasurementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement [axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other current liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherCurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other current liabilities [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsReceivedInCollaborationAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds Received In Collaboration Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsReceivedInCollaborationAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds received in collaboration agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_ProceedsReceivedInCollaborationAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Proceeds reallocated to the JRCA</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfActivitiesOfCompanyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disclosure of Activities of Company Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfActivitiesOfCompanyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of Activities of Company Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DisclosureOfActivitiesOfCompanyExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">The Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Financial assets at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Financial assets at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_FinancialAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total financial assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfQuantitativeInformationAboutRightofuseAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of quantitative information about right-of-use assets [text block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfQuantitativeInformationAboutRightofuseAssetsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Right-of-use&#160;assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeLossFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other comprehensive income (loss) from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeLossFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other comprehensive income (loss) from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeLossFromDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other comprehensive income (loss) from discontinued operations.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsFairValueOfRetainedInvestment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of the retained investment</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DiscontinuedOperationsFairValueOfRetainedInvestment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Discontinued operations, fair value of retained investment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NetAssetsLiabilitiesAndEquityDerecognized_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Net assets, liabilities and equity derecognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NetAssetsLiabilitiesAndEquityDerecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Assets, Liabilities And Equity Derecognized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NetAssetsLiabilitiesAndEquityDerecognized_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Net assets, liabilities and equity derecognized.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfClassesOfShareCapitalAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of classes of share capital [abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssuedCapitalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Issued capital [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssuedCapitalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share Capital Issued Capital [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IssuedCapitalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share capital [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TaxEffectOfNonRecognitionOfDeferredTaxAssetsRelatedToTaxLossesAndTemporaryDifferences_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Non recognition of deferred tax assets related to tax losses and temporary differences</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TaxEffectOfNonRecognitionOfDeferredTaxAssetsRelatedToTaxLossesAndTemporaryDifferences_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Tax Effect Of Non Recognition Of Deferred Tax Assets Related To Tax Losses And Temporary Differences</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_TaxEffectOfNonRecognitionOfDeferredTaxAssetsRelatedToTaxLossesAndTemporaryDifferences_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Tax effect of non recognition of deferred tax assets related to tax losses and temporary differences.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsMayTwentySixAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Put Options May Twenty Six And Twenty Twenty Six [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsMayTwentySixAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Put options may twenty six and twenty twenty six.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PutOptionsMayTwentySixAndTwentyTwentySixMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Put options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (decrease) through other changes, equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other movements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanOneYearAndNotLaterThanFiveYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Later than one year and not later than five years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanOneYearAndNotLaterThanFiveYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">One to Five Years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesToBeIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Shares To Be Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesToBeIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of shares to be issued.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesToBeIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_NumberOfSharesToBeIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Number of shares to be issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateGuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">State Guaranteed Loan.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateGuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">State Guaranteed Loan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_StateGuaranteedLoanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">State Guaranteed Loan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForConsolidatedEntitiesAndNonControllingInterestsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consolidated entities and non-controlling interests</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForConsolidatedEntitiesAndNonControllingInterestsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Description Of Accounting Policy For Consolidated Entities And Non controlling Interests Explanatory</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_DescriptionOfAccountingPolicyForConsolidatedEntitiesAndNonControllingInterestsExplanatory_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Description of accounting policy for consolidated entities and noncontrolling interests explanatory.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageRemainingContractualLifeOfOutstandingShareOptions2019_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted average remaining contractual life of outstanding share options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_WeightedAverageRemainingContractualLifeOfOutstandingShareOptions2019_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Remaining Average Useful Life</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanThreeYearsAndNotLaterThanFiveYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Later than three years and not later than five years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_LaterThanThreeYearsAndNotLaterThanFiveYearsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">3-5 years [member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_LocalPhoneNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Local Phone Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_OtherCurrentLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total&#160;other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementTwoDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Agreement two.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_AgreementTwoDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Agreement Two [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubscriptionPricePerShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subscription Price Per Share Options Granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubscriptionPricePerShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Subscription price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_SubscriptionPricePerShareOptionsGranted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subscription price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOffsettingOfFinancialLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disclosure of offsetting of financial liabilities [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_DisclosureOfOffsettingOfFinancialLiabilitiesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disclosure of offsetting of financial liabilities [table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughFinancingCashFlowsExcludingInterestPaymentsLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase (decrease) in liabilities arising from financing activities resulting from financing cash flows, excluding interest payments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughFinancingCashFlowsExcludingInterestPaymentsLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) Through Financing Cash Flows (Excluding Interest Payments), Liabilities Arising from Financing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDecreaseThroughFinancingCashFlowsExcludingInterestPaymentsLiabilitiesArisingFromFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt repayments financial liabilities and lease debts</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AuditorOpinionTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Auditor Opinion [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AuditorOpinionTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Auditor Opinion</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_WarrantsValuationAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants Valuation [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDecreaseInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of decrease in discount rate.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDecreaseInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Decrease In Discount Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_PercentageOfDecreaseInDiscountRate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of decrease in discount rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other comprehensive income that will be reclassified to profit or loss net of tax from continuing operations.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income That Will Be Reclassified To Profit Or Loss Net Of Tax From Continuing Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Other comprehensive income (loss) that will be reclassified subsequently to income or loss from continuing operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="clls_IncreaseDueToConsiderationReceivedFromCustomersContractLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase in contract liability balances resulting from consideration received from customers.</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="ifrs-full_EmployeeBenefitsExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Personnel expenses</link:label>
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  <xsd:element id="clls_OtherCurrentFinancialLiabilitiesMember" name="OtherCurrentFinancialLiabilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SharesReceivableOnConversionOfWarrantsAsAPercentageOfSharesEntitlementOnConversionOnNotesReceivable" name="SharesReceivableOnConversionOfWarrantsAsAPercentageOfSharesEntitlementOnConversionOnNotesReceivable" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_FinancialInstitutionAxis" name="FinancialInstitutionAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FairValueOfExpectedVolatilityPercentage" name="FairValueOfExpectedVolatilityPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_NonCurrentProvisionsUsedDuringThePeriod" name="NonCurrentProvisionsUsedDuringThePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_SharePriceOfWarrant" name="SharePriceOfWarrant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AmendmentAgreementOneMember" name="AmendmentAgreementOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsLineItems" name="DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionsForEmployeeLitigationAndSeverance" name="ProvisionsForEmployeeLitigationAndSeverance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_IntangibleAssetsOtherThanGoodwillEstimatedUsefulLife" name="IntangibleAssetsOtherThanGoodwillEstimatedUsefulLife" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ResearchTaxCreditLitigationSettled" name="ResearchTaxCreditLitigationSettled" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_TypeOneNovemberNineTwoThousandTwentyMember" name="TypeOneNovemberNineTwoThousandTwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PutOptionsMayFifteenthAndTwentyTwentySixMember" name="PutOptionsMayFifteenthAndTwentyTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ConvertibleNoteNominalAmount" name="ConvertibleNoteNominalAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncreaseDecreaseInFairValueOfWarrants" name="IncreaseDecreaseInFairValueOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_FinancialLiabilitiesAndLeaseDebts" name="FinancialLiabilitiesAndLeaseDebts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ExpectedLifeOfDerivative" name="ExpectedLifeOfDerivative" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ExpectedVolatilityPlusFivePercentMember" name="ExpectedVolatilityPlusFivePercentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CapitalEvolution2024Member" name="CapitalEvolution2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_StateAndLocalTaxAuthorityMember" name="StateAndLocalTaxAuthorityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_TaxAndSocialReceivablesCurrent" name="TaxAndSocialReceivablesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_TradeReceivablesAndOtherCurrentAssetsExplanatory" name="TradeReceivablesAndOtherCurrentAssetsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_TechnicalEquipmentsMember" name="TechnicalEquipmentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProceedsFromSaleOfPreferredShares" name="ProceedsFromSaleOfPreferredShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ClassOfWarrantsOrRightDomain" name="ClassOfWarrantsOrRightDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_WarrantsValuationAbstract" name="WarrantsValuationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PropertyPlantAndEquipmentAccumulatedDepreciationAmortisationAndImpairment" name="PropertyPlantAndEquipmentAccumulatedDepreciationAmortisationAndImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_NumberOfWarrantGranted" name="NumberOfWarrantGranted" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_RevenueFromProductsServices" name="RevenueFromProductsServices" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ProvisionsForEmployeeLitigationAndSeveranceReversal" name="ProvisionsForEmployeeLitigationAndSeveranceReversal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_SocialSecurityContributionsIncludingPriorPeriodAdjustments" name="SocialSecurityContributionsIncludingPriorPeriodAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FairValueExpectedLifeOfDerivativeEstimatedByManagement" name="FairValueExpectedLifeOfDerivativeEstimatedByManagement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_RiskFreeInterestRateWarrants" name="RiskFreeInterestRateWarrants" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseCashCashEquiventAndCurrentFinancialAssets" name="IncreaseDecreaseCashCashEquiventAndCurrentFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NumberOfCandidateProductsForNovelCellAndGeneTherapy" name="NumberOfCandidateProductsForNovelCellAndGeneTherapy" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ProvisionsForEmployeeLitigationAndSeveranceOtherComprehensiveIncome" name="ProvisionsForEmployeeLitigationAndSeveranceOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AdditionForCurrentProvision" name="AdditionForCurrentProvision" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_EquityNetOfTaxWeakeningMember" name="EquityNetOfTaxWeakeningMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DescriptionOfAccountingPolicyForTransactionsWithAstraZeneaExplanatory" name="DescriptionOfAccountingPolicyForTransactionsWithAstraZeneaExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DecreaseInFinancialInvestmentsGain" name="DecreaseInFinancialInvestmentsGain" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_OperatingExpensesAndOtherOperatingIncome" name="OperatingExpensesAndOtherOperatingIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations" name="OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_IncomeTaxAuthoritiesAxis" name="IncomeTaxAuthoritiesAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProceedsFromIssuingSharesNetOfIssuanceCost" name="ProceedsFromIssuingSharesNetOfIssuanceCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_GainsLossesOnChangeInFairValueOfInvestments" name="GainsLossesOnChangeInFairValueOfInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_GainLossOnFairValueMeasurement" name="GainLossOnFairValueMeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_TypeOfEquityInstrumentGranted" name="TypeOfEquityInstrumentGranted" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ProfitAndLossWeakeningMember" name="ProfitAndLossWeakeningMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CurrentAccruedLiabilitiesForPersonnelRelatedExpenses" name="CurrentAccruedLiabilitiesForPersonnelRelatedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CurrentPortionOfState-GuaranteedLoanMember" name="CurrentPortionOfState-GuaranteedLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_StateGuarantedLoanMember" name="StateGuarantedLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SeptemberEightTwoThousandFifteenMember" name="SeptemberEightTwoThousandFifteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionForTaxLitigationAdditions" name="ProvisionForTaxLitigationAdditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ExpectedDividendAsPercentage" name="ExpectedDividendAsPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_RevenueFromCollaborationAgreements" name="RevenueFromCollaborationAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AdjustmentsForDecreaseIncreaseInSubsidiesAndTaxReceivables" name="AdjustmentsForDecreaseIncreaseInSubsidiesAndTaxReceivables" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ExpenseByNatureTable" name="ExpenseByNatureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AdjustmentForDecreaseIncreaseInTradeReceivablesAndOtherCurrentAssets" name="AdjustmentForDecreaseIncreaseInTradeReceivablesAndOtherCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CarryingAmountAndValueMember" name="CarryingAmountAndValueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionsForEmployeeLitigationAndSeveranceAmountsUsedDuringThePeriod" name="ProvisionsForEmployeeLitigationAndSeveranceAmountsUsedDuringThePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CalyxtMember" name="CalyxtMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_EquityAwardsMember" name="EquityAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CalyxtAtmProgramMember" name="CalyxtAtmProgramMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncomeTaxEffectOnRevenue" name="IncomeTaxEffectOnRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ExpenseByNatureLineItems" name="ExpenseByNatureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_TrancheBWarrantsMember" name="TrancheBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_BuildingsAndOtherOutsideImprovementsMember" name="BuildingsAndOtherOutsideImprovementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_JuneTwentySixThousandAndTwentyFourMember" name="JuneTwentySixThousandAndTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ClassOfWarrantsOrRightAxis" name="ClassOfWarrantsOrRightAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FairValueExpectedLifeOfDerivativeLessOneMonth" name="FairValueExpectedLifeOfDerivativeLessOneMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_LiabilityAssetOfDefinedBenefitPlansReclassification" name="LiabilityAssetOfDefinedBenefitPlansReclassification" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_MayTwelveTwoThousandAndTwentyOneMember" name="MayTwelveTwoThousandAndTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfFinancialLiabilitiesAndLeaseDebtsExplanatoryTextBlock" name="DisclosureOfFinancialLiabilitiesAndLeaseDebtsExplanatoryTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_UnusedProvisionsReversedIncludingEmployeeBenefits" name="UnusedProvisionsReversedIncludingEmployeeBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_SharesEntitlementPerOption" name="SharesEntitlementPerOption" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfAssumptionsUsedToEstimateFairValueOfWarrantsExplanatory" name="DisclosureOfAssumptionsUsedToEstimateFairValueOfWarrantsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationAboutShareBasedPaymentArrangementsTextBlock" name="DisclosureOfDetailedInformationAboutShareBasedPaymentArrangementsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_BPIRefundableAdvanceAgreementMember" name="BPIRefundableAdvanceAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PriorServiceCostsAmendmentMember" name="PriorServiceCostsAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SalesOfNon-CurrentFinancialAssetsClassifiedAsInvestingActivities" name="SalesOfNon-CurrentFinancialAssetsClassifiedAsInvestingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_VestingPeriodShare-BasedPaymentArrangements" name="VestingPeriodShare-BasedPaymentArrangements" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AmountConvertibleNoteDueAndPayableInFullCash" name="AmountConvertibleNoteDueAndPayableInFullCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CapitalEvolution2025Member" name="CapitalEvolution2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_InterestIncomeOnCashCashEquivalentsAndFinancialAssets" name="InterestIncomeOnCashCashEquivalentsAndFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ConsolidatedOperationsAbstract" name="ConsolidatedOperationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactionsEquityAndOtherIfrsAdjustments" name="DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactionsEquityAndOtherIfrsAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_TrancheAWarrantsMember" name="TrancheAWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_InitialTermForSelectionOfCandidateProducts" name="InitialTermForSelectionOfCandidateProducts" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AgreementAxis" name="AgreementAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FairValueExpectedProbabilityOfTransactionCompletionEstimatedByManagement" name="FairValueExpectedProbabilityOfTransactionCompletionEstimatedByManagement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsTable" name="DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DiscontinuedOperationsAbstract" name="DiscontinuedOperationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DerivativeInstrumentsExercisePrice" name="DerivativeInstrumentsExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_ExpectedVolatilityWarrants" name="ExpectedVolatilityWarrants" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationAboutProvisionsExplanatory" name="DisclosureOfDetailedInformationAboutProvisionsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_NumberOfExercisableShareOptionsForfeitedInShareBasedPaymentArrangement" name="NumberOfExercisableShareOptionsForfeitedInShareBasedPaymentArrangement" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DerivativeInstrumentsMaturityDate" name="DerivativeInstrumentsMaturityDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_EffectsOfProfitAndLossAndEquityNetOfTaxDomain" name="EffectsOfProfitAndLossAndEquityNetOfTaxDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseInPersonnelExpenses" name="DecreaseInPersonnelExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_RemainingContractualLifeOfOption" name="RemainingContractualLifeOfOption" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfPropertyPlantAndEquipmentEstimatedUsefulLivesExplanatory" name="DisclosureOfPropertyPlantAndEquipmentEstimatedUsefulLivesExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CallOptionsMayFifteenthAndTwentyTwentySixMember" name="CallOptionsMayFifteenthAndTwentyTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AprilTwentyFourTwoThousandNineteenMember" name="AprilTwentyFourTwoThousandNineteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfBasisOfConsolidationAndMaterialAccountingPolicyInformationExplanatory" name="DisclosureOfBasisOfConsolidationAndMaterialAccountingPolicyInformationExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ExerciseOfShareWarrantsAndEmployeeWarrantsAmount" name="ExerciseOfShareWarrantsAndEmployeeWarrantsAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_NumberOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements" name="NumberOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_EuropeanInvestmentBankLoanTrancheBMember" name="EuropeanInvestmentBankLoanTrancheBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CurrentProvisionsUsedDuringThePeriod" name="CurrentProvisionsUsedDuringThePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ClassACommonStockMember" name="ClassACommonStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NumberOfDerivativeInstrumentsWarrantGranted" name="NumberOfDerivativeInstrumentsWarrantGranted" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_OtherProvisionForChargesUsedDuringThePeriod" name="OtherProvisionForChargesUsedDuringThePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ProceedsReceivedInCollaborationAgreement" name="ProceedsReceivedInCollaborationAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_SellingGeneralAndAdministrativeExpenses1Member" name="SellingGeneralAndAdministrativeExpenses1Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseInForeignExchangeGainsLosses" name="DecreaseInForeignExchangeGainsLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NumberOfPotentialOrdinarySharesIssuedInShareBasedPaymentArrangement" name="NumberOfPotentialOrdinarySharesIssuedInShareBasedPaymentArrangement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DecreaseInEmployeeBenefitsExpense" name="DecreaseInEmployeeBenefitsExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ClassesOfCommitmentsDomain" name="ClassesOfCommitmentsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_JanuaryTwentyFourTwoThousandAndTwentyThreeMember" name="JanuaryTwentyFourTwoThousandAndTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ITLicensingAgreementMember" name="ITLicensingAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CollaborationAgreementUpfrontPaymentReceived" name="CollaborationAgreementUpfrontPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncreaseInNumberOfPreferredSharesIssued" name="IncreaseInNumberOfPreferredSharesIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DiscontinuedOperationsConsiderationReceived" name="DiscontinuedOperationsConsiderationReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CibusIncMember" name="CibusIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_WeightedAverageExercisePriceOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourSharebasedPaymentArrangement2019" name="WeightedAverageExercisePriceOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourSharebasedPaymentArrangement2019" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_EuropeanInvestmentBankLoanMember" name="EuropeanInvestmentBankLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionUsedIncludingProvisionForEmployeeBenefits" name="ProvisionUsedIncludingProvisionForEmployeeBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CytoviaAgreementMember" name="CytoviaAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_LeasedPremisesMember" name="LeasedPremisesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationOfShareCapitalExplanatoryTextBlock" name="DisclosureOfDetailedInformationOfShareCapitalExplanatoryTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate" name="IncreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_BpifranceMember" name="BpifranceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CellectisSaMember" name="CellectisSaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CallOptionJulyEleventhTwoThousandAndTwentyFiveMember" name="CallOptionJulyEleventhTwoThousandAndTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfNonCurrentFinancialAssetsExplanatoryTextBlock" name="DisclosureOfNonCurrentFinancialAssetsExplanatoryTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseInNonCashStockBasedCompensationExpense" name="IncreaseDecreaseInNonCashStockBasedCompensationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ExpectedVolatilityLessFivePercentMember" name="ExpectedVolatilityLessFivePercentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DeferredTaxLiabilitiesRightOfUseAssetsAndOtherLeasesRelatedEffects" name="DeferredTaxLiabilitiesRightOfUseAssetsAndOtherLeasesRelatedEffects" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_KeyManagementPersonnelNoncashStockbasedCompensationExpenseRecognized" name="KeyManagementPersonnelNoncashStockbasedCompensationExpenseRecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_UnrealizedGainsLossesMember" name="UnrealizedGainsLossesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDueToConsiderationReceivedFromCustomersContractLiabilities" name="IncreaseDueToConsiderationReceivedFromCustomersContractLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_LeaseOptionToExtendLeaseAgreement" name="LeaseOptionToExtendLeaseAgreement" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DescriptionOfInputsUsedInFairValueMeasurementLiabilitiesTableTextBlock" name="DescriptionOfInputsUsedInFairValueMeasurementLiabilitiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AgreementsExtendedMaturityDate" name="AgreementsExtendedMaturityDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_SpotForeignExchangeRate" name="SpotForeignExchangeRate" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_CashAndCashEquivalentsFromDiscontinuedOperations" name="CashAndCashEquivalentsFromDiscontinuedOperations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ProvisionForTaxLitigationUsedDuringThePeriod" name="ProvisionForTaxLitigationUsedDuringThePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DisclosureOfSensitivityAnalysisOnTheExpectedVolatilityTableTextBlock" name="DisclosureOfSensitivityAnalysisOnTheExpectedVolatilityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IntangibleAssetsAbstract" name="IntangibleAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FinancialInstitutionDomain" name="FinancialInstitutionDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MarchThreeThousandTwentyTwoMember" name="MarchThreeThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInContractLiabilities" name="IncreaseDecreaseInContractLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncreaseInPersonnelExpenses" name="IncreaseInPersonnelExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DecreaseInNon-CurrentRestrictedCash" name="DecreaseInNon-CurrentRestrictedCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_EstimationOfRetirementIndemnityToEmployeeSocialSecurityContributionsPercentage" name="EstimationOfRetirementIndemnityToEmployeeSocialSecurityContributionsPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ClassOfSharesAxis" name="ClassOfSharesAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionForTaxLitigationOtherComprehensiveIncome" name="ProvisionForTaxLitigationOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ConvertibleNotesMember" name="ConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FairValueOfOrdinaryShares" name="FairValueOfOrdinaryShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncreaseDecreaseInCapitalFromOperatingActivities" name="IncreaseDecreaseInCapitalFromOperatingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CallOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember" name="CallOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DeferredTaxAssetGross" name="DeferredTaxAssetGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_SubsidiesReceivablesCurrent" name="SubsidiesReceivablesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_SIACashProceeds" name="SIACashProceeds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_GainInFairValueMeasurement" name="GainInFairValueMeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ProvisionForTaxLitigationMember" name="ProvisionForTaxLitigationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MilestonePaymentFor10Candidate" name="MilestonePaymentFor10Candidate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_PercentageOfVotingEquityInterest" name="PercentageOfVotingEquityInterest" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseInDepreciationAndAmortizationExpenses" name="IncreaseInDepreciationAndAmortizationExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NovemberSixTwoThousandNineteenMember" name="NovemberSixTwoThousandNineteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ResearchAndDevelopmentExpensesMember" name="ResearchAndDevelopmentExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenuesAndContractLiabilities" name="AdjustmentsForIncreaseDecreaseInDeferredRevenuesAndContractLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_OptionLifeShareOptionGranted" name="OptionLifeShareOptionGranted" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_WeightedAverageExercisePriceOfShareOptionsExercisableForfeitedOrExpiredInShareBasedPaymentArrangements" name="WeightedAverageExercisePriceOfShareOptionsExercisableForfeitedOrExpiredInShareBasedPaymentArrangements" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CytoviaMember" name="CytoviaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NumberOfVotingRights" name="NumberOfVotingRights" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_OctoberEightTwoThousandEighteenMember" name="OctoberEightTwoThousandEighteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncomeTaxEffectOnChangeInFairValueOfFinancialInstruments" name="IncomeTaxEffectOnChangeInFairValueOfFinancialInstruments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ReinvoicingToAzIrelandOfResearchCostsRechargeableMember" name="ReinvoicingToAzIrelandOfResearchCostsRechargeableMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AdjustmentsForRealizedForeignExchangeLossesGains" name="AdjustmentsForRealizedForeignExchangeLossesGains" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncreaseDecreaseInOtherIncome" name="IncreaseDecreaseInOtherIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_PercentageOfFinancingTaxReceivableRelatedToResearchTaxCredit" name="PercentageOfFinancingTaxReceivableRelatedToResearchTaxCredit" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ChangeInFairValueOfEuropenInvestmentBank" name="ChangeInFairValueOfEuropenInvestmentBank" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_WarrantsGrantDate" name="WarrantsGrantDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_FurnitureFixturesAndOfficeEquipmentMember" name="FurnitureFixturesAndOfficeEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MarchThirteenTwoThousandTwentyFiveMember" name="MarchThirteenTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MayTwentyFourTwoThousandAndTwentyTwoMember" name="MayTwentyFourTwoThousandAndTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseInTheNumberOfSharesGranted" name="IncreaseInTheNumberOfSharesGranted" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DeferredTaxAssetsRevaluationsOfFinancialAssets" name="DeferredTaxAssetsRevaluationsOfFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_TotalCurrentFinancialLiabilitiesAndCurrentLeaseDebtsMember" name="TotalCurrentFinancialLiabilitiesAndCurrentLeaseDebtsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OfficeAndLaboratoryEquipmentMember" name="OfficeAndLaboratoryEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseThroughCapitalizationOfInterestExpenseNon-CashLiabilitiesArisingFromFinancingActivities" name="IncreaseThroughCapitalizationOfInterestExpenseNon-CashLiabilitiesArisingFromFinancingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_TrancheAAndTrancheBWarrantsMember" name="TrancheAAndTrancheBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NonExecutiveEmployeesMember" name="NonExecutiveEmployeesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseThroughReclassificationBetweenCurrentAndNon-CurrentLiabilitiesArisingFromFinancingActivities" name="IncreaseDecreaseThroughReclassificationBetweenCurrentAndNon-CurrentLiabilitiesArisingFromFinancingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ReversalOfNonCurrentProvisions" name="ReversalOfNonCurrentProvisions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesTable" name="DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionForTaxLitigation" name="ProvisionForTaxLitigation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ClassBPrefereredSharesWithNoVotingRightsMember" name="ClassBPrefereredSharesWithNoVotingRightsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_TotalUpfrontPayments" name="TotalUpfrontPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_MayFourTwoThousandAndTwentyThreeMember" name="MayFourTwoThousandAndTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseInSellingGeneralAndAdministrativeExpenses" name="IncreaseInSellingGeneralAndAdministrativeExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ProfitAndLossStrengtheningMember" name="ProfitAndLossStrengtheningMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PercentageOfDebtRepaymentTerms" name="PercentageOfDebtRepaymentTerms" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_JulyTwentyTwoThousandAndTwentyMember" name="JulyTwentyTwoThousandAndTwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OtherSubsidiesReceivables" name="OtherSubsidiesReceivables" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NovemberfivetwothousandtwentyMember" name="NovemberfivetwothousandtwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DescriptionOfAccountingPolicyForConsolidatedEntitiesAndNonControllingInterestsExplanatory" name="DescriptionOfAccountingPolicyForConsolidatedEntitiesAndNonControllingInterestsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_LicenceOfPatentsMember" name="LicenceOfPatentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationAboutDeferredIncomeAndContractLiabilitiesExplanatory" name="DisclosureOfDetailedInformationAboutDeferredIncomeAndContractLiabilitiesExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_SoftwareAndPatentsMember" name="SoftwareAndPatentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncomeTaxEffectOnShare-BasedCompensation" name="IncomeTaxEffectOnShare-BasedCompensation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationAboutCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock" name="DisclosureOfDetailedInformationAboutCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseInInterestIncomeFromCashCashEquivalentsAndFinancialAssets" name="IncreaseDecreaseInInterestIncomeFromCashCashEquivalentsAndFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ReallocatedProceedsFromSaleOfOrdinaryShares" name="ReallocatedProceedsFromSaleOfOrdinaryShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ScheduleOfBreakdownOfRightOfUseAssetsAbstract" name="ScheduleOfBreakdownOfRightOfUseAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_LeaseLiabilitiesDiscontinuedOperation" name="LeaseLiabilitiesDiscontinuedOperation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AccrualsAndDeferredIncomeIncludingContractLiabilitiesLineItems" name="AccrualsAndDeferredIncomeIncludingContractLiabilitiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfRevenueLineItems" name="DisclosureOfRevenueLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AugustSevenThousandAndTwentyFourMember" name="AugustSevenThousandAndTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AugustFourTwoThousandTwentyFiveMember" name="AugustFourTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ExpectedAmountOfDiscountingAdjustment" name="ExpectedAmountOfDiscountingAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLossesExpirationPeriod" name="ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLossesExpirationPeriod" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_USDollarMember" name="USDollarMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_Warrant1Member" name="Warrant1Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsTable" name="ScheduleOfIncomeStatementOfDiscontinuedOperationsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DepreciationAndAmortizationExpensesInclusiveRightOfUseAmortization" name="DepreciationAndAmortizationExpensesInclusiveRightOfUseAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_JointCollaborationAndResearchAgreementMember" name="JointCollaborationAndResearchAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseInResearchAndDevelopmentExpense" name="DecreaseInResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_UnderlyingStockPriceAtGrantDate" name="UnderlyingStockPriceAtGrantDate" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_JanuaryThirtyTwoThousandTwentyFiveMember" name="JanuaryThirtyTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NonVotingRightsPeriod" name="NonVotingRightsPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ScheduleOfDerivativeInstrumentsPutAndCallOptionsTableTextBlpck" name="ScheduleOfDerivativeInstrumentsPutAndCallOptionsTableTextBlpck" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AdditionalProvisionsIncludingProvisionsForEmployeeBenefits" name="AdditionalProvisionsIncludingProvisionsForEmployeeBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CashInForeignCurrenciesPercentage" name="CashInForeignCurrenciesPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_NumberOfOptionsOrWarrantsExercisedInShareBasedPaymentArrangement" name="NumberOfOptionsOrWarrantsExercisedInShareBasedPaymentArrangement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ProvisionsForRetirementIndemnitiesAdditions" name="ProvisionsForRetirementIndemnitiesAdditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_TypesOfWarrantsAxis" name="TypesOfWarrantsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations" name="OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTaxFromContinuingOperations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_FinancialLiabilityMaturity" name="FinancialLiabilityMaturity" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ShareIssuancePrice" name="ShareIssuancePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_AccruedAndUnpaidInterestAccruedMember" name="AccruedAndUnpaidInterestAccruedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DeconsolidationOfMergedEntity" name="DeconsolidationOfMergedEntity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DiscontinuedOperationsFairValueOfRetainedInvestment" name="DiscontinuedOperationsFairValueOfRetainedInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_FairValueOfExpectedLifeOfDerivativePlusOneMonth" name="FairValueOfExpectedLifeOfDerivativePlusOneMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ProvisionsForEmployeeLitigationAndSeveranceAdditions" name="ProvisionsForEmployeeLitigationAndSeveranceAdditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_MarchFourthTwoThousandAndTwentyOnememberMember" name="MarchFourthTwoThousandAndTwentyOnememberMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AdditionalResearchPlansUnderTheAZJRCAOneMember" name="AdditionalResearchPlansUnderTheAZJRCAOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OtherComprehensiveIncomeLossFromDiscontinuedOperations" name="OtherComprehensiveIncomeLossFromDiscontinuedOperations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AmountToBeRepaid" name="AmountToBeRepaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CashCashAndCashEquivalentsAndCurrentAssetsMember" name="CashCashAndCashEquivalentsAndCurrentAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseInNetDefinedBenefitLiabilityInDiscountRate" name="DecreaseInNetDefinedBenefitLiabilityInDiscountRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_PrincipalMember" name="PrincipalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProceedsFromSaleOfOrdinaryShares" name="ProceedsFromSaleOfOrdinaryShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ConditionalAdvances" name="ConditionalAdvances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsTableTextBlock" name="ScheduleOfCashFlowStatementOfDiscontinuedOperationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ContractualCommitments" name="ContractualCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ResearchTaxCreditSubsidyAmount" name="ResearchTaxCreditSubsidyAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DeferredTaxAssetsFromOtherDeductibleDifferences" name="DeferredTaxAssetsFromOtherDeductibleDifferences" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FunctionalCurrencyPercentage" name="FunctionalCurrencyPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_StateGuaranteedLoanMember" name="StateGuaranteedLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncomeTaxReceivableCurrent" name="IncomeTaxReceivableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FreeSharesMember" name="FreeSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_EstimatedFairValueMember" name="EstimatedFairValueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MarchTwentySevenTwoThousandFifteenMember" name="MarchTwentySevenTwoThousandFifteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_Non-CurrentFixedTermBankDepositsMaturityDate" name="Non-CurrentFixedTermBankDepositsMaturityDate" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_CibusSharesMember" name="CibusSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NumberOfSharesEntitledPerOption" name="NumberOfSharesEntitledPerOption" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsLineItems" name="ScheduleOfCashFlowStatementOfDiscontinuedOperationsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MinimumRevenueToBeAchieved" name="MinimumRevenueToBeAchieved" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_WeightedAverageFairValueAtMeasurementDateShareOptionsGrantedPerShare" name="WeightedAverageFairValueAtMeasurementDateShareOptionsGrantedPerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseInForeignExchangeLosses" name="IncreaseDecreaseInForeignExchangeLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FederalTaxAuthorityMember" name="FederalTaxAuthorityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OctoberElevenTwoThousandSeventeenMember" name="OctoberElevenTwoThousandSeventeenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CommercialLitigationOtherComprehensiveIncome" name="CommercialLitigationOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ProvisionsForEmployeeLitigationAndServerance" name="ProvisionsForEmployeeLitigationAndServerance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_EffectiveInterestRateOfLoan" name="EffectiveInterestRateOfLoan" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_PutOptionsMayTwentySixAndTwentyTwentySixMember" name="PutOptionsMayTwentySixAndTwentyTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ValuationMethod" name="ValuationMethod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_VestingPeriodForShareBasedPaymentArrangements" name="VestingPeriodForShareBasedPaymentArrangements" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CollaborationAgreementDomain" name="CollaborationAgreementDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseInNonCurrentRestrictedCashDueToReclassificationInCurrentAssets" name="DecreaseInNonCurrentRestrictedCashDueToReclassificationInCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_GrantAndRefundableAdvanceAgreementMember" name="GrantAndRefundableAdvanceAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AllocationOfPriorPeriodGainLoss" name="AllocationOfPriorPeriodGainLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_PrepaidExpensesAndOtherCurrentAssetsLineItems" name="PrepaidExpensesAndOtherCurrentAssetsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInCashCashEquivalentsAndFinancialAssets" name="IncreaseDecreaseInCashCashEquivalentsAndFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_IntangibleAssetsAndGoodwillGross" name="IntangibleAssetsAndGoodwillGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FairValuesPerOptions" name="FairValuesPerOptions" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_FinancialLiabilitiesExcludingEIBWarrants" name="FinancialLiabilitiesExcludingEIBWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DescriptionOfPresentationCurrencyExplanatory" name="DescriptionOfPresentationCurrencyExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_SummaryOfCashAndCashEquivalentsAndCurrentFinancialAssetsDenominatedInUnitedStatesDollarsAffectedEquityAndProfitOrLossTableTextBlock" name="SummaryOfCashAndCashEquivalentsAndCurrentFinancialAssetsDenominatedInUnitedStatesDollarsAffectedEquityAndProfitOrLossTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AgreementTwoAxis" name="AgreementTwoAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MarchTwentyNinethousandtwentyTwoMember" name="MarchTwentyNinethousandtwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SeptemberFiveThousandAndTwentyFourMember" name="SeptemberFiveThousandAndTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_TrancheCWarrantsMember" name="TrancheCWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DiscountRate" name="DiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_VotingAgreementWithCibusMember" name="VotingAgreementWithCibusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PersonnelExpensesMember" name="PersonnelExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInPurchasesExternalExpensesAndOther" name="IncreaseDecreaseInPurchasesExternalExpensesAndOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ExpectedDividendsWarrants" name="ExpectedDividendsWarrants" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_FixedTermBankDepositIncludingAccruedInterest" name="FixedTermBankDepositIncludingAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_AgreementExtendedPeriodMember" name="AgreementExtendedPeriodMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_BPIAgreementMember" name="BPIAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseThroughTransferBetweenRetainedEarningsIntoSharePremium" name="IncreaseDecreaseThroughTransferBetweenRetainedEarningsIntoSharePremium" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_NetAssetsLiabilitiesAndEquityDerecognized" name="NetAssetsLiabilitiesAndEquityDerecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FinancialLiabilitiesExcludingEIBWarrantLiability" name="FinancialLiabilitiesExcludingEIBWarrantLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DisclosureOfActivitiesOfCompanyExplanatory" name="DisclosureOfActivitiesOfCompanyExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CollaborationAgreementMilestonePaymentsPlusTieredRoyalties" name="CollaborationAgreementMilestonePaymentsPlusTieredRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DisclosureOfAccountingPolicyForChangesInAccountingEstimatesExplanatory" name="DisclosureOfAccountingPolicyForChangesInAccountingEstimatesExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CurrentFinancialLiabilitiesMember" name="CurrentFinancialLiabilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AgreementOneAxis" name="AgreementOneAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_InitialFairValueOfLoan" name="InitialFairValueOfLoan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_PercentageOfDecreaseInSalaryIncreaseRate" name="PercentageOfDecreaseInSalaryIncreaseRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_StateOperatingLossCarryforwardsExpirationYear" name="StateOperatingLossCarryforwardsExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CurrentFinancialAssetsMember" name="CurrentFinancialAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeSharesAndStockOptionExercises" name="IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeSharesAndStockOptionExercises" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsForfeited" name="WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsForfeited" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CibusGlobalLlcMember" name="CibusGlobalLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_JuneTwentyThreeTwoThousandTwentyFiveMember" name="JuneTwentyThreeTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CashAndCashEquivalentMember" name="CashAndCashEquivalentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ClassBConvertiblePreferredSharesMember" name="ClassBConvertiblePreferredSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CommercialLitigations" name="CommercialLitigations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DescriptionOfVotingRight" name="DescriptionOfVotingRight" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_SocialSecurityContributionsOnStockOptionGrants" name="SocialSecurityContributionsOnStockOptionGrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CompanySharePrice" name="CompanySharePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_CurrentFinancialAssetsAndCashAndCashEquivalents" name="CurrentFinancialAssetsAndCashAndCashEquivalents" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NonCurrentFinancialLiabilitiesMember" name="NonCurrentFinancialLiabilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AdditionForNonCurrentProvision" name="AdditionForNonCurrentProvision" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_FairValueOfSharesInAmount" name="FairValueOfSharesInAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_InitialFairValueAmount" name="InitialFairValueAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DisclosureOfSensitivityOfTheDerivativeFairValueToTheExpectedLifeOfTheDerivativeTextBlock" name="DisclosureOfSensitivityOfTheDerivativeFairValueToTheExpectedLifeOfTheDerivativeTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CurrentSubsidiesReceivables" name="CurrentSubsidiesReceivables" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DescriptionOfAccountingPolicyForGoingConcernExplanatory" name="DescriptionOfAccountingPolicyForGoingConcernExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ImpactOfDeconsolidationOfFinancialStatementsTableTextBlock" name="ImpactOfDeconsolidationOfFinancialStatementsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfTradeReceivablesLineItems" name="DisclosureOfTradeReceivablesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MarchTwentyTwoTwoThousandAndTwentyThreeMember" name="MarchTwentyTwoTwoThousandAndTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfEstimationOfRetirementIndemnityToEmployeeExplanatory" name="DisclosureOfEstimationOfRetirementIndemnityToEmployeeExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisposalsOfRightOfUseAssets" name="DisposalsOfRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_IncomeLossMember" name="IncomeLossMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NovemberThirtyTwoThousandAndTwentyOneMember" name="NovemberThirtyTwoThousandAndTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ExpectedVolatility" name="ExpectedVolatility" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_SensitivityOfDerivativeFairValueToExpectedLifePeriod" name="SensitivityOfDerivativeFairValueToExpectedLifePeriod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseThroughOtherNon-CashMovementsLiabilitiesArisingFromFinancingActivities" name="IncreaseDecreaseThroughOtherNon-CashMovementsLiabilitiesArisingFromFinancingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ReclassificationAdjustmentsOnIntangibleAssets" name="ReclassificationAdjustmentsOnIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_OtherProvisionForChargesMember" name="OtherProvisionForChargesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_StepUpInterestRatePercentageOnNotesReceivable" name="StepUpInterestRatePercentageOnNotesReceivable" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfScopeOfConsolidationAndNonConsolidatedEntitiesAbstract" name="DisclosureOfScopeOfConsolidationAndNonConsolidatedEntitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NumberOfSharesWithADoubleVotingRight" name="NumberOfSharesWithADoubleVotingRight" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_DescriptionOfExpectedTermOfShareOptionsGranted" name="DescriptionOfExpectedTermOfShareOptionsGranted" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_GrantDateAxis" name="GrantDateAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseInPurchasesAndExternalExpenses" name="DecreaseInPurchasesAndExternalExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_MarchFifthTwoThousandAndTwentyOneMember" name="MarchFifthTwoThousandAndTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseDueToRevenueRecognitionContractLiabilities" name="DecreaseDueToRevenueRecognitionContractLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CommercialLitigationAmountsUsedDuringThePeriod" name="CommercialLitigationAmountsUsedDuringThePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DisclosureOfInformationAboutAssumptionsUsedAndValuationResultsTextBlock" name="DisclosureOfInformationAboutAssumptionsUsedAndValuationResultsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_NumberOfAdditionalSharesDueToChangeInConversationRatioExercisableOptions" name="NumberOfAdditionalSharesDueToChangeInConversationRatioExercisableOptions" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_MayTwentyEightTwoThousandAndTwentyOneMember" name="MayTwentyEightTwoThousandAndTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsTable" name="DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfTradeReceivablesTable" name="DisclosureOfTradeReceivablesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FairValueOfWarrants" name="FairValueOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_OtherOperatingIncome1" name="OtherOperatingIncome1" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ExpirationDate" name="ExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CurrentProvisionsOtherComprehensiveIncome" name="CurrentProvisionsOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_MilestoneDomain" name="MilestoneDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OptionVestingPeriod" name="OptionVestingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_TotalNon-CurrentFinancialLiabilitiesAndNon-CurrentLeaseDebtsMember" name="TotalNon-CurrentFinancialLiabilitiesAndNon-CurrentLeaseDebtsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfitAmount" name="AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfitAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ContractualLifeOptions" name="ContractualLifeOptions" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_PercentageOfFairMarketValue" name="PercentageOfFairMarketValue" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseThroughFinancingCashFlowsExcludingInterestPaymentsLiabilitiesArisingFromFinancingActivities" name="IncreaseDecreaseThroughFinancingCashFlowsExcludingInterestPaymentsLiabilitiesArisingFromFinancingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_BankDepositsNotClassifiedAsCashEquivalents" name="BankDepositsNotClassifiedAsCashEquivalents" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_Non-RecurringGainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss" name="Non-RecurringGainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_LegalAndFinanceExternalSupportMember" name="LegalAndFinanceExternalSupportMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_TypesOfWarrantsDomain" name="TypesOfWarrantsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DescriptionOfExpectedTermsOfYearsShareOptionsGranted" name="DescriptionOfExpectedTermsOfYearsShareOptionsGranted" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DeferredTaxLiabilitiesGross" name="DeferredTaxLiabilitiesGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DisclosureOfFinancialAssetsAndLiabilitiesLineItems" name="DisclosureOfFinancialAssetsAndLiabilitiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInInterestExpenseOnLeaseLiabilities" name="IncreaseDecreaseInInterestExpenseOnLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_TypeOfEquityInstrumentsGranted" name="TypeOfEquityInstrumentsGranted" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_OtherProvisionForCharges" name="OtherProvisionForCharges" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_OctoberTwentyEightTwoThousandSixteenMember" name="OctoberTwentyEightTwoThousandSixteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SubscriptionPricePerShare" name="SubscriptionPricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_CellectisMember" name="CellectisMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionsForRetirementIndemnitiesOtherComprehensiveIncome" name="ProvisionsForRetirementIndemnitiesOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ResearchTaxCreditAmount" name="ResearchTaxCreditAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_PutOptionJulyEleventhTwoThousandAndTwentyFiveMember" name="PutOptionJulyEleventhTwoThousandAndTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OtherCurrentLiabilitiesAbstract" name="OtherCurrentLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FinancialDerivativeDerecognized" name="FinancialDerivativeDerecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DisclosureOfRevenueTable" name="DisclosureOfRevenueTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfInformationConcerningGroupsConsolidatedOperartionsExplanatory" name="DisclosureOfInformationConcerningGroupsConsolidatedOperartionsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DeferredTaxAssetsAccumulatedTaxLossCarryforwardsAndFederalResearchAndDevelopmentTaxCredits" name="DeferredTaxAssetsAccumulatedTaxLossCarryforwardsAndFederalResearchAndDevelopmentTaxCredits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CellectisS.a.Member" name="CellectisS.a.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_GrantRefundableAdvanceReceived" name="GrantRefundableAdvanceReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ProvisionOfReversalTaxLitigation" name="ProvisionOfReversalTaxLitigation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ClassAPreferredSharesWithSingleVotingRightsMember" name="ClassAPreferredSharesWithSingleVotingRightsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PrimeraTherapeuticsIncMember" name="PrimeraTherapeuticsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ResearchTaxCreditFinancingsMember" name="ResearchTaxCreditFinancingsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInTaxBenefitArisingFromPermanentDifferences" name="IncreaseDecreaseInTaxBenefitArisingFromPermanentDifferences" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentGranted" name="WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentGranted" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ConversionOfNotesReceivableIntoTradeReceivable" name="ConversionOfNotesReceivableIntoTradeReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLosses" name="ResearchAndDevelopmentTaxCreditsTaxEffectOfTaxLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncreaseInNumberOfPreferredShares" name="IncreaseInNumberOfPreferredShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_PreferredSharesConversionRatio" name="PreferredSharesConversionRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_NonCurrentLeaseDebtsMember" name="NonCurrentLeaseDebtsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FairValueSIADerivative" name="FairValueSIADerivative" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NumberOfOperatingAndReportableSegments" name="NumberOfOperatingAndReportableSegments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_OtherComprehensiveIncomeReclassificationAdjustmentOnDeconsolidationOfMergedEntity" name="OtherComprehensiveIncomeReclassificationAdjustmentOnDeconsolidationOfMergedEntity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DeferredTaxAssetsCreditsAndNetOperatingLossCarryforwards" name="DeferredTaxAssetsCreditsAndNetOperatingLossCarryforwards" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_AverageLifeOfOptions" name="AverageLifeOfOptions" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ChangeInFairValue" name="ChangeInFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsTableTextBlock" name="ScheduleOfIncomeStatementOfDiscontinuedOperationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CurrentLiabilitiesOtherMember" name="CurrentLiabilitiesOtherMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NonCurrentDerivativeInstrumentsMember" name="NonCurrentDerivativeInstrumentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfRevenueAndOtherIncomeExplanatoryTableTextBlock" name="DisclosureOfRevenueAndOtherIncomeExplanatoryTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsOutstanding" name="WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentsOutstanding" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_DerecognitionOfDerivative" name="DerecognitionOfDerivative" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_NoncurrentFinancialLiabilitiesAndNoncurrentLeaseDebtsProceedsFromDebts" name="NoncurrentFinancialLiabilitiesAndNoncurrentLeaseDebtsProceedsFromDebts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesLineItems" name="DisclosureOfInformationAboutConsolidatedAndNonConsolidatedStructuredEntitiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfPotentiallyDilutiveInstrumentsExplanatory" name="DisclosureOfPotentiallyDilutiveInstrumentsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ProvisionsForRetirementIndemnitiesReversals" name="ProvisionsForRetirementIndemnitiesReversals" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CellectisIncMember" name="CellectisIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AgreementTwoDomain" name="AgreementTwoDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CommercialLitigationMember" name="CommercialLitigationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AstraZenecaMember" name="AstraZenecaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_EuropeanInvestmentBankWarrantsMember" name="EuropeanInvestmentBankWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NonCurrentFinancialAssetsMember" name="NonCurrentFinancialAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SubsidiesReceivablesMember" name="SubsidiesReceivablesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ResearchTaxCreditsFinancingArrangement" name="ResearchTaxCreditsFinancingArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_IncreaseInNetDefinedBenefitLiabilityInDiscountRate" name="IncreaseInNetDefinedBenefitLiabilityInDiscountRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_WarrantExercisePrice" name="WarrantExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_OtherProvisionForChargesOtherComprehensiveIncome" name="OtherProvisionForChargesOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_MilestoneAxis" name="MilestoneAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_BorrowingExtendedPeriod" name="BorrowingExtendedPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_FollowOnOfferingMember" name="FollowOnOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MarchTwentyFourTwoThousandFifteenMember" name="MarchTwentyFourTwoThousandFifteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfFinancialAssetsAndLiabilitiesTable" name="DisclosureOfFinancialAssetsAndLiabilitiesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AverageLifeOptions" name="AverageLifeOptions" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_AstraZenecaIrelandMember" name="AstraZenecaIrelandMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_RetirementIndemnitiesMember" name="RetirementIndemnitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DerivativesByNameDomain" name="DerivativesByNameDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_Receivables1Abstract" name="Receivables1Abstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ClassAConvertiblePreferredSharesMember" name="ClassAConvertiblePreferredSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FairValueOfDerivative" name="FairValueOfDerivative" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_OperationBetweenShareholder" name="OperationBetweenShareholder" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_RetirementAge" name="RetirementAge" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ConsolidatedOperationsTable" name="ConsolidatedOperationsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CellectisBiologicsIncMember" name="CellectisBiologicsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CapitalEvolution2023Member" name="CapitalEvolution2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DeferredTaxLiabilitiesFromOtherTaxableDifferences" name="DeferredTaxLiabilitiesFromOtherTaxableDifferences" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AgreeementAxis" name="AgreeementAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_JointResearchAndCollaborationAgreementInitialInvestmentAgreementSubsequentInvestmentAgreementMember" name="JointResearchAndCollaborationAgreementInitialInvestmentAgreementSubsequentInvestmentAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeShares" name="IncreaseInNumberOfOrdinarySharesIssuedDueToVestingOfFreeShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreasedInBaseRentForSettingTheAmountOfDeposit" name="IncreasedInBaseRentForSettingTheAmountOfDeposit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FairValueOfExpectedVolatilityAmountPlusFivePercentage" name="FairValueOfExpectedVolatilityAmountPlusFivePercentage" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncomeTaxAuthoritiesDomain" name="IncomeTaxAuthoritiesDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ScheduleOfOutstandingBalancesWithRelatedPartiesExplanatoryTableTextBlock" name="ScheduleOfOutstandingBalancesWithRelatedPartiesExplanatoryTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_NumberOfSharesToBeIssued" name="NumberOfSharesToBeIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_FairValuePerOptions" name="FairValuePerOptions" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AdjustmentsForIncreaseDecreaseInTradeAccountPayableAndOtherCurrentLiabilities" name="AdjustmentsForIncreaseDecreaseInTradeAccountPayableAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NonRecognitionOfDeferredTaxAssets" name="NonRecognitionOfDeferredTaxAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_MilestoneReceived" name="MilestoneReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_SignificantUnobservableInputProbabilityOfTransactionCompletion" name="SignificantUnobservableInputProbabilityOfTransactionCompletion" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_ReclassificationInCurrentFinancialAssets" name="ReclassificationInCurrentFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_SubleaseStartTerm" name="SubleaseStartTerm" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationAboutOtherCurrentLiabilitiesExplanatory" name="DisclosureOfDetailedInformationAboutOtherCurrentLiabilitiesExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_LicenseAgreementWithServierMember" name="LicenseAgreementWithServierMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ResearchTaxCredit" name="ResearchTaxCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_MaximumNumberOfExclusiveLicenseForProductCandidates" name="MaximumNumberOfExclusiveLicenseForProductCandidates" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_PercentageOfProbabilityOfTransactionCompletion" name="PercentageOfProbabilityOfTransactionCompletion" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_ConsolidatedOperationsLineItems" name="ConsolidatedOperationsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CollaborationAgreementAxis" name="CollaborationAgreementAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_TotalCurrentFinancialLiabilitiesAndLeaseDebts" name="TotalCurrentFinancialLiabilitiesAndLeaseDebts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_LicenseAndCollaborationAgreementsMember" name="LicenseAndCollaborationAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PercentageOfShareholdingDilutedOfMergedEntity" name="PercentageOfShareholdingDilutedOfMergedEntity" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_WeightedAverageExercisePriceOfShareOptionsExercisableExercisedInShareBasedPaymentArrangements" name="WeightedAverageExercisePriceOfShareOptionsExercisableExercisedInShareBasedPaymentArrangements" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AdjustmentsForIncreaseDecreaseInDeferredRevenueAndContractLiabilities" name="AdjustmentsForIncreaseDecreaseInDeferredRevenueAndContractLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DecemberNineTwoThousandTwentyFiveMember" name="DecemberNineTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_StockOption1Member" name="StockOption1Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfNumberAndWeightedAverageGrantDateFairValueOfOtherEquityInstrumentsExplanatory" name="DisclosureOfNumberAndWeightedAverageGrantDateFairValueOfOtherEquityInstrumentsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DeferredExpensesAndOtherCurrentAssets" name="DeferredExpensesAndOtherCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_AugustfivetwothousandtwentyMember" name="AugustfivetwothousandtwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ClassBPreferredSharesMember" name="ClassBPreferredSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SubscriptionPricePerShareOptionsGranted" name="SubscriptionPricePerShareOptionsGranted" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseOnLoanInterest" name="IncreaseDecreaseOnLoanInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_KeyManagementPersonnelCompensationShareBasedPaymentsInShares" name="KeyManagementPersonnelCompensationShareBasedPaymentsInShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfit" name="AnnualLimitToCarryforwardsUseAgainstFutureTaxableProfit" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_CommercialLitigationsReversal" name="CommercialLitigationsReversal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_FairValueInstrumentRemeasured" name="FairValueInstrumentRemeasured" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_CallOptionMayThirteenthTwoThousandAndTwentyFiveMember" name="CallOptionMayThirteenthTwoThousandAndTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NumberOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourShareBasedPaymentArrangement" name="NumberOfShareOptionsAdditionalSharesDueToMayTwentyTwentyFourShareBasedPaymentArrangement" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ProceedsFromIssueOfShareCapitalAndOtherEquityInstrumentsAfterDeductionOfTransactionCosts" name="ProceedsFromIssueOfShareCapitalAndOtherEquityInstrumentsAfterDeductionOfTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ProvisionForTaxLitigationReversals" name="ProvisionForTaxLitigationReversals" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_OperatingExpenseAbstract" name="OperatingExpenseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseThroughFinancingCashFlowsInterestPaymentLiabilitiesArisingFromFinancingActivities" name="DecreaseThroughFinancingCashFlowsInterestPaymentLiabilitiesArisingFromFinancingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DeferredRevenues" name="DeferredRevenues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DecreaseInOtherOperatingIncomeExpenses" name="DecreaseInOtherOperatingIncomeExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AdditionalManufacturingActivitiesToSupportRDPipelineMember" name="AdditionalManufacturingActivitiesToSupportRDPipelineMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ConditionalAdvancesMember" name="ConditionalAdvancesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AcquisitionRelatedRightToLicence" name="AcquisitionRelatedRightToLicence" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FixedInterestRate" name="FixedInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_LeaseRemainingPeriod" name="LeaseRemainingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_NovemberSevenTwoThousandTwentyFiveMember" name="NovemberSevenTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PutOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember" name="PutOptionsFebruaryTwentyFifthTwoThousandAndTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CashReceivedRelatedToIncreaseDecreaseInWorkingCapital" name="CashReceivedRelatedToIncreaseDecreaseInWorkingCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_FixedTermBankDepositMaturityPeriod" name="FixedTermBankDepositMaturityPeriod" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_RiskFreeInterestRate" name="RiskFreeInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_AmendedAndRestatedAgreementMember" name="AmendedAndRestatedAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseInPurchasesAndExternalExpenses" name="IncreaseInPurchasesAndExternalExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_AgreementOneDomain" name="AgreementOneDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInAccrualsForPersonnelRelatedExpense" name="IncreaseDecreaseInAccrualsForPersonnelRelatedExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CalyxtIncMember" name="CalyxtIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProportionOfOwnershipInterest" name="ProportionOfOwnershipInterest" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_PercentageOfIncreaseInSalaryIncreaseRate" name="PercentageOfIncreaseInSalaryIncreaseRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseInNonCurrentDeposits" name="IncreaseInNonCurrentDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DecreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate" name="DecreaseInNetDefinedBenefitLiabilityInSalaryIncreaseRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_GainInFairValueOfForeignExchangeDerivatives" name="GainInFairValueOfForeignExchangeDerivatives" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_NumberOfFreeSharesVested" name="NumberOfFreeSharesVested" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CommercialLitigationsAdditions" name="CommercialLitigationsAdditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_EmployeeLitigationAndSeveranceMember" name="EmployeeLitigationAndSeveranceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInWagesAndSalaries" name="IncreaseDecreaseInWagesAndSalaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_LossInFinancialExpenses" name="LossInFinancialExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DeferredTaxAssetsPensionCommitments" name="DeferredTaxAssetsPensionCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DisclosureOfScheduleOfOffBalanceSheetCommitmentsExplanatory" name="DisclosureOfScheduleOfOffBalanceSheetCommitmentsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_CurrentLeaseLiabilitiesMember" name="CurrentLeaseLiabilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FinanceIncomeExpenseAbstract" name="FinanceIncomeExpenseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DerivativesByNameAxis" name="DerivativesByNameAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CarryforwardsThatCanBeOffsetAgainstFutureTaxableProfitPercentageProfitExceedingLimit" name="CarryforwardsThatCanBeOffsetAgainstFutureTaxableProfitPercentageProfitExceedingLimit" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_EuropeanInvestmentBankLoanTrancheCMember" name="EuropeanInvestmentBankLoanTrancheCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OctoberOneThreeTwoThousandTwentyOneMember" name="OctoberOneThreeTwoThousandTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NumberOfWarrantsIssued" name="NumberOfWarrantsIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsLineItems" name="DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_Non-CurrentLeaseLiabilitiesMember" name="Non-CurrentLeaseLiabilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DerivativeInstrumentsFairValue" name="DerivativeInstrumentsFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_TransactionCosts" name="TransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_WeightedAverageExercisePriceOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements" name="WeightedAverageExercisePriceOfShareOptionsExercisableGrantedInShareBasedPaymentArrangements" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_VolatilityMember" name="VolatilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ReserachTaxCreditReceivableCurrent" name="ReserachTaxCreditReceivableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ClassAPreferredSharesMember" name="ClassAPreferredSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PercentageOfDerivativeFairValueProbabilityOfTransactionCompletion" name="PercentageOfDerivativeFairValueProbabilityOfTransactionCompletion" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_FairValueOfExpectedVolatilityAmountLessFivePercentage" name="FairValueOfExpectedVolatilityAmountLessFivePercentage" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_TextBlock1Abstract" name="TextBlock1Abstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DeferredTaxAssetsCapitalizationOfResearchAndDevelopmentExpenses" name="DeferredTaxAssetsCapitalizationOfResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_JanuaryTwentyFiveThousandAndTwentyFourMember" name="JanuaryTwentyFiveThousandAndTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NovemberTwentyFifthTwoThousandAndTwentyOneMember" name="NovemberTwentyFifthTwoThousandAndTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfOtherReceivablesPrepaymentsAndOtherCurrentAssetsAbstract" name="DisclosureOfOtherReceivablesPrepaymentsAndOtherCurrentAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FinancingTaxReceivblePercentage" name="FinancingTaxReceivblePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_MarchFourteenTwoThousandSixteenMember" name="MarchFourteenTwoThousandSixteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NonCurrentProvisionsOtherComprehensiveIncome" name="NonCurrentProvisionsOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_WarrantsIssued" name="WarrantsIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationAboutFairValueSharePriceTextBlock" name="DisclosureOfDetailedInformationAboutFairValueSharePriceTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_OtherProvisionForChargesAdditions" name="OtherProvisionForChargesAdditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_OtherSubsidiesAmount" name="OtherSubsidiesAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DevelopmentMilestoneReceived" name="DevelopmentMilestoneReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_MaturityByGrantDateDomain" name="MaturityByGrantDateDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PercentageOfTaxableIncomeSubjectToAnnualLimitation" name="PercentageOfTaxableIncomeSubjectToAnnualLimitation" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_MilestonePayment" name="MilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_InitialInvestmentAgreementMember" name="InitialInvestmentAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ClassesOfCommitmentsAxis" name="ClassesOfCommitmentsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SpotSharePricePerShare" name="SpotSharePricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_NumberOfExercisableShareOptionsExercisedInShareBasedPaymentArrangement" name="NumberOfExercisableShareOptionsExercisedInShareBasedPaymentArrangement" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_PercentageOfIncreaseInDiscountRate" name="PercentageOfIncreaseInDiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ResearchTaxCreditReceivable" name="ResearchTaxCreditReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CellectisIncAndCellectisBiologicsIncMember" name="CellectisIncAndCellectisBiologicsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_TermsOfRepayment" name="TermsOfRepayment" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_TotalFairValue" name="TotalFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ReversalOfCurrentProvisions" name="ReversalOfCurrentProvisions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ServierMember" name="ServierMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_NumberOfCashGeneratingUnit" name="NumberOfCashGeneratingUnit" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsAbstract" name="DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsAndAwardsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_GainInFinancialExpenses" name="GainInFinancialExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_PensionMember" name="PensionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_SubsequentInvestmentAgreementMember" name="SubsequentInvestmentAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfRevenueByNatureExplanatory" name="DisclosureOfRevenueByNatureExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DeferredRevenueIncludingUpfrontPayment" name="DeferredRevenueIncludingUpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_AdditionalResearchPlansUnderTheAZJRCATwoMember" name="AdditionalResearchPlansUnderTheAZJRCATwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DeferredTaxLiabilitiesAcceleratedDepreciationOfAssetsForTaxPurposes" name="DeferredTaxLiabilitiesAcceleratedDepreciationOfAssetsForTaxPurposes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock" name="DisclosureOfCurrentFinancialAssetsAndCashAndCashEquivalentsExplanatoryTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_OtherOperatingExpenses" name="OtherOperatingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_NovemberFourTwoThousandAndTwentyFourMember" name="NovemberFourTwoThousandAndTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PrepaidExpensesAndOtherCurrentAssetsTable" name="PrepaidExpensesAndOtherCurrentAssetsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IssuancePricePerShare" name="IssuancePricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_NumberOfOrdinarySharesReceived" name="NumberOfOrdinarySharesReceived" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfDeferredIncomeAndContractLiabilitiesExplanatory" name="DisclosureOfDeferredIncomeAndContractLiabilitiesExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfDetailedInformationAboutBreakdownOfRightOfUseAssetsExplanatory" name="DisclosureOfDetailedInformationAboutBreakdownOfRightOfUseAssetsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_GauranteedBorrowingAmountPercentage" name="GauranteedBorrowingAmountPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_FairValueProbabilityOfTransactionCompletionLessTwoPercent" name="FairValueProbabilityOfTransactionCompletionLessTwoPercent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_EffectsOfProfitAndLossAndEquityNetOfTaxAxis" name="EffectsOfProfitAndLossAndEquityNetOfTaxAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecemberNineteenTwoThousandAndTwentyTwoMember" name="DecemberNineteenTwoThousandAndTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_InterestAccrued" name="InterestAccrued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_NovemberEightThousAndTwentyTwoMember" name="NovemberEightThousAndTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseInResearchAndDevelopmentExpense" name="IncreaseInResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_SharePriceWarrants" name="SharePriceWarrants" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_InvesteeDomain" name="InvesteeDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_MilestoneAchievementRelatedToDosingOfFirstSubjectInPhaseIMember" name="MilestoneAchievementRelatedToDosingOfFirstSubjectInPhaseIMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_OtherProvisionForChargesReversals" name="OtherProvisionForChargesReversals" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_VariableConsiderationAmount" name="VariableConsiderationAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_PercentageChangeSensistivity" name="PercentageChangeSensistivity" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ScheduleOfIncomeStatementOfDiscontinuedOperationsLineItems" name="ScheduleOfIncomeStatementOfDiscontinuedOperationsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInIncomeFromCashCashEquivalentsAndFinancialAssets" name="IncreaseDecreaseInIncomeFromCashCashEquivalentsAndFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_EquityNetOfTaxStrengtheningMember" name="EquityNetOfTaxStrengtheningMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PutOptionMayThirteenthTwoThousandAndTwentyFiveMember" name="PutOptionMayThirteenthTwoThousandAndTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DepreciationImpairmentExpense" name="DepreciationImpairmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_LeasePotentialObligations" name="LeasePotentialObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ClinicalAndRdAgreementsMember" name="ClinicalAndRdAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_GainInFairValueOfSiaDerivativeInstrument" name="GainInFairValueOfSiaDerivativeInstrument" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_ClassOfSharesDomain" name="ClassOfSharesDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DisclosureOfDetailedFinancialLiabilitiesExplanatory" name="DisclosureOfDetailedFinancialLiabilitiesExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_PerformanceStockUnitMember" name="PerformanceStockUnitMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ResearchTaxCreditFinancingMember" name="ResearchTaxCreditFinancingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ClassAAndBPreferredSharesMember" name="ClassAAndBPreferredSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AggregateCreditFacility" name="AggregateCreditFacility" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_IncreaseDecreaseInResearchTaxCredit" name="IncreaseDecreaseInResearchTaxCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_LeaseAgreementTerm" name="LeaseAgreementTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_FixturesFittingsAndOtherEquipmentMember" name="FixturesFittingsAndOtherEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DecreaseInFinancialIncome" name="DecreaseInFinancialIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DilutedEarningsLossPerShareFromDiscontinuedOperationsAttributableToOrdinaryEquityHoldersOfParentEntity" name="DilutedEarningsLossPerShareFromDiscontinuedOperationsAttributableToOrdinaryEquityHoldersOfParentEntity" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ExpirationPeriodOfStockOptionPlan" name="ExpirationPeriodOfStockOptionPlan" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ExerciseOfShareWarrantsAndEmployeeWarrantsShares" name="ExerciseOfShareWarrantsAndEmployeeWarrantsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IntangibleAssetsAndGoodwillAccumulatedDepreciationAndImpairment" name="IntangibleAssetsAndGoodwillAccumulatedDepreciationAndImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentVested" name="WeightedAverageFairValueAtMeasurementDateOtherEquityInstrumentVested" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_TaxEffectOfNonRecognitionOfDeferredTaxAssetsRelatedToTaxLossesAndTemporaryDifferences" name="TaxEffectOfNonRecognitionOfDeferredTaxAssetsRelatedToTaxLossesAndTemporaryDifferences" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_LeasedEquipmentMember" name="LeasedEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_PercentageOfDecreaseInDiscountRate" name="PercentageOfDecreaseInDiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_DisclosureOfDetailedFinancialLiabilitiesAndLeaseDebtsExplanatory" name="DisclosureOfDetailedFinancialLiabilitiesAndLeaseDebtsExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_IncreaseDecreaseInFinancialExpenses" name="IncreaseDecreaseInFinancialExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_ResearchTaxCreditNonCurrentFinancialAssets" name="ResearchTaxCreditNonCurrentFinancialAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_DescriptionOfAccountingPolicyForAccountingTreatmentOfSignificantTransactionsOfPeriodExplanatory" name="DescriptionOfAccountingPolicyForAccountingTreatmentOfSignificantTransactionsOfPeriodExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clls_ItLicensingAgreementsMember" name="ItLicensingAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ScheduleOfCashFlowStatementOfDiscontinuedOperationsTable" name="ScheduleOfCashFlowStatementOfDiscontinuedOperationsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_FinancialLiabilitiesExcludingTradesPayableAndOtherCurrentLiabilities" name="FinancialLiabilitiesExcludingTradesPayableAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_FairValueProbabilityOfTransactionCompletionPlusTwoPercent" name="FairValueProbabilityOfTransactionCompletionPlusTwoPercent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_RiskFreeRateMember" name="RiskFreeRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AgreementDomain" name="AgreementDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_ProvisionsForRetirementIndemnitiesAmountsUsedDuringThePeriod" name="ProvisionsForRetirementIndemnitiesAmountsUsedDuringThePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AmericanDepositorySharesMember" name="AmericanDepositorySharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_CallOptionsMayTwentySixAndTwentyTwentySixMember" name="CallOptionsMayTwentySixAndTwentyTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_IncreaseDecreaseInFinancialIncome" name="IncreaseDecreaseInFinancialIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_AccumulatedTaxLosses" name="AccumulatedTaxLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_CurrentLeaseDebtsMember" name="CurrentLeaseDebtsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_DeferredTaxAssetsLeasesLiabilities" name="DeferredTaxAssetsLeasesLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_IncreaseDecreaseThroughChangesInForeignExchangeRatesContractLiabilities" name="IncreaseDecreaseThroughChangesInForeignExchangeRatesContractLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_WarrantExpirationDate" name="WarrantExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clls_FinanceAdvance" name="FinanceAdvance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clls_OtherNonCurrentFinancialLiabilitiesMember" name="OtherNonCurrentFinancialLiabilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_LaboratoryEquipmentMember" name="LaboratoryEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clls_AdditionsDeletionsOtherThanThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill" name="AdditionsDeletionsOtherThanThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clls_PurchasesAndExternalExpenses" name="PurchasesAndExternalExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
</xsd:schema>
