Stock Option Plans and Warrants to Purchase Common Stock (Tables)
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12 Months Ended |
Dec. 31, 2025 |
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| Grant 2025 plan |
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| Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
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| Schedule of shares available for grant under the 2015 plan |
| | | Shares available for grant at plan approval | | 6,000,000 | Shares granted | | (20,000) | Options granted | | (670,088) | Shares available for grant at December 31, 2025 | | 5,309,912 |
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| Stock options |
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| Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
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| Schedule of activity under the 2005 plan and the 2015 plan |
| | | | | | | | | | Weighted | | | | | Average | | | | | Exercise | | | Options | | Price | Balance outstanding at December 31, 2023 | | 56,609 | | $ | 90.58 | Granted | | 173,740 | | | 3.35 | Forfeited | | (430) | | | 1,549.28 | Balance outstanding at December 31, 2024 | | 229,919 | | $ | 21.94 | Granted | | 670,088 | | | 1.64 | Forfeited | | (6,652) | | | 96.46 | Balance outstanding at December 31, 2025 | | 893,355 | | $ | 6.15 |
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| Schedule of weighted-average exercise price, by price range, for outstanding options to purchase common stock |
| | | | | | | | | Weighted | | | | | | | Average | | | | | | | Remaining | | | | | | | Contractual | | Outstanding | | Exercisable | Price Range | | Life in Years | | Options | | Options | $1.37 - $10.78 | | 9.62 | | 882,107 | | 321,844 | $129.60 - $640.80 | | 4.83 | | 11,168 | | 11,168 | $1,776.00 | | 0.46 | | 80 | | 80 | Total | | 9.56 | | 893,355 | | 333,092 |
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| Share-based Payment Arrangement |
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| Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
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| Schedule of share-based compensation expense |
| | | | | | | Share-based compensation | | 2025 | | 2024 | Research and development | | $ | 204,848 | | $ | 131,917 | General and administrative | | | 382,735 | | | 197,898 | Total | | $ | 587,583 | | $ | 329,815 |
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| Warrants |
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| Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
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| Schedule of warrant activity |
| | | | | | | | | | | | Weighted | | | | | | Average | | | | | | Exercise | | | Warrants | | Price | Balance at December 31, 2023 | | | 408,640 | | $ | 24.00 | Granted | | | 2,334,382 | | | 2.73 | Exercised | | | (1,275,441) | | | 3.71 | Balance at December 31, 2024 | | | 1,467,581 | | $ | 11.01 | Granted (1) | | | 7,047,040 | | | 1.06 | Exercised | | | (1,716,480) | | | 0.18 | Balance at December 31, 2025 | | | 6,798,141 | | $ | 2.36 |
| (1) | Excludes pre-funded warrants issued in connection with public offerings. |
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| Schedule of remaining life, by grant date, for outstanding warrants |
| | | | | | | | | | | | | | | Remaining | | | | | | | Exercise | | Contractual | | Outstanding | | Exercisable | Grant Date | | Price | | Life in Years | | Warrants | | Warrants | May 09, 2023 | | $ | 24.00 | | 2.35 | | 303,139 | | 303,139 | April 22, 2024 | | | 6.40 | | 3.31 | | 2,377 | | 2,377 | September 25, 2025 | | | 1.35 | | 4.74 | | 1,162,065 | | 1,162,065 | September 29, 2025 | | | 1.35 | | 4.75 | | 5,330,560 | | 5,330,560 | Total | | | | | | | 6,798,141 | | 6,798,141 |
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